CN102539806A - Multi-channel liquid sampling equivalent distancing device - Google Patents

Multi-channel liquid sampling equivalent distancing device Download PDF

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Publication number
CN102539806A
CN102539806A CN2012100350487A CN201210035048A CN102539806A CN 102539806 A CN102539806 A CN 102539806A CN 2012100350487 A CN2012100350487 A CN 2012100350487A CN 201210035048 A CN201210035048 A CN 201210035048A CN 102539806 A CN102539806 A CN 102539806A
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CN
China
Prior art keywords
apart
sample needle
distancing
sample
leading screw
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Granted
Application number
CN2012100350487A
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Chinese (zh)
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CN102539806B (en
Inventor
赵建文
刘亚欣
范生荣
路士洲
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Harbin Institute of Technology Weihai
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Harbin Institute of Technology Weihai
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Priority to CN 201210035048 priority Critical patent/CN102539806B/en
Publication of CN102539806A publication Critical patent/CN102539806A/en
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Publication of CN102539806B publication Critical patent/CN102539806B/en
Expired - Fee Related legal-status Critical Current
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Abstract

The invention relates to a multi-channel liquid sampling equivalent distancing device, which comprises a distancing motor, a distancing lead screw, a guide rail, a plurality of sampling pins corresponding to channels and guiding sliding blocks. Each guiding sliding block is provided with a thread matched with the distancing lead screw, the distancing lead screw is provided with a 2m sectional thread, and the number of sections of the 2m sectional thread equal to the number of the channels, wherein the screwing directions of threads of the left half part and the right half part of the distancing lead screw are opposite, and the pitch ratio of each section of thread from exterior to interior is (2m-1): (2m-3)...:1. The distancing motor drives the distancing lead screw to rotate through a coupling so as to drive each guiding sliding block to move at corresponding displacement along the guide rail, thus the equivalent regulation of channel intervals is realized, and the distances among the channels are always same. According to the multi-channel liquid sampling equivalent distancing device disclosed by the invention, the equivalent simultaneous regulation of the distance of each channel sampling pin is realized by utilizing a variable-pitch and variable-rotation-direction distancing lead screw, thus the structure is reasonable; and in addition, the sampling pin of each channel can independently move in a vertical direction, thus the movement conveyance is simple and reliable.

