CN102639550B - 用于生产蔗糖-6-酯的低温、单一溶剂方法 - Google Patents

用于生产蔗糖-6-酯的低温、单一溶剂方法 Download PDF

Info

Publication number
CN102639550B
CN102639550B CN201080054223.6A CN201080054223A CN102639550B CN 102639550 B CN102639550 B CN 102639550B CN 201080054223 A CN201080054223 A CN 201080054223A CN 102639550 B CN102639550 B CN 102639550B
Authority
CN
China
Prior art keywords
sucrose
reaction mixture
ester
polar aprotic
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080054223.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102639550A (zh
Inventor
爱德华·米钦斯基
戴维·克尔曼
詹姆斯·埃德温·威利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tate and Lyle PLC
Original Assignee
Tate and Lyle PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tate and Lyle PLC filed Critical Tate and Lyle PLC
Publication of CN102639550A publication Critical patent/CN102639550A/zh
Application granted granted Critical
Publication of CN102639550B publication Critical patent/CN102639550B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2224—Compounds having one or more tin-oxygen linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201080054223.6A 2009-10-12 2010-10-12 用于生产蔗糖-6-酯的低温、单一溶剂方法 Active CN102639550B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25068109P 2009-10-12 2009-10-12
US61/250,681 2009-10-12
PCT/GB2010/001904 WO2011045566A1 (en) 2009-10-12 2010-10-12 Low temperature, single solvent process for the production of sucrose-6-ester

Publications (2)

Publication Number Publication Date
CN102639550A CN102639550A (zh) 2012-08-15
CN102639550B true CN102639550B (zh) 2016-01-27

Family

ID=41565635

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080054223.6A Active CN102639550B (zh) 2009-10-12 2010-10-12 用于生产蔗糖-6-酯的低温、单一溶剂方法

Country Status (8)

Country Link
US (1) US8921540B2 (https=)
EP (1) EP2488541A1 (https=)
JP (1) JP5726195B2 (https=)
KR (1) KR20120089718A (https=)
CN (1) CN102639550B (https=)
GB (1) GB2474311B (https=)
IE (1) IE86139B1 (https=)
WO (1) WO2011045566A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349300A (zh) * 2016-08-30 2017-01-25 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201110520D0 (en) * 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
CN104098617A (zh) * 2013-04-08 2014-10-15 南京工业大学 一种蔗糖-6-乙酸酯的制备方法
US10047038B2 (en) 2013-11-27 2018-08-14 Tate & Lyle Technology Limited Waste treatment process
WO2015092374A1 (en) 2013-12-16 2015-06-25 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
WO2016020635A1 (en) 2014-08-08 2016-02-11 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
CN104774226A (zh) * 2015-04-08 2015-07-15 常州市牛塘化工厂有限公司 一种蔗糖-6-乙酯的制备方法
CN105254684B (zh) * 2015-11-03 2019-01-01 浙江新和成股份有限公司 一种蔗糖-6-乙酸酯的制备方法
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN108558962B (zh) * 2018-05-22 2020-06-30 山东新和成精化科技有限公司 一种用于合成蔗糖-6-酯的方法
CN109575069A (zh) * 2018-12-10 2019-04-05 安徽金禾实业股份有限公司 一种三氯蔗糖生产中催化剂的回收方法
CN109438533A (zh) * 2018-12-10 2019-03-08 安徽金禾实业股份有限公司 一种三氯蔗糖生产中高温连续酰化的方法
CN112973166B (zh) * 2019-12-17 2024-04-30 无锡弘鼎华化工设备有限公司 一种三氯蔗糖中和液溶剂的回收装置及方法
CN111574572A (zh) * 2020-05-22 2020-08-25 安徽金禾实业股份有限公司 一种三氯蔗糖生产中有机锡催化剂连续性制备补充的方法
CN112218874A (zh) 2020-09-10 2021-01-12 安徽金禾实业股份有限公司 一种蔗糖-6-酯的制备方法
CN112808048B (zh) * 2021-01-04 2022-05-31 安徽金禾实业股份有限公司 蔗糖-6-酯的制造设备及制造方法
WO2022174382A1 (zh) * 2021-02-19 2022-08-25 安徽金禾实业股份有限公司 蔗糖-6-酯的生产设备及生产方法
CN113039001B (zh) * 2021-02-19 2022-10-18 安徽金禾实业股份有限公司 蔗糖-6-酯的生产设备及生产方法
CN112973164B (zh) * 2021-03-04 2022-09-02 安徽金禾实业股份有限公司 一种高效率的蔗糖6酯连续生产设备及方法
CN112933634B (zh) * 2021-03-04 2022-04-08 安徽金禾实业股份有限公司 一种环列式的蔗糖-6-酯连续生产设备及生产工艺流程
CN116075519B (zh) 2022-10-19 2025-11-28 安徽金禾实业股份有限公司 一种三氯蔗糖精品的制备方法
CN115894579A (zh) * 2022-11-17 2023-04-04 安徽金禾实业股份有限公司 一种三氯蔗糖生产中b糖的处理方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
CN1316428A (zh) * 2001-04-12 2001-10-10 河南兴泰科技实业有限公司 三氯蔗糖－6－酯制备新工艺
CN1446223A (zh) * 2000-07-31 2003-10-01 塔特和莱利有限公司 用于合成蔗糖－6－酯类的改进方法
CN1453284A (zh) * 2003-05-23 2003-11-05 广东省食品工业研究所 一种三氯蔗糖的合成方法

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062467D1 (en) 1979-12-20 1983-04-28 Tate & Lyle Plc Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose
EP0043649B1 (en) 1980-07-08 1984-09-12 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
CA1183133A (en) 1980-10-28 1985-02-26 Tate & Lyle Public Limited Company Sweet chlorine-substituted disaccharides
GB8525954D0 (en) 1985-10-21 1985-11-27 Mcneilab Inc Chlorination of carbohydrates &c alcohols
GB8525871D0 (en) 1985-10-21 1985-11-27 Tate & Lyle Plc Chemical compound
GB8622345D0 (en) 1986-09-17 1986-10-22 Tate & Lyle Plc Sucrose derivatives
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8822673D0 (en) 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
GB8822674D0 (en) 1988-09-27 1988-11-02 Tate & Lyle Plc Preparation of acylated sucrose derivatives
NZ234143A (en) 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
US4980463A (en) 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
GR910100356A (el) * 1990-08-27 1992-08-31 Mcneil Ppc Inc Καταλυόμενη μέ?οδος εστέρος-6-σακχαρόζης.
NZ240818A (en) 1990-12-14 1993-08-26 Mcneil Ppc Inc Liquid sucralose concentrate compositions containing preservative, buffer and liquid
GB9110931D0 (en) 1991-05-21 1991-07-10 Tate & Lyle Plc Process for the preparation of sucrose 6-esters
US5272137A (en) 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5397588A (en) 1992-06-18 1995-03-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5270071A (en) 1992-06-18 1993-12-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5354902A (en) 1992-10-26 1994-10-11 Mcneil-Ppc, Inc. Stabilized sorbic acid or salt thereof
CA2110313C (en) 1992-12-01 2004-10-26 Edward John Roche Pharmaceutical compositions containing a guanidinothiazole compound and antacids
US5298611A (en) 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production
US5530106A (en) 1993-03-12 1996-06-25 Mcneil-Ppc, Inc. Recovery of sucralose intermediates
CA2121435C (en) 1993-04-16 2002-01-22 Sheila M. Ratnaraj Aqueous pharmaceutical suspension and process for preparation thereof
CA2128820A1 (en) 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
US5674522A (en) 1993-10-07 1997-10-07 Mcneil-Ppc, Inc. Beverage concentrate for drug delivery
DE4429134A1 (de) 1994-08-17 1996-02-22 Henkel Kgaa Verfahren zur Herstellung von Alkyl- und/oder Alkenyloligoglykosiden
US5498709A (en) 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
US5593696A (en) 1994-11-21 1997-01-14 Mcneil-Ppc, Inc. Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders
DK0776903T3 (da) * 1995-11-28 2003-05-12 Mcneil Ppc Inc Fremgangsmåde til fremstilling af en saccharose-6-ester
US5902628A (en) 1996-11-14 1999-05-11 Pepsico., Inc. Beverage with reduction of lingering sweet aftertaste of sucralose
EP0970096B1 (en) 1997-02-13 2004-11-10 Tate & Lyle Public Limited Company Chromatographic purification of chlorinated sucrose
AU753587B2 (en) 1997-11-14 2002-10-24 Johnson & Johnson Consumer Companies, Inc. Highly flavored dental floss
US6394230B1 (en) 1997-12-16 2002-05-28 Cognis Corporation Sterol esters as food additives
TR200100345T2 (tr) 1998-07-07 2001-08-21 Mcneil Specialty Products Company, Division Of Mcneil- Sükraloza tat vermenin geliştirilmesine ilişkin metod
US6090401A (en) 1999-03-31 2000-07-18 Mcneil-Ppc, Inc. Stable foam composition
US6211246B1 (en) 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
DE19938980A1 (de) 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
US6277409B1 (en) 2000-02-11 2001-08-21 Mcneil-Ppc, Inc. Protective coating for tablet
US6258381B1 (en) 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
CN1294139C (zh) 2000-11-17 2007-01-10 塔特和莱利有限公司 改进的三氯蔗糖组合物及其制备方法
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6890581B2 (en) 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
US6943248B2 (en) 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
WO2005090376A1 (en) 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
EA200601742A1 (ru) 2004-03-19 2007-02-27 Фармед Медикэр Прайвит Лимитед Усовершенствованный способ производства хлорированной сахарозы
GB2437442B (en) 2004-12-10 2010-03-31 Pharmed Medicare Pvt Ltd Improved process for purification of 6 acetyl 4,1',6' trichlorogalactosucrose and 4,1'6' trichlorogalactosucrose by chromatography on silanized silica gel
CN101098971B (zh) 2004-12-10 2010-04-21 V.B.医疗保险私人有限公司 有助于从含水反应混合物中选择性萃取4,1',6'三氯半乳蔗糖的盐
US20060188629A1 (en) 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US20090105470A1 (en) * 2005-02-22 2009-04-23 Pharmed Medicare Private Limited , A Corporation Tin Mediated Regioselective Synthesis of Sucrose-6-Esters
US20060205936A1 (en) 2005-03-14 2006-09-14 Sl Laboratories, Llc Chlorination of Sucrose-6-esters
US20060276639A1 (en) 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CN102124017A (zh) 2005-06-01 2011-07-13 V.B.医疗保险私人有限公司 利用溶剂萃取法纯化氯化蔗糖衍生物的方法
US20100197906A1 (en) 2005-06-06 2010-08-05 Pharmed Medicare Private Limited Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography
US7951937B2 (en) 2005-08-30 2011-05-31 V.B. Medicare Private Limited Process for purification of trichlorogalactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal of solvent
US20070100139A1 (en) 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US7741477B2 (en) 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN100418976C (zh) 2006-04-03 2008-09-17 广州科宏食品添加物有限公司 一种三氯蔗糖的制备方法
GB0702854D0 (en) 2007-01-09 2007-03-28 Tate & Lyle Plc Method for the synthesis of sucrose-6-esters
US20090076261A1 (en) * 2007-09-13 2009-03-19 Polymed Therapeutics, Inc. Novel process for preparing sucrose-6-esters

