CN102641325B - Health care product having function of resisting fatigue and enhancing immunity and preparation method thereof - Google Patents
Health care product having function of resisting fatigue and enhancing immunity and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a health care product having function of resisting fatigue and enhancing immunity and a preparation method of the health care product; the preparation method comprises the following steps: taking American ginseng, astragalus mongholicus, lucid ganoderma and rhodiola rosea in proportion to add into deionized water, extracting at 50-100 degrees centigrade for 2-5 h, repeating at once, combining supernate obtained at two times, rotatably evaporating and freeze-drying to obtain extract powder; taking honey, freeze-drying in vacuum, grinding by a 60-mesh sieve to obtain honey powder. Traditional Chinese medicinal materials with dual-purpose of drug and food such as American ginseng, astragalus mongholicus, lucid ganoderma and rhodiola rosea are selected as raw materials, and honey is added to regulate to obtain a health care product preparation with significant activity. Furthermore, advanced production technologies are adopted in the invention, so that actions of active ingredients of obtained products are reliable.
Description
Technical field
The present invention discloses a kind of health product and preparation method that has resisting fatigue, improves immunity, belongs to health product preparing technical field.
Background technology
At present, along with social competition is fierce, rhythm of life is fast, and life stress is large, and a lot of people are for a long time under keen competition condition, daily life system is irregular, diet is unbalanced, causes health in sub-health state, immunologic hypofunction, the impact that the reduction level of immunity is large the health of human body, cause the generation of various diseases.
World Health Organization (WHO) without organic disease, still has the state of some changing functions to be called " third state ", " sub-health state " that namely we are commonly called as body.There is investigation to show, current more than 75% crowd of China is in sub-health state, although this part crowd does not have disease and the defect of organ, function of organization, but but can feel uncomfortable, overtired, vigor reduces, adaptive faculty declines, often in anxiety, agitation, feel dizzy, inappetence state.For this situation, increasing people comes to realise the importance that improves immunity, so the market demand and market capacity that resisting fatigue improves the health product of immunity be huge, and its Social benefit and economic benefit also beyond doubt preferably.
Summary of the invention
The present invention aims to provide a kind of health product and preparation method that has resisting fatigue, improves immunity, and these health product have that convenient drug administration, stable curative effect, toxic and side effects are little, feature that can be edible for a long time.
Composition of usining the medicine-food two-purposes such as Radix Panacis Quinquefolii, Ganoderma, the Radix Astragali, Radix Rhodiolae of the present invention is as main active, and in addition honey powder is as regulating composition, and the health product of gained can significantly improve body immunity, and have the effect of resisting fatigue.
The health product with resisting fatigue and enhancing immunity effect provided by the invention, is characterized in that mainly by the raw material of following weight portion, being made:
5～20 parts of Radix Panacis Quinquefoliis, 50～100 parts of the Radixs Astragali, 5～10 parts of Ganodermas, 50～100 parts of Radix Rhodiolaes, 3～5 parts of Mel.
The preparation method of resisting fatigue of the present invention, raising immunity health product, is characterized in that comprising the following steps
(1) get in proportion Radix Panacis Quinquefolii, the Radix Astragali, Ganoderma, Radix Rhodiolae, according to the mass volume ratio example of 10～40:1, add deionized water, 50～100 ℃ are extracted 2～5 hours, repeat once, merge the supernatant of twice, and lyophilizing after rotary evaporation, obtains extract dry powder.
(2) get Mel, after vacuum freeze-drying, ground 60 mesh sieves, obtain honey powder.
(3) by step 1), step 2) resulting dry powder carries out the production of health-care preparation and get final product according to conventional method after mixing in proportion.
good effect of the present invention is:select the Chinese crude drug of the medicine-food two-purposes such as Radix Panacis Quinquefolii, Ganoderma, the Radix Astragali, Radix Rhodiolae as base stock, and add Mel as adjusting, obtain having the health-care preparation of remarkable activity.The production technology of uses advanced of the present invention in addition, products obtained therefrom active component reliable effect.
