CN102552688B - Healthcare product for treating hyperlipidemia and preparation method thereof - Google Patents
Healthcare product for treating hyperlipidemia and preparation method thereof Download PDFInfo
- Publication number
- CN102552688B CN102552688B CN2012100634671A CN201210063467A CN102552688B CN 102552688 B CN102552688 B CN 102552688B CN 2012100634671 A CN2012100634671 A CN 2012100634671A CN 201210063467 A CN201210063467 A CN 201210063467A CN 102552688 B CN102552688 B CN 102552688B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- weight
- chinese medicine
- radix
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 239000003814 drug Substances 0.000 claims abstract description 56
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 30
- 239000000654 additive Substances 0.000 claims abstract description 19
- 230000000996 additive effect Effects 0.000 claims abstract description 19
- 241000190633 Cordyceps Species 0.000 claims abstract description 17
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 17
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 17
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 17
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 17
- 235000008434 ginseng Nutrition 0.000 claims abstract description 17
- 241000489492 Arisaema Species 0.000 claims abstract description 16
- 241000959626 Calvatia Species 0.000 claims abstract description 16
- 210000000941 bile Anatomy 0.000 claims abstract description 16
- 229940088594 vitamin Drugs 0.000 claims abstract description 16
- 229930003231 vitamin Natural products 0.000 claims abstract description 16
- 235000013343 vitamin Nutrition 0.000 claims abstract description 16
- 239000011782 vitamin Substances 0.000 claims abstract description 16
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960000304 folic acid Drugs 0.000 claims abstract description 15
- 235000019152 folic acid Nutrition 0.000 claims abstract description 15
- 239000011724 folic acid Substances 0.000 claims abstract description 15
- 229940024606 amino acid Drugs 0.000 claims abstract description 14
- 235000001014 amino acid Nutrition 0.000 claims abstract description 14
- 150000001413 amino acids Chemical class 0.000 claims abstract description 14
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 10
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 6
- 238000011282 treatment Methods 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 239000000843 powder Substances 0.000 claims description 35
- 230000036541 health Effects 0.000 claims description 33
- 241000208340 Araliaceae Species 0.000 claims description 16
- 241000218628 Ginkgo Species 0.000 claims description 16
- 238000005325 percolation Methods 0.000 claims description 16
- 241000218236 Cannabis Species 0.000 claims description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 229940085605 saccharin sodium Drugs 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 235000005911 diet Nutrition 0.000 claims description 6
- 230000000378 dietary effect Effects 0.000 claims description 6
- -1 sodium bicarbonate, vitamin Chemical class 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 235000012343 cottonseed oil Nutrition 0.000 claims description 4
- 238000012856 packing Methods 0.000 claims description 4
- 238000005453 pelletization Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 229960001407 sodium bicarbonate Drugs 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 49
- 239000008280 blood Substances 0.000 abstract description 34
- 210000004369 blood Anatomy 0.000 abstract description 32
- 150000002632 lipids Chemical class 0.000 abstract description 14
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 235000007162 Ferula assa foetida Nutrition 0.000 abstract 1
- 244000228957 Ferula foetida Species 0.000 abstract 1
- 235000012850 Ferula foetida Nutrition 0.000 abstract 1
- 244000194101 Ginkgo biloba Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000004308 marijuana Species 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 description 22
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 20
- 230000007812 deficiency Effects 0.000 description 20
- 206010011224 Cough Diseases 0.000 description 19
- 210000003734 kidney Anatomy 0.000 description 17
- 210000004185 liver Anatomy 0.000 description 15
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 8
- 108010023302 HDL Cholesterol Proteins 0.000 description 7
- 108010028554 LDL Cholesterol Proteins 0.000 description 7
- 208000006673 asthma Diseases 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 230000001603 reducing effect Effects 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- 208000001848 dysentery Diseases 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 201000001881 impotence Diseases 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 206010000087 Abdominal pain upper Diseases 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 210000003026 hypopharynx Anatomy 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 238000010791 quenching Methods 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
- 239000004473 Threonine Substances 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000003143 atherosclerotic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003172 expectorant agent Substances 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 229930182817 methionine Natural products 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 239000004380 Cholic acid Substances 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010067171 Regurgitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000019416 cholic acid Nutrition 0.000 description 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 2
- 229960002471 cholic acid Drugs 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000589562 Brucella Species 0.000 description 1
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 208000032928 Dyslipidaemia Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000010282 Emodin Substances 0.000 description 1
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 102000000853 LDL receptors Human genes 0.000 description 1
- 108010001831 LDL receptors Proteins 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033971 Paratyphoid fever Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010039020 Rhabdomyolysis Diseases 0.000 description 1
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000015606 cardiovascular system disease Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 1
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
- 229960001123 epoprostenol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 235000005955 light diet Nutrition 0.000 description 1
- 230000008604 lipoprotein metabolism Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 description 1
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 1
- OISYIJRGMYJBRH-UHFFFAOYSA-N physcione Natural products COc1cc(O)c2C(=O)c3ccc(O)cc3C(=O)c2c1 OISYIJRGMYJBRH-UHFFFAOYSA-N 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000002407 reforming Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a healthcare product for treating hyperlipidemia. The healthcare product comprises a traditional Chinese medicine composition additive, sodium bicarbonate, folic acid, vitamin and amino acid, wherein the traditional Chinese medicine composition additive comprises rhizoma polygoni cuspidati, rhizoma polygonati, ginkgo leaf, rhubarb, ginseng, bulbus allii macrostemonis, Chinese asafetida, cordyceps, fructus lycii, bile arisaema, fructus corni, herba taxilli, rhizoma anemarrhenae, fructus cannabis, herba taraxaci, lasiosphaera seu calvatia, radix cynanchi atrati, fructus evodiae and radix platycodonis. The healthcare product containing the traditional Chinese medicine composition additive provided by the invention has little side effect, low cost, good curative effect and no drug resistance, is advantageous in multiple blood lipid lowering ways and the like, and realizes a perfect effect in treating hyperlipidemia.
