CN104126609A - Disinfectant for cleaning colposcope and preparation method of disinfectant - Google Patents
Disinfectant for cleaning colposcope and preparation method of disinfectant Download PDFInfo
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- CN104126609A CN104126609A CN201410411179.XA CN201410411179A CN104126609A CN 104126609 A CN104126609 A CN 104126609A CN 201410411179 A CN201410411179 A CN 201410411179A CN 104126609 A CN104126609 A CN 104126609A
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- thimerosal
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- 238000004140 cleaning Methods 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 239000000645 desinfectant Substances 0.000 title abstract description 16
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- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 58
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- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000224483 Coccidia Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a disinfectant for cleaning a colposcope. The disinfectant consists of the following components in percentage by weight: 0.5-1.0 percent of peroxyacetic acid, 2.0-5.0 percent of hydrogen peroxide, 0.1-0.5 percent of chlorhexidine hydrochloride, 0.01-0.05 percent of phenol, 1.0-5.0 percent of salicylic acid, 2.0-6.0 percent of trichloroisocyanuric acid and the rest of water. The colposcope cleaning disinfectant prepared by the preparation method disclosed by the invention is colorless and transparent in appearance; the physical and chemical index performance is stable; during use, crystals, turbidity and precipitates are not generated; all physical and chemical indexes are stable. Compared with the prior art, the disinfectant has the advantages that the production cost is low, the preparation technology is simple, the technical conditions are easy to implement, and the product stability is high.
Description
Technical field
The present invention relates to a kind of thimerosal, be specifically related to a kind of for cleaning colpomicroscopic thimerosal and preparation method thereof.
Background technology
Vaginoscope (colposcope) is one of gynaecology's endoscope, also be the important way of male women's diseases early diagnosis, be applicable to the diagnosis of various cervical diseases and genital lesion, it can amplify 10～60 times by the image observing, and finds the not detectable minute lesion of naked eyes.By this amplification effect, doctor can be clear that focus details extremely small on uterine cervix epidermis and sexual organ epidermis, contribute to improve the accuracy rate of the pathologies such as judgement uterine neck, sexual organ, for the early diagnosis of disease provides foundation, patient is obtained the effective treatment in advance, the cure rate of disease is improved greatly.When carrying out vaginoscopy, only need expose vagina, uterine neck and sexual organ with vaginal speculum, apart from introitus or sexual organ approximately 20 centimeters, by vaginoscope alignment lens uterine neck or sexual organ epicuticle tissue, bring into focus, by computer screen, observe uterine neck image or the sexual organ epicuticle image amplifying.Computer can store and these images of playback, is convenient to follow-up observation result for the treatment of.In checking process, patient's no pain.Therefore, vaginoscope has been widely used in the inspection of vagina, cervical disease, genital lesion, is described as doctor's " piercing eye ".Thereby be deeply subject to liking of extensive patients and doctor, be widely used.
Vaginoscope classification: 1. by Function Classification: (1) diagnosis type vaginoscope claims again standard type vaginoscope: this vaginoscope is only applicable to conduct a survey, and supply vaginoscope menisectomy without any particular energy source coupling.(2) diagnoses and treatment type vaginoscope: this type vaginoscope is that plain edition vaginoscope and any particular energy source are combined, as laser associative form vaginoscope etc., this vaginoscope can be done local laser surgey making the colposcopic coaxial laser that is equipped with simultaneously.2. by imaging genealogical classification: (1) Optical colposcope: refer to by the vaginoscope of optical lens system imaging.(2) electronic colposcope: refer to by CCD, optical information be changed into the vaginoscope of digital information imaging.3. by data storage mode, classify: (1) plain edition vaginoscope: refer to not contain calculator part in vaginoscope annex, colposcopy consults reference materials and still with traditional handwriting mode, preserves.IMAQ take take a picture and camera as main.(2) computerization vaginoscope: refer to include in optics or electronic colposcope annex calculator picture and text information management system part, vaginoscope data is stored in calculator with the computerization language of standard and real time image collection the mode of depositing.4. by machinery classification: vaginoscope is divided into two large series, is respectively electronic colposcope and photoelectric integral vaginoscope.Electronic colposcope is use at first a kind of, utilizes digital electric image technology to diagnose cervical disease by vaginoscope imaging system; Photoelectric integral vaginoscope integrates microscope optical system and electronic colposcope imaging system advantage and a new generation of designing is applied to the sophisticated equipment of cervical lesions clinical diagnosis.
