CN102579786A - 一种治疗精液不液化的中药 - Google Patents
一种治疗精液不液化的中药 Download PDFInfo
- Publication number
- CN102579786A CN102579786A CN2012100580864A CN201210058086A CN102579786A CN 102579786 A CN102579786 A CN 102579786A CN 2012100580864 A CN2012100580864 A CN 2012100580864A CN 201210058086 A CN201210058086 A CN 201210058086A CN 102579786 A CN102579786 A CN 102579786A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- semen
- chinese medicine
- grams
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000582 semen Anatomy 0.000 title claims abstract description 69
- 239000003814 drug Substances 0.000 title claims abstract description 26
- 241000756943 Codonopsis Species 0.000 claims abstract description 15
- 239000009636 Huang Qi Substances 0.000 claims abstract description 12
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 4
- 238000011282 treatment Methods 0.000 claims description 19
- 241000283956 Manis Species 0.000 claims description 11
- 241000241550 Cyathula Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 3
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 230000007812 deficiency Effects 0.000 description 9
- 208000006820 Arthralgia Diseases 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 6
- 208000004880 Polyuria Diseases 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 208000033809 Suppuration Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 208000025747 Rheumatic disease Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000000552 rheumatic effect Effects 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 3
- 206010013935 Dysmenorrhoea Diseases 0.000 description 3
- 208000019255 Menstrual disease Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 241000045403 Astragalus propinquus Species 0.000 description 2
- 241000007126 Codonopsis pilosula Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241001278898 Glycyrrhiza inflata Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 241000961970 Plantago depressa Species 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 235000006533 astragalus Nutrition 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 210000005002 female reproductive tract Anatomy 0.000 description 2
- 230000004720 fertilization Effects 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229940012957 plasmin Drugs 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 201000010653 vesiculitis Diseases 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 206010009168 Chyluria Diseases 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 241000357628 Codonopsis pilosula subsp. tangshen Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000514824 Cyathula officinalis Species 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 241001547125 Fritillaria thunbergii Species 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 241000931143 Gleditsia sinensis Species 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 241000142952 Hamamelidaceae Species 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000244365 Ligusticum sinense Species 0.000 description 1