Description
Technical field
The present invention relates to health product technology field, relate in particular to a kind of health product for the treatment of hyperlipidemia.
Background technology
arriving along with aging society, people's living standard improves constantly, cardiovascular disease has become worldwide one " modern popular is sick ", in the M ﹠ M statistics of the hyperlipidemia disease of countries in the world, cardiovascular system diseases holds pride of place, its sickness rate and case fatality rate raise increasingly, only there are every year 2600000 people to die from cardiovascular disease in China, therefore the level of preventing and treating that improves cardiovascular disease is very urgent, and one of risk factor in the hyperlipidemia cardiovascular disease, it generally refers to blood cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) overrun, or follow HDL-C (HDL-C) low.Studies confirm that, in the morbidity of atherosclerosis, crown atherosclerotic heart disease and blood, the LDL-C level is proportionate, and is negative correlation with the HDL-G level, regulates blood fat, revise lipid metabolic disorder and can treat and alleviate atherosclerosis, reduce the incidence rate of crown atherosclerotic heart disease.
The main mechanism of the Western medicine medicine for the treatment of hyperlipidemia can be divided into following 5 approach: 1, stop cholic acid or cholesterol from intestinal absorption, promote cholic acid or cholesterol to discharge with feces; 2, suppress interior the synthesizing of body of cholesterol, or promote the conversion of cholesterol; 3, promote ldl receptor expression on cell membrane, accelerate lipoprotein and decompose; 4, activate the lipoprotein metabolism enzyme, promote the hydrolysis of triglyceride; 5, stop the interior metabolism of synthesizing or promoting other lipids of body of other lipids.
Though the western medicine hyperlipidemia has sure curative effect, but side effect is in various degree arranged, and the most effective and Western medicine extensive use of the treatment hyperlipidemia of generally acknowledging at present is Statins, but expense is high, and the side effect such as liver and musclar toxicity are arranged, and severe patient can cause rhabdomyolysis.
Chinese medicine composition is subject to gradually the world of medicine and pays close attention to because of its good effect, the characteristics such as active strong, untoward reaction is little.Traditional medicine and modern pharmacology experiment show that Chinese medicine composition has good curative effect to treatment and the treatment of hyperlipidemia.
Summary of the invention
Technical problem to be solved by this invention is, overcome the deficiency of existing western medicine and treatment hyperlipidemia, utilize the traditional theory of Chinese medical science of China, the health product that contain the Chinese medicine composition additive component are provided, these health product have that side effect is little, cost is low, therapeutic effect is good, have no drug resistance, the advantages such as multiple effect for reducing blood fat approach are arranged, the treatment hyperlipidemia is had good effect.
Ask in order to solve above-mentioned technology, the invention provides a kind of health product for the treatment of hyperlipidemia, it comprises Chinese medicine composition additive, sodium bicarbonate, folic acid, vitamin and aminoacid, and described Chinese medicine composition additive comprises Rhizoma Polygoni Cuspidati, Rhizoma Polygonati, Folium Ginkgo, Radix Et Rhizoma Rhei, Radix Ginseng, Bulbus Allii Macrostemonis, Resina Ferulae, Cordyceps, Fructus Lycii, Arisaema Cum Bile, Fructus Corni, Herba Taxilli, the Rhizoma Anemarrhenae, Fructus Cannabis, Herba Taraxaci, Lasiosphaera Seu Calvatia, Radix Cynanchi Atrati, Fructus Evodiae and Radix Platycodonis.
Wherein, the percentage by weight of described Chinese medicine composition additive is preferably 2%～4%, the percentage by weight of described vitamin is preferably 4%～8%, described amino acid whose percentage by weight is preferably 4%～8%, the percentage by weight of sodium bicarbonate is preferably 1%～3%, and the percentage by weight of folic acid is preferably 3%～6%.
wherein, in described Chinese medicine composition additive, the ratio of weight and number of various components can be Rhizoma Polygoni Cuspidati 25～35 weight portions, Rhizoma Polygonati 65～75 weight portions, Folium Ginkgo 25～35 weight portions, Radix Et Rhizoma Rhei 15～25 weight portions, Radix Ginseng 50～60 weight portions, Bulbus Allii Macrostemonis 25～35 weight portions, Resina Ferulae 8～12 weight portions, Cordyceps 20～30 weight portions, Fructus Lycii 15～25 weight portions, Arisaema Cum Bile 10～20 weight portions, Fructus Corni 12～18 weight portions, Herba Taxilli 12～18 weight portions, the Rhizoma Anemarrhenae 25～35 weight portions, Fructus Cannabis 8～12 weight portions, Herba Taraxaci 25～35 weight portions, Lasiosphaera Seu Calvatia 15～25 weight portions, Radix Cynanchi Atrati 12～18 weight portions, Fructus Evodiae 10～20 weight portions and Radix Platycodonis 6～10 weight portions.
wherein, in described Chinese medicine composition additive, the ratio of weight and number of various components can be Rhizoma Polygoni Cuspidati 30～35 weight portions, Rhizoma Polygonati 70～75 weight portions, Folium Ginkgo 30～35 weight portions, Radix Et Rhizoma Rhei 20～25 weight portions, Radix Ginseng 55～60 weight portions, Bulbus Allii Macrostemonis 30～35 weight portions, Resina Ferulae 10～12 weight portions, Cordyceps 25～30 weight portions, Fructus Lycii 20～25 weight portions, Arisaema Cum Bile 15～20 weight portions, Fructus Corni 15～18 weight portions, Herba Taxilli 15～18 weight portions, the Rhizoma Anemarrhenae 30～35 weight portions, Fructus Cannabis 10～12 weight portions, Herba Taraxaci 30～35 weight portions, Lasiosphaera Seu Calvatia 20～25 weight portions, Radix Cynanchi Atrati 15～18 weight portions, Fructus Evodiae 15～20 weight portions and Radix Platycodonis 8～10 weight portions.