Description

A kind of hyperchannel liquid application of sample equivalent is divided apart from device
Technical field
The present invention relates to a kind of liquid sample charging mechanism, specifically a kind of hyperchannel liquid application of sample equivalent of utilizing one degree of freedom to realize that all channel pitch equivalent are regulated is divided apart from device.
Background technology
As everyone knows; The liquid sample charging mechanism can be widely used in industries such as molecular biology experiment, immune detection, gene sequencing, biochemical analysis; In molecular biology research; Often need carry out the experimental result comparison of different parameters, thereby obtain to have the result of statistical significance through the great amount of samples experiment; On the other hand, immune detection is also increasingly high to the requirement of speed, so the multichannel liquid sample charging mechanism of active demand high flux in the industry.But in the different liquid processing procedure, the pitch-row of liquid vessel differs, and needs the spacing of adjustment passage, so multi-channel loading mechanism also should have the ability of adjustment channel pitch.At present, existing liquid sample charging mechanism needs a plurality of motions to cooperate completion when channel pitch is adjusted, and mechanism is comparatively complicated.
Summary of the invention
Technical matters to be solved by this invention is the deficiency that overcomes above-mentioned prior art; Provide a kind of rational in infrastructure; The sample needle of each passage can be at the vertical direction independently moving; Can accomplish whole interchannel equidistance adjustment through one degree of freedom, power transmission is simple, hyperchannel liquid application of sample equivalent is divided apart from device reliably.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of hyperchannel liquid application of sample equivalent is divided apart from device; It is characterized in that: it comprise branch apart from motor, divide sample needle and guide runner apart from leading screw, guide rail, some each passages of correspondence; Said guide runner is provided with and divides the screw thread that cooperates apart from leading screw; Guide runner is installed on the said guide rail, can move along guide rail; Said branch is provided with 2m section screw thread (m is a natural number) apart from leading screw; The screw thread hop count equates with port number; Wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged; Branch is opposite apart from the thread rotary orientation of leading screw left-half and right half part, and the pitch ratio of each section screw thread is 2m-1:2m-3 from outside to inside ...: 1; The one section threaded engagement transmission on the leading screw of screw thread on the guide runner of said each passage of correspondence and said branch; Divide apart from motor and rotate apart from leading screw through shaft coupling drive branch; And then drive each guide runner and carry out corresponding displacement along guide rail; Realize the adjusting of channel pitch equivalent, guarantee that the distance between each passage is identical all the time.
Screw thread on the guide runner according to the invention is an internal thread, and the one section corresponding threaded engagement transmission on the leading screw of internal thread and said branch has the pilot hole that cooperates with sample needle on also on the guide runner, and sample needle can move up and down along this hole.
Each is driven the sample needle of each passage according to the invention by an elevating mechanism; Said elevating mechanism comprises lifting motor, gear, lifter rack, sample needle contiguous block; Gear is installed on the lifting motor axle, and lifter rack is vertically mounted on the sample needle contiguous block, and sample needle is fixedly connected with the sample needle contiguous block; The lifting motor driven gear rotates; And then the lifter rack of drive and gearing mesh moves up and down, and drives sample needle through the sample needle contiguous block again and moves up and down along guide runner, realizes independently moving up and down of each sample needle.
The thickness of gear according to the invention manys 10-15mm than the width of lifter rack.Gear thickness is wide than lifter rack, can guarantee like this lifter rack in the channel pitch adjustment process all the time with gearing mesh, thereby but guarantee each passage independently moving of distance adjustment back.
The present invention adopts said structure, utilize a varying pitch, mutarotation to branch realize that apart from leading screw the equivalent of each passage sample needle distance adjusts simultaneously, a branch is only arranged apart from motor-driven, make the channel pitch adjusting mechanism become simple; Each passage all has the lifting motor of oneself to drive, and realizes moving up and down of sample needle, thereby guarantees the independence that each passage moves up and down.Against existing technologies; The present invention is rational in infrastructure, and the sample needle of each passage can be accomplished whole interchannel equidistance adjustment through one degree of freedom at the vertical direction independently moving; It is simple, reliable that motion is transmitted, and is that a kind of desirable hyperchannel liquid application of sample equivalent is divided apart from device.
Description of drawings
Below in conjunction with accompanying drawing the present invention is made and to further specify.
Fig. 1 is a kind of composition structural representation of the present invention.
Fig. 2 is that a kind of branch of the present invention is apart from the leading screw synoptic diagram.
Fig. 3 is a sample needle elevating mechanism synoptic diagram of the present invention.
Fig. 4 is a kind of application state synoptic diagram of the present invention.
Label among the figure: 11. minutes apart from motor, 12. shaft couplings, 13. guide rails, 14. bracing frames, 151. sample needles, 152. sample needles; 153. sample needle, 154. sample needles, 16. minutes apart from leading screw, 171. guide runners, 172. guide runners; 173. guide runner, 174. guide runners, 21. sample needle contiguous blocks, 22. lifter racks, 23. lifting motors; 24. gear, 25. worktable back up pads, 31.X direction leading screw, 32.X direction motor, 33.Y direction motor; 34. test tube rack, 35.X traversing guide, 36.Y traversing guide, 37.Y direction leading screw, 38. test tube racks.
Embodiment
As can be seen from Figure 1, a kind of hyperchannel liquid application of sample equivalent is divided apart from device, and it is a four-way liquid application of sample.It comprises branch apart from motor 11, divide sample needle 151,152,153,154 and guide runner 171,172,173,174 apart from leading screw 16, guide rail 13, some each passages of correspondence, divide apart from motor 11 to be connected apart from leading screw 16 with branch through shaft coupling 12.Divide and be installed on the worktable back up pad through bracing frame 14 apart from motor 11.Guide rail 13 also is installed on the worktable back up pad through support.
Have the pilot hole that cooperates with corresponding sample needle 151,152,153,154 on the said guide runner 171,172,173,174, each sample needle passes corresponding pilot hole, and sample needle can move up and down along this hole.Said guide runner 171,172,173,174 is provided with and divides the screw thread that cooperates apart from leading screw 16, and guide runner 171,172,173,174 is installed on the said guide rail 13, can move along guide rail 13.
Said branch is provided with 2m section screw thread apart from leading screw 16, and (m is a natural number; As 2,3,4,5); The screw thread hop count equates that with port number wherein dividing apart from leading screw left-half and right half part respectively has m section screw thread, divides opposite apart from the thread rotary orientation of leading screw 16 left-half and right half part; Dividing that the pitch ratio of each section screw thread is the same from outside to inside apart from leading screw 16 left-half and right half part, all is 2m-1:2m-3 ...: 1.
The synoptic diagram that is a kind of branch of 4 channel liquid application of samples apart from leading screw shown in Figure 2.Whole branch is apart from totally 4 sections on the screw thread of leading screw, two sections of left-half, two sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing apart from leading screw left-half and two sections screw threads of right half part pitch ratio from outside to inside all is 3:1.
Screw thread on the guide runner of each passage of correspondence according to the invention and said branch one section threaded engagement on the leading screw 16; Divide apart from motor 11 and drive branch apart from leading screw 16 rotations through shaft coupling 12; And then drive each guide runner and carry out corresponding displacement along guide rail; Guide runner 171,172,173,174 drives sample needle 151,152,153,154 respectively and moves along guide rail 13; The ratio 3:1 of sample needle 151 and the speed of sample needle 152, sample needle 154 also is 3:1 with the ratio of the speed of sample needle 153, but 151,152 velocity reversal and 153,154 velocity reversal are opposite.What sample needle will be according to the hand of spiral and pitch like this is different, produces different direction and speed, realizes that promptly equidistance separates, and realizes that channel pitch equivalent regulates, and guarantees that the distance between each passage is identical all the time.
For 6 channel liquid application of samples, divide apart from totally 6 sections on the screw thread of leading screw, three sections of left-half, three sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing apart from leading screw left-half and three sections screw threads of right half part pitch ratio from outside to inside all is 5:3:1.
For 8 tunnel liquid application of samples, divide apart from totally 8 sections on the screw thread of leading screw, four sections of left-half, four sections of right half parts.Divide opposite apart from the thread rotary orientation of leading screw left-half and right half part.Dividing apart from the ratio of leading screw left-half and four sections screw threads of right half part pitch from outside to inside is 7:5:3:1.
Screw thread on the guide runner 171,172,173,174 according to the invention is an internal thread; The one section corresponding threaded engagement transmission on the leading screw 16 of internal thread and said branch; Have the pilot hole that cooperates with sample needle on also on the guide runner, sample needle can move up and down along this hole.
Each is driven the sample needle of each passage according to the invention by an elevating mechanism.As shown in Figure 3; Said elevating mechanism comprises lifting motor 23, gear 24, lifter rack 22, sample needle contiguous block 21, and gear 24 is installed on 23 of the lifting motors through reducing gear, and lifter rack 22 is vertically mounted on the sample needle contiguous block 21; Sample needle 154 is fixedly connected with sample needle contiguous block 21; Like this, lifter rack 22 is fixed together through sample needle contiguous block 21 with sample needle 154, so the motion of the mobile drive sample needle 154 of lifter rack 22.Whole elevating mechanism is installed on the worktable back up pad 25.Lifting motor 23 driven gears 24 rotate, and then the lifter rack 22 of drive and gearing mesh moves up and down, and move up and down along guide runner 174 through sample needle contiguous block 21 drive sample needles 154 again, realize independently moving up and down of each sample needle.In the multi-channel loading device, each is driven the sample needle of each passage by an elevating mechanism, and the motion of each sample needle is separate, is satisfied with the application of sample of different liquid level test tubes like this.
Gear of the present invention 24 designs than lifter rack 22 wide 10-15mm, can guarantee like this lifter rack in the detachment process of channel pitch equivalent along the gear axial slip, all the time with gearing mesh, thereby but guarantee each passage independently moving of distance adjustment back.So both realize each sample needle vertical direction self-movement, realized the single-degree-of-freedom control that the sample needle equidistance separates again.Here, the length of lifter rack 22 horizontal directions is defined as the lifter rack width, and the height of lifter rack 22 vertical direction is defined as lifter rack length.Lifter rack length has determined the heave amplitude of sample needle.
The version of each passage elevating mechanism of the present invention and the components and parts of use are all identical, just according to number of active lanes what, receive structural limitations to place the both sides of guide rail respectively.
Fig. 4 is a kind of application state synoptic diagram of the present invention.It is the Y direction that definition equivalent is divided apart from direction, and sample needle up-down direction is the Z direction, with equivalent divide apart from direction vertical be directions X.On directions X; Directions X motor 32 drags directions X leading screw 31 and rotates, and then drives whole slide holder, moves along directions X guide rail 35; When arriving given position to slide holder; Motor stops, and slide holder is stop motion also, has so just increased the work space of sample needle directions X; In the Y direction, Y direction motor 33 drags Y direction leading screw 37 rotation, and then drive bracing frame and move along Y traversing guide 36 and reach a certain given position, stop motion, increased like this sample needle Y to work space.Satisfy the different application of sample requirements of test tube rack 34 and test tube rack 38.
On the Z direction; Lifting motor 23 drives lifter wheel 24 and rotates, and through the meshing relation of gear and lifter rack, drives lifter rack 22 and moves up and down in the Z direction; Lifter rack is given sample needle motion transmission through sample needle contiguous block 21, moves in the Z direction thereby drive sample needle.For the multi-channel loading device, each lifting motor can only drive a sample needle, and the motion of each sample needle is separate like this.
Divide apart from the course of work for hyperchannel liquid sample adding device equivalent, divide apart from explaining with four-way equivalent.Sample needle just can arrive the given position in space according to above-mentioned description, but carries out application of sample for the test tube rack 34,38 of different size, needs constantly to regulate the distance between the sample needle.As shown in Figure 4, when above spacing is 10mm test tube rack 34, working, needing the spacing of adjustment sample needle is 10mm, and when above spacing is 15mm test tube rack 38, working, the sample needle spacing becomes 15mm, therefore need carry out equidistance to sample needle and separate.After having worked above the 10mm test tube rack; Divide apart from motor and begin to rotate; Drive the leading screw rotation through shaft coupling; Sample needle 151,152 and sample needle 153,154 move towards opposite direction along track, and sample needle 151 moves with the speed of 3:1 respectively with sample needle 153 and 154 with 152 in the same way simultaneously, has so just realized the equidistance separation of sample needle.

Claims (4)

1. a hyperchannel liquid application of sample equivalent is divided apart from device; It is characterized in that: it comprise branch apart from motor, divide sample needle and guide runner apart from leading screw, guide rail, some each passages of correspondence; Said guide runner is provided with and divides the screw thread that cooperates apart from leading screw; Guide runner is installed on the said guide rail, can move along guide rail; Said branch is provided with 2m section screw thread (m is a natural number) apart from leading screw; The screw thread hop count equates with port number; Wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged; Branch is opposite apart from the thread rotary orientation of leading screw left-half and right half part, and the pitch ratio of each section screw thread is 2m-1:2m-3 from outside to inside ...: 1; The one section threaded engagement transmission on the leading screw of screw thread on the guide runner of said each passage of correspondence and said branch; Divide apart from motor and rotate apart from leading screw through shaft coupling drive branch; And then drive each guide runner and carry out corresponding displacement along guide rail; Realize the adjusting of channel pitch equivalent, guarantee that the distance between each passage is identical all the time.
2. hyperchannel liquid application of sample equivalent according to claim 1 is divided apart from device; It is characterized in that: the screw thread on the said guide runner is an internal thread; The one section corresponding threaded engagement transmission on the leading screw of internal thread and said branch; Have the pilot hole that cooperates with sample needle on also on the guide runner, sample needle can move up and down along this hole.
3. hyperchannel liquid application of sample equivalent according to claim 1 is divided apart from device; It is characterized in that: each is driven the sample needle of said each passage by an elevating mechanism, and said elevating mechanism comprises lifting motor, gear, lifter rack, sample needle contiguous block, and gear is installed on the lifting motor axle through reducing gear; Lifter rack is vertically mounted on the sample needle contiguous block; Sample needle is fixedly connected with the sample needle contiguous block, and the lifting motor driven gear rotates, and then the lifter rack of drive and gearing mesh moves up and down; Drive sample needle through the sample needle contiguous block again and move up and down, realize independently moving up and down of each sample needle along guide runner.
4. hyperchannel liquid application of sample equivalent according to claim 3 is divided apart from device, it is characterized in that: the thickness of said gear manys 10-15mm than the width of lifter rack.
CN 201210035048 2012-02-16 2012-02-16 Multi-channel liquid sampling equivalent distancing device Expired - Fee Related CN102539806B (en)

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102580801A (en) * 2012-03-13 2012-07-18 苏州捷美电子有限公司 Multi-channel sample feed equipment
CN103278656A (en) * 2013-05-16 2013-09-04 华南理工大学 Multiple Tip head distance varying device applied to full-automatic sample feeder
CN104117298A (en) * 2013-04-24 2014-10-29 苏州捷美电子有限公司 Liquid distribution mechanism
CN105004576A (en) * 2015-07-31 2015-10-28 深圳市检验检疫科学研究院 Sample taking and adding all-in-one machine
CN106865164A (en) * 2017-04-19 2017-06-20 山东大学 Divide away from device and method
CN107283146A (en) * 2017-08-04 2017-10-24 上海金标生物科技有限公司 A kind of liquid transfer gun head distributor and liquid transfer gun head automatic assembling machine
CN108097341A (en) * 2018-01-08 2018-06-01 江苏师范大学 A kind of automatic ration gradient sample adding device
CN108176419A (en) * 2018-01-08 2018-06-19 江苏师范大学 A kind of automatic gradient sample adding device
CN108187771A (en) * 2018-01-08 2018-06-22 江苏师范大学 A kind of automatic ration gradient is loaded multichannel pipettor piston component
CN108454935A (en) * 2018-03-30 2018-08-28 广东美味鲜调味食品有限公司 A kind of recrater being applicable in multi-bottle type
CN108980290A (en) * 2018-07-09 2018-12-11 嘉兴科瑞迪医疗器械有限公司 A kind of sample loading gun minute hand transmission mechanism
CN109230449A (en) * 2018-08-22 2019-01-18 威海威高生物科技有限公司 Turn to sample rack
CN109975075A (en) * 2019-04-10 2019-07-05 陕西能源职业技术学院 A kind of biochemical test sample extraction device
CN110433891A (en) * 2019-08-09 2019-11-12 汪霞莲 A kind of type rack for test tube easy to use for hematology
CN112426808A (en) * 2020-11-03 2021-03-02 赵会阳 Filter paper alternately gets and puts device for empty gas detection surveys
CN115791361A (en) * 2023-02-07 2023-03-14 安徽海峰分析测试科技有限公司 A preprocessing equipment for soil sample detects

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Publication number Priority date Publication date Assignee Title
CN102580801A (en) * 2012-03-13 2012-07-18 苏州捷美电子有限公司 Multi-channel sample feed equipment
CN104117298A (en) * 2013-04-24 2014-10-29 苏州捷美电子有限公司 Liquid distribution mechanism
CN104117298B (en) * 2013-04-24 2016-09-28 苏州捷美电子有限公司 A kind of fluid body
CN103278656A (en) * 2013-05-16 2013-09-04 华南理工大学 Multiple Tip head distance varying device applied to full-automatic sample feeder
CN105004576A (en) * 2015-07-31 2015-10-28 深圳市检验检疫科学研究院 Sample taking and adding all-in-one machine
CN105004576B (en) * 2015-07-31 2017-11-10 深圳市检验检疫科学研究院 Sampling sample-adding all-in-one
CN106865164A (en) * 2017-04-19 2017-06-20 山东大学 Divide away from device and method
CN106865164B (en) * 2017-04-19 2018-07-31 山东大学 Divide away from device and method
CN107283146A (en) * 2017-08-04 2017-10-24 上海金标生物科技有限公司 A kind of liquid transfer gun head distributor and liquid transfer gun head automatic assembling machine
CN108187771A (en) * 2018-01-08 2018-06-22 江苏师范大学 A kind of automatic ration gradient is loaded multichannel pipettor piston component
CN108176419A (en) * 2018-01-08 2018-06-19 江苏师范大学 A kind of automatic gradient sample adding device
CN108097341A (en) * 2018-01-08 2018-06-01 江苏师范大学 A kind of automatic ration gradient sample adding device
CN108454935A (en) * 2018-03-30 2018-08-28 广东美味鲜调味食品有限公司 A kind of recrater being applicable in multi-bottle type
CN108980290A (en) * 2018-07-09 2018-12-11 嘉兴科瑞迪医疗器械有限公司 A kind of sample loading gun minute hand transmission mechanism
CN109230449A (en) * 2018-08-22 2019-01-18 威海威高生物科技有限公司 Turn to sample rack
CN109230449B (en) * 2018-08-22 2024-03-12 威海威高生物科技有限公司 Steering sample rack
CN109975075A (en) * 2019-04-10 2019-07-05 陕西能源职业技术学院 A kind of biochemical test sample extraction device
CN109975075B (en) * 2019-04-10 2022-03-29 陕西能源职业技术学院 Sample extraction element is used in biochemistry inspection
CN110433891A (en) * 2019-08-09 2019-11-12 汪霞莲 A kind of type rack for test tube easy to use for hematology
CN110433891B (en) * 2019-08-09 2021-07-02 金华市中心医院 A convenient to use type test-tube rack for hematology branch of academic or vocational study
CN112426808A (en) * 2020-11-03 2021-03-02 赵会阳 Filter paper alternately gets and puts device for empty gas detection surveys
CN115791361A (en) * 2023-02-07 2023-03-14 安徽海峰分析测试科技有限公司 A preprocessing equipment for soil sample detects

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