CN102596186B - 芯稳定的微胶囊、它们的制备方法以及它们的用途 - Google Patents

芯稳定的微胶囊、它们的制备方法以及它们的用途 Download PDF

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Publication number
CN102596186B
CN102596186B CN201080042302.5A CN201080042302A CN102596186B CN 102596186 B CN102596186 B CN 102596186B CN 201080042302 A CN201080042302 A CN 201080042302A CN 102596186 B CN102596186 B CN 102596186B
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microcapsules
phase
agent
mixture
metal oxide
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CN102596186A (zh
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奥弗·托莱达诺
哈伊姆·巴尔-西曼托夫
哈南·塞尔特库克
S·菲尔曼-斯霍尔什
D·马尔考-达甘
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Shenzhen Beimei Pharmaceutical Co Ltd
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Sol Gel Technologies Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201080042302.5A 2009-12-31 2010-12-30 芯稳定的微胶囊、它们的制备方法以及它们的用途 Active CN102596186B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29159409P 2009-12-31 2009-12-31
US61/291,594 2009-12-31
PCT/IL2010/001092 WO2011080741A2 (en) 2009-12-31 2010-12-30 Core stabilized microcapsules, method of their preparation and uses thereof

Publications (2)

Publication Number Publication Date
CN102596186A CN102596186A (zh) 2012-07-18
CN102596186B true CN102596186B (zh) 2017-08-11