Wherein, in described Chinese medicine composition additive, the ratio of weight and number of various components can be Rhizoma Polygoni Cuspidati 32 weight portions, Rhizoma Polygonati 72 weight portions, Folium Ginkgo 32 weight portions, Radix Et Rhizoma Rhei 22 weight portions, Radix Ginseng 58 weight portions, Bulbus Allii Macrostemonis 32 weight portions, Resina Ferulae 11 weight portions, Cordyceps 28 weight portions, Fructus Lycii 22 weight portions, Arisaema Cum Bile 18 weight portions, Fructus Corni 16 weight portions, Herba Taxilli 16 weight portions, the Rhizoma Anemarrhenae 32 weight portions, Fructus Cannabis 11 weight portions, Herba Taraxaci 32 weight portions, Lasiosphaera Seu Calvatia 22 weight portions, Radix Cynanchi Atrati 16 weight portions, Fructus Evodiae 18 weight portions and Radix Platycodonis 9 weight portions.
Wherein, described health product can be oral liquid or tablet.
The present invention also provides the preparation method of above-mentioned health product, and when described health product were oral liquid, it comprised,
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, with fine powder and the folic acid that obtains, sodium bicarbonate, vitamin, aminoacid is mixed in proportion, obtain mixture, further add saccharin sodium, correctives and antiseptic mix and are dissolved in water with respect to 25～50 times of the quality of Chinese medicine fine powder, sodium carboxymethyl cellulose is dispersed in hot water, cooling, then add in the aqueous solution of front, become volume required preparing solution and mix homogeneously, concentrated, packing after sterilization, namely get healthcare dietetic liquid, mixture with respect to 100 weight portions, described saccharin sodium is 2～4 weight portions, the weight fraction of described sodium carboxymethyl cellulose is 3～5 weight portions, correctives 0.5～1 weight portion, antiseptic 0.5～1 weight portion.
The present invention also provides the preparation method of above-mentioned health product, and when described health product were tablet, it comprised,
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
Second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, the fine powder and folic acid, sodium bicarbonate, vitamin, the aminoacid that obtain are mixed in proportion, obtain mixture, with the mixture that obtains, adding starch to carry out mixing processes, the weight ratio of described mixture and described starch is 1: 0.2～0.4, carry out subsequently pelletization treatment, dried, the granule and Pulvis Talci, the magnesium stearate that obtain are carried out mixing processing, tabletting processing, Cotton seeds successively, namely get the troche of health products finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3.
Beneficial effect of the present invention:
The health product that contain the Chinese medicine composition additive component provided by the invention have that side effect is little, cost is low, therapeutic effect is good, have no drug resistance, and the advantages such as multiple effect for reducing blood fat approach are arranged, and the treatment hyperlipidemia is had good effect.
The specific embodiment
The main path that Chinese medicine composition is regulated blood fat comprises: 1, suppress the absorption of exogenous lipid; 2, suppress the synthetic of endogenous lipid; 3, promote running and the excretion of body lipid; Affect the metabolism of endosome lipid.
The traditional Chinese medical science is thought this disease, and many polyphagia is moving less because having a liking for the delicious food savoury, and it is unsuccessful that institute is willing to, and air flue is stopped up stagnant, precise and tiny not reforming consequently, and the cream fat obstacle that turns round, the fiery Lu Buchang in imperial road, QI-blood circulation is not normal, due to turbid fat stagnation of blood stasis.Therefore, the key that Chinese traditional treatment should disease is " a leading to " word, and with the blood stasis dispelling path, the turbid descending fat, regulating QI and blood are method.
Based on this, the invention provides a kind of Chinese medicine composition, it comprises: Rhizoma Polygoni Cuspidati, Rhizoma Polygonati, Folium Ginkgo, Radix Et Rhizoma Rhei, Radix Ginseng, Bulbus Allii Macrostemonis, Resina Ferulae, Cordyceps, Fructus Lycii, Arisaema Cum Bile, Fructus Corni, Herba Taxilli, the Rhizoma Anemarrhenae, Fructus Cannabis, Herba Taraxaci, Lasiosphaera Seu Calvatia, Radix Cynanchi Atrati, Fructus Evodiae and Radix Platycodonis.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature is returned liver, gallbladder, lung meridian, has heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, the dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm is used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus, Rhizoma Polygoni Cuspidati have certain thrombus dissolving, suppress platelet aggregation and improve sanguimotor effect.
Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, have the nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI is used for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair, the Rhizoma Polygonati serum High Density Lipoprotein Cholesterol level that can raise shows effect for reducing blood fat preferably.
Folium Ginkgo: sweet in the mouth, hardship, puckery, property is put down, and enters the heart, lung meridian, and having astringes the lung relievings asthma, invigorate blood circulation nourish heart, the effect of relieving diarrhea with astringents, be used for cough and asthma due to lung deficiency, uncomfortable in chest pained, dizziness headache, have loose bowels, the cards such as dysentery, Folium Ginkgo have the effect that reduces serum cholesterol, coronary artery dilator, and treatment hypertension, hyperlipidemia and angina pectoris are had certain effect.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, has purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation, cure mainly the excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, the edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spit blood, spitting of blood, epistaxis, have blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, the cards such as scald, Radix Et Rhizoma Rhei has the effect of broad-spectrum antiseptic, can control the infection of wound surface, effective ingredient chrysophanic acid in Radix Et Rhizoma Rhei, emodin, chrysophanol, physcione has the effect that reduces blood pressure with cholesterol.