Vaginoscope structure: 1. Optical colposcope Optical colposcope mainly contains mirror body, support, light source and the most of composition of annex four.(1) mirror body: be positioned at the top of support, be provided with gradient and regulate and left and right adjusting handle, guarantee that mirror body can freely rotate.There are two object lens in the place ahead, light source outlet and color filter film.There is binocular eyepiece rear end, and binocular spacing regulates and is as the criterion with examiner's interocular distance, makes the doubling of the image of bilateral eyepiece, becomes the stereo-picture an of the best.(2) support: two kinds of minute land formula and suspension types.The selection of support depends primarily on the condition of vaginoscope clinic.(3) light source: have two kinds of the outer cold light sources of mirror inner light source and mirror.(4) annex: comprise photographic system (common photograph, stereographic and Polaroid system), pick-up and picture recording system, print system and calculator picture and text information management system etc.2. electronic colposcope: electronic colposcope comprises camera part, processor part, the Lights section, holder part and software section.Photoelectric integral vaginoscope comprises cold light source part, opticator, processor part and software section.
At present, in existing patent, seldom there is the colpomicroscopic thimerosal of special cleaning, publication number 101720760A(application number 200810157978.3) patent discloses a kind of multifunctional disinfectant for haemodialysis machine, it take Peracetic acid and hydrogen peroxide is primary raw material, interpolation stabilizing agent salicylic acid, EDETATE DISODIUM, oxine mix, the concrete percentage by weight that forms is: Peracetic acid 4.0%-6.0%, hydrogen peroxide 18.0%-22.0%, salicylic acid 0.3%-1.5%, EDETATE DISODIUM 0.3%-1.0%, oxine 0.3%-1.0%, surplus is water.Publication number 103766377A(application number 201210416140.8) patent discloses a kind of citric acid decalcification thimerosal that is applied in dialysis machine and water treatment and preparation method thereof, this thimerosal comprises polyhexamethylene guanide, citric acid, lactic acid, malic acid, and surplus is deionized water.The component proportion of described thimerosal is that polyhexamethylene guanide 0.001-5.0%, citric acid 10-50%, lactic acid 20.0%-40%, malic acid 10%～30%, surplus are deionized water.This thimerosal is to be that primary raw material is formulated by citric acid, polyhexamethylene guanide, lactic acid and malic acid.Publication number 101664043(application number 200910307991.7) patent disclose a kind of for sterilizing, the thimerosal of cleaning water channel of hemodialysis machine and preparation method thereof, by citric acid, acid regulator, acid protease, high purity water and hydrogen peroxide, made; Wherein the mass concentration of acid regulator in sterilization, cleaning water channel of hemodialysis machine thimerosal is that 2%-5%, the mass concentration of acid protease in sterilization, cleaning water channel of hemodialysis machine thimerosal are that 3000-6000 SAPU/100ml, the mass concentration of hydrogen peroxide in sterilization, cleaning water channel of hemodialysis machine thimerosal are 8%-10%, and the mass concentration of citric acid in sterilization, cleaning water channel of hemodialysis machine thimerosal is 40%-50%.
As can be seen here, thimerosal, aspect cleaning Medical Devices, has good bactericidal effect, but the prior art that comprises above-mentioned patent documentation also comes with some shortcomings, first, existing correlation technique is also fewer, and the door not having is for cleaning the thimerosal of vagina illuminating apparatus.