- 241000112528 Ligusticum striatum Species 0.000 description 1
- 241000893545 Liquidambar formosana Species 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- 241000283967 Manidae Species 0.000 description 1
- 241001282397 Manis pentadactyla Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 235000006089 Phaseolus angularis Nutrition 0.000 description 1
- 244000087211 Phaseolus calcaratus Species 0.000 description 1
- 235000012874 Phaseolus calcaratus Nutrition 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241001499733 Plantago asiatica Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010039954 Seminal vesiculitis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 240000007098 Vigna angularis Species 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000008492 tangshen Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Abstract
本发明涉及一种治疗精液不液化的中药，它是由以下重量份的药材组成：浙贝母10-20份、当归10-20份、皂角刺8-12份、萆薢15-25份、川牛膝10-20份、车前子10-15份、穿山甲2-6份、赤小豆8-12份、路路通8-12份、白芍10-20份、川芎10-20份、黄芪10-20份、党参10-15份、甘草8-12份。临床试验证明，本发明能够安全有效治疗精液不液化。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗精液不液化的中药。
背景技术
正常情况下，男性的精液在刚刚射出体外时属于液化状态，而在很短的时间内，就会凝固成胶冻状或凝块状，大约经10-30分钟的时间，精液就液化成水样液体，这个过程就是精液的液化，这种现象属正常的生理现象。如精液排出体外，超过30分钟仍呈胶冻状，则属于病理情况，称为精液不液化。这个过程，是非常符合人类生育要求的。精液开始的液化状态，非常有利于射精，接着变为胶冻状能让精液能在女性阴道内停留而不轻易流出，以后又液化能够让精液中的精子充分活动，以便沿女性生殖道向输卵管部位游动，利于精卵结合和受精。不液化的精液在显微镜下可见精子凝集成团，不能活动或只缓慢蠕动。此种精液中的精子在女性生殖道内的运动明显受到阻碍，精子不可能上行进入宫颈管、子宫腔及输卵管，不能与卵子相遇，使受精发生障碍。
精液凝固成胶冻状态，是由于精囊腺分泌的凝固蛋白造成的。而精液中由前列腺分泌的蛋白水解酶和纤维蛋白溶酶，可以分解这种凝固蛋白，促使精液液化。因此，现代医学认为，精液不液化是凝固蛋白增多或蛋白水解酶、纤维蛋白溶酶减少造成的。但是目前却缺乏公认安全有效的治疗药物。
本发明中药所涉及的药材来源及应用现状如下：
浙贝母【来源】本品为百合科植物浙贝母Fritillaria thunbergii Miq.的干燥鳞茎。【功能主治】清热散结，化痰止咳，用于风热犯肺，痰火咳嗽，肺痈，乳痈，瘰疬，疮毒。
当归【来源】本品为伞形科植物当归Angelica sinensis （Oliv.） Diels 的干燥根。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
皂角刺【来源】本品为豆科植物皂荚Gleditsia sinensis Lam. 的干燥棘刺。【功能主治】消肿托毒，排脓，杀虫。用于痈疽初起或脓成不溃；外治疥癣麻风。
萆薢【来源】拉丁植物动物矿物名：Rhizoma Dioscoreae Collettii 萆薢，别名：黄萆薢、土黄莲、黄姜。【功能主治】利湿去浊，祛风通痹。用于膏淋，白浊，白带过多，风湿痹痛，关节不利，腰膝疼痛。
川牛膝【来源】本品为苋科植物川牛膝Cyathula officinalis Kuan 的干燥根。【功能主治】逐瘀通经，通利关节，利尿通淋。用于经闭症瘕，胞衣不下，关节痹痛，足痿筋挛，尿血血淋，跌扑损伤。
车前子【来源】本品为车前科植物车前Plantago asiatica L. 或平车前Plantago depressa Willd.的干燥成熟种子。【功能主治】清热利尿，渗湿通淋，明目，祛痰。用于水肿胀满，热淋涩痛，暑湿泄泻，目赤肿痛，痰热咳嗽。
穿山甲【来源】本品为鲮鲤科动物穿山甲Manis pentadactyla Linnaeus的鳞甲。【功能主治】通经下乳，消肿排脓，搜风通络。用于经闭癓瘕，乳汁不通，痈肿疮毒，关节痹痛，麻木拘挛。