The specific embodiment
In order to understand better technology contents of the present invention, below by concrete case study on implementation, describe the present invention.
case study on implementation 1
(a) get Radix Panacis Quinquefolii 20g, Radix Astragali 50g, Ganoderma 10g, Radix Rhodiolae 100g, according to the ratio of mass volume ratio 1:10, add deionized water 1.8L, 80 ℃ are extracted 3h, repeat once, merge the supernatant of twice, and after rotary evaporation, lyophilizing obtains extract dry powder.
(b) get Mel 5g, after vacuum freeze-drying, ground 60 mesh sieves, obtain honey powder.
(c) honey powder obtaining and extract dry powder are mixed, obtain preparation 1.
case study on implementation 2
(a) get Radix Panacis Quinquefolii 10g, Radix Astragali 100g, Ganoderma 5g, Radix Rhodiolae 50g, according to the ratio of mass volume ratio 1:20, add deionized water 3.3L, 60 ℃ are extracted 5h, repeat once, merge the supernatant of twice, and after rotary evaporation, lyophilizing obtains extract dry powder.
(b) get Mel 4g, after vacuum freeze-drying, ground 60 mesh sieves, obtain honey powder.
(c) honey powder obtaining and extract dry powder are mixed, obtain preparation 2.
Case study on implementation 3
(a) get Radix Panacis Quinquefolii 20g, Radix Astragali 50g, Ganoderma 6g, Radix Rhodiolae 100g, according to the ratio of mass volume ratio 1:40, add deionized water 7.04L, 100 ℃ are extracted 4h, repeat once, merge the supernatant of twice, and after rotary evaporation, lyophilizing obtains extract dry powder.
(b) get Mel 5g, after vacuum freeze-drying, ground 60 mesh sieves, obtain honey powder.
(c) honey powder obtaining and extract dry powder are mixed, obtain preparation 3.
below test show the present invention in resisting fatigue, improve the effect of immunity:
1, materials and methods
The health-care preparation of preparation in 1.1 tested material embodiment 1 ~ 3.
1.2 laboratory animal
By Jilin University's Experimental Animal Center, provide 160 of the female white mice of healthy Kunming kind, body weight 18-22g.Be divided at random 4 groups, 40 every group.Unification gives normal laboratory feeding conditions.
1.3 zoopery room environmentals
22 ℃ of temperature, humidity 45%.
1.4 dosage are selected
The recommended dose of this health-care preparation is adult's (calculating by body weight 60kg) 2g, by 10 times of human body recommended amounts, mice is carried out to administration, three groups of tested materials are configured to desired concn with normal saline respectively, and mouse stomach administration was measured indices after 30 days, and gastric infusion volume is 0.1ml/10g.One blank group is set simultaneously, by physiologic saline for substitute tested material, carries out administration, gavage volume is identical with tested material.
1.5 experimental technique
1.5.1 the mouse spleen lymphocyte transformation experiment that ConA induces
In administration, after 30 days, choose at random 10 mices for every group, mice is carried out to the aseptic spleen of getting, make single cell suspension, with RPMI1640 complete medium, regulating cell concentration is 3 * 10
6/ ml.The cell suspension of gained is joined in 24 porocyte culture plates, every hole 1mL, every kind of splenocyte suspension adds two holes, and every hole adds 75 μ L ConA liquid in addition, and another hole adds the normal saline of same amount, puts 5%, 37 ℃ of CO
2in incubator, cultivate 72h.Cultivation finishes front 4h, and every hole sucks supernatant 0.7 mL gently, adds 0.7mL not containing the RPMI1640 culture fluid of calf serum, adds MTT(5mg/ mL simultaneously) 50 μ L/ holes, continue to cultivate 4h.After cultivation finishes, every hole adds 1 mL acid isopropyl alcohol, and piping and druming mixes, and purple crystal is dissolved completely, then divides and installs in 96 well culture plates, and 3 parallel holes are made in each hole, measures the optical density value at 570nm place by microplate reader.Experimental result is as shown in table 1,
The mouse spleen lymphocyte transformation experiment of table 1 ConA induction
As can be seen from Table 1, in three kinds of health-care preparation groups all there is significant difference (p<0.01) with matched group in absorbance difference.But between three kinds of different preparation groups there is not marked difference in absorbance difference.
1.5.2 study the impact of health-care preparation on mouse immune organ
Mouse stomach administration the 25th day, get at random 10 mices for every group, get mouse immune device, to weigh, result is as shown in table 2:
The impact of table 2 on mouse immune organ weight index
Compare with negative control group, p<0.05, illustrates the increase significantly effect of immunity of this health-care preparation tool.
1.5.3 mice delayed allergy (DTH) is measured:
With gavage the 25th day, to mouse peritoneal, inject 2% Mianyang erythrocyte 0.2mL/ and only carry out sensitization, immunity stimulated at the SRBC of the left back toes subcutaneous injection of mice 0.1mL 10% after 72 hours, measure stimulate before and stimulate mice toes varied in thickness after 24h, calculate the height change of mice toes swelling.Result is as shown in table 3:
Table 3 mouse DTH measurement result
As can be seen from the table, after each dosage group is attacked with SRBC, mice toes thickness difference all has significantly and increases compared with normal saline group, and its difference has statistical significance.
1.5.4 swimming with a load attached to the body experiment
After last administration 30min, put mice in constant temperature swimming trunk went swimming, depth of water 20cm, 30 ℃ of water temperatures, mouse tail root bundlees the aluminium block of 5% body weight, records mice from starting swimming to dead time (s), and result is as shown in table 4:
Table 4 mice burden swimming time result
As seen from the above table, compare with normal saline group, each health-care preparation group all can significantly increase the time of mice burden swimming, and P<0.05, illustrates that this result has statistical significance.
Claims (2)
1. health product with resisting fatigue and enhancing immunity effect, is characterized in that being made by the raw material of following weight portion:
5～20 parts of Radix Panacis Quinquefoliis, 50～100 parts of the Radixs Astragali, 5～10 parts of Ganodermas, 50～100 parts of Radix Rhodiolaes, 3～5 parts of Mel.
2. according to the preparation method of resisting fatigue, raising immunity health product described in claim 1, it is characterized in that comprising the following steps
1) get in proportion Radix Panacis Quinquefolii, the Radix Astragali, Ganoderma, Radix Rhodiolae, according to the ratio of mass volume ratio 10～40:1, add deionized water, 50～100 ℃ are extracted 2～5 hours, repeat once, merge the supernatant of twice, and lyophilizing after rotary evaporation, obtains extract dry powder;
2) get Mel, after vacuum freeze-drying, ground 60 mesh sieves, obtain honey powder;
3) by step 1), step 2) resulting above-mentioned dry powder mixes in proportion and get final product.
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| CN102641325B true CN102641325B (en) | 2014-03-05 |
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| CN105919136A (en) * | 2016-05-21 | 2016-09-07 | 陕西泓逺金道生物科技有限公司 | Nutrition supplement composition with fatigue resisting and immunity improving effects and preparation and preparation method thereof |
| CN113424960A (en) * | 2021-08-16 | 2021-09-24 | 吉林大学 | Anti-fatigue traditional Chinese medicine health product and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706280A (en) * | 2004-12-09 | 2005-12-14 | 桂林莱茵生物制品有限公司 | Health food capable of raising immunity and its production process |
| CN101181351A (en) * | 2007-12-14 | 2008-05-21 | 彭志燊 | Chinese medicine composition for resisting tiredness and reinforcing immune as well as method of making the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706280A (en) * | 2004-12-09 | 2005-12-14 | 桂林莱茵生物制品有限公司 | Health food capable of raising immunity and its production process |
| CN101181351A (en) * | 2007-12-14 | 2008-05-21 | 彭志燊 | Chinese medicine composition for resisting tiredness and reinforcing immune as well as method of making the same |
Non-Patent Citations (4)
| Title |
|---|
| 抗疲劳功能食品的研究进展;郑哲君等;《食品科技》;20060220(第02期);5 * |
| 抗运动性疲劳中药研究现状;杜朝辉等;《中国运动医学杂志》;20080301;第27卷(第02期);260-263 * |
| 杜朝辉等.抗运动性疲劳中药研究现状.《中国运动医学杂志》.2008,第27卷(第02期), |
| 郑哲君等.抗疲劳功能食品的研究进展.《食品科技》.2006,(第02期), |
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