Summary of the invention
The technical problem to be solved in the present invention is the shortcoming that overcomes the cleaning of prior art medial vagina illuminating apparatus and thimerosal poor stability, one of object of the present invention be to provide a kind of formula rationally, stable performance, easy to use, safety, nontoxic stability are cleaned for vagina illuminating apparatus and the thimerosal of sterilization preferably.Another object is just to provide the preparation method of above-mentioned thimerosal.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Be used for cleaning colpomicroscopic thimerosal, in components by weight percent, Peracetic acid 0.5%-1.0%, hydrogen peroxide 2.0%-5.0%, chlorhexidine hydrochloride 0.1%-0.5%, phenol 0.01%-0.05%, salicylic acid 1.0%-5.0%(is preferred, salicylic acid 1.2%-4.5%; Be more preferably salicylic acid 3.5%), sym-closene 2.0%-6.0%, surplus is water.
According to foregoing for cleaning colpomicroscopic thimerosal, preferred scheme is: in components by weight percent: Peracetic acid 0.6%-0.9%, hydrogen peroxide 2.5%-4.5%, chlorhexidine hydrochloride 0.2%-0.4%, phenol 0.02%-0.04%, salicylic acid 2.0%-4.0%, sym-closene 3.0%-5.0%, surplus is water.
According to foregoing, for cleaning colpomicroscopic thimerosal, better preferred scheme is, in components by weight percent, and Peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, salicylic acid 3.0%, sym-closene 4.0%, surplus is water.
According to described in any one above for cleaning the preparation method of colpomicroscopic thimerosal, comprise the following steps:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 2-6 minute, add sym-closene, after standing 1-3 hour, add water, at 40-60 ℃, stir after 0.5-1.5 hour and obtain buffer solution, then by be down to-5-0 ℃ of buffer solution temperature;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.5-1 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
According to foregoing preparation method, preferred scheme is: step (1) added sym-closene after 3-5 minute, added water (preferably add sym-closene after 4 minutes, add water after standing 2 hours) after standing 1.5-2.5 hour.
According to foregoing preparation method, preferred scheme is: step (1) stirs after 0.6-0.8 hour to obtain buffer solution (preferably stir at 50 ℃ after 1 hour buffer solution) at 45-55 ℃.
According to foregoing preparation method, preferred scheme is: step (1) is down to-4 to-2 ℃ (preferably buffer solution temperature being down to-3 ℃) by buffer solution temperature.
According to foregoing preparation method, preferred scheme is: step (2) continues to stir 0.5-0.8 hour obtaining thimerosal (preferably continuing to stir 0.6 hour to obtain thimerosal).
According to foregoing preparation method, preferred scheme is: the aperture of the described miillpore filter of step (3) is that the preferred aperture of 0.10-0.45 μ m(is 0.22 μ m).
According to arbitrary described for cleaning the application of colpomicroscopic thimerosal when the thimerosal for the preparation of vagina illuminating apparatus, B ultrasonic instrument, CT machine above.
Being described below of each raw material:
Peracetic acid: be colourless liquid, there is the typical smell of acetic acid.Peracetic acid is strong oxidizer.Medical industry is used as drinking-water, food and prevents the disinfectant of infectious disease.Peracetic acid is strong oxidizer, there is very strong oxidisability, chance organic matter is emitted nascent oxygen and is played oxidation, be used as medical treatment or the use of life disinfecting drug with clorox (having another name called 84 thimerosals), bleaching powder etc., for efficient, quick-acting, low toxicity, wide-spectrum bactericide, bacterial propagule, gemma, virus, mould are all had to killing action.Therefore can carry out sterilization, sterilization with it.In addition, because Peracetic acid has stronger volatility in air, to air carry out sterilization, sterilization has good effect, and low price, our sterilization, the disinfectant when prevention SARS is exactly mainly Peracetic acid at present.