Radix Ginseng: property is flat, tepor, sweet in the mouth, little hardship, return spleen, lung meridian, heart channel, has strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the calm the nerves effect of Fructus Alpiniae Oxyphyllae, be used for impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies, Radix Ginseng has dual regulation to blood fat, can significantly promote the biosynthesis of lipoprotein in cholesterol and blood on the one hand, also can accelerate its decomposition on the other hand.
Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature, return lung, the heart, stomach, large intestine channel, have activating YANG and eliminating stagnation, the effect of circulation of qi promoting intestinal stasis relieving cures mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, weigh leucorrhea, the cards such as furuncle carbuncle after letting out dysentery, Bulbus Allii Macrostemonis can reduce blood fat, and is especially better to the reducing effect of serum cholesterol, triglyceride, can reduce Serum LPO Levels simultaneously, improve prostacyclin content, thereby play inhibition thrombosis, alleviate the effect of atherosclerotic lesion.
Resina Ferulae: bitter in the mouth, suffering, warm in nature, return kidney, stomach warp, have removing food stagnancy, loose painful abdominal mass, the effect of parasite killing is used for meat stagnation, blood stasis lump in the abdomen, mass in abdomen, the cards such as abdominal pain due to worm stagnation.
Cordyceps: sweet in the mouth, property is flat, enters lung, kidney channel, has kidney invigorating and YANG supporting, tonifying the lung is relievingd asthma, and the effect of hemostasis and phlegm, the traditional Chinese medical science think, Cordyceps enters lung kidney two warps, can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough expectorant blood, spontaneous sweatings etc. are unique a kind of balance simultaneously, the Chinese medicine composition of adjusting negative and positive, cure mainly senile chronic bronchitis, emphysema, pulmonary tuberculosis, bronchial asthma, cough is breathed hard, the dyspnea due to deficiency spitting of blood; The empty hyperhidrosis of body, spontaneous perspiration, night sweat; Weak after being ill, prolonged deficiency is not multiple, or the labor that declines is weak, and various chronic expendable; Deficiency of kidney-QI, soreness of waist and knee joint, impotence and seminal emission; Cancer; The diabetes patient, lupus erythematosus, the cards such as chronic nephritis and aplastic anemia and leukopenia.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, liver and kidney tonifying is arranged, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Arisaema Cum Bile: bitter in the mouth, little suffering, cool in nature, return lung, liver, spleen channel, have removing heat-phlegm, the effect of dispelling wind and relieving convulsion is used for phlegm-heat cough, coughs up phlegm yellow thick, middle wind-phlegm fan, the cards such as demented infantile convulsion.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature enters liver, kidney channel, the effect that has liver and kidney tonifying, arresting seminal emission, arresting sweating admittedly to take off, be mainly used in soreness of the waist and knees, the dizziness and tinnitus of the hepatic and renal YIN deficiency, excessive rising of liver-YANG, sexual impotence, essence is closed the cards such as not solid seminal emission, spermatorrhea, metrostaxis.
Herba Taxilli: bitter in the mouth, sweet, property is flat, enters liver, kidney channel, effect with invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit is used for the soreness of waist pain due to deficiency of the liver and kindey, and the muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood is empty to be lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.
The Rhizoma Anemarrhenae: be plant amedica, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.
Fructus Cannabis: sweet in the mouth, property is flat, returns spleen, stomach, large intestine channel, has the effect of strengthening the spleen tonify deficiency, nourishing YIN to relieve dryness, relieving constipation, is used for beriberi and swells and ache, the empty senilism of body, insufficiency of heart-YIN, palpitation and restlessness, blood deficiency Tianjin wound, the cards such as dryness of the intestine constipation.
Herba Taraxaci: also claim Herba crotalariae albidae, sweet in the mouth, bitter, cold in nature, enter liver, the stomach warp, has heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, the effect of inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to the acute mastitis effect, also can be used for the treatment of the symptoms such as conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, the effect that also has promoting urination to remove dampness, be used for controlling jaundice due to damp-heat, dysuria, the treatment of the diseases such as urinary system infection, common reply Staphyloccocus aureus, escherichia coli, bacillus pyocyaneus, shigella flexneri, paratyphoid fever, white beads Niu Jun, cattle type Brucella has certain bacteriostasis, to Trichophyton concentricunm, permitted haze achorion, the little sporeformer of rust, Gypsum Fibrosum sample budlet spore tinea bacterium etc. bacteriostasis all arranged.
Radix Cynanchi Atrati: bitter salty, cold in nature, enter lung, stomach, kidney channel, have the effect of clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment, be used for the heating disease, especially be suitable for the cards such as fever due to yin deficiency, puerperal deficiency-heat, also be used for the cards such as pyretic stranguria, stranguria with blood, sore and toxic, laryngopharynx swelling and pain.
Lasiosphaera Seu Calvatia: acrid in the mouth, property are put down, and enter lung meridian, have moistening lung and nourishing throat, and the effect of detoxifcation hemostasis is used for laryngopharynx swelling and pain, lung-heat cough with asthma, pharyngitis, hoarseness, hemorrhage, chilblain, the cards such as decubital ulcer.
Radix Platycodonis: bitter in the mouth, suffering, slightly warm in nature enters lung meridian, has expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged, and cures mainly: cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.
Fructus Evodiae: hot in nature, acrid in the mouth, hardship have dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, and the effect of supporing yang antidiarrheal is used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha, the cards such as hypertension.
