CN102655880A - Il-1结合蛋白 - Google Patents
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- CN102655880A CN102655880A CN2010800563660A CN201080056366A CN102655880A CN 102655880 A CN102655880 A CN 102655880A CN 2010800563660 A CN2010800563660 A CN 2010800563660A CN 201080056366 A CN201080056366 A CN 201080056366A CN 102655880 A CN102655880 A CN 102655880A
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107074942A (zh) * | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑IL‑1β抗体和使用方法 |
WO2020034941A1 (zh) * | 2018-08-14 | 2020-02-20 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009134776A2 (en) * | 2008-04-29 | 2009-11-05 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
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US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
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WO2018150265A1 (en) | 2017-02-16 | 2018-08-23 | Xbiotech, Inc. | Treatment of hidradenitis suppurativa |
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WO2020128636A1 (en) * | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
US11434291B2 (en) | 2019-05-14 | 2022-09-06 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
KR102087743B1 (ko) * | 2019-06-10 | 2020-03-12 | 을지대학교 산학협력단 | IL-1beta에 특이적으로 결합하는 항체 및 그의 용도 |
CN115605507A (zh) | 2020-03-13 | 2023-01-13 | 基因泰克公司(Us) | 抗白介素-33抗体及其用途 |
CA3182445A1 (en) | 2020-06-11 | 2021-12-16 | Francisco Leon | Methods and compositions for preventing type 1 diabetes |
JP2023537422A (ja) * | 2020-08-13 | 2023-08-31 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Il-11の抗体及びその使用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050042664A1 (en) * | 2003-08-22 | 2005-02-24 | Medimmune, Inc. | Humanization of antibodies |
CN1780855A (zh) * | 2003-01-24 | 2006-05-31 | 应用分子进化公司 | 人IL-1β拮抗剂 |
US20070071675A1 (en) * | 2005-08-19 | 2007-03-29 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
US20080118506A1 (en) * | 2006-11-02 | 2008-05-22 | Genentech, Inc. | Humanized Anti-Factor D Antibodies and Uses Thereof |
CN101228188A (zh) * | 2005-06-21 | 2008-07-23 | 佐马技术有限公司 | IL-1β结合抗体及其片段 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995001997A1 (en) * | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
EP2042518A3 (en) | 2000-06-29 | 2009-04-08 | Abbott Laboratories | Dual specificity antibodies and methods of making and using |
US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
WO2003073982A2 (en) * | 2002-02-28 | 2003-09-12 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
GB0303337D0 (en) * | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
US20090215992A1 (en) | 2005-08-19 | 2009-08-27 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
DK2848258T3 (en) * | 2005-10-26 | 2018-03-19 | Novartis Ag | Treatment of familial Mediterranean fever with anti-IL-1beta antibodies |
EP2851373A1 (en) * | 2007-12-20 | 2015-03-25 | Xoma (Us) Llc | Methods for the treatment of gout |
JP2012516153A (ja) | 2009-01-29 | 2012-07-19 | アボット・ラボラトリーズ | Il−1結合タンパク質 |
US20110016506A1 (en) | 2009-07-15 | 2011-01-20 | Yung-Yu Lu | Set-Top Box |
MX350723B (es) | 2010-05-14 | 2017-09-14 | Abbvie Inc | Proteínas de unión a il-1. |
-
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1780855A (zh) * | 2003-01-24 | 2006-05-31 | 应用分子进化公司 | 人IL-1β拮抗剂 |
US20050042664A1 (en) * | 2003-08-22 | 2005-02-24 | Medimmune, Inc. | Humanization of antibodies |
CN101228188A (zh) * | 2005-06-21 | 2008-07-23 | 佐马技术有限公司 | IL-1β结合抗体及其片段 |
US20070071675A1 (en) * | 2005-08-19 | 2007-03-29 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
US20080118506A1 (en) * | 2006-11-02 | 2008-05-22 | Genentech, Inc. | Humanized Anti-Factor D Antibodies and Uses Thereof |
Cited By (4)
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CN107074942A (zh) * | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑IL‑1β抗体和使用方法 |
WO2020034941A1 (zh) * | 2018-08-14 | 2020-02-20 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
CN112654640A (zh) * | 2018-08-14 | 2021-04-13 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
US12286473B2 (en) | 2018-08-14 | 2025-04-29 | Akeso Biopharma, Inc. | Anti-IL-1β antibody and pharmaceutical composition thereof and use of same |
Also Published As
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WO2011047266A1 (en) | 2011-04-21 |
KR20120104542A (ko) | 2012-09-21 |
IN2012DN02634A (enrdf_load_stackoverflow) | 2015-09-04 |
AR078650A1 (es) | 2011-11-23 |
EP2488201A1 (en) | 2012-08-22 |
MX2012004412A (es) | 2012-05-08 |
EP2488201A4 (en) | 2013-12-25 |
TW201124427A (en) | 2011-07-16 |
JP2013507929A (ja) | 2013-03-07 |
RU2012119788A (ru) | 2013-11-20 |
AU2010306681A1 (en) | 2012-04-19 |
CA2775402A1 (en) | 2011-04-21 |
UY32949A (es) | 2011-02-28 |
US20130295004A1 (en) | 2013-11-07 |
BR112012007365A2 (pt) | 2016-11-22 |
US8398966B2 (en) | 2013-03-19 |
US20110142761A1 (en) | 2011-06-16 |
IL219202A0 (en) | 2012-06-28 |
ZA201202610B (en) | 2012-12-27 |
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