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Country Link
US (2) US10512796B2 (https=)
EP (1) EP2467132B1 (https=)
JP (1) JP5934107B2 (https=)
KR (1) KR20130008002A (https=)
CN (1) CN102596186B (https=)
AU (1) AU2010337830B2 (https=)
BR (1) BR112012012023A2 (https=)
CA (1) CA2773544C (https=)
EA (1) EA201200347A1 (https=)
ES (1) ES2611499T3 (https=)
MX (1) MX344128B (https=)
WO (1) WO2011080741A2 (https=)
ZA (1) ZA201203582B (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008211554B2 (en) 2007-02-01 2013-12-19 Sol-Gel Technologies Ltd. Method for preparing particles comprising metal oxide coating and particles with metal oxide coating
JP2011529392A (ja) 2008-07-31 2011-12-08 ゾル−ゲル テクノロジー リミテッド 活性成分および金属酸化物シェルを含むマイクロカプセル、その製造方法およびその使用
US11071878B2 (en) 2009-12-31 2021-07-27 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
US10653899B2 (en) 2009-12-31 2020-05-19 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
BR112012012023A2 (pt) 2009-12-31 2016-05-17 Sol Gel Technologies Ltd processo para preparar microcápsulas, microcápsulas, composição, método para tratar uma condição superficial em um indivíduo, e, uso das microcápsulas
ES2902498T3 (es) 2011-06-29 2022-03-28 Sol Gel Tech Ltd Formulaciones tópicas estabilizadas que contienen microcápsulas de núcleo-cubierta
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
EP2822743A1 (en) * 2012-04-18 2015-01-14 Rohm and Haas Company Wax-biocide wood treatment
US10806697B2 (en) * 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN102726383B (zh) * 2012-07-05 2015-03-18 常州美胜生物材料有限公司 一种缓释型害虫引诱剂微胶囊及其制备方法
FI126168B (en) 2012-09-18 2016-07-29 Novaldmedical Ltd Oy A method for coating pharmaceutical substrates
EP2925296B1 (en) * 2012-11-27 2021-01-06 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
CN104624125B (zh) * 2013-11-11 2018-03-02 中国人民银行印制科学技术研究所 一种光致变色双壳微胶囊及其制备方法和应用
CN103908912A (zh) * 2014-03-13 2014-07-09 安徽明讯新材料科技有限公司 一种相变恒温配胶容器
US9480960B2 (en) * 2014-12-01 2016-11-01 National Chung Shan Institute Of Science And Technology Process for preparing phase change microcapsule having thermally conductive shell
US10383798B2 (en) * 2015-05-13 2019-08-20 Conopco, Inc. Benefit delivery particle comprising a phenylalanine chitosan salt
WO2017029665A1 (en) 2015-08-20 2017-02-23 Sol-Gel Technologies Ltd. Compositions for topical application comprising benzoyl peroxide and adapalene
KR101779846B1 (ko) 2015-08-31 2017-10-10 주식회사 티케이케미칼 나노다공성을 갖는 서방성 미분말과 그 제조방법
CN105754554B (zh) * 2016-02-02 2019-02-19 中南林业科技大学 一种含纳米TiO2的纤维素基低温相变储能微胶囊及其制备方法
EP3419659A1 (en) 2016-02-23 2019-01-02 The Regents of the University of Colorado, A Body Corporate Compositions and methods for making and using thermostable immunogenic formulations with increased compatibility of use as vaccines against one or more pathogens
ES2979065T3 (es) * 2016-03-04 2024-09-24 Arkema Inc Encapsulación de peróxidos para aplicaciones cutáneas
CN105797659B (zh) * 2016-04-08 2018-12-14 东南大学 一种二氧化硅壳聚糖双壳储热微胶囊的制备方法
CA3069359C (en) * 2017-07-12 2023-01-10 Sol-Gel Technologies Ltd. Compositions comprising encapsulated tretinoin
EP3651755A4 (en) 2017-07-12 2021-03-24 Sol-Gel Technologies Ltd. METHODS AND COMPOSITIONS FOR TREATMENT OF ACNE
CN107213806B (zh) * 2017-07-13 2018-03-06 广州达济医学科技有限公司 一种用于滤除白细胞的滤膜及其制备方法
US11643584B2 (en) * 2017-11-16 2023-05-09 Georgia Tech Research Corporation Incorporation of microencapsulated phase change materials into wet-spin dry jet polymeric fibers
EP3740197A4 (en) 2018-01-16 2021-11-10 Applied Materials, Inc. METAL OXIDE ENCAPSULATED COMPOSITIONS OF THE ACTIVE SUBSTANCE AND PROCESS FOR THEIR MANUFACTURING
CN109338135B (zh) * 2018-10-11 2020-07-14 西北工业大学 一种核壳结构Al@Ti-Al2O3相变蓄热复合材料及制备方法
RU2701030C1 (ru) * 2018-12-29 2019-09-24 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Способ получения полых кремнеземных нанокапсул
WO2020170029A2 (en) 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for first-line treatment of rosacea
MX2021012434A (es) 2019-04-17 2022-01-19 Procter & Gamble Capsulas.
WO2020214878A1 (en) 2019-04-17 2020-10-22 The Procter & Gamble Company Methods of making capsules
JP7395612B2 (ja) 2019-04-17 2023-12-11 ザ プロクター アンド ギャンブル カンパニー カプセル
CN114080212B (zh) * 2019-07-09 2024-12-27 株式会社Lg生活健康 化妆品用胶囊
KR20220051385A (ko) 2019-08-27 2022-04-26 어플라이드 머티어리얼스, 인코포레이티드 약제 용해도 조절을 위한 증기상 코팅들
WO2021132729A1 (ja) * 2019-12-27 2021-07-01 花王株式会社 マイクロカプセルの製造方法
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
AU2021274996B2 (en) 2020-05-22 2026-04-09 Sol-Gel Technologies Ltd. Stabilized microcapsules, method of their preparation and uses thereof
TWI870622B (zh) 2020-10-02 2025-01-21 美商應用材料股份有限公司 製備氧化矽塗佈藥品的低溫處理
US11938349B2 (en) 2020-10-16 2024-03-26 The Procter & Gamble Company Antiperspirant and deodorant compositions comprising capsules
US12077728B2 (en) 2020-10-16 2024-09-03 The Procter & Gamble Company Laundry care additive particles
HUE069038T2 (hu) 2020-10-16 2025-02-28 Procter & Gamble Mag/héj szerkezetû kapszulát tartalmazó vízoldékony egyedi csomagolású árucikk
JP7544969B2 (ja) 2020-10-16 2024-09-03 ザ プロクター アンド ギャンブル カンパニー カプセルを含む液体布地ケア組成物
US12458942B2 (en) 2020-10-16 2025-11-04 The Procter & Gamble Company Capsules
CN112143476B (zh) * 2020-10-21 2022-03-04 南京工业大学 一种采用微流场反应技术制备纳米包覆驱油剂的方法及装置
CN121797207A (zh) 2020-12-28 2026-04-07 花王株式会社 微胶囊
EP4269550A4 (en) * 2020-12-28 2025-03-26 Kao Corporation PROCESS FOR MANUFACTURING SILICA MICROCAPSULES
CN116806141A (zh) * 2020-12-29 2023-09-26 株式会社Lg生活健康 利用矿物质材料的有效成分稳定化方法
EP4408402A4 (en) 2021-09-30 2025-08-06 Applied Materials Inc LOW TEMPERATURE SILICON OXIDE COATING FOR PHARMACEUTICAL APPLICATIONS
CN116919939B (zh) * 2022-04-02 2026-02-03 南京毓浠医药技术有限公司 一种维a酸和过氧化苯甲酰组合物及其制备方法和用途
US12275885B2 (en) * 2022-07-13 2025-04-15 King Fahd University Of Petroleum And Minerals Doped phase change material and method of preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015243A2 (en) * 2005-08-02 2007-02-08 Sol-Gel Technologies Ltd. Metal oxide coating of water insoluble ingredients
WO2008072239A2 (en) * 2006-12-12 2008-06-19 Sol-Gel Technologies Ltd. Formation of nanometric core-shell particles having a metal oxide shell

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906108A (en) 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
GB9021061D0 (en) 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
ATE249196T1 (de) 1993-02-26 2003-09-15 Estee Lauder Inc Titandioxiddispersionen, kosmetische präparate und verfahren für ihre verwendung
US5401517A (en) 1993-11-15 1995-03-28 Elizabeth Arden Company, Division Of Conopco, Inc. Cosmetic method for treatment of skin
US5720949A (en) 1996-05-06 1998-02-24 Bristol-Myers Squibb Company Foamable cosmetic mask product
US5891476A (en) 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
ES2216360T3 (es) 1998-02-06 2004-10-16 Seiwa Kasei Co., Ltd. Microcapsula con pared particular y su procedimiento de fabricacion.
US6099894A (en) 1998-07-27 2000-08-08 Frisby Technologies, Inc. Gel-coated microcapsules
DE1104287T1 (de) 1998-08-13 2001-12-20 Sol-Gel Technologies Ltd., Tel Aviv Verfahren zur herstellung von mit funktionalisierten molekülen beladene oxid-mikrokapseln und die daraus erhaltenen produkte
US6238650B1 (en) 1999-05-26 2001-05-29 Sol-Gel Technologies Ltd. Sunscreen composition containing sol-gel microcapsules
US6468509B2 (en) 1998-12-18 2002-10-22 Sol-Gel Technologies Ltd. Sunscreen composition containing sol-gel microcapsules
AU4775400A (en) 1999-05-25 2000-12-12 Sol-Gel Technologies Ltd. A method for obtaining photostable sunscreen compositions
US7758888B2 (en) * 2000-04-21 2010-07-20 Sol-Gel Technologies Ltd. Composition exhibiting enhanced formulation stability and delivery of topical active ingredients
ES2366886T1 (es) 2000-04-21 2011-10-26 Sol-Gel Technologies Ltd. Composición que presenta estabilidad de formulación potenciada y administración de ingredientes activos tópicos potenciado.
WO2004081222A2 (en) 2003-03-14 2004-09-23 Sol-Gel Technologies Ltd. Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same
JP2007500590A (ja) 2003-07-31 2007-01-18 ゾル−ゲル テクノロジーズ エルティーディー． 活性成分が充填されたマイクロカプセル及びその製造方法
DE102004017221A1 (de) 2004-04-05 2005-10-20 Cognis Ip Man Gmbh O/W-Gel-Zusammensetzungen mit Estern des Pentaerythrits oder dessen Oligomeren
EP1750659A1 (de) 2004-04-05 2007-02-14 Cognis IP Management GmbH Wachmischung auf basis von partialglyceriden und pentaerythritestern
WO2007092312A2 (en) 2006-02-03 2007-08-16 Stiefel Laboratories, Inc. Topical skin treating compositions
US20100047357A1 (en) 2007-02-01 2010-02-25 Sol-Gel Technologies Ltd. Compositions for topical application comprising a peroxide and retinoid
KR100837558B1 (ko) 2007-04-30 2008-06-12 (주)아모레퍼시픽 이중으로 안정된 세라마이드 나노 캡슐 포함 에멀젼조성물, 그의 제조방법 및 이를 이용한 피부 화장료 조성물
EP2158031B1 (en) 2007-05-08 2011-08-03 Givaudan SA Wax encapsulation
JP2011529392A (ja) * 2008-07-31 2011-12-08 ゾル−ゲル テクノロジー リミテッド 活性成分および金属酸化物シェルを含むマイクロカプセル、その製造方法およびその使用
BR112012012023A2 (pt) 2009-12-31 2016-05-17 Sol Gel Technologies Ltd processo para preparar microcápsulas, microcápsulas, composição, método para tratar uma condição superficial em um indivíduo, e, uso das microcápsulas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015243A2 (en) * 2005-08-02 2007-02-08 Sol-Gel Technologies Ltd. Metal oxide coating of water insoluble ingredients
WO2008072239A2 (en) * 2006-12-12 2008-06-19 Sol-Gel Technologies Ltd. Formation of nanometric core-shell particles having a metal oxide shell

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MX344128B (es) 2016-12-06
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US10512796B2 (en) 2019-12-24
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AU2010337830A1 (en) 2012-03-22
US20120202695A1 (en) 2012-08-09
MX2012006636A (es) 2012-07-10
US20180117369A1 (en) 2018-05-03
ES2611499T3 (es) 2017-05-09
EA201200347A1 (ru) 2012-07-30
CA2773544A1 (en) 2011-07-07
JP2013516404A (ja) 2013-05-13
KR20130008002A (ko) 2013-01-21
BR112012012023A2 (pt) 2016-05-17
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