Further preferred, the Chinese medicine composition of described treatment hyperlipidemia only is made of said components.
in the Chinese medicine composition of described treatment hyperlipidemia, the ratio of weight and number of various components can be preferably: Rhizoma Polygoni Cuspidati 25～35 weight portions, Rhizoma Polygonati 65～75 weight portions, Folium Ginkgo 25～35 weight portions, Radix Et Rhizoma Rhei 15～25 weight portions, Radix Ginseng 50～60 weight portions, Bulbus Allii Macrostemonis 25～35 weight portions, Resina Ferulae 8～12 weight portions, Cordyceps 20～30 weight portions, Fructus Lycii 15～25 weight portions, Arisaema Cum Bile 10～20 weight portions, Fructus Corni 12～18 weight portions, Herba Taxilli 12～18 weight portions, the Rhizoma Anemarrhenae 25～35 weight portions, Fructus Cannabis 8～12 weight portions, Herba Taraxaci 25～35 weight portions, Lasiosphaera Seu Calvatia 15～25 weight portions, Radix Cynanchi Atrati 12～18 weight portions, Fructus Evodiae 10～20 weight portions and Radix Platycodonis 6～10 weight portions.
in the Chinese medicine composition of described treatment hyperlipidemia, the ratio of weight and number of various components also can be more preferably: Rhizoma Polygoni Cuspidati 30～35 weight portions, Rhizoma Polygonati 70～75 weight portions, Folium Ginkgo 30～35 weight portions, Radix Et Rhizoma Rhei 20～25 weight portions, Radix Ginseng 55～60 weight portions, Bulbus Allii Macrostemonis 30～35 weight portions, Resina Ferulae 10～12 weight portions, Cordyceps 25～30 weight portions, Fructus Lycii 20～25 weight portions, Arisaema Cum Bile 15～20 weight portions, Fructus Corni 15～18 weight portions, Herba Taxilli 15～18 weight portions, the Rhizoma Anemarrhenae 30～35 weight portions, Fructus Cannabis 10～12 weight portions, Herba Taraxaci 30～35 weight portions, Lasiosphaera Seu Calvatia 20～25 weight portions, Radix Cynanchi Atrati 15～18 weight portions, Fructus Evodiae 15～20 weight portions and Radix Platycodonis 8～10 weight portions.
in the Chinese medicine composition of described treatment hyperlipidemia, the ratio of weight and number of various components also can be more preferably: Rhizoma Polygoni Cuspidati 32 weight portions, Rhizoma Polygonati 72 weight portions, Folium Ginkgo 32 weight portions, Radix Et Rhizoma Rhei 22 weight portions, Radix Ginseng 58 weight portions, Bulbus Allii Macrostemonis 32 weight portions, Resina Ferulae 11 weight portions, Cordyceps 28 weight portions, Fructus Lycii 22 weight portions, Arisaema Cum Bile 18 weight portions, Fructus Corni 16 weight portions, Herba Taxilli 16 weight portions, the Rhizoma Anemarrhenae 32 weight portions, Fructus Cannabis 11 weight portions, Herba Taraxaci 32 weight portions, Lasiosphaera Seu Calvatia 22 weight portions, Radix Cynanchi Atrati 16 weight portions, Fructus Evodiae 18 weight portions and Radix Platycodonis 9 weight portions.
The present invention also provides a kind of health product, and these health product can be oral liquid, tablet.
Described health product comprise above-mentioned Chinese medicine composition additive, sodium bicarbonate, folic acid, vitamin and aminoacid, the percentage by weight of described Chinese medicine composition additive is preferably 2%～4%, the percentage by weight of described vitamin is preferably 4%～8%, described amino acid whose percentage by weight is preferably 4%～8%, the percentage by weight of sodium bicarbonate is preferably 1%～3%, and the percentage by weight of folic acid is preferably 3%～6%.
Adopt the well blood fat reducing of above-mentioned health product, can treat hyperlipidemia.
Described vitamin is vitamin A, vitamin C, vitamin B more preferably
1, vitamin B
2, one or more mixing in vitamin E.
Described aminoacid is one or more mixing in methionine, lysine, threonine, tryptophan more preferably.
When described health product were oral liquid, its preparation method comprised:
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, with fine powder and the folic acid that obtains, sodium bicarbonate, vitamin, aminoacid is mixed in proportion, obtain mixture, further add saccharin sodium, correctives and antiseptic mix and are dissolved in water with respect to 25～50 times of the quality of Chinese medicine fine powder, sodium carboxymethyl cellulose is dispersed in hot water, cooling, then add in the aqueous solution of front, become volume required preparing solution and mix homogeneously, concentrated, packing after sterilization, namely get healthcare dietetic liquid, mixture with respect to 100 weight portions, described saccharin sodium is 2～4 weight portions, the weight fraction of described sodium carboxymethyl cellulose is 3～5 weight portions, correctives 0.5～1 weight portion, antiseptic 0.5～1 weight portion.
When described health product were tablet, its preparation method comprised:
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
Second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, the fine powder and folic acid, sodium bicarbonate, vitamin, the aminoacid that obtain are mixed in proportion, obtain mixture, with the mixture that obtains, adding starch to carry out mixing processes, the weight ratio of described mixture and described starch is 1: 0.2～0.4, carry out subsequently pelletization treatment, dried, the granule and Pulvis Talci, the magnesium stearate that obtain are carried out mixing processing, tabletting processing, Cotton seeds successively, namely get the troche of health products finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 healthcare dietetic liquid of the present invention
with Rhizoma Polygoni Cuspidati 32g, Rhizoma Polygonati 72g, Folium Ginkgo 32g, Radix Et Rhizoma Rhei 22g, Radix Ginseng 58g, Bulbus Allii Macrostemonis 32g, Resina Ferulae 11g, Cordyceps 28g, Fructus Lycii 22g, Arisaema Cum Bile 18g, Fructus Corni 16g, Herba Taxilli 16 g, the Rhizoma Anemarrhenae 32 g, Fructus Cannabis 11 g, Herba Taraxaci 32 g, Lasiosphaera Seu Calvatia 22 g, Radix Cynanchi Atrati 16 g, Fructus Evodiae 18 g and Radix Platycodonis 9 g mix, be that 90% ethanol 1500g is as solvent with determining alcohol, flooded 12 hours, adopt percolation with the speed of 1ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, powder after pulverizing is screened into 50 purpose Chinese medicine fine powders, with fine powder and the 400g folic acid that obtains, the 200g sodium bicarbonate, the 800g vitamin A, vitamin C, the vitamin mixtures that vitamin B1 and vitamin E consist of, the 700g methionine, lysine, the ispol that threonine consists of mixes, and obtains mixture, further adds saccharin sodium 70g, correctives Oleum menthae 15g, preservative sodium benzoate 15g mixes and is dissolved in the water of 15000g, the 100g sodium carboxymethyl cellulose is dispersed in the hot water of 300g, cooling, then add in the aqueous solution of front, become volume required preparing solution and mix homogeneously, concentrated, packing after sterilization namely gets healthcare dietetic liquid.