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
CN1446223A (zh) * 2000-07-31 2003-10-01 塔特和莱利有限公司 用于合成蔗糖－6－酯类的改进方法
CN1316428A (zh) * 2001-04-12 2001-10-10 河南兴泰科技实业有限公司 三氯蔗糖－6－酯制备新工艺
CN1453284A (zh) * 2003-05-23 2003-11-05 广东省食品工业研究所 一种三氯蔗糖的合成方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349300A (zh) * 2016-08-30 2017-01-25 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法
CN106349300B (zh) * 2016-08-30 2019-02-26 安徽金禾实业股份有限公司 三氯蔗糖酯化单溶剂反应方法

Also Published As

Publication number Publication date
JP2013507349A (ja) 2013-03-04
EP2488541A1 (en) 2012-08-22
IE86139B1 (en) 2013-02-27
GB2474311B (en) 2012-10-17
GB2474311A (en) 2011-04-13
CN102639550A (zh) 2012-08-15
JP5726195B2 (ja) 2015-05-27
US8921540B2 (en) 2014-12-30
IE20100653A1 (en) 2011-05-11
US20110087018A1 (en) 2011-04-14
KR20120089718A (ko) 2012-08-13
GB0920385D0 (en) 2010-01-06
WO2011045566A1 (en) 2011-04-21

Similar Documents

Publication Publication Date Title
CN102639550B (zh) 用于生产蔗糖-6-酯的低温、单一溶剂方法
CN102639551B (zh) 蔗糖-6-酯的生产方法
JP3012355B2 (ja) サツカロース−６−エステルの製造法
JP2882548B2 (ja) 有機錫エステルを含む反応混合物から同化合物の回収法及び回収した有機錫化合物の再使用
JPH04225993A (ja) サツカロース−６−エステルの製造法
CN103648602B (zh) 用锡化合物提取羧酸
JP5586683B2 (ja) スズスクロース付加物の塩基を利用した形成
JP5653416B2 (ja) ジメチルアミンを除去するプロセス
CN101981044B (zh) 碳水化合物浓度对三氯半乳蔗糖萃取效率的影响
JPH04225992A (ja) 新規白金錯体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant