CN102715503A - Immunity-regulating TCM (traditional Chinese medicine) health food and preparation method thereof - Google Patents

Immunity-regulating TCM (traditional Chinese medicine) health food and preparation method thereof Download PDF

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Publication number
CN102715503A
CN102715503A CN2012102004506A CN201210200450A CN102715503A CN 102715503 A CN102715503 A CN 102715503A CN 2012102004506 A CN2012102004506 A CN 2012102004506A CN 201210200450 A CN201210200450 A CN 201210200450A CN 102715503 A CN102715503 A CN 102715503A
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China
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immunity
health food
chinese medicine
mouse
american ginseng
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王伟
田拥军
李永禄
王永弟
徐晓丽
杨心刚
李珂
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HENAN ZHENGCHANG BIOMEDICINE TECHNOLOGY CO LTD
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HENAN ZHENGCHANG BIOMEDICINE TECHNOLOGY CO LTD
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Priority to CN2012102004506A priority Critical patent/CN102715503A/en
Publication of CN102715503A publication Critical patent/CN102715503A/en
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Abstract

The invention relates to an immunity-regulating TCM (traditional Chinese medicine) health food and a preparation method thereof. The immunity-regulating TCM health food mainly comprises 25-40% of American ginseng, 40-50% of longan pulp and 15-30% of excipient. Both the American ginseng and the longan pulp have the effects of aging resistance, immunity regulation, tumor resistance, endocrine regulation and the like and have evident immunity enhancement effect. Combination of the longan pulp and the American ginseng is warm but not dry and cool but not cold, and is a top-grade pharmaceutical and dietary tonic. By the immunity-regulating TCM health food, the problem of in-vivo heat accumulation easily caused by general immunity-enhancing health foods is solved.

Description

A kind of Chinese medicine and health food that is used to regulate immunity and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine and health food that is used to regulate immunity, also relate to the preparation method of this health food simultaneously.
Background technology
Immunity is the defense mechanism of human body self; Be human body identification and any foreign matter of eliminating external intrusion; Handle the ability of self cell and identification and the processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, sex change, modern immunology thinks that immunity is human body identification and the physiological reaction of getting rid of " dissident "; The health of hypoimmunity is easy to infected or cancer stricken; Immunity is extraordinary also can to produce insalubrious result, as causing allergic reaction, autoimmune disease etc.The improvement of Along with people's material and culture and growth in the living standard, people more and more pay attention to self health, simultaneously; Fast pace along with life; The appearance of problem such as environmental pollution and food security makes the immunity of human body also receive influence to a certain degree, also emerges various health foods and health medicine etc. on the market; But at present health food common exist on the high side, the situation that effect is not satisfactory.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine and health food that is used to regulate immunity, to regulate body immunity.
Simultaneously, the present invention also aims to provide a kind of preparation method who is used to regulate the Chinese medicine and health food of immunity.
To achieve these goals, technical scheme of the present invention has adopted a kind of Chinese medicine and health food of regulating immunity, mainly comprises following component: American Ginseng 25-40%; Arillus longan 40-50%; Excipient 15-30%.
Described excipient is a sweet mellow wine, sucrose, glucose, xylitol, a kind of or combination in any in starch or the dextrin.
Can be pharmaceutically acceptable any formulation.
Described formulation is preferably chewable tablets.
Simultaneously, technical scheme of the present invention also provides a kind of preparation method who regulates the Chinese medicine and health food of immunity, it is characterized in that: may further comprise the steps: get American Ginseng and pulverize, sieve; Arillus longan adds solvent and extracts 2-3 time, merges extract, and extract concentrates, and is concentrated into the thick paste that relative density is 1.20-1.28; Ginseng powder and mixed with excipients are even, add arillus longan and extract medicinal extract mixing, drying; It is broken to mix dried cream powder, sieves, and granulates, and sieves, and wet granular is 45-50 ℃ of drying, and the control pellet moisture adds the lubricant compressing tablet of 1-2% at 3-5%, promptly gets.
Described lubricant is a dolomol, a kind of or combination in any in talcum powder or the superfine silica gel powder.
Described excipient is a sweet mellow wine, sucrose, glucose, xylitol, a kind of or combination in any in starch or the dextrin.
Described solvent is a water.
Described mixing dried cream powder is broken with i.e. 60%-90% the alcohol granulation of suitable concentration.
The Chinese medicine and health food that is used to regulate immunity of the present invention also can adopt the preparation method of all the other conventional tablets to prepare.