The preparation of embodiment 2 troche of health products of the present invention
with Rhizoma Polygoni Cuspidati 32g, Rhizoma Polygonati 72g, Folium Ginkgo 32g, Radix Et Rhizoma Rhei 22g, Radix Ginseng 58g, Bulbus Allii Macrostemonis 32g, Resina Ferulae 11g, Cordyceps 28g, Fructus Lycii 22g, Arisaema Cum Bile 18g, Fructus Corni 16g, Herba Taxilli 16 g, the Rhizoma Anemarrhenae 32 g, Fructus Cannabis 11 g, Herba Taraxaci 32 g, Lasiosphaera Seu Calvatia 22 g, Radix Cynanchi Atrati 16 g, Fructus Evodiae 18 g and Radix Platycodonis 9 g mix, be that 90% ethanol 1500g is as solvent with determining alcohol, flooded 12 hours, adopt percolation with the speed of 1ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, powder after pulverizing is screened into 50 purpose Chinese medicine fine powders, with fine powder and the 400g folic acid that obtains, the 200g sodium bicarbonate, the 800g vitamin A, vitamin C, the vitamin mixtures that vitamin B1 and vitamin E consist of, the 700g methionine, lysine, the ispol that threonine consists of mixes, and obtains mixture, adds 800g starch to carry out mixing and processes, and carries out subsequently pelletization treatment, dried is with granule and the 70g Pulvis Talci that obtains, the 7g magnesium stearate is carried out successively mixing and is processed, tabletting is processed, Cotton seeds namely gets the troche of health products finished product.
Embodiment 3 clinical experiments
1.1 physical data
These experiment 128 routine patient diagnosis meet the Lipid increase standard that China's " dyslipidemia control suggestion " formulates: serum total cholesterol (TC) 〉=5. 7mmol/L, triglyceride (TG) 〉=1.80mmol/L, HDL-C (HDL-C) man≤0.78mmol/L, female≤0. 86mmol/L, low-density lipoprotein cholesterol (LDL-C) is 6mmol/L 3..Be divided at random 2 groups for the treatment of group and matched groups.Treatment group 80 examples, female's 31 examples wherein, male 49 examples; 34～73 years old age, average 46 years old.Matched group 48 examples, female's 25 examples, male 23 examples; 35～71 years old age, average 47 years old.The data no significant differences such as two groups of patient genders, age, the course of disease (P〉0. 05), have comparability.
1.2 Therapeutic Method
Treatment group: the healthcare dietetic liquid of the embodiment of the present invention 1 preparation for oral administration, each 300ml, each 1 time sooner or later, decoction being taken warmly, continue 3 months after meal.
Matched group: oral Zhibituo Tabiet (Chengdu Diao 9 Wang pharmaceutical factory, traditional Chinese medicines Z20025688), each 3, every day 3 times, warm water delivery service continues 3 months.After after treatment finishes, the evaluation curative effect, advise in medication period and stop all blood fat reducing Chinese medicine and western medicine, and light diet is balanced nutritious, suitably increases physical training, gives up bad life habits with partner treatment.
1.3 efficacy assessment standard
Standard with reference to Ministry of Public Health " new Chinese medicine guideline of clinical investigations (trying) ".Clinic control: clinical symptoms, sign disappear, and it is normal that the lab testing indices recovers.Produce effects: clinical symptoms, sign are obviously improved, and lipids detection reaches following any 1 person.1. TC descends 〉=20%, and 2. TG descends 〉=40%, 3. HDL-C rising 0.26mmol/L.Effectively: clinical symptoms, sign make moderate progress, and lipids detection reaches following any 1 person.1. TC descends 10%～20%, and 2. TG descends 20% or 40%, 3. HDL-C 0. 1～0. 26mmol/L that rises.Invalid: clinical symptoms, sign are without improvement, and lipids detection does not reach above-mentioned standard person.
1.4 statistical procedures
Experimental data with
± s represents, analyzes with statistic software SPSS 10. 0, and between group, mean relatively adopts one factor analysis of variance.
1.5 result
Two groups of curative effects relatively
Treatment group: clinic control 42 examples, produce effects 26 examples, effective 10 examples, invalid 2 examples, total effective rate is 97. 5%.Matched group: clinic control 6 examples, produce effects 12 examples, effective 18 examples, invalid 12 examples, total effective rate is 75%.Two groups of total effective rates are learned processing by statistics, and there is significant difference P＜0. 05.
Before and after two groups of treatments, the lipid determination value relatively
After two groups of treatments, TC, TG, LDL-C all descend, and before and after the indices treatment, comparing difference has significant, P＜0. 05.See Table 1.
Lipid determination value comparison before and after table 1 liang group treatment (mmol/L,
± s)
| Group | n | Time | TC | TG | HDL-C | LDL-C |
| Treatment group | 80 | Before treatment | 7.03±0.97 | 3.25±1.06 | 1.38±0.48 | 4.45±1.18 |
| ? | ? | After treatment | 5.12±0.89 | 2.37±1.03 | 1.17±0.37 | 3.07±1.08 |
| Matched group | 48 | Before treatment | 6.83±0.91 | 3.15±1.02 | 1.39±0.41 | 4.48±1.20 |
| ? | ? | After treatment | 5. 89±0. 90 | 2.82±0.93 | 1.08±0.40 | 3.78±0.97 |
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, is not to be the present invention to be done the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (6)
1. health product for the treatment of hyperlipidemia, it is characterized in that, the composition of described health product is Chinese medicine composition additive, sodium bicarbonate, folic acid, vitamin and aminoacid, and described Chinese medicine composition additive comprises Rhizoma Polygoni Cuspidati, Rhizoma Polygonati, Folium Ginkgo, Radix Et Rhizoma Rhei, Radix Ginseng, Bulbus Allii Macrostemonis, Resina Ferulae, Cordyceps, Fructus Lycii, Arisaema Cum Bile, Fructus Corni, Herba Taxilli, the Rhizoma Anemarrhenae, Fructus Cannabis, Herba Taraxaci, Lasiosphaera Seu Calvatia, Radix Cynanchi Atrati, Fructus Evodiae and Radix Platycodonis;
The percentage by weight of described Chinese medicine composition additive is preferably 2%～4%, the percentage by weight of described vitamin is preferably 4%～8%, described amino acid whose percentage by weight is preferably 4%～8%, the percentage by weight of sodium bicarbonate is preferably 1%～3%, and the percentage by weight of folic acid is preferably 3%～6%;
in described Chinese medicine composition additive, the ratio of weight and number of various components is Rhizoma Polygoni Cuspidati 25～35 weight portions, Rhizoma Polygonati 65～75 weight portions, Folium Ginkgo 25～35 weight portions, Radix Et Rhizoma Rhei 15～25 weight portions, Radix Ginseng 50～60 weight portions, Bulbus Allii Macrostemonis 25～35 weight portions, Resina Ferulae 8～12 weight portions, Cordyceps 20～30 weight portions, Fructus Lycii 15～25 weight portions, Arisaema Cum Bile 10～20 weight portions, Fructus Corni 12～18 weight portions, Herba Taxilli 12～18 weight portions, the Rhizoma Anemarrhenae 25～35 weight portions, Fructus Cannabis 8～12 weight portions, Herba Taraxaci 25～35 weight portions, Lasiosphaera Seu Calvatia 15～25 weight portions, Radix Cynanchi Atrati 12～18 weight portions, Fructus Evodiae 10～20 weight portions and Radix Platycodonis 6～10 weight portions.
2. health product as claimed in claim 1, it is characterized in that: in described Chinese medicine composition additive, the ratio of weight and number of various components is Rhizoma Polygoni Cuspidati 30～35 weight portions, Rhizoma Polygonati 70～75 weight portions, Folium Ginkgo 30～35 weight portions, Radix Et Rhizoma Rhei 20～25 weight portions, Radix Ginseng 55～60 weight portions, Bulbus Allii Macrostemonis 30～35 weight portions, Resina Ferulae 10～12 weight portions, Cordyceps 25～30 weight portions, Fructus Lycii 20～25 weight portions, Arisaema Cum Bile 15～20 weight portions, Fructus Corni 15～18 weight portions, Herba Taxilli 15～18 weight portions, the Rhizoma Anemarrhenae 30～35 weight portions, Fructus Cannabis 10～12 weight portions, Herba Taraxaci 30～35 weight portions, Lasiosphaera Seu Calvatia 20～25 weight portions, Radix Cynanchi Atrati 15～18 weight portions, Fructus Evodiae 15～20 weight portions and Radix Platycodonis 8～10 weight portions.
3. health product as claimed in claim 1, it is characterized in that: in described Chinese medicine composition additive, the ratio of weight and number of various components is Rhizoma Polygoni Cuspidati 32 weight portions, Rhizoma Polygonati 72 weight portions, Folium Ginkgo 32 weight portions, Radix Et Rhizoma Rhei 22 weight portions, Radix Ginseng 58 weight portions, Bulbus Allii Macrostemonis 32 weight portions, Resina Ferulae 11 weight portions, Cordyceps 28 weight portions, Fructus Lycii 22 weight portions, Arisaema Cum Bile 18 weight portions, Fructus Corni 16 weight portions, Herba Taxilli 16 weight portions, the Rhizoma Anemarrhenae 32 weight portions, Fructus Cannabis 11 weight portions, Herba Taraxaci 32 weight portions, Lasiosphaera Seu Calvatia 22 weight portions, Radix Cynanchi Atrati 16 weight portions, Fructus Evodiae 18 weight portions and Radix Platycodonis 9 weight portions.
4. described health product as arbitrary in claim 1 to 3, it is characterized in that: described health product are oral liquid or tablet.
5. as the preparation method of the arbitrary described health product of claim 1 to 3, it is characterized in that:
When described health product were oral liquid, it comprised,
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, with fine powder and the folic acid that obtains, sodium bicarbonate, vitamin, aminoacid is mixed in proportion, obtain mixture, further add saccharin sodium, correctives and antiseptic mix and are dissolved in water with respect to 25～50 times of the quality of Chinese medicine fine powder, sodium carboxymethyl cellulose is dispersed in hot water, cooling, then add in the aqueous solution of front, become volume required preparing solution and mix homogeneously, concentrated, packing after sterilization, namely get healthcare dietetic liquid, mixture with respect to 100 weight portions, described saccharin sodium is 2～4 weight portions, the weight fraction of described sodium carboxymethyl cellulose is 3～5 weight portions, correctives 0.5～1 weight portion, antiseptic 0.5～1 weight portion.
6. as the preparation method of the arbitrary described health product of claim 1 to 3, it is characterized in that:
When described health product were tablet, it comprised,
The first step, each component in described Chinese medicine composition is mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, and adopted percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrated and dry, be ground into powder, wherein, the amount of the ethanol that adds is 2～4 times of first step mixture quality;
Second step, powder after pulverizing is screened into 50 orders～100 purpose Chinese medicine fine powders, the fine powder and folic acid, sodium bicarbonate, vitamin, the aminoacid that obtain are mixed in proportion, obtain mixture, with the mixture that obtains, adding starch to carry out mixing processes, the weight ratio of described mixture and described starch is 1: 0.2～0.4, carry out subsequently pelletization treatment, dried, the granule and Pulvis Talci, the magnesium stearate that obtain are carried out mixing processing, tabletting processing, Cotton seeds successively, namely get the troche of health products finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100634671A CN102552688B (en) | 2012-03-13 | 2012-03-13 | Healthcare product for treating hyperlipidemia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100634671A CN102552688B (en) | 2012-03-13 | 2012-03-13 | Healthcare product for treating hyperlipidemia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102552688A CN102552688A (en) | 2012-07-11 |
| CN102552688B true CN102552688B (en) | 2013-06-26 |
Family
ID=46400142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100634671A Expired - Fee Related CN102552688B (en) | 2012-03-13 | 2012-03-13 | Healthcare product for treating hyperlipidemia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102552688B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315287A (en) * | 2013-01-09 | 2013-09-25 | 秦世昌 | Food therapy for three high diseases (hypertension, hyperglycemia and hyperlipidemia) |
| CN105125957A (en) * | 2015-09-02 | 2015-12-09 | 江淑芬 | Medicine for treating ulcerative colitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361886A (en) * | 2007-08-07 | 2009-02-11 | 北京北大维信生物科技有限公司 | Chinese herbal medicine extract with lipase activity inhibition and new use thereof |
| CN101607063A (en) * | 2008-06-20 | 2009-12-23 | 天科仁祥技术（北京）有限责任公司 | Drug regimen of a kind of fat-reducing liver-protecting and preparation method thereof |
-
2012
- 2012-03-13 CN CN2012100634671A patent/CN102552688B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361886A (en) * | 2007-08-07 | 2009-02-11 | 北京北大维信生物科技有限公司 | Chinese herbal medicine extract with lipase activity inhibition and new use thereof |
| CN101607063A (en) * | 2008-06-20 | 2009-12-23 | 天科仁祥技术（北京）有限责任公司 | Drug regimen of a kind of fat-reducing liver-protecting and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中药降脂研究进展;王宇辉等;《中国中药杂志》;19990325;第24卷(第03期);184-186 * |
| 吕兰薰.降血脂中药的研究动态.《陕西中医》.1987,第08卷(第01期),28-29. |
| 王宇辉等.中药降脂研究进展.《中国中药杂志》.1999,第24卷(第03期),184-186. |
| 降血脂中药的研究动态;吕兰薰;《陕西中医》;19870105;第08卷(第01期);28-29 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102552688A (en) | 2012-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104873763A (en) | Health-care product for conditioning Qi deficiency constitution | |
| CN101954006B (en) | Chinese medicament for treating insomnia | |
| CN107308097A (en) | A kind of cosmetic constituent | |
| CN102430024B (en) | Traditional Chinese medicine composition, traditional Chinese medicinal preparation and traditional Chinese medicinal face mask | |
| CN102716339A (en) | Chinese medicinal composition for treating uremia, and preparation method and application thereof | |
| CN102552688B (en) | Healthcare product for treating hyperlipidemia and preparation method thereof | |
| CN102805834B (en) | Drug for curing gastritis and preparation method thereof | |
| CN103611021B (en) | Be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof | |
| CN105233099A (en) | Traditional Chinese medicine composition capable of increasing milk yield of cows and preparation method thereof | |
| CN105079676A (en) | Medicine for treating fatty liver and preparing method of medicine | |
| CN102772777B (en) | Medicine for treating infantile pneumonia and preparation method thereof | |
| CN103330259A (en) | Food composition with functions of nourishing yin, moisturizing lung and clearing way heat and preparation method thereof | |
| CN103055218A (en) | Traditional Chinese medicine composition for treating neonatal jaundice and preparation method thereof | |
| CN106038995A (en) | Traditional Chinese medicine granules for treating perioral dermatitis and preparation method | |
| CN104491364B (en) | A kind of pill and preparation method for treating chronic lymphocytic thyroiditis | |
| CN102166300B (en) | Traditional Chinese medicine preparation for treating pulmonary yin deficiency, gastric yin deficiency and diabetic yin deficiency | |
| CN104524312B (en) | A kind of Chinese medicine composition and preparation method for the treatment of expectorant knot blood stasis type thyroid adenoma | |
| CN103877484A (en) | Traditional Chinese medicine oral liquid for treating oral liquid | |
| CN107583029A (en) | Chinese medicine composition for treating chronic enteritis and preparation method thereof | |
| CN103285182B (en) | External-use ointment for treating skin diseases and preparation method thereof | |
| CN103285116B (en) | Traditional Chinese medicine preparation for treating influenza of infant | |
| CN106039030A (en) | Granules capable of clearing bowels, expelling toxins and beautifying face | |
| CN107095961A (en) | A kind of instant particles as Chinese medicine and preparation method for being used to treat adolescent acne | |
| CN105998831A (en) | Traditional Chinese medicine for treating seborrheic dermatitis and preparation method thereof | |
| CN106110191A (en) | A kind of medicine pill treating gastroenteropathy and complication thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SANJIU JUNDA PHARMACEUTICALS (XIAMEN) CO., LTD. Free format text: FORMER OWNER: CHANGSHU HUAGANG PHARMACEUTICAL CO., LTD. Effective date: 20150707 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150707 Address after: 361000 Fujian Province, Haicang District of Xiamen City pharmaceutical Gang Ding Road No. 1-3 Patentee after: 39JUNDA PHARMACEUTICAL (XIAMEN) CO.,LTD. Address before: 215500, Jiangsu Province, Suzhou City, Changshou City Province town of Tong Yu Lane Village Patentee before: CHANGSHU HUAGANG PHARMACEUTICAL Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130626 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |