CN102497909B - 中空微针阵列 - Google Patents

中空微针阵列 Download PDF

Info

Publication number
CN102497909B
CN102497909B CN201080040166.6A CN201080040166A CN102497909B CN 102497909 B CN102497909 B CN 102497909B CN 201080040166 A CN201080040166 A CN 201080040166A CN 102497909 B CN102497909 B CN 102497909B
Authority
CN
China
Prior art keywords
applicator
reservoir
energy storage
fluid
storage device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080040166.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102497909A (zh
Inventor
伯纳德·A·冈萨雷斯
斯科特·A·伯顿
胡佳
伍振裕
瑞安·帕特里克·希默斯
托马斯·J·吉尔伯特
肖恩·M·布尔克
罗伯特·A·哈金斯
拉里·A·施莱夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CN102497909A publication Critical patent/CN102497909A/zh
Application granted granted Critical
Publication of CN102497909B publication Critical patent/CN102497909B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
CN201080040166.6A 2009-07-31 2010-07-27 中空微针阵列 Expired - Fee Related CN102497909B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23034709P 2009-07-31 2009-07-31
US61/230,347 2009-07-31
PCT/US2010/043414 WO2011014514A1 (en) 2009-07-31 2010-07-27 Hollow microneedle arrays

Publications (2)

Publication Number Publication Date
CN102497909A CN102497909A (zh) 2012-06-13
CN102497909B true CN102497909B (zh) 2014-10-29

Family

ID=43017143

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080040166.6A Expired - Fee Related CN102497909B (zh) 2009-07-31 2010-07-27 中空微针阵列

Country Status (11)

Country Link
US (2) US10010706B2 (enExample)
EP (2) EP3354312A1 (enExample)
JP (1) JP5702384B2 (enExample)
KR (1) KR101712226B1 (enExample)
CN (1) CN102497909B (enExample)
AU (1) AU2010276511B2 (enExample)
BR (1) BR112012001685B8 (enExample)
CA (1) CA2769102C (enExample)
ES (1) ES2661063T3 (enExample)
RU (1) RU2508135C2 (enExample)
WO (1) WO2011014514A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107913460A (zh) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 一种液体定量输送系统
CN107913459A (zh) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 一种液体定量输送装置

