CN102655880A - Il-1结合蛋白 - Google Patents

Il-1结合蛋白 Download PDF

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Publication number
CN102655880A
CN102655880A CN2010800563660A CN201080056366A CN102655880A CN 102655880 A CN102655880 A CN 102655880A CN 2010800563660 A CN2010800563660 A CN 2010800563660A CN 201080056366 A CN201080056366 A CN 201080056366A CN 102655880 A CN102655880 A CN 102655880A
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China
Prior art keywords
disease
seq
antibody
associated proteins
cdr
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CN2010800563660A
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Chinese (zh)
Inventor
C.谢
C.吴
R.米勒
D.J.安布罗西
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AbbVie Inc
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Abbott GmbH and Co KG
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Publication of CN102655880A publication Critical patent/CN102655880A/zh
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/245IL-1
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
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