1. dosage form selection
Formulation of the present invention is a tablet, adopts modern crafts to process the chewable tablets that is easy to by consumers in general's acceptance, compares with conventional tablet; Chewable tablets has the following advantages: good dispersing state, and disintegration time is short, and the medicine stripping is rapid; Absorb soon, bioavilability is high, taking convenience.
2. process route is confirmed
The American Ginseng precious medicinal material of running after fame in the raw material of the present invention, its main component also is easy to directly absorbed by human body, directly feeds intake so adopt to pulverize.Arillus longan mainly contains glucose, tartaric acid, sucrose; Vitamin B1, vitamin B2, citrin; Vitamin C, polysaccharide etc. are mainly water soluble ingredient; The longan pulp water-soluble extractive to normal mouse immune regulating action greater than the longan pulp, so water adopts traditional water boiling and extraction as extracting solvent.Auxiliary material is selected sweet mellow wine for use, because the sweet mellow wine no hygroscopicity, particle is easy to drying, and heat absorption is pleasantly sweet when dissolving simultaneously, and there is comfort sense in the oral cavity, and is proper as the excipient of chewable tablets.Simultaneously, arillus longan medicinal extract mixes the back drying with ginseng powder and sweet mellow wine, to improve drying efficiency.
The present invention adopts American Ginseng and arillus longan compatibility, and arillus longan is sweet in flavor and warm in property in the side, and the function heart-spleen boosting fills blood, and the intelligence development of calming the nerves cures mainly internal lesion caused by overexertion heart spleen, insufficiency of vital energy and blood, and palpitation and insomnia, refreshing tired body is tired, sallow complexion, diet is not good enough to wait disease.The sweet cold of American Ginseng nature and flavor, the function replenishing and restoring lung qi, kidney qi, nourishing Yin and promoting production of body fluid, it is tired tired to cure mainly the cloudy abnormal heat of losing of the deficiency of vital energy, quenches one's thirst dryness of the mouth and throat.Arillus longan and American Ginseng compatibility adopt the sweet temperature of arillus longan to help mutually with the sweet cold of American Ginseng, and temperature is not and dry, cool and not cold, and replenishing blood for nourishing heart, beneficial lung promote the production of body fluid, and make the body qi and blood sufficient, enhancing body immunity.Both invigorating kidney qi consolidated, and tonifying lung to be to strengthen the distribution of qi-blood-body fluid again, simultaneously heart-spleen boosting and make ying, wei, qi, xue sufficient.
The physiological function of American Ginseng has: 1. improve immunity,, immunologic hypofunction weak to middle-aged and old organ functions, accommodative ability of environment go down, and certain health-care effect is arranged, but enhancing body are to the special defence capability of various destructive stimuluses.2. brain there is sedation, nerve center is had the moderate excitation.3. the traditional Chinese medical science is thought: person cool in nature can mend, and can tonifying lung fall fire, and easy gas promotes the production of body fluid, and can calm the nerves and improve intelligence, has tonifying kidney and benefiting sperm, transfers effects such as tonifying five zang organs.Arillus longan contains abundant nutrition as food; Has unique physiologically active again as medicine simultaneously; Through the research of Arillus Longan extract physiological function and active component thereof, measure the relevant physiological index, find its have anti-ageing, regulate immunity, antitumor, regulate effect such as endocrine.
Arillus longan and American Ginseng compatibility temperature and not dry, cool and cold, be that the nourishing of medicine-food two-purpose is top grade, solve the general problem that the immunity health food causes body inner product heat easily of regulating, and American Ginseng, arillus longan to regulate the immunity effect remarkable.
The specific embodiment
Embodiment 1
The Chinese medicine and health food of the adjusting immunity of present embodiment mainly is that following weight percentage component is formed: American Ginseng 31%; Arillus longan 44%; Sweet mellow wine 25%.
The preparation method of the Chinese medicine and health food of present embodiment is following: American Ginseng, sweet mellow wine are pulverized, sieved; Arillus longan extracting in water 2 times merges extract, and extract concentrates, and being concentrated into relative density is the thick paste of 1.25 (70 ℃); Ginseng powder and sweet mellow wine mix, and place trough type mixing machine, add arillus longan and extract medicinal extract mixing, drying; Mix broken 85% alcohol granulation of using of dried cream powder, sieve, wet granular is 45 ℃ of dryings, and the control pellet moisture adds lubricant (dolomol) compressing tablet that accounts for raw material gross weight 1% 3%, promptly gets chewable tablets.
Embodiment 2
The Chinese medicine and health food of the adjusting immunity of present embodiment mainly is that following weight percentage component is formed: American Ginseng 25%; Arillus longan 50%; Sucrose 25%.
The preparation method is following: American Ginseng, sweet mellow wine are pulverized, sieved; Arillus longan extracting in water 3 times merges extract, and extract concentrates, and being concentrated into relative density is the thick paste of 1.28 (70 ℃); Ginseng powder and sucrose mix, and place trough type mixing machine, add arillus longan and extract medicinal extract mixing, drying; Mix broken 70% alcohol granulation of using of dried cream powder, sieve, wet granular is 48 ℃ of dryings, and the control pellet moisture adds lubricant (talcum powder) compressing tablet that accounts for raw material gross weight 1.5% 4%, promptly gets chewable tablets.
Embodiment 3
The Chinese medicine and health food of the adjusting immunity of present embodiment mainly is that following weight percentage component is formed: American Ginseng 40%; Arillus longan 40%; Sweet mellow wine 20%.
The preparation method is following: American Ginseng, sweet mellow wine are pulverized, sieved; Arillus longan extracting in water 3 times merges extract, and extract concentrates, and being concentrated into relative density is the thick paste of 1.20 (70 ℃); Ginseng powder and xylitol mix, and place trough type mixing machine, add arillus longan and extract medicinal extract mixing, drying; Mix broken 90% alcohol granulation of using of dried cream powder, sieve, granulate, sieve, wet granular is 50 ℃ of dryings, and the control pellet moisture adds lubricant (superfine silica gel powder) compressing tablet that accounts for raw material gross weight 2% 5%, promptly gets chewable tablets.
The experiment of adjusting immunity function
One, material and method
1 sample
The chewable tablets that embodiment 1 is prepared is pulverized the back as given the test agent with pulverizer.
2 animals
Female BALB/c mouse is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., the certificate of competency: 0191492, and the SPF level.Experimental animal room credit number: SYXK (Henan) 2007-0008, barrier environment.Mouse is divided into four batches, 48 every batch, body weight 18g~22g, every batch is divided into four groups, 12 every group at random by body weight.Immune a collection of carry out internal organs/body weight ratio, the clearance test of mouse carbon; Delayed allergy, antibody-producting cell detection, HC are carried out in two batches of immunity 50Measure; Three batches of immunity are carried out Turnover of Mouse Peritoneal Macrophages and are engulfed the chicken red blood cell test; Mouse lymphocyte transformation experiment, the NK cytoactive mensuration that ConA induces is carried out in four batches of immunity.
3 dosage are selected
Three basic, normal, high 5 times, 10 times, 30 times of being respectively the human body recommended amounts of dose groups; Be 0.34g/kg, 0.68g/kg, 2.04g/kg; Get 1.7g, 3.4g, 10.2g sample adding distil water respectively to 100ml; As the test solution that receives of basic, normal, high three dose groups, other establishes solvent control group is distilled water.Per os gives once a day, and irritating the stomach amount is 20ml/kg, and the equal continuous irrigation stomach of each test group is surveyed corresponding immune indexes after 30 days.
4 experimental techniques and observation index
1. internal organs/weight ratio pH-value determination pH
Dislocation was put to death after mouse was weighed, and got spleen and thymus gland, and filter paper blots surperficial blood stains and weighs, and calculated spleen/body weight ratio and thymus gland/body weight ratio.
2. mouse carbon clearance test
The india ink of mouse tail vein injection 1:3 dilution calculates by every 10g body weight 0.1ml, treats that prepared Chinese ink injects timing immediately.Prepared Chinese ink injects back 2,10min, gets blood 20 μ l from the angular vein clump respectively, and existing side by side, soon it is added in 2ml 0.1% sodium carbonate liquor.Measure optical density (OD) with semi-automatic biochemical analyzer in the 600nm wavelength, make blank with sodium carbonate liquor.Mouse is put to death, gets liver and spleen, blot the organ surface blood stains, weigh, calculate phagocytic index a with filter paper:
K=(lgOD 1-lgOD 2)/(t 2-t 1) a=body weight ÷ (liver weight+spleen is heavy) * K 1/3
3. delayed allergy
Sheep red blood cell (SRBC) is brought out mouse DTH (the sufficient sole of the foot thickens method): get sheep blood, with 3 times (2000r/min, 10 minutes) of physiological saline washing; Every mouse is through lumbar injection 2% (v/v; Prepare with physiological saline) hematocrit SRBC0.2ml, after the sensitization 4 days, measurement of left metapedes sole of the foot portion thickness; Same position is measured three times, averages; The hypodermic injection 20% in the measuring point (v/v prepares with physiological saline) hematocrit SRBC20 μ l in back 24 hours measurement of left metapedes sole of the foot portion thickness of injection, representes the degree of DTH with the difference of sufficient sole of the foot thickness before and after attacking then.