赤小豆【来源】本品为豆科植物赤小豆Phaseolus calcaratus Roxb. 或赤豆Phaseolus angularis Wight的干燥成熟种子。秋季果实成熟而未开裂时拔取全株，晒干，打下种子，除去杂质， 再晒干。【功能主治】利水消肿，解毒排脓。用于水肿胀满，脚气肢肿，黄疸尿赤，风湿热痹，痈肿疮毒，肠痈腹痛。
路路通【来源】本品为金缕梅科植物枫香树Liquidambar formosana Hance的干燥成熟果序。【功能主治】祛风活络，利水通经。用于关节痹痛，麻木拘挛，水肿胀满，乳少经闭。
白芍【来源】本品为毛茛科植物芍药Paeonia lactiflora Pall. 的干燥根。【功能主治】平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。
川芎【来源】本品为伞形科植物川芎Ligusticum chuanxiong Hort.（或Ligusticum wallichii Franch.）的干燥根茎。【功能主治】活血行气，祛风止痛。用于月经不调，经闭痛经，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
黄芪【来源】本品为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
党参【来源】本品为桔梗科植物党参 Codonopsis pilosula （Franch.） Nannf.、素花党参（西党参）Codonopsis pilosula Nannf. var. modesta （Nannf.） L. T. Shen或川党参Codonopsis tangshen Oliv.的干燥根。【功能主治】补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。
甘草【来源】本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。【功能主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
发明内容
本发明旨在提供一种治疗精液不液化的中药，通过选择合适的药材及其重量配比，以达到安全有效治疗精液不液化的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗精液不液化的中药，其特征在于：它是由以下重量份的药材组成：浙贝母10-20份、当归10-20份、皂角刺8-12份、萆薢15-25份、川牛膝10-20份、车前子10-15份、穿山甲2-6份、赤小豆8-12份、路路通8-12份、白芍10-20份、川芎10-20份、黄芪10-20份、党参10-15份、甘草8-12份。其中优选：浙贝母15份、当归15份、皂角刺10份、萆薢20份、川牛膝15份、车前子12份、穿山甲4份、赤小豆10份、路路通10份、白芍15份、川芎15份、黄芪15份、党参12份、甘草10份。
本发明具体使用方法：口服，每天需服用：使用“浙贝母10-20克、当归10-20克、皂角刺8-12克、萆薢15-25克、川牛膝10-20克、车前子10-15克、穿山甲2-6克、赤小豆8-12克、路路通8-12克、白芍10-20克、川芎10-20克、黄芪10-20克、党参10-15克、甘草8-12克，其中优选：浙贝母15克、当归15克、皂角刺10克、萆薢20克、川牛膝15克、车前子12克、穿山甲4克、赤小豆10克、路路通10克、白芍15克、川芎15克、黄芪15克、党参12克、甘草10克”制得的制剂。
下面结合中医理论说明本方明的有益效果：
发明人在临床实践过程中发现，男子不育精液不液化大多是由于脾肾阳虚，痰湿内结，治疗应温补脾肾，化痰除湿。本发明中药运用：白芍、当归、川芎养血活血；党参、甘草补脾益气；浙贝母清热除湿；皂角刺、萆薢、川牛膝、车前子、穿山甲、赤小豆、路路通、黄芪清热利尿通淋、化痰排毒；诸药合用，温补脾肾、化痰除湿，从而治愈精液不液化。
下面结合临床试验数据说明本发明的有益效果：
1、来源
2007年3月-2010年10月间，发明人共收集精液不液化患者240例。治疗前精液液化时间均>60min，年龄24-47岁，平均35.5岁，病程最长5年，最短1年。婚后同居1年以上，性生活正常，未避孕而不育，性激素水平正常，排除前列腺炎，精囊炎、尿道炎，并排除器质性病变。随机分为治疗组180例、对照组60例。两组患者在年龄、病程及病情轻重程度的差异无统计学意义（P>0.01），具有可比性。
2、诊断与纳入标准
精液不液化诊断标准参照世界卫生组织主编的《WHO人类精液及精子-宫颈粘液相互作用实验事检验手册》”。所有患者禁欲4-7 d后来取精室取精液置干燥消毒玻璃离心管中，置37℃水浴箱内，60min后仍不液化即诊为精液不液化症，连续检查两次不液化者纳为研究对象。
3、治疗方法
治疗组每天早晚两次服用本发明优选配方按照具体实施例1制得的煎剂，连续服用1个疗程（1个月）。
对照组服用复合蛋白锌片，按照其说明书服用，连续服用1个疗程（1个月）。
4、观察项目与统计方法
两组治疗前后均观察并记录精液液化时间。使用SPSS 12.0进行统计学分析。
5、疗效判断标准
痊愈：女方怀孕，或精液液化时间<30min；好转：精液液化时间<60min；无效：精液液化时间≥60min。
6、结果
治疗统计结果见表1。
表1 治疗统计结果
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 180 | 80 | 91 | 9 | 0（0%） | 95% |
| 对照组 | 60 | 20 | 28 | 12 | 3（5%） | 80% |
治疗组治疗前后，精液液化时间显著缩短（P<0.01），治愈率与对照组相比具有显著性差异（P<0.01）。
可见，本发明优选实施方式制得的药物能够安全有效用于精液不液化的治疗。
根据上述临床实验数据，结合发明人对本发明中药作用机理的分析和本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，在最佳重量份附近取值，至少在“浙贝母10-20份、当归10-20份、皂角刺8-12份、萆薢15-25份、川牛膝10-20份、车前子10-15份、穿山甲2-6份、赤小豆8-12份、路路通8-12份、白芍10-20份、川芎10-20份、黄芪10-20份、党参10-15份、甘草8-12份”的范围内，可以取得与本发明优选实施方式制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
一种治疗精液不液化的中药，由以下药材制成：浙贝母15克、当归15克、皂角刺10克、萆薢20克、川牛膝15克、车前子12克、穿山甲4克、赤小豆10克、路路通10克、白芍15克、川芎15克、黄芪15克、党参12克、甘草10克。
所述中药的制备方法为：称取上述药材，按照常规工艺加水提取两次，合并滤液，浓缩，包装。即得符合正常成人一天用量的煎剂。
用于治疗精液不液化，每日分早晚两次服用，1个月为一疗程。
具体实施例2
一种治疗精液不液化的中药，由以下药材制成：浙贝母10克、当归10克、皂角刺8克、萆薢15克、川牛膝10克、车前子10克、穿山甲2克、赤小豆8克、路路通8克、白芍10克、川芎10克、黄芪10克、党参10克、甘草8克。
所述中药的制备方法为：称取上述药材，按照常规工艺加水提取两次，合并滤液，浓缩，干燥，得提取物，加入适量聚乙二醇6000，按照常规制药工艺制备成滴丸，即得符合正常成人一天用量的滴丸剂。
用于治疗精液不液化，每天一次，1个月为一疗程。
具体实施例3
一种治疗精液不液化的中药，由以下药材制成：浙贝母20克、当归20克、皂角刺12克、萆薢25克、川牛膝20克、车前子15克、穿山甲6克、赤小豆12克、路路通12克、白芍20克、川芎20克、黄芪20克、党参15克、甘草12克。
所述中药的制备方法为：称取上述药材，按照常规工艺加水提取两次，合并滤液，浓缩，干燥，得提取物，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗精液不液化，每日分早中晚三次服用，1个月为一疗程。
Claims (2)
1.一种治疗精液不液化的中药，其特征在于：它是由以下重量份的药材组成：浙贝母10-20份、当归10-20份、皂角刺8-12份、萆薢15-25份、川牛膝10-20份、车前子10-15份、穿山甲2-6份、赤小豆8-12份、路路通8-12份、白芍10-20份、川芎10-20份、黄芪10-20份、党参10-15份、甘草8-12份。
2.按照权利要求1所述的治疗精液不液化的中药，其特征在于：它是由以下重量份的药材组成：浙贝母15份、当归15份、皂角刺10份、萆薢20份、川牛膝15份、车前子12份、穿山甲4份、赤小豆10份、路路通10份、白芍15份、川芎15份、黄芪15份、党参12份、甘草10份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100580864A CN102579786B (zh) | 2012-03-07 | 2012-03-07 | 一种治疗精液不液化的中药 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100580864A CN102579786B (zh) | 2012-03-07 | 2012-03-07 | 一种治疗精液不液化的中药 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102579786A true CN102579786A (zh) | 2012-07-18 |
| CN102579786B CN102579786B (zh) | 2013-11-27 |
Family
ID=46469388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100580864A Expired - Fee Related CN102579786B (zh) | 2012-03-07 | 2012-03-07 | 一种治疗精液不液化的中药 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579786B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056189A (zh) * | 2015-08-20 | 2015-11-18 | 孙涛 | 一种用于精液不化症的中药 |
| CN105943989A (zh) * | 2016-06-25 | 2016-09-21 | 董艳丽 | 一种治疗精液不液化的中药组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772159A (zh) * | 2005-05-26 | 2006-05-17 | 李琦白 | 一种治疗精液不液化的中药方剂 |
| CN101066413A (zh) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | 治疗精液不液化性不育症的中药制剂 |
-
2012
- 2012-03-07 CN CN2012100580864A patent/CN102579786B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772159A (zh) * | 2005-05-26 | 2006-05-17 | 李琦白 | 一种治疗精液不液化的中药方剂 |
| CN101066413A (zh) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | 治疗精液不液化性不育症的中药制剂 |
Non-Patent Citations (2)
| Title |
|---|
| 徐福松: "慢性前列腺炎与男子不育症", 《实用男科杂志》, vol. 2, no. 02, 30 June 1996 (1996-06-30), pages 125 - 134 * |
| 胡发明: "中医药治疗精液不液化不育症的近况", 《现代诊断与治疗》, vol. 16, no. 05, 30 September 2005 (2005-09-30), pages 286 - 288 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056189A (zh) * | 2015-08-20 | 2015-11-18 | 孙涛 | 一种用于精液不化症的中药 |
| CN105943989A (zh) * | 2016-06-25 | 2016-09-21 | 董艳丽 | 一种治疗精液不液化的中药组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102579786B (zh) | 2013-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104352776B (zh) | 一种治疗月经过少致不孕的中药制剂及其制备方法 | |
| CN104258066A (zh) | 一种治疗肾阴虚型功能失调性子宫出血的中药制剂及其制备方法 | |
| CN106110043A (zh) | 一种治疗前列腺炎的中药组合物及其制备方法 | |
| CN110917326A (zh) | 一种促进子宫内膜修复中药组合物及其应用 | |
| CN104055932A (zh) | 一种淫羊藿汤 | |
| CN104958701A (zh) | 一种用于高泌乳素血症的中药制剂及其制备方法 | |
| CN102579786B (zh) | 一种治疗精液不液化的中药 | |
| CN103212054A (zh) | 一种治疗妇女不孕不育症的中药组合物及其制备方法 | |
| CN104922538A (zh) | 一种用于IgA肾病中药制剂及其制备方法 | |
| CN104258236A (zh) | 用于产褥期妇女阴道护理的中药组合物 | |
| CN104042760A (zh) | 一种益肾壮精汤 | |
| CN103272189A (zh) | 一种治疗胆结石的药物 | |
| CN105709035B (zh) | 一种治疗奶牛子宫内膜炎的中药组合物 | |
| CN103656533B (zh) | 一种治疗慢性前列腺炎的中药组合物 | |
| CN105106419A (zh) | 一种用于治疗盆腔炎的药物制剂 | |
| CN102526601B (zh) | 一种治疗少精子症的中药 | |
| CN104826077A (zh) | 一种用于银屑病膝关节炎中药制剂及其制备方法 | |
| CN104042778A (zh) | 一种固本生精汤 | |
| CN104815136A (zh) | 一种用于治疗男子不育症的中药 | |
| CN102133287B (zh) | 一种治疗风疹的中药组合物 | |
| CN104587256A (zh) | 一种治疗前列腺炎的中药组合物 | |
| CN104758830A (zh) | 一种治疗骨病及皮肤损伤的中药组合物及其制备方法 | |
| CN104225177A (zh) | 一种治疗肾虚髓亏证型脑鸣的中药 | |
| CN103784660A (zh) | 治疗不孕症的中草药制剂 | |
| CN113827677A (zh) | 一种纯中药治疗痛风的组合方及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: LIANG LIZHOU Free format text: FORMER OWNER: WANG XIONG Effective date: 20131023 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Zhimin Inventor after: Liang Lizhou Inventor before: Wang Xiong |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WANG XIONG TO: WANG ZHIMIN LIANG LIZHOU Free format text: CORRECT: ADDRESS; FROM: 264000 YANTAI, SHANDONG PROVINCE TO: 265400 YANTAI, SHANDONG PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20131023 Address after: 265400 Zhaoyuan, Shandong, spa Road, No. 111, No. Applicant after: Liang Lizhou Address before: 264000 No. 5, Tak Tak Street, Zhifu District, Shandong, 23, No. 2, attached, Yantai Applicant before: Wang Xiong |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: RUGAO BINJIANG URBAN CONSTRUCTION INVESTMENT CO., Free format text: FORMER OWNER: LIANG LIZHOU Effective date: 20150424 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 265400 YANTAI, SHANDONG PROVINCE TO: 226534 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150424 Address after: 226534 Jiangsu city of Nantong province Rugao City Jiangan town Fu Road No. 166 Patentee after: RUGAO BINJIANG URBAN CONSTRUCTION INVESTMENT CO., LTD. Address before: 265400 Zhaoyuan, Shandong, spa Road, No. 111, No. Patentee before: Liang Lizhou |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131127 Termination date: 20190307 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |