CN102539806B - Multi-channel liquid sampling equivalent distancing device - Google Patents
Multi-channel liquid sampling equivalent distancing device Download PDFInfo
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- CN102539806B CN102539806B CN 201210035048 CN201210035048A CN102539806B CN 102539806 B CN102539806 B CN 102539806B CN 201210035048 CN201210035048 CN 201210035048 CN 201210035048 A CN201210035048 A CN 201210035048A CN 102539806 B CN102539806 B CN 102539806B
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- 239000007788 liquid Substances 0.000 title claims abstract description 25
- 238000005070 sampling Methods 0.000 title claims abstract description 16
- 230000008878 coupling Effects 0.000 claims abstract description 7
- 238000010168 coupling process Methods 0.000 claims abstract description 7
- 238000005859 coupling reaction Methods 0.000 claims abstract description 7
- 238000006073 displacement reaction Methods 0.000 claims abstract description 4
- 230000003028 elevating effect Effects 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 7
- 230000033001 locomotion Effects 0.000 abstract description 9
- 238000012360 testing method Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
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Abstract
The invention relates to a multi-channel liquid sampling equivalent distancing device, which comprises a distancing motor, a distancing lead screw, a guide rail, a plurality of sampling pins corresponding to channels and guiding sliding blocks. Each guiding sliding block is provided with a thread matched with the distancing lead screw, the distancing lead screw is provided with a 2m sectional thread, and the number of sections of the 2m sectional thread equal to the number of the channels, wherein the screwing directions of threads of the left half part and the right half part of the distancing lead screw are opposite, and the pitch ratio of each section of thread from exterior to interior is (2m-1): (2m-3)...:1. The distancing motor drives the distancing lead screw to rotate through a coupling so as to drive each guiding sliding block to move at corresponding displacement along the guide rail, thus the equivalent regulation of channel intervals is realized, and the distances among the channels are always same. According to the multi-channel liquid sampling equivalent distancing device disclosed by the invention, the equivalent simultaneous regulation of the distance of each channel sampling pin is realized by utilizing a variable-pitch and variable-rotation-direction distancing lead screw, thus the structure is reasonable; and in addition, the sampling pin of each channel can independently move in a vertical direction, thus the movement conveyance is simple and reliable.
Description
Technical field
The present invention relates to a kind of liquid sample charging mechanism, specifically a kind of one degree of freedom of utilizing realizes the Multi-channel liquid sampling equivalent distancing device that all channel pitch equivalent are regulated.
Background technology
As everyone knows, the liquid sample charging mechanism can be widely used in the industries such as molecular biology experiment, immune detection, gene sequencing, biochemical analysis, in molecular biology research, often need to carry out the experimental result comparison of different parameters, obtain to have the result of statistical significance thereby test by great amount of samples; On the other hand, immune detection is also more and more higher to the requirement of speed, so the multichannel liquid sample charging mechanism of active demand high flux in industry.But in different liquid handling processes, the pitch-row of liquid vessel differs, and need to adjust the spacing of passage, so multi-channel loading mechanism also should have the ability of adjusting channel pitch.At present, existing liquid sample charging mechanism needs a plurality of motions cooperations to complete when channel pitch is adjusted, and mechanism is comparatively complicated.
Summary of the invention
Technical matters to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of rational in infrastructure, the sample needle of each passage can be at the vertical direction independently moving, can complete all interchannel equidistant adjustment by one degree of freedom, simple, the reliable Multi-channel liquid sampling equivalent distancing device of power transmission.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Multi-channel liquid sampling equivalent distancing device, it is characterized in that: it comprises minute apart from motor, minute apart from sample needle and the guide runner of leading screw, guide rail, some each passages of correspondence, described guide runner is provided with and divides the screw thread that coordinates apart from leading screw, guide runner is arranged on described guide rail, can move along guide rail; Be provided with 2m section screw thread (m is natural number) apart from leading screw in described minute, the screw thread hop count equates with port number, wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged, minute opposite apart from the thread rotary orientation of leading screw left-half and right half part, the pitch ratio of each section screw thread is 2m-1:2m-3 from outside to inside ...: 1; Screw thread on the guide runner of described each passage of correspondence and described minute one section threaded engagement transmission on the leading screw, minute drive by shaft coupling apart from motor and minute to rotate apart from leading screw, and then drive each guide runner and carry out corresponding displacement along guide rail, realize the adjusting of channel pitch equivalent, guarantee that the distance between each passage is identical all the time.