4. antibody-producting cell detects (Jerne improvement slide glass method)
Hematocrit SRBC is made into 2% cell suspension with physiological saline, and every mouse lumbar injection 0.2ml carries out immunity, after five days; The dislocation of mouse cervical vertebra is put to death, take out spleen, be placed in the mill that fills Hank ' s liquid; Grind spleen gently, process cell suspension, filter through 200 eye mesh screens; Centrifugal (1000r/min) 10min uses Hank ' s liquid to wash 2 times, at last cell is suspended in the 8ml RPMI RPMI-1640.After top layer culture medium (the 1g agarose adds distilled water to 100ml) heating for dissolving, put 45 ℃ of water bath heat preservations, mix the packing small test tube with Hank ' the s liquid of equivalent pH7.2-7.4,2 times of concentration; Every pipe 0.5ml adds 50 μ l 10%SRBC (v/v is with the preparation of SA liquid), 25 μ l splenocyte suspensions again in pipe; Mixing inclines on the slide of brushing the agarose thin layer rapidly, does parallel plate; After treating that agar solidifies, the slide level buckled be placed on the horse, put into CO2gas incubator incubation 1.5h; Complement (1:6) with the dilution of SA buffer solution joins in the slide frame groove then, behind the continuation incubation 1.5h, and counting hemolysis plaque number.
5. HD50 value (HC 50) mensuration
Hematocrit SRBC is made into 2% cell suspension with physiological saline, and every mouse lumbar injection 0.2ml carries out immunity, after five days, plucks eyeball and gets blood, separation of serum.Serum is with 300 times of SA buffer solution dilutions, gets the serum 1ml after the dilution, adds 10%SRBC0.5ml successively, complement 1ml (press 1:6 with the SA buffer solution dilutes), and other establishes not increase serum control tube (with the replacement of SA buffer solution).Put 37 ℃ of water bath with thermostatic control 30min, the ice bath cessation reaction.The centrifugal 10min of 2000r/min gets supernatant 1ml, and Dou Shi agent 3ml gets 10%SRBC (v/v) 0.25ml simultaneously in vitro, add the Dou Shi agent to 4ml in another in vitro, abundant mixing, place 10min after, mensuration is respectively managed OD value in 540nm place.
6. Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell test (in vitro method)
Test and inject 2% hematocrit sheep red blood cell (SRBC) 0.2ml in preceding 4 days every mouse peritoneal.Put to death mouse with the cervical vertebra dislocation method, only give Hank ' s liquid 5ml/ that mouse contains 5% calf serum, extract abdominal cavity cleaning fluid 2ml after gently rubbing belly 20 times through lumbar injection; Get 0.5ml abdominal cavity cleaning fluid and add and fill Hank ' s liquid and be mixed with 1% chicken RBC suspension 0.5ml in vitro, mixing is got suspension 0.5ml smear; Put into the porcelain dish that is lined with wet gauze; Put 15min in 37 ℃ of incubators, sheet is fixed, dyes, read in the taking-up back from the slide backside rinse, with physiological saline.Calculate phagocytic rate and phagocytic index.
7. the ConA mouse spleen lymphocyte transformation experiment (mtt assay) of inducing
The aseptic spleen of getting places in the mill that fills an amount of aseptic Hank ' s liquid, grinds spleen gently, processes cell suspension, filters through 200 eye mesh screens.Use Hank ' s liquid to wash 2 times, each centrifugal 10min (1000r/min).Then cell is suspended in the complete culture solution of 2mL, the living cell counting number, the adjustment cell concentration is 3 * 10 6Individual/ml.Divide two holes to add in 24 well culture plates cell suspension again, every hole 1ml, a hole adds 75 μ l ConA liquid (being equivalent to 7.5 μ g/ml) therein, and 5%CO2 is put as contrast in another hole, 37 ℃ of CO 2Cultivate 72h in the incubator.Cultivate and finish preceding 4h, supernatant 0.7ml is inhaled in every hole gently, adds the RPMI RPMI-1640 that 0.7ml does not contain calf serum, adds MTT (5mg/mL) 50 μ l/ holes simultaneously, continues to cultivate 4h.After cultivating end, every hole adds 1ml acid isopropyl alcohol, and the piping and druming mixing dissolves purple crystal fully.With semi-automatic biochemical analyzer with 570nm place photometry density value.Lymphocytic multiplication capacity deducts the OD value that does not add the ConA hole with the OD value that adds the ConA hole and representes.
8. the NK cytoactive is measured
The aseptic spleen of getting places in the mill that fills an amount of aseptic Hank ' s liquid, grinds spleen gently; Process cell suspension, filter, use Hank ' s liquid to wash 2 times through 200 eye mesh screens; Each centrifugal 10min (1000r/min), using RPMI1640 complete culture solution adjustment cell concentration at last is 2 * 10 7Individual/ml, get each 100 μ l of target cell and effector cell (imitating target) than 50:1, add U type 96 well culture plates; Target cell nature release aperture adds target cell and each 100 μ l of nutrient solution, and the maximum release aperture of target cell adds target cell and each 100 μ l of 1%NP40; Above-mentioned each item is all established three multiple holes, in 37 ℃, 5%CO 2Cultivate 4h in the incubator; Then with 96 well culture plates with the centrifugal 5min of 1500r/min; 96 well culture plates at the bottom of every hole absorption supernatant 100 μ l horizontalizations add LDH matrix liquid 100 μ l, reaction 3min simultaneously; Every hole adds the hydrochloric acid 30 μ l of 1mol/L, measures OD value (OD) at ELIASA 490nm place.
5 experimental datas are carried out variance analysis with SPSS software.
Two, result
The influence of 1 pair of experimental animal body weight
The initial body weight of each batch of table 1 mouse
The body weight in mid-term of each batch of table 2 mouse
The body weight in latter stage of each batch of table 3 mouse
Visible by table 1, each initial body weight of organizing mouse is balanced; Visible by table 2, table 3, each dose groups mouse mid-term body weight and latter stage body weight and the equal nonsignificance of solvent control group comparing difference (P>0.05), point out that chewable tablets of the present invention does not have obvious influence to the mouse body weight under this experimental condition.
The influence of 2 pairs of internal organs/body weight ratios
The influence of table 4 pair internal organs/body weight ratio
Visible by table 4, dirty/body ratio of each dose groups mouse and solvent control group comparing difference nonsignificance (P>0.05), point out under this experimental condition chewable tablets of the present invention to mouse dirty/body ratio do not have obvious effect.3 pairs of mouse carbon clearance test influences
Table 5 pair mouse carbon is cleaned up ability (phagocytic index effect a)
Visible by table 5; Each dose groups mouse carbon clean up ability (phagocytic index a) with solvent control group comparing difference nonsignificance (P>0.05); Pointing out under this experimental condition chewable tablets of the present invention that the carbon of mouse is cleaned up ability does not have humidification, and this experimental result is negative.
The influence of 4 pairs of sheep red blood cell (SRBC)s (SRBC) inducing mouse DTH
The effect of table 6 couple sheep red blood cell (SRBC) inducing mouse DTH
Visible by table 6; 0.68g/kg, the swelling degree of the paw of 2.04g/kg dose groups mouse is higher than solvent control group; Difference has extremely significantly meaning (P < 0.01), points out chewable tablets of the present invention under this experimental condition that the delayed allergy ability of mouse is had humidification, and this experimental result is positive.
The influence of 5 antagonist cellulation numbers
The influence of table 7 antagonist cellulation number
Visible by table 7; 0.68g/kg, 2.04g/kg dose groups mouse hemolysis plaque number is higher than solvent control group; (P < 0.05 for the difference significance; P 0.01), and point out chewable tablets of the present invention under this experimental condition that the generation of mouse antibodies cellulation is had facilitation, this experimental result is positive.
6 couples of mice serum hemolysin (HD50 value HC 50) influence
Table 8 couple mouse HD50 value (HC 50) effect
Visible by table 8,0.68g/kg, 2.04g/kg dose groups mouse HC 50Be higher than solvent control group, difference significance (P<0.01), point out that chewable tablets of the present invention has the effect of increasing to mouse HD50 value under this experimental condition, this experimental result is positive.
7 pairs of Turnover of Mouse Peritoneal Macrophages are engulfed the influence of chicken red blood cell test
Table 9 pair Turnover of Mouse Peritoneal Macrophages is engulfed the influence of chicken red blood cell test
Visible by table 9; Each dose groups mouse macrophage is engulfed chicken red blood cell phagocytic percentage and phagocytic index and solvent control group comparing difference nonsignificance (P>0.05); Pointing out under this experimental condition chewable tablets of the present invention that mouse macrophage is engulfed the chicken red blood cell ability does not have tangible rising effect, and this experimental result is negative.
The mouse lymphocyte transformation experiment that 8ConA induces
The influence of the mouse lymphocyte transformation experiment that table 10 couple ConA induces
Visible by table 10; The multiplication capacity of the mouse lymphocyte that three dose groups ConA induce all is higher than solvent control group; (P < 0.05 for the difference significance; P 0.01), and the mouse lymphocyte of pointing out chewable tablets of the present invention under this experimental condition that ConA is induced transforms has humidification, and this experimental result is positive.
9 chewable tablets are to the active influence of NK cells in mice
The active influence of table 11 pair NK cells in mice
See by table 11, each dose groups NK cells in mice active with solvent control group relatively, difference nonsignificance (P>0.05) points out that chewable tablets of the present invention does not have the raising effect to the NK cytoactive under this experimental condition, this experimental result is negative.
Three, brief summary
Under this experimental condition; Per os gives the chewable tablets 30 days of the embodiment of the invention 1 of mouse various dose continuously, and chewable tablets is cleaned up ability, macrophage phagocytic chicken red blood cell ability and NK cytoactive to the carbon of the body weight of mouse, dirty/body ratio (spleen/body weight and thymus gland/body weight), mouse does not all have obvious influence; To delayed allergy (the sufficient sole of the foot thickens method), antibody-producting cell number, HC 50And the ConA mouse lymphocyte of inducing transforms remarkable effect all arranged, and points out the cellular immunity of Chinese medicine and health food of the present invention to mouse, humoral immunity that facilitation is all arranged, and promptly has the adjusting immunity function.

Claims (9)

1. a Chinese medicine and health food that is used to regulate immunity is characterized in that: mainly comprise following component: American Ginseng 25-40%; Arillus longan 40-50%; Excipient 15-30%.
2. the Chinese medicine and health food that is used to regulate immunity according to claim 1 is characterized in that: described excipient is a sweet mellow wine, sucrose, glucose, xylitol, a kind of or combination in any in starch or the dextrin.
3. the Chinese medicine and health food that is used to regulate immunity according to claim 1 is characterized in that: can be pharmaceutically acceptable any formulation.
4. the Chinese medicine and health food that is used to regulate immunity according to claim 3 is characterized in that: described formulation is preferably chewable tablets.
5. a preparation method who is used to regulate the Chinese medicine and health food of immunity according to claim 1 is characterized in that: may further comprise the steps: get American Ginseng and pulverize, sieve; Arillus longan adds solvent and extracts 2-3 time, merges extract, and extract concentrates, and is concentrated into the thick paste that relative density is 1.20-1.28; Ginseng powder and mixed with excipients are even, add arillus longan and extract medicinal extract mixing, drying; It is broken to mix dried cream powder, granulates, and wet granular is 45-50 ℃ of drying, and the control pellet moisture is at 3-5%, and adding accounts for the always mixed back of the lubricant compressing tablet that raw material total amount percentage by weight is 1-2%, promptly gets.
6. preparation method according to claim 5 is characterized in that: described lubricant can be dolomol, a kind of or combination in any in talcum powder or the superfine silica gel powder.
7. preparation method according to claim 5 is characterized in that: described excipient is a sweet mellow wine, sucrose, glucose, xylitol, a kind of or its combination in any in starch or the dextrin.
8. preparation method according to claim 5 is characterized in that: described solvent is a water.
9. preparation method according to claim 5 is characterized in that: after described mixing dried cream powder is broken, with the alcohol granulation of 60-90% concentration.
CN2012102004506A 2012-06-18 2012-06-18 Immunity-regulating TCM (traditional Chinese medicine) health food and preparation method thereof Pending CN102715503A (en)

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CN103652559A (en) * 2013-12-11 2014-03-26 罗永祺 Blood tonifying and nourishing chewable tablets and preparation method
CN106235331A (en) * 2016-07-30 2016-12-21 南京正宽医药科技有限公司 A kind of extracting method of Arillus Longan

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CN103652559A (en) * 2013-12-11 2014-03-26 罗永祺 Blood tonifying and nourishing chewable tablets and preparation method
CN106235331A (en) * 2016-07-30 2016-12-21 南京正宽医药科技有限公司 A kind of extracting method of Arillus Longan

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Application publication date: 20121010