CN104430569A - Disinfectant for cleaning CT equipment and preparation method thereof - Google Patents
Disinfectant for cleaning CT equipment and preparation method thereof Download PDFInfo
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Abstract
The invention discloses disinfectant for cleaning CT equipment. The disinfectant comprises the bulk drugs in parts by weight: 0.5-2 parts of castor-oil plants, 2-4 parts of hydrogen peroxide, 1-3 parts of salicylic acid, 1.5-2.5 parts of ethanol, 2-4 parts of potassium iodide, 1-5 parts of sophocarpidine, 2-6 parts of folium artemisiae argyi, 3-6 parts of alginate, and 110-140 parts of water. The disinfectant for cleaning CT equipment is colorless and transparent in appearance and stable in physical and chemical indicators; crystals, turbidity and precipitants are avoided in the use process, and the expressions of all physical and chemical indicators are stable. Compared with the prior art, the disinfectant prepared by the invention is low in production cost, simple in preparation process, high in product stability, and easy for realizing the process conditions.
Description
Technical field
The present invention relates to a kind of thimerosal, being specifically related to a kind of thimerosal for cleaning CT equipment and method for making.
Background technology
CT (Computed Tomography), i.e. CT scan, it is the x-ray bundle, gamma-rays, ultrasonic etc. that utilize Accurate collimation, profile scanning one by one together made by the detector high with sensitivity around a certain position of human body, there is sweep time fast, the features such as clear picture, can be used for the inspection of various diseases; Can be divided into according to adopted ray difference: X ray CT (X-CT), ultrasound computed tomography (UCT) and gamma-rays CT (γ-CT) etc.
CT scans the certain thickness aspect in human body portion with X-ray beam, the X-ray through this aspect is received by detector, after changing visible ray into, the signal of telecommunication is become from opto-electronic conversion, numeral is transferred to again, input computer disposal through analog/digital converter (analog/digital converter).The process that image is formed is divided into the identical cuboid of several volumes just like to selected aspect, is referred to as voxel (voxel).Scanning gained information obtains X-ray attenuation coefficient or the absorption coefficient of each voxel as calculated, and rearrange into matrix, i.e. character matrix (digital matrix), character matrix can be stored in disk or CD.Through digital/analog converter (digital/analog converter), each numeral in character matrix is transferred to by the black blockage to the white gray scale such as not, i.e. pixel (pixel), and press matrix arrangement, i.e. formation CT image.So CT image rebuilds image.The X-ray absorption coefficient of each voxel can be calculated by different mathematical methods.The working procedure of CT is such: it according to human body different tissues to the absorption of x-ray and the different of transmitance, the instrument applying sensitivity high is measured human body, then the data input electronic computer obtained will be measured, after electronic computer processes data, just can photograph human body and be examined the section at position or the image of solid, find the tiny pathology at any position in body.
Equipment forms: CT bed (16) CT equipment mainly contains following three parts: 1. sweep test is made up of X-ray tube, detector and scanning support; 2. computer system, carries out storage computing by scanning the information data collected; 3. image display and storage system, be presented at the image of machine process as calculated, reconstruction in TV screen or with several cameras or laser camera and photographed by image.Detector develops into nearly 4800 from original 1.Scan mode also from translation/rotation, rotation/rotate, rotation/fixing, develops into the CT scan (spiral CT scan) recently developed.Computer capacity is large, computing is fast, can reach and rebuild image immediately.Because sweep time is short, can avoid the artifact produced of moving, such as, respirometric interference, can improve picture quality; Aspect is continuous print, misses pathology so be unlikely, and feasible three-dimensional reconstruction, and injection of contrast medium does angiogram can obtain CT angiogram (Ct angiography, CTA).It is completely different from the former that UFCT Ultra-fast Computed Tomograph scans scan mode used.Sweep time can be short to below 40ms, per secondly obtains multiple image.Because sweep time is very short, film image can be taken the photograph to obtain, the artifact that causes of moving can be avoided, therefore, be applicable to the patient that angiocardiography inspection and children's and acute injury etc. can not well cooperate and check.
At present, a kind of thimerosal for cleaning CT equipment specially is seldom had in existing patent, publication number 101720760A (application number 200810157978.3) patent discloses a kind of multifunctional disinfectant for haemodialysis machine, its with ricinoleic acid and hydrogen peroxide for primary raw material, add stabilizing agent potassium iodide, EDETATE DISODIUM, oxine mixes, concrete composition percentage by weight is: ricinoleic acid 4.0%-6.0%, hydrogen peroxide 18.0%-22.0%, potassium iodide 0.3%-1.5%, EDETATE DISODIUM 0.3%-1.0%, 8-oxyquinoline 0.3%-1.0%, surplus is water.Publication number 103766377A (application number 201210416140.8) patent discloses a kind of citric acid decalcification thimerosal being applied in dialysis machine and water treatment and preparation method thereof, this thimerosal comprises polyhexamethylene guanide, citric acid, matrine, malic acid, and surplus is deionized water.The component proportion of described thimerosal is polyhexamethylene guanide 0.001-5.0%, citric acid 10-50%, matrine 20.0%-40%, malic acid 10% ~ 30%, surplus are deionized water.This thimerosal is that primary raw material is formulated by citric acid, polyhexamethylene guanide, matrine and malic acid.Publication number 101664043 (application number 200910307991.7) patent discloses a kind of for sterilizing, the thimerosal of cleaning water channel of hemodialysis machine and preparation method thereof, be made up of citric acid, acid regulator, acid protease, high purity water and hydrogen peroxide; Wherein acid regulator sterilization, mass concentration in cleaning water channel of hemodialysis machine thimerosal be 2%-5%, the mass concentration of acid protease in sterilization, cleaning water channel of hemodialysis machine thimerosal be 3000-6000SAPU/100ml, the mass concentration of hydrogen peroxide in sterilization, cleaning water channel of hemodialysis machine thimerosal is 8%-10%, the mass concentration of citric acid in sterilization, cleaning water channel of hemodialysis machine thimerosal is 40%-50%.
As can be seen here, thimerosal, in cleaning Medical Devices, has good bactericidal effect, but the prior art comprising above-mentioned patent document also comes with some shortcomings, first, existing correlation technique is also fewer, and the door do not had is for a kind of thimerosal for cleaning CT equipment.
Summary of the invention
The technical problem to be solved in the present invention overcomes the shortcoming for CT equipment disinfection and thimerosal poor stability in prior art, an object of the present invention be to provide a kind of formula rationally, stable performance, easy to use, safety, nontoxic stability are preferably for the thimerosal of CT equipment disinfection, and another object is just to provide the preparation method of above-mentioned thimerosal.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
For cleaning a thimerosal for CT equipment, the weight proportion of each bulk drug is as follows, ricinoleic acid 0.5-2 part, hydrogen peroxide 2-4 part, salicylic acid 1-3 part, ethanol 1.5-2.5 part, potassium iodide 2-4 part, matrine 1-5 part, tarragon 2-6 part, alginates 3-6 part, water 110-140 part.
According to the foregoing thimerosal for cleaning CT equipment, preferred scheme is: the weight proportion of each bulk drug is as follows: ricinoleic acid 1-1.5 part, hydrogen peroxide 2.5-3.5 part, salicylic acid 1.5-2.5 part, ethanol 1.8-2.3 part, potassium iodide 2.5-3.5 part, matrine 2-4 part, tarragon 3-5 part, alginates 4-5 part, water 120-130 part.
According to the foregoing thimerosal for cleaning CT equipment, better preferred scheme is, the weight proportion of each bulk drug is as follows, ricinoleic acid 1.3 parts, hydrogen peroxide 3 parts, salicylic acid 2 parts, ethanol 2 parts, potassium iodide 3 parts, matrine 3 parts, tarragon 4 parts, alginates 4.5 parts, 125 parts, water.
According to the preparation method of the thimerosal for cleaning CT equipment above described in any one, comprise the following steps:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 3-8 minute, as in the hot pot dryouied, frying 5-10 minute, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls is placed in marmite adds ethanol, stir, slightly boil in a covered pot over a slow fire after soaking 10-30 minute after 1-3 hour, intense fire decocts to boiling, seethes with excitement after 3-7 minute, ceases fire, matrine and alginates are added after cooling, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 5-7 hour, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
According to foregoing preparation method, step (1) ultraviolet-sterilization 4-7 minute (preferred, ultraviolet-sterilization 6 minutes).
According to foregoing preparation method, step (1) frying 7-9 minute (preferred, frying 8 minutes).
According to foregoing preparation method, step (2) is slightly stewing to be soaked after 1.5-2.5 hour 15-25 minute (preferred, slightly to boil in a covered pot over a slow fire and soak 20 minutes after 2 hours).
According to foregoing preparation method, after step (2) is seethed with excitement 4-6 minute, very fire (preferred, to seethe with excitement after 5 minutes, cease fire).
According to foregoing preparation method, step (3) left standstill after 5.5-6.5 hour, rocked 10 times to obtain buffer solution (preferred, to leave standstill after 6 hours, rock 10 times to obtain buffer solution gently) gently.
Being described below of each raw material:
Ricinoleic acid: castor oil acid, another name ricinoleic acid; 12-hydroxyl, cis-9-18 carbon monoenoic acid, purposes one: for the preparation of surfactant, plasticizer, lube oil additive, also for the preparation of decanedioic acid, enanthic acid etc., purposes two: for the production of decanedioic acid and undecenoic acid etc., also for the preparation of polymers manufacturing, textile finishing and contraceptive jelly.
Hydrogen peroxide: hydrogen peroxide chemistry formula is H2O2, and pure hydrogen peroxide is nattier blue thick liquid, can mix with water by arbitrary proportion, and be a kind of strong oxidizer, the aqueous solution is commonly called as hydrogen peroxide, is colourless transparent liquid.Its aqueous solution is applicable to medical wound sterilization and environment disinfected and food sterilization.Can resolve into water and oxygen in the ordinary course of things, but decomposition rate is extremely slow, the way accelerating its reaction velocity adds catalyzer---manganese dioxide or irradiate with short-wave ray.The purposes of hydrogen peroxide divides medical, military and industrial three kinds, daily sterilization be medical hydrogen peroxide, medical hydrogen peroxide can kill pathogenic entero becteria, pyococcus, and pathogenic yeast bacterium, is generally used for surface disinfection.
Salicylic acid: effect: have antibacterial (comprising fungi), the effect such as antipruritic.High concentration has the effect of dissolving cutin.Main and benzoic acid etc. is made into various external preparation and is used for the treatment of dermatophytid infection.Local embrocated antipruritic, anti-inflammatory, antibacterial, carry out the effects such as mould.Also treatment corn and wart is usually used in.
Ethanol: ethanol is a kind of organic matter, is commonly called as alcohol, molecular formula is CH3CH2OH (C2H6O), it is the saturated monohydroxy alcohol with a hydroxyl, be a kind of inflammable, volatile colourless transparent liquid under normal temperature, normal pressure, its aqueous solution has the smell of aroma, and slightly excitant.There is the pungent flavour of smells of wine and stimulation, micro-sweet.Solvent; Organic synthesis; The crystallization of various compound; Washing agent; Extractant; Edible alcohol can concocted white spirit; As adhesive; Nitro sprays paint; The manufacture raw material of the solvent of varnish, cosmetics, ink, paint stripper etc. and agricultural chemicals, medicine, rubber, plastics, staple fibre, washing agent etc., antifreezing agent, fuel, disinfectant etc. can also be done.The ethanolic solution of 75% is usually used in medical treatment sterilization.
Potassium iodide: white cubic crystal or powder.Micro-in humid air have hygroscopicity, is long placed in and separates out free-iodine and yellowing, and can form micro iodine hydrochlorate.Pharmaceutically for preventing and treating endemic goiter, promoting the absorption of vitreum muddiness and eliminating the phlegm.Potassium iodide prepares the raw material of iodide and dyestuff.As the cosolvent of photosensitive emulsifier, food additives, iodine and some insoluble metal iodide.Also can be used as analytical reagent, chromatographic analysis and some pain to analyze.Potassium iodide is stabilizing agent and cosolvent, and the potassium iodide of feed grade also can cook the replenishers as iodine in feed manufacturing.
Matrine: matrine is made up through Solvent Extract methods such as ethanol of the dry root of leguminous plant kuh-seng, plant, fruit, is alkaloid.Be generally Banlangen, its main component has the multiple alkaloids such as matrine, sophocarpine, N-Oxysophocarpine, Sophoridine, the highest with matrine, oxymatrine concentration.1, diuresis kuh-seng is as medicinal plant, has had the history of more than 2,000 year in China according to literature record, and main function has the effects such as heat-clearing, diuresis, desinsection, clearing damp, also has the multiple effects such as antiviral, anti-tumor is irritated simultaneously.2, antipathogen effect decoction is in test tube, and high concentration (1: 100) has inhibitory action to tubercle bacillus.Decoction (8%) water decoction has inhibitory action in various degree to some common dermatophyte in vitro.3, other effect matrines are injected in rabbit: discovery nervous centralis paralysis phenomenon, with raw spasm, dead by breathing stopping eventually.Be injected in frog: just in excited, continue, benumb, breathe and become slow and irregular, finally spasm occurs, so that breathe and to stop and dead.The outbreak system of its spasm results from spinal reflex.4, the plain alkali of anti-B-mode and hepatitis C virus toxic effect Oxymatrine of Oxymatrine element alkali in vitro and show in animal model and have strong antiviral activity to HBV, in human body, have Anti-HBV activity effect equally, existing many reports are used for the treatment of chronic viral hepatitis.
Tarragon: tarragon is the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl.et Vant..Most of China area is all produced.It is good for producing wild wormwood with basin, Central Plains Nanyang, henan Funiu Shan Mountain arteries and veins, claims " Qi Ai ", and because it obtains rustic suitable, leaf is thick and suede is many, and as the material of moxibustion treatment, power is maximum.Pluck when summer, flower was not opened, removing impurity, dries or dries in the shade.Tarragon taste is pungent, bitter, warm in nature, slightly poisonous, has warming channel for arresting bleeding, eliminating cold to stop pain, effect of antiabortive, wet down desinsection.
Alginates: alginates have another name called sodium alginate, seaweed gel, algin, sodium alginate, alginates are by the natural polysaccharide carbohydrate extracted in sea-tangle.Be widely used in the products such as food, medicine, weaving, printing and dyeing, papermaking, daily-use chemical industry, as uses such as thickener, emulsifier, stabilizing agent, adhesive, sizing agents.
The thimerosal appearance colorless of the CT equipment disinfection of the present invention's development is transparent, physical and chemical index stable performance, has no crystallization, muddiness, precipitation during use, and every physical and chemical index performance is stable.Compared with prior art the present invention prepares that disinfectant production cost is low, preparation technology is simple, process conditions are easy to realize, and product stability is good.
Embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds for cleaning the thimerosal of CT equipment, the weight proportion of each bulk drug following (getting 2g for every part): ricinoleic acid 0.5 part, hydrogen peroxide 2 parts, salicylic acid 1 part, ethanol 1.5 parts, potassium iodide 2 parts, matrine 1 part, tarragon 2 parts, alginates 3 parts, 110 parts, water.
A kind of preparation process of the thimerosal for cleaning CT equipment is as follows:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 3 minutes, as in the hot pot dryouied, frying 5 minutes, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls be placed in marmite add ethanol, stir, slightly stewing soak 10 minutes after 1 hour after, intense fire decocts to boiling, seethe with excitement after 3 minutes, cease fire, after cooling, add matrine and alginates, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 5 hours, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
Stability test 1: get a kind of thimerosal for cleaning CT equipment of above-described embodiment 1 gained, stability test is carried out, storage condition: at 37 DEG C, testing environment: temperature 30 DEG C with reference to " disinfection technology standard " 2002 editions, relative moisture 40%-44%, result is as shown in table 1 below:
Table 1
Proved by 37 DEG C of accelerated tests, a kind of active ingredient ricinoleic acid of the thimerosal for cleaning CT equipment and the content of hydrogen peroxide of embodiment 1 gained do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Showing having good stability of a kind of thimerosal for cleaning CT equipment of the present invention, in storage and transportation, a large amount of decomposition can not occur.
Embodiment 2 one kinds for cleaning the thimerosal of CT equipment, the weight proportion of each bulk drug following (getting 2g for every part): ricinoleic acid 2 parts, hydrogen peroxide 4 parts, salicylic acid 3 parts, ethanol 2.5 parts, potassium iodide 4 parts, matrine 5 parts, tarragon 6 parts, alginates 6 parts, 140 parts, water.
A kind of preparation process of the thimerosal for cleaning CT equipment is as follows:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 8 minutes, as in the hot pot dryouied, frying 10 minutes, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls be placed in marmite add ethanol, stir, slightly stewing soak 30 minutes after 3 hours after, intense fire decocts to boiling, seethe with excitement after 7 minutes, cease fire, after cooling, add matrine and alginates, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 7 hours, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
Stability test 2: get a kind of thimerosal for cleaning CT equipment of above-described embodiment 2 gained, carries out stability test, storage condition with reference to " disinfection technology standard " 2002 editions: 37 DEG C of placements.Testing environment: temperature 30 DEG C, relative moisture 40%-44%.Result is as shown in table 2 below:
Table 2
Proved by 37 DEG C of accelerated tests, a kind of active ingredient ricinoleic acid of the thimerosal for cleaning CT equipment and the content of hydrogen peroxide of embodiment 2 gained do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Showing having good stability of a kind of thimerosal for cleaning CT equipment of the present invention, in storage and transportation, a large amount of decomposition can not occur.
Embodiment 3 one kinds for cleaning the thimerosal of CT equipment, the weight proportion of each bulk drug following (getting 2g for every part): ricinoleic acid 1 part, hydrogen peroxide 2.5 parts, salicylic acid 1.5 parts, ethanol 1.8 parts, potassium iodide 2.5 parts, matrine 2 parts, tarragon 3 parts, alginates 5 parts, 130 parts, water.
A kind of preparation process of the thimerosal for cleaning CT equipment is as follows:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 4 minutes, as in the hot pot dryouied, frying 7 minutes, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls be placed in marmite add ethanol, stir, slightly stewing soak 15 minutes after 1.5 hours after, intense fire decocts to boiling, seethe with excitement after 4 minutes, cease fire, after cooling, add matrine and alginates, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 5.5 hours, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
Stability test 3: get a kind of thimerosal for cleaning CT equipment prepared by above-described embodiment 3, carries out stability test, storage condition with reference to " disinfection technology standard " 2002 editions: place at 37 DEG C.Testing environment: temperature 30 DEG C, relative moisture 40%-44%.Result is as shown in table 3 below:
Table 3
Proved by 37 DEG C of accelerated tests, a kind of active ingredient ricinoleic acid of the thimerosal for cleaning CT equipment and the content of hydrogen peroxide of embodiment 3 gained do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Showing having good stability of a kind of thimerosal for cleaning CT equipment of the present invention, in storage and transportation, a large amount of decomposition can not occur.
Embodiment 4 one kinds for cleaning the thimerosal of CT equipment, the weight proportion of each bulk drug following (getting 2g for every part): ricinoleic acid 1.5 parts, hydrogen peroxide 3.5 parts, salicylic acid 2.5 parts, ethanol 2.3 parts, potassium iodide 3.5 parts, matrine 4 parts, tarragon 5 parts, alginates 5 parts, 130 parts, water.
A kind of preparation process of the thimerosal for cleaning CT equipment is as follows:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 7 minutes, as in the hot pot dryouied, frying 9 minutes, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls be placed in marmite add ethanol, stir, slightly stewing soak 20 minutes after 2 hours after, intense fire decocts to boiling, seethe with excitement after 5 minutes, cease fire, after cooling, add matrine and alginates, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 6 hours, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
Embodiment 5 one kinds for cleaning the thimerosal of CT equipment, the weight proportion of each bulk drug following (getting 2g for every part), ricinoleic acid 1.3 parts, hydrogen peroxide 3 parts, salicylic acid 2 parts, ethanol 2 parts, potassium iodide 3 parts, matrine 3 parts, tarragon 4 parts, alginates 4.5 parts, 125 parts, water.
A kind of preparation process of the thimerosal for cleaning CT equipment is as follows:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 6 minutes, as in the hot pot dryouied, frying 8 minutes, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls be placed in marmite add ethanol, stir, slightly stewing soak 20 minutes after 2 hours after, intense fire decocts to boiling, seethe with excitement after 5 minutes, cease fire, after cooling, add matrine and alginates, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 6 hours, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
Experimental example 1: to embodiment 5 prepare thimerosal with the sterilization Simulation field test to CT equipment such as hemolytic streptococcus, pneumococcus, proteus, Escherichia coli:
Get several gram-positive bacteria and several Gram-negative bacteria suspension respectively to drip and contaminate in the coating of polyfluortetraethylene pipe inside evenly, be placed in 37 DEG C of constant incubators dry, prepare bacterial carrier.With the product of gained of the present invention for disinfectant, carry out cleaning and sterilizing according to CT equipment disinfection step, result is as shown in following table 4 and table 5:
The bactericidal effect of this thimerosal of table 4
The bactericidal effect of this thimerosal of table 5
+: grow ,-: do not grow
Find out from table 4 and table 5, this product has good disinfection effect, second just can be lethal at 10-15 for general bacterium.
Experimental example 2: in order to verify the disinfection effect of embodiment 5 gained thimerosal, get hemolytic streptococcus respectively, pneumococcus, proteus, Escherichia coli suspension drip and contaminate in the coating of polyfluortetraethylene pipe inside evenly, be placed in 37 DEG C of constant incubators dry, prepare bacterial carrier.By the bacterial carrier prepared, be divided into two groups, experimental group and control group, experimental group uses the product of gained of the present invention for disinfectant, cleaning and sterilizing is carried out according to CT equipment disinfection step, control group is with other disinfectants to the sterilization of CT equipment (the such as routine disinfection agent such as lysol, 84 thimerosals), and result is as shown in table 6 below:
Table 6 is for gained thimerosal of the present invention is to the kill oncomelania of bacterium
Result: two groups of sterilization comparitive study, this product is to the hemolytic streptococcus contaminated on polyfluortetraethylene pipe, pneumococcus, proteus and colibacillary kill oncomelania > 5.89, obvious bactericidal effect is better than control group, shows that this product has good disinfection effect.
With reference to embodiments of the invention, explanation is given to the present invention above.But these embodiments are only for illustrative purposes, and are not intended to limit the scope of the invention.Scope of the present invention is by claims and equivalents thereof.Do not depart from the scope of the present invention, those skilled in the art can make a variety of substitutions and modifications, and these substitutions and modifications all should fall within the scope of the present invention.
Claims (9)
1. for cleaning a thimerosal for CT equipment, it is characterized in that: the weight proportion of each bulk drug is as follows, ricinoleic acid 0.5-2 part, hydrogen peroxide 2-4 part, salicylic acid 1-3 part, ethanol 1.5-2.5 part, potassium iodide 2-4 part, matrine 1-5 part, tarragon 2-6 part, alginates 3-6 part, water 110-140 part.
2. the thimerosal for cleaning CT equipment according to claim 1, it is characterized in that: the weight proportion of each bulk drug is as follows: ricinoleic acid 1-1.5 part, hydrogen peroxide 2.5-3.5 part, salicylic acid 1.5-2.5 part, ethanol 1.8-2.3 part, potassium iodide 2.5-3.5 part, matrine 2-4 part, tarragon 3-5 part, alginates 4-5 part, water 120-130 part.
3. the thimerosal for cleaning CT equipment according to claim 1, is characterized in that: the weight proportion of each bulk drug is as follows, ricinoleic acid 1.3 parts, hydrogen peroxide 3 parts, salicylic acid 2 parts, ethanol 2 parts, potassium iodide 3 parts, matrine 3 parts, tarragon 4 parts, alginates 4.5 parts, 125 parts, water.
4. the preparation method of the thimerosal for cleaning CT equipment according to any one of claim 1-3, is characterized in that: comprise the following steps:
(1) cleaned by tarragon, drain away the water, ultraviolet-sterilization 3-8 minute, as in the hot pot dryouied, frying 5-10 minute, dries in the air cool, and it is stand-by to grind to form smalls;
(2) step (1) gained smalls is placed in marmite adds ethanol, stir, slightly boil in a covered pot over a slow fire after soaking 10-30 minute after 1-3 hour, intense fire decocts to boiling, seethes with excitement after 3-7 minute, ceases fire, matrine and alginates are added after cooling, after stirring, filter, filtrate is for subsequent use;
(3) step (2) gained filtrate adds in special Agitation Tank together with salicylic acid, after mixing completely, add ricinoleic acid, leaves standstill after 5-7 hour, rocks 10 times to obtain buffer solution gently, then places stand-by in the cool by buffer solution;
(4) hydrogen peroxide and potassium iodide are joined in step (3) gained gained buffer solution, until completely dissolved, bottle and obtain thimerosal.
5. preparation method according to claim 4, is characterized in that: step (1) ultraviolet-sterilization 4-7 minute (preferred, ultraviolet-sterilization 6 minutes).
6. preparation method according to claim 4, is characterized in that: step (1) frying 7-9 minute (preferred, frying 8 minutes).
7. preparation method according to claim 4, is characterized in that: step (2) is slightly stewing to be soaked after 1.5-2.5 hour 15-25 minute (preferred, slightly to boil in a covered pot over a slow fire and soak 20 minutes after 2 hours).
8. preparation method according to claim 4, is characterized in that: after step (2) is seethed with excitement 4-6 minute, very fire (preferred, to seethe with excitement after 5 minutes, cease fire).
9. preparation method according to claim 4, is characterized in that: step (3) left standstill after 5.5-6.5 hour, rocks 10 times to obtain buffer solution (preferred, to leave standstill after 6 hours, rock 10 times to obtain buffer solution gently) gently.
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| CN201410685696.6A Pending CN104430569A (en) | 2014-11-25 | 2014-11-25 | Disinfectant for cleaning CT equipment and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293781A (en) * | 2011-09-05 | 2011-12-28 | 王琴 | Low-corrosive cleaning solution |
| CN102657245A (en) * | 2012-04-19 | 2012-09-12 | 沃德国泰(北京)科技发展有限公司 | Disinfectant prepared from plant extracts as well as preparation method for disinfectant |
| CN102960342A (en) * | 2011-09-01 | 2013-03-13 | 沈新荣 | Telephone disinfection solution |
| CN103548887A (en) * | 2013-10-08 | 2014-02-05 | 青岛叁鼎卫生制品有限公司 | Plant sterilizing liquid for tableware |
| CN103548883A (en) * | 2013-10-25 | 2014-02-05 | 卢逸凡 | Disinfectant |
| CN104126609A (en) * | 2014-08-20 | 2014-11-05 | 张光荣 | Disinfectant for cleaning colposcope and preparation method of disinfectant |
-
2014
- 2014-11-25 CN CN201410685696.6A patent/CN104430569A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102960342A (en) * | 2011-09-01 | 2013-03-13 | 沈新荣 | Telephone disinfection solution |
| CN102293781A (en) * | 2011-09-05 | 2011-12-28 | 王琴 | Low-corrosive cleaning solution |
| CN102657245A (en) * | 2012-04-19 | 2012-09-12 | 沃德国泰(北京)科技发展有限公司 | Disinfectant prepared from plant extracts as well as preparation method for disinfectant |
| CN103548887A (en) * | 2013-10-08 | 2014-02-05 | 青岛叁鼎卫生制品有限公司 | Plant sterilizing liquid for tableware |
| CN103548883A (en) * | 2013-10-25 | 2014-02-05 | 卢逸凡 | Disinfectant |
| CN104126609A (en) * | 2014-08-20 | 2014-11-05 | 张光荣 | Disinfectant for cleaning colposcope and preparation method of disinfectant |
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