Screw thread on guide runner of the present invention is internal thread, and internal thread is the one section corresponding threaded engagement transmission on the leading screw with described minute, has the pilot hole that coordinates with sample needle on also on guide runner, and sample needle can move up and down along this hole.
Each drives lifting by an elevating mechanism sample needle of each passage of the present invention, described elevating mechanism comprises lifting motor, gear, lifter rack, sample needle contiguous block, gear is arranged on the lifting motor axle, lifter rack is vertically mounted on the sample needle contiguous block, sample needle is fixedly connected with the sample needle contiguous block, the lifting motor driven gear rotates, and then the lifter rack of drive and gear engagement moves up and down, drive sample needle through the sample needle contiguous block again and move up and down along guide runner, realize independently moving up and down of each sample needle.
The many 10-15mm of width of the Thickness Ratio lifter rack of gear of the present invention.Gear thickness is wide than lifter rack, can guarantee that like this lifter rack meshes with gear in the channel pitch adjustment process all the time, thereby but guarantees rear each passage independently moving of distance adjustment.
The present invention adopts said structure, utilize a varying pitch, mutarotation to minute realize that apart from leading screw the equivalent of each passage sample needle distance adjusts simultaneously, only have one minute apart from motor-driven, make the channel pitch adjusting mechanism become simple; Each passage all has the lifting motor of oneself to drive, and realizes moving up and down of sample needle, thereby guarantees the independence that each passage moves up and down.Against existing technologies, the present invention is rational in infrastructure, and the sample needle of each passage can at the vertical direction independently moving, can be completed all interchannel equidistant adjustment by one degree of freedom, it is simple, reliable that motion is transmitted, and is a kind of desirable Multi-channel liquid sampling equivalent distancing device.
Description of drawings
Below in conjunction with accompanying drawing, the present invention is made and further illustrating.
Fig. 1 is a kind of composition structural representation of the present invention.
Fig. 2 be a kind of minute of the present invention apart from the leading screw schematic diagram.
Fig. 3 is sample needle elevating mechanism schematic diagram of the present invention.
Fig. 4 is a kind of application state schematic diagram of the present invention.
Number in the figure: 11. minutes apart from motor, 12. shaft couplings, 13. guide rails, 14. bracing frame, 151. sample needles, 152. sample needles, 153. sample needle, 154. sample needles, 16. minutes apart from leading screw, 171. guide runner, 172. guide runners, 173. guide runners, 174. guide runner, 21. sample needle contiguous blocks, 22. lifter racks, 23. lifting motor, 24. gears, 25. worktable support plates, 31.X direction leading screw, 32.X the direction motor, 33.Y direction motor, 34. test tube racks, 35.X traversing guide, 36.Y traversing guide, 37.Y direction leading screw, 38. test tube racks.
Embodiment
As can be seen from Figure 1, a kind of Multi-channel liquid sampling equivalent distancing device, it is four-way liquid application of sample.It comprises minute apart from motor 11, minute apart from the sample needle 151,152,153 of leading screw 16, guide rail 13, some each passages of correspondence, 154 and guide runner 171,172,173,174, minute is connected apart from leading screw 16 with dividing by shaft coupling 12 apart from motor 11.Divide and be arranged on the worktable support plate by bracing frame 14 apart from motor 11.Guide rail 13 also is arranged on the worktable support plate by support.
Have on described guide runner 171,172,173,174 and corresponding sample needle 151,152,153,154 pilot holes that coordinate, each sample needle passes corresponding pilot hole, and sample needle can move up and down along this hole.Described guide runner 171,172,173,174 is provided with and divides the screw thread that coordinates apart from leading screw 16, and guide runner 171,172,173,174 is arranged on described guide rail 13, can move along guide rail 13.
(m is natural number to be provided with 2m section screw thread apart from leading screw 16 in described minute, as 2,3,4,5), the screw thread hop count equates with port number, wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged, divide opposite apart from the thread rotary orientation of leading screw 16 left-half and right half part, minute the pitch ratio of each section screw thread is the same from outside to inside apart from leading screw 16 left-half and right half part, is all 2m-1:2m-3 ...: 1.
Shown in Figure 2 be a kind of 4 channel liquid application of samples minute apart from the schematic diagram of leading screw.Whole minute apart from totally 4 sections, the screw thread of leading screw, two sections of left-half, two sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing is all 3:1 apart from leading screw left-half and two sections screw threads of right half part pitch ratio from outside to inside.
screw thread on the guide runner of each passage of correspondence of the present invention and described minute one section threaded engagement on the leading screw 16, divide to drive to divide apart from leading screw 16 by shaft coupling 12 apart from motor 11 and rotate, and then drive each guide runner and carry out corresponding displacement along guide rail, guide runner 171, 172, 173, 174 drive respectively sample needle 151, 152, 153, 154 move along guide rail 13, the ratio 3:1 of sample needle 151 and the speed of sample needle 152, sample needle 154 is also 3:1 with the ratio of the speed of sample needle 153, but 151, 152 velocity reversal and 153, 154 velocity reversal is opposite.What sample needle will be according to the hand of spiral and pitch like this is different, produces different direction and speed, namely realizes equidistant the separation, realizes that channel pitch equivalent regulates, and guarantees that the distance between each passage is identical all the time.
For 6 channel liquid application of samples, minute apart from totally 6 sections, the screw thread of leading screw, three sections of left-half, three sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing is all 5:3:1 apart from leading screw left-half and three sections screw threads of right half part pitch ratio from outside to inside.
For 8 passage channel liquid application of samples, minute apart from totally 8 sections, the screw thread of leading screw, four sections of left-half, four sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing apart from the ratio of leading screw left-half and four sections screw threads of right half part pitch from outside to inside is 7:5:3:1.
Screw thread on guide runner 171 of the present invention, 172,173,174 is internal thread, internal thread is the one section corresponding threaded engagement transmission on the leading screw 16 with described minute, have the pilot hole that coordinates with sample needle on also on guide runner, sample needle can move up and down along this hole.
Each drives lifting by an elevating mechanism sample needle of each passage of the present invention.As shown in Figure 3, described elevating mechanism comprises lifting motor 23, gear 24, lifter rack 22, sample needle contiguous block 21, gear 24 is arranged on lifting motor 23 axles by reducing gear, lifter rack 22 is vertically mounted on sample needle contiguous block 21, sample needle 154 is fixedly connected with sample needle contiguous block 21, like this, lifter rack 22 is fixed together by sample needle contiguous block 21 with sample needle 154, so the mobile motion that drives sample needle 154 of lifter rack 22.Whole elevating mechanism is arranged on worktable support plate 25.Lifting motor 23 driven gears 24 rotate, and then the lifter rack 22 of drive and gear engagement moves up and down, then move up and down along guide runner 174 through sample needle contiguous block 21 drive sample needles 154, realize independently moving up and down of each sample needle.In the multi-channel loading device, each drives lifting by an elevating mechanism sample needle of each passage, and the motion of each sample needle is separate, is satisfied with like this application of sample of different liquid level test tubes.
Gear of the present invention 24 designs than the wide 10-15mm of lifter rack 22, can guarantee like this lifter rack in the detachment process of channel pitch equivalent along the gear axial slip, all the time with the gear engagement, thereby but guarantee distance adjust after each passage independently moving.So both realize each sample needle vertical direction self-movement, realized again the equidistant single-degree-of-freedom control that separates of sample needle.Here, the length of lifter rack 22 horizontal directions is defined as the lifter rack width, and the height of lifter rack 22 vertical direction is defined as lifter rack length.Lifter rack length has determined the heave amplitude of sample needle.
The version of each passage elevating mechanism of the present invention and the components and parts of use are all identical, just according to number of active lanes what, are subjected to structural limitations to be placed in respectively the both sides of guide rail.
Fig. 4 is a kind of application state schematic diagram of the present invention.To divide apart from direction be Y-direction to definition equivalent, and sample needle lifting direction is the Z direction, divides the directions X that is apart from perpendicular direction with equivalent.On directions X, directions X motor 32 drags directions X leading screw 31 and rotates, and then drive whole slide holder, move along directions X guide rail 35, when arriving given position to slide holder, motor stops, and slide holder is stop motion also, has so just increased the work space of sample needle directions X; In Y-direction, Y-direction motor 33 drags Y-direction leading screw 37 rotation, and then drives bracing frame and move along Y-direction guide rail 36 and reach a certain given position, and stop motion has increased the work space of sample needle Y-direction like this.Satisfy the different application of sample requirements of test tube rack 34 and test tube rack 38.
On the Z direction, lifting motor 23 drives lifter wheel 24 and rotates, and by the meshing relation of gear and lifter rack, drives lifter rack 22 and moves up and down in the Z direction, lifter rack is given sample needle motion transmission by sample needle contiguous block 21, moves in the Z direction thereby drive sample needle.For the multi-channel loading device, each lifting motor can only drive a sample needle, and the motion of each sample needle is separate like this.
Divide apart from the course of work for Multi-channel liquid sample adding device equivalent, divide apart from illustrating with four-way equivalent.Sample needle just can arrive the given position in space according to above-mentioned description, but carries out application of sample for the test tube rack 34,38 of different size, needs constantly to regulate the distance between sample needle.As shown in Figure 4, when working above spacing is 10mm test tube rack 34, spacing that need to adjust sample needle is 10mm, and when working above spacing is 15mm test tube rack 38, the sample needle spacing becomes 15mm, therefore need to equidistantly separate sample needle.After having worked above the 10mm test tube rack, divide apart from motor and begin to rotate, drive the leading screw rotation by shaft coupling, sample needle 151,152 moves towards opposite direction along track with sample needle 153,154, simultaneously sample needle 151 and 152 and sample needle 153 and 154 move in the same way with the speed of 3:1 respectively, so just realized the equidistant separation of sample needle.
Claims (4)
1. Multi-channel liquid sampling equivalent distancing device, it is characterized in that: it comprises minute apart from motor, minute apart from sample needle and the guide runner of leading screw, guide rail, some each passages of correspondence, described guide runner is provided with and divides the screw thread that coordinates apart from leading screw, guide runner is arranged on described guide rail, can move along guide rail; Be provided with 2m section screw thread apart from leading screw in described minute, wherein m is natural number, the screw thread hop count equates with port number, wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged, minute opposite apart from the thread rotary orientation of leading screw left-half and right half part, the pitch ratio of each section screw thread is 2m-1:2m-3 from outside to inside ...: 1; Screw thread on the guide runner of described each passage of correspondence and described minute one section threaded engagement transmission on the leading screw, minute drive by shaft coupling apart from motor and minute to rotate apart from leading screw, and then drive each guide runner and carry out corresponding displacement along guide rail, realize the adjusting of channel pitch equivalent, guarantee that the distance between each passage is identical all the time.
2. Multi-channel liquid sampling equivalent distancing device according to claim 1, it is characterized in that: the screw thread on described guide runner is internal thread, internal thread is the one section corresponding threaded engagement transmission on the leading screw with described minute, have the pilot hole that coordinates with sample needle on also on guide runner, sample needle can move up and down along this hole.
3. Multi-channel liquid sampling equivalent distancing device according to claim 1, it is characterized in that: each drives lifting by an elevating mechanism sample needle of described each passage, described elevating mechanism comprises lifting motor, gear, lifter rack, the sample needle contiguous block, gear is arranged on the lifting motor axle by reducing gear, lifter rack is vertically mounted on the sample needle contiguous block, sample needle is fixedly connected with the sample needle contiguous block, the lifting motor driven gear rotates, and then the lifter rack of drive and gear engagement moves up and down, driving sample needle through the sample needle contiguous block again moves up and down along guide runner, realize independently moving up and down of each sample needle.
4. Multi-channel liquid sampling equivalent distancing device according to claim 3, is characterized in that: the many 10-15mm of width of the Thickness Ratio lifter rack of described gear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210035048 CN102539806B (en) | 2012-02-16 | 2012-02-16 | Multi-channel liquid sampling equivalent distancing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210035048 CN102539806B (en) | 2012-02-16 | 2012-02-16 | Multi-channel liquid sampling equivalent distancing device |
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| Publication Number | Publication Date |
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| CN102539806A CN102539806A (en) | 2012-07-04 |
| CN102539806B true CN102539806B (en) | 2013-05-08 |
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| CN 201210035048 Expired - Fee Related CN102539806B (en) | 2012-02-16 | 2012-02-16 | Multi-channel liquid sampling equivalent distancing device |
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