Hydrogen peroxide: be commonly called as hydrogen peroxide, have faint special odor, can be used as disinfectant.Pure hydrogen peroxide is nattier blue oily liquids.Can with any ratio, mix with water, ethanol or ether.Hydrogen peroxide is the liquid of colourless irritant smell.In medical treatment, conventional 3% hydrogen peroxide carries out wound or tympanitis sterilization.When wound, fester or the dirt of it and skin, oral cavity and mucous membrane meet, decompose immediately and generate oxygen.This oxygen atom that is not yet combined into oxygen molecule, has very strong oxidability, while contacting with bacterium, can destroy bacterium thalline, kills bacterium.After kill bacteria, remaining material is without any murder by poisoning, without the water of any spread effect.Can not form secondary pollution.Therefore, hydrogen peroxide is the desirable disinfectant of wound disinfection.But it should be noted that and can not carry out wound disinfection with the large hydrogen peroxide of concentration, in case skin ambustion and affected part.
Chlorhexidine hydrochloride: chlorhexidine hydrochloride is disinfection preservative, its restraining and sterilizing bacteria effect is wide and strong, stronger than the antibacterial effects of negative mattress to Gram-positive mattress, than quaternary cationic surfactant, is strong, also effective to fungi, but invalid to acid fast bacteria, brood cell and virus.Still effective when having serum, blood to exist.To organizing nonirritant, be white or white crystalline powder almost; Odorless, bitter.Atomic water-soluble, be slightly soluble in ethanol, be slightly dissolved in propane diols.
Phenol: phenol (Phenol, C6H5OH) is a kind of colourless acicular crystal with special odor, poisonous is the important source material of producing some resin, bactericide, preservative and medicine (as aspirin).Also can be used for for surgical instruments and the excremental processing of sterilizing skin sterilization, antipruritic and tympanitis.Under normal temperature, be slightly soluble in water, be soluble in organic solvent; When temperature is during higher than 65 ℃, can with arbitrary proportion, dissolve each other with water.Phenol is corrosive, and after contact, can make local protein denaturation, and its solution is stained with available alcohol washing on skin.Phenol is exposed in air and is oxidized by oxygen as quinone pinkiness.
Salicylic acid: salicylic acid is a kind of fat-soluble organic acid, so it can easily disintegrate the unnecessary sebum of skin surface, suppress sebum excessive secretion simultaneously, for also having stronger dissolution because sebum stops up the keratotic plug, the small pox that form, improve the unclean state of follicular wall, help sebum to get rid of smoothly from pore, by antibacterial characteristic, receive fast dry small pox simultaneously.Salicylic acid can dissolved cell and cell between material for connecting, make aging cutin cell from skin surface fast-falling, thereby promote the metabolism of skin, recover the careful sense of touch of skin.The pigment deposition on skin top layer usually occurs in unsound horn cell layer, uses salicylic acid can help to peel off this one deck aging cutin cell, just as mirror, is wiped clean and again recovers bright and clear impression clearly afterwards.In addition, salicylic acid can be assisted the infiltration of other acids whitening compositions, and salicylic acid is often made stabilizing agent and used.
Sym-closene, organic compound, white crystalline powder or granular solids, have strong chlorine pungent taste.Sym-closene is a kind of extremely strong oxidant and chlorinating agent, has efficient, wide spectrum, safer disinfective action, and bacterium, virus, fungi, gemma etc. are had to killing action, and coccidian oocyst is also had to certain killing effect.Almost all fungies, bacterium, viral gemma are had to killing action, to killing hepatitis A, hepatitis B has special efficacy, venereal disease poison and AIDS virus are also had to good Disinfection Effect, and safe and convenient to use, this product can also be widely used in food, dairy produce, rice paddy seed is processed, fruit freshness preserving, fiber bleached, wool shrinkproof, daily-use chemical industry decolouring, wood mould papermaking, the aspects such as rubber oxidation and battery material.
The vaginoscope of the present invention's development cleans and thimerosal appearance colorless is transparent, physical and chemical index stable performance, has no during use crystallization, muddiness, precipitation, and every physical and chemical index performance is stable.Compared with prior art the present invention prepares that disinfectant production cost is low, preparation technology is simple, process conditions are easy to realize, and product stability is good.
Embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1for cleaning a colpomicroscopic thimerosal, in components by weight percent: Peracetic acid 0.5%, hydrogen peroxide 2.0%, chlorhexidine hydrochloride 0.1%, phenol 0.01%, salicylic acid 1.0%, sym-closene 2.0%, surplus is water.
A kind of as follows for cleaning the preparation process of colpomicroscopic thimerosal:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 2 minutes, add sym-closene, after standing 1 hour, add water, at 40 ℃, stir after 0.5 hour and obtain buffer solution, then buffer solution temperature is down to-5 ℃;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.3 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 1:get above-described embodiment 1 gained for the thimerosal of vaginoscope cleaning and sterilizing, with reference to < < disinfection technology standard > > 2002 editions, carry out stability test, storage condition: at 37 ℃, testing environment: 30 ℃ of temperature, relative moisture 40%-44%.Result is as shown in table 1 below:
Table 1
By 37 ℃ of accelerated tests, prove, the active ingredient Peracetic acid of the thimerosal for vaginoscope cleaning and sterilizing of embodiment 1 gained and the content of hydrogen peroxide do not have to decline substantially, only have a small amount of hydrogen peroxide to decompose; Show that the present invention, for the having good stability of the thimerosal of vaginoscope cleaning and sterilizing, a large amount of decomposition can not occur in storage and transportation.
embodiment 2for cleaning a colpomicroscopic thimerosal, in components by weight percent: Peracetic acid 1.0%, hydrogen peroxide 5.0%, chlorhexidine hydrochloride 0.5%, phenol 0.05%, salicylic acid 5.0%, sym-closene 6.0%, surplus is water.
A kind of as follows for cleaning the preparation process of colpomicroscopic thimerosal:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 6 minutes, add sym-closene, after standing 3 hours, add water, at 60 ℃, stir after 1.5 hours and obtain buffer solution, then buffer solution temperature is down to 0 ℃;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 1 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 2:get above-described embodiment 2 gained for the thimerosal of vaginoscope cleaning and sterilizing, with reference to < < disinfection technology standard > > 2002 editions, carry out stability test, storage condition: 37 ℃ of placements.Testing environment: 30 ℃ of temperature, relative moisture 40%-44%.Result is as shown in table 2 below:
Table 2
By 37 ℃ of accelerated tests, prove, the active ingredient Peracetic acid of the thimerosal for vaginoscope cleaning and sterilizing of embodiment 2 gained and the content of hydrogen peroxide do not have to decline substantially, only have a small amount of hydrogen peroxide to decompose; Show that the present invention, for the having good stability of the thimerosal of vaginoscope cleaning and sterilizing, a large amount of decomposition can not occur in storage and transportation.
embodiment 3for cleaning a colpomicroscopic thimerosal, in components by weight percent: Peracetic acid 0.6%, hydrogen peroxide 2.5%, chlorhexidine hydrochloride 0.2%, phenol 0.02%, salicylic acid 2.0%, sym-closene 3.0%, surplus is water.
A kind of as follows for cleaning the preparation process of colpomicroscopic thimerosal:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 3 minutes, add sym-closene, after standing 1.5 hours, add water, at 45 ℃, stir after 0.8 hour and obtain buffer solution, then buffer solution temperature is down to-4 ℃;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.5 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 3:get the thimerosal for vaginoscope cleaning and sterilizing of above-described embodiment 3 preparations, with reference to < < disinfection technology standard > > 2002 editions, carry out stability test, storage condition: at 37 ℃, place.Testing environment: 30 ℃ of temperature, relative moisture 40%-44%.Result is as shown in table 3 below:
Table 3
By 37 ℃ of accelerated tests, prove, the active ingredient Peracetic acid of the thimerosal for vaginoscope cleaning and sterilizing of embodiment 3 gained and the content of hydrogen peroxide do not have to decline substantially, only have a small amount of hydrogen peroxide to decompose; Show that the present invention, for the having good stability of the thimerosal of vaginoscope cleaning and sterilizing, a large amount of decomposition can not occur in storage and transportation.
embodiment 4for cleaning a colpomicroscopic thimerosal, in components by weight percent: Peracetic acid 0.9%, hydrogen peroxide 4.5%, chlorhexidine hydrochloride 0.4%, phenol 0.04%, salicylic acid 4.0%, sym-closene 5.0%, surplus is water.
