CN102526696B - 一种胃膜素胶囊的组合物及其制备方法 - Google Patents
一种胃膜素胶囊的组合物及其制备方法 Download PDFInfo
- Publication number
- CN102526696B CN102526696B CN2012100310916A CN201210031091A CN102526696B CN 102526696 B CN102526696 B CN 102526696B CN 2012100310916 A CN2012100310916 A CN 2012100310916A CN 201210031091 A CN201210031091 A CN 201210031091A CN 102526696 B CN102526696 B CN 102526696B
- Authority
- CN
- China
- Prior art keywords
- gastric mucin
- capsule
- regulator
- filler
- percentage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 102000009338 Gastric Mucins Human genes 0.000 title claims abstract description 64
- 108010009066 Gastric Mucins Proteins 0.000 title claims abstract description 64
- PQMWYJDJHJQZDE-UHFFFAOYSA-M Methantheline bromide Chemical group [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(CC)CC)C3=CC=CC=C3OC2=C1 PQMWYJDJHJQZDE-UHFFFAOYSA-M 0.000 title claims abstract description 64
- 239000002775 capsule Substances 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000000945 filler Substances 0.000 claims abstract description 14
- 238000005550 wet granulation Methods 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 24
- 235000019359 magnesium stearate Nutrition 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 229920001353 Dextrin Polymers 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 6
- 235000019425 dextrin Nutrition 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 229920000881 Modified starch Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 4
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 4
- 235000013539 calcium stearate Nutrition 0.000 claims description 4
- 239000008116 calcium stearate Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000007779 soft material Substances 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 238000005538 encapsulation Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000002950 deficient Effects 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 3
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- -1 drying Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 208000000718 duodenal ulcer Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 102000001621 Mucoproteins Human genes 0.000 description 1
- 108010093825 Mucoproteins Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
组分 | 克/粒 |
胃膜素 | 0.4 |
淀粉 | 0.02 |
硬脂酸镁 | 0.02 |
总重量 | 0.44 |
组分 | 克/粒 |
胃膜素 | 0.392 |
硬脂酸镁 | 0.008 |
总重量 | 0.4 |
组分 | 克/粒 |
胃膜素 | 0.2 |
糊精 | 0.12 |
硬脂酸镁 | 0.08 |
总重量 | 0.4 |
组分 | 克/粒 |
胃膜素 | 0.4 |
乳糖 | 0.05 |
硬脂酸镁 | 0.05 |
总重量 | 0.5 |
组分 | 克/粒 |
胃膜素 | 0.36 |
硬脂酸钙 | 0.04 |
总重量 | 0.4 |
组分 | 克/粒 |
胃膜素 | 0.4 |
糊精 | 0.05 |
预胶化淀粉 | 0.025 |
硬脂酸镁 | 0.025 |
总重量 | 0.5 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012100310916A CN102526696B (zh) | 2012-02-13 | 2012-02-13 | 一种胃膜素胶囊的组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012100310916A CN102526696B (zh) | 2012-02-13 | 2012-02-13 | 一种胃膜素胶囊的组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102526696A CN102526696A (zh) | 2012-07-04 |
CN102526696B true CN102526696B (zh) | 2013-09-11 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2012100310916A Active CN102526696B (zh) | 2012-02-13 | 2012-02-13 | 一种胃膜素胶囊的组合物及其制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN102526696B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104497122A (zh) * | 2014-12-23 | 2015-04-08 | 青岛康原药业有限公司 | 一种从猪胃粘膜中提取胃膜素的制备方法 |
CN112794896B (zh) * | 2021-01-12 | 2022-08-05 | 四川菲德力制药有限公司 | 一种胃膜素的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3626M (fr) * | 1963-11-13 | 1965-10-18 | Lucien Nouvel | Médicament pour affections intestinales. |
CN101024083A (zh) * | 2007-01-29 | 2007-08-29 | 徐英权 | 一种治疗胃病的药物 |
-
2012
- 2012-02-13 CN CN2012100310916A patent/CN102526696B/zh active Active
Also Published As
Publication number | Publication date |
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CN102526696A (zh) | 2012-07-04 |
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Denomination of invention: Composition of gastric mucin capsule and preparation method for composition Effective date of registration: 20160909 Granted publication date: 20130911 Pledgee: Merchants Bank of Hefei Economic Development Zone Branch Pledgor: HEFEI JINYUE PHARMACEUTICAL Co.,Ltd. Registration number: 2016990000780 |
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Date of cancellation: 20170525 Granted publication date: 20130911 Pledgee: Merchants Bank of Hefei Economic Development Zone Branch Pledgor: HEFEI JINYUE PHARMACEUTICAL Co.,Ltd. Registration number: 2016990000780 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Composition of gastric mucin capsule and preparation method for composition Effective date of registration: 20170602 Granted publication date: 20130911 Pledgee: Merchants Bank of Hefei Economic Development Zone Branch Pledgor: HEFEI JINYUE PHARMACEUTICAL Co.,Ltd. Registration number: 2017340000077 |
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Date of cancellation: 20190701 Granted publication date: 20130911 Pledgee: Merchants Bank of Hefei Economic Development Zone Branch Pledgor: HEFEI JINYUE PHARMACEUTICAL Co.,Ltd. Registration number: 2017340000077 |
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Denomination of invention: A composition of gastric mucosal capsule and its preparation method Effective date of registration: 20240103 Granted publication date: 20130911 Pledgee: Huishang Bank Co.,Ltd. Hefei Economic Development Zone sub branch Pledgor: HEFEI JINYUE PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980000208 |
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