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
TWI527603B (zh) 2006-06-30 2016-04-01 艾伯維生物技術有限責任公司 自動注射裝置
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
JP5653217B2 (ja) 2007-10-02 2015-01-14 メディモップ メディカル プロジェクツ、エル・ティー・ディー 外部薬剤ポンプ
ES2896727T3 (es) 2010-03-25 2022-02-25 New Injection Systems Ltd Inyector
CA3032974C (en) 2010-04-21 2022-04-12 Abbvie Biotechnology Ltd. Wearable automatic injection device for controlled delivery of therapeutic agents
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP5934188B2 (ja) * 2010-05-20 2016-06-15 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 薬物送達装置
AU2015203703B2 (en) * 2010-05-20 2018-01-18 Becton, Dickinson And Company Drug delivery device
GB2483505B (en) * 2010-09-13 2012-10-10 Ndm Technologies Ltd Devices for transdermal drug delivery
US8668675B2 (en) * 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
SG10201600576QA (en) 2011-01-24 2016-02-26 Abbvie Biotechnology Ltd Automatic injection devices having overmolded gripping surfaces
WO2012126784A1 (en) * 2011-03-18 2012-09-27 Universite Libre De Bruxelles Devices for puncturing a human or animal body's membrane
CN102727992A (zh) * 2011-03-31 2012-10-17 株式会社汉比特科技与创新 印章式针组件
CA2832729A1 (en) * 2011-04-21 2012-10-26 Abbvie Inc. Wearable automatic injection device for controlled administration of therapeutic agents
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
EP2753377B1 (en) 2011-09-07 2022-05-04 Kindeva Drug Delivery L.P. Delivery system for hollow microneedle arrays
EP2731643B2 (en) 2011-09-13 2019-06-05 Unitract Syringe Pty Ltd Sterile fluid pathway connection to drug containers for drug delivery pumps
AU2012323392A1 (en) 2011-10-12 2014-04-24 3M Innovative Properties Company Integrated microneedle array delivery system
CN102327656B (zh) * 2011-10-18 2013-05-08 清华大学 一次性阵列式微型注射针头
WO2013082427A1 (en) 2011-11-30 2013-06-06 3M Innovative Properties Company Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
US10272233B2 (en) * 2012-03-16 2019-04-30 National University Of Singapore Method to fabricate polymeric microneedles
JP5903016B2 (ja) 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
EP2906284B8 (en) 2012-10-10 2021-01-20 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
US10300260B2 (en) 2012-10-10 2019-05-28 3M Innovative Properties Company Applicator and method for applying a microneedle device to skin
WO2014062538A1 (en) 2012-10-19 2014-04-24 3M Innovative Properties Company Polysaccharide-containing hydrogels, compositions, articles, and methods
USD693921S1 (en) 2012-10-26 2013-11-19 3M Innovative Properties Company Microneedle applicator
USD705422S1 (en) 2012-10-26 2014-05-20 3M Innovative Properties Company Microneedle applicator
CN104797287B (zh) 2012-11-16 2017-12-26 3M创新有限公司 力控施用装置
EP4234694A3 (en) 2012-11-21 2023-09-06 Amgen Inc. Drug delivery device
CA2890764C (en) 2012-11-23 2021-05-04 New Injection Systems Ltd Auto-injector assembly
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
US10549079B2 (en) 2012-12-21 2020-02-04 3M Innovative Properties Company Adhesive assemblies and microneedle injection apparatuses comprising same
CN104884119B (zh) 2012-12-27 2018-04-20 3M创新有限公司 具有中空微针的制品及其制备方法
WO2014110016A1 (en) 2013-01-08 2014-07-17 3M Innovative Properties Company Applicator for applying a microneedle device to skin
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
KR102571835B1 (ko) * 2013-02-28 2023-08-30 소렌토 쎄라퓨틱스, 인코포레이티드 경피 약물 전달 장치
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル， インコーポレイテッド 微小突起アプリケータ
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
AU2014237357B2 (en) * 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
WO2014153447A2 (en) 2013-03-22 2014-09-25 3M Innovative Properties Company Microneedle applicator comprising a counter assembly
BR112015026199B1 (pt) * 2013-04-15 2022-03-22 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico e sistema de separação de fluido biológico
KR102274902B1 (ko) * 2013-05-31 2021-07-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 주사 및 주입 장치 및 그의 사용 방법
WO2014193727A1 (en) * 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection apparatus comprising a dual cover
ES2686362T3 (es) 2013-05-31 2018-10-17 3M Innovative Properties Company Aparato de inyección de microagujas que comprende una accionador inverso
EP3020445A4 (en) 2013-07-08 2017-03-08 Toppan Printing Co., Ltd. Hollow needle-like body device
WO2015009524A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle with beveled tip
US10099043B2 (en) 2013-07-16 2018-10-16 3M Innovative Properties Company Hollow microneedle array article
JP6430501B2 (ja) 2013-07-16 2018-11-28 スリーエム イノベイティブ プロパティズ カンパニー 斜角開口部を有する中空マイクロニードル
WO2015009531A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Article comprising a microneedle
JP2017507165A (ja) 2013-12-16 2017-03-16 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または３次元印刷されたパルス放出ワクチン製剤
EP3906951A1 (en) * 2013-12-19 2021-11-10 Medtronic MiniMed, Inc. On-body injector
GB201401133D0 (en) * 2014-01-23 2014-03-12 Renephra Ltd Fluid extraction device, applicator device and associated methods
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
GB201402261D0 (en) * 2014-02-10 2014-03-26 Owen Mumford Ltd Injector apparatus
PT3834824T (pt) 2014-03-28 2025-11-18 Univ Duke Tratamento do cancro da mama positivo para o receptor de estrogénio utilizando um modulador seletivo do recetor de estrogénio
EP3137154B1 (en) 2014-04-30 2019-09-04 Sorrento Therapeutics, Inc. Cartridge portion of transdermal drug delivery apparatus
EP3137150B1 (en) * 2014-04-30 2019-09-04 Sorrento Therapeutics, Inc. Receptacle portion of transdermal drug delivery apparatus
AU2015253253B2 (en) 2014-04-30 2019-09-12 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus and methods
CN104056346B (zh) * 2014-06-16 2017-04-26 游学秋 异平面微针阵列及其制作方法
JPWO2016006409A1 (ja) 2014-07-09 2017-04-27 凸版印刷株式会社 液剤注入装置
CN104117138A (zh) * 2014-07-24 2014-10-29 河南科技大学 一种超声微针复合经皮给药装置
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JPWO2016072060A1 (ja) 2014-11-05 2017-09-14 凸版印刷株式会社 マイクロニードルセット
US10010708B2 (en) * 2014-12-20 2018-07-03 Esthetic Education LLC Microneedle cartridge and nosecone assembly
EP3037124A1 (en) 2014-12-22 2016-06-29 Universite Libre De Bruxelles Drug delivery device with microneedles
AU2016209496B2 (en) 2015-01-21 2018-06-28 Kindeva Drug Delivery L.P. Microneedle array and method of use
CN107206066A (zh) 2015-01-27 2017-09-26 3M创新有限公司 用于微针疫苗贴剂的含明矾的涂层制剂
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
EP3260160A4 (en) 2015-02-16 2018-09-05 Toppan Printing Co., Ltd. Microneedle
KR102707701B1 (ko) 2015-03-10 2024-09-23 리제너론 파아마슈티컬스, 인크. 무균 관통 시스템 및 방법
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
HUE054394T2 (hu) * 2015-03-26 2021-09-28 Enable Injections Inc Gyógyszerátvitel nyomás alatt lévõ gáz energiájával, valamint újraszuszpendáló készülék és eljárás
US10893865B2 (en) 2015-04-13 2021-01-19 Mayo Foundation For Medical Education And Research Magnetic wound closure systems
CA2984357A1 (en) 2015-04-29 2016-11-03 Radius Pharmaceuticals, Inc. Methods for treating cancer
CN113181477B (zh) 2015-06-04 2023-07-14 麦迪麦珀医疗工程有限公司 用于药物释放装置的筒插入
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10576207B2 (en) * 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108472438B (zh) 2015-10-09 2022-01-28 西医药服务以色列分公司 至预填充的流体储存器的弯曲流体路径附加装置
US10518071B2 (en) * 2015-12-29 2019-12-31 Gajanan Kulkarni Transdermal microneedle drug delivery device and method
EP3405229A1 (en) 2016-01-21 2018-11-28 West Pharma. Services Il, Ltd. Needle insertion and retraction mechanism
JP6885960B2 (ja) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド 視覚的インジケータを有する薬剤デリバリデバイス
US10610638B