A kind of as follows for cleaning the preparation process of colpomicroscopic thimerosal:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 5 minutes, add sym-closene, after standing 2.5 hours, add water, at 55 ℃, stir after 1.3 hours and obtain buffer solution, then buffer solution temperature is down to-4 ℃;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.8 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
embodiment 5for cleaning a colpomicroscopic thimerosal, in components by weight percent, Peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, salicylic acid 3.0%, sym-closene 4.0%, surplus is water.
A kind of as follows for cleaning the preparation process of colpomicroscopic thimerosal:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 4 minutes, add sym-closene, after standing 2 hours, add water, at 50 ℃, stir after 1 hour and obtain buffer solution, then buffer solution temperature is down to-3 ℃;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.7 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
experimental example 1:the sterilization simulated field test to medicine equipment with candida albicans, mould, staphylococcus and diplococcus to the thimerosal of embodiment 5 preparations:
Get respectively candida albicans suspension, mould bacteria suspension, staphylococcus suspension and diplococcus suspension and drip and dye in the inner coating of polyfluortetraethylene pipe evenly, be placed in 37 ℃ of constant incubators dry, prepare bacterial carrier.The product of gained of the present invention of take is disinfectant, according to vagina illuminating apparatus operation instructions sterilization rules, carries out cleaning and sterilizing, and result is as shown in table 4 below:
The kill logarithm value of this thimerosal of table 4 to bacterium
Result shows that this product, to dying candida albicans, mould, staphylococcus and the gonococcal logarithm value >5.89 that kills on polyfluortetraethylene pipe, shows that this product has good disinfection effect.
experimental example 2:in order to verify the disinfection effect of embodiment 5 gained thimerosals, getting respectively candida albicans suspension, mould bacteria suspension, staphylococcus suspension and diplococcus suspension drips and dyes in the inner coating of polyfluortetraethylene pipe evenly, be placed in 37 ℃ of constant incubators dry, prepare bacterial carrier.By the bacterial carrier preparing, be divided into two groups, experimental group and control group, it is disinfectant that experimental group be take the product of gained of the present invention, according to vagina illuminating apparatus operation instructions sterilization rules, carry out cleaning and sterilizing, control group carries out cleaning and sterilization (routine disinfection agent such as citric acid disinfectant, the low bubble cleaning agent of medical alkalescence) with other disinfectants to vagina illuminating apparatus, and result is as shown in table 5 below:
Table 5 is the kill logarithm value of gained thimerosal of the present invention to bacterium
Result: two groups of sterilization curative effects comparison, this product is to dying candida albicans, mould, staphylococcus and the gonococcal logarithm value >5.89 that kills on polyfluortetraethylene pipe, obviously bactericidal effect is better than control group, shows that this product has good disinfection effect.
With reference to embodiments of the invention, the present invention has been given to explanation above.But these embodiment are only for illustrative purposes, and are not intended to limit the scope of the invention.Scope of the present invention is limited by claims and equivalent thereof.Do not depart from the scope of the present invention, those skilled in the art can make a variety of substitutions and modifications, and these substitutions and modifications all should fall within the scope of the present invention.
Claims (10)
1. for cleaning colpomicroscopic thimerosal, it is characterized in that: in components by weight percent, Peracetic acid 0.5%-1.0%, hydrogen peroxide 2.0%-5.0%, chlorhexidine hydrochloride 0.1%-0.5%, phenol 0.01%-0.05%, salicylic acid 1.0%-5.0%, sym-closene 2.0%-6.0%, surplus is water.
2. according to claim 1 for cleaning colpomicroscopic thimerosal, it is characterized in that: Peracetic acid 0.6%-0.9%, hydrogen peroxide 2.5%-4.5%, chlorhexidine hydrochloride 0.2%-0.4%, phenol 0.02%-0.04%, salicylic acid 2.0%-4.0%, sym-closene 3.0%-5.0%, surplus is water.
3. according to claim 1 for cleaning colpomicroscopic thimerosal, it is characterized in that: in components by weight percent, Peracetic acid 0.8%, hydrogen peroxide 3.0%, chlorhexidine hydrochloride 0.3%, phenol 0.03%, salicylic acid 3.0%, sym-closene 4.0%, surplus is water.
According to described in claim 1-3 any one for cleaning the preparation method of colpomicroscopic thimerosal, it is characterized in that: comprise the following steps:
(1) chlorhexidine hydrochloride, phenol and salicylic acid are added in Agitation Tank, after 2-6 minute, add sym-closene, after standing 1-3 hour, add water, at 40-60 ℃, stir after 0.5-1.5 hour and obtain buffer solution, then by be down to-5-0 ℃ of buffer solution temperature;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.5-1 hour to obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
5. preparation method according to claim 4, is characterized in that: step (1) added sym-closene after 3-5 minute, adds water (preferably add sym-closene after 4 minutes, add water after standing 2 hours) after standing 1.5-2.5 hour.
6. preparation method according to claim 4, is characterized in that: step (1) stirs after 0.6-0.8 hour to obtain buffer solution (preferably stir at 50 ℃ after 1 hour buffer solution) at 45-55 ℃.
7. preparation method according to claim 4, is characterized in that: step (1) is down to-4 to-2 ℃ (preferably buffer solution temperature being down to-3 ℃) by buffer solution temperature.
8. preparation method according to claim 4, is characterized in that: step (2) continues to stir 0.5-0.8 hour obtaining thimerosal (thimerosal is stirred 0.6 hour to obtain in preferred continuation).
9. preparation method according to claim 4, is characterized in that: the aperture of the described miillpore filter of step (3) is that the preferred aperture of 0.10-0.45 μ m(is 0.22 μ m).
10. arbitrary described for cleaning the application of colpomicroscopic thimerosal when the thimerosal for the preparation of haemodialysis control unit, B ultrasonic instrument, CT machine according to claim 1-3.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104430569A (en) * | 2014-11-25 | 2015-03-25 | 邓建军 | Disinfectant for cleaning CT equipment and preparation method thereof |
| CN104782671A (en) * | 2015-03-25 | 2015-07-22 | 彭新国 | Bacteriostatic disinfecting disinfectant for laboratory department and preparation method for bacteriostatic disinfecting disinfectant |
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| EP0147207A1 (en) * | 1983-12-22 | 1985-07-03 | Albright & Wilson Limited | Disinfectants |
| CN101426539A (en) * | 2006-02-28 | 2009-05-06 | 贝克顿·迪金森公司 | Antimicrobial compositions and methods for locking catheters |
| CN101720760A (en) * | 2008-10-17 | 2010-06-09 | 山东威高药业有限公司 | Multifunctional disinfectant for haemodialysis machine |
| CN103766377A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Citric acid decalcified disinfectant applied to dialysis machinery and water treatment and preparation method of citric acid decalcified disinfectant |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0147207A1 (en) * | 1983-12-22 | 1985-07-03 | Albright & Wilson Limited | Disinfectants |
| CN101426539A (en) * | 2006-02-28 | 2009-05-06 | 贝克顿·迪金森公司 | Antimicrobial compositions and methods for locking catheters |
| CN101720760A (en) * | 2008-10-17 | 2010-06-09 | 山东威高药业有限公司 | Multifunctional disinfectant for haemodialysis machine |
| CN103766377A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Citric acid decalcified disinfectant applied to dialysis machinery and water treatment and preparation method of citric acid decalcified disinfectant |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104430569A (en) * | 2014-11-25 | 2015-03-25 | 邓建军 | Disinfectant for cleaning CT equipment and preparation method thereof |
| CN104782671A (en) * | 2015-03-25 | 2015-07-22 | 彭新国 | Bacteriostatic disinfecting disinfectant for laboratory department and preparation method for bacteriostatic disinfecting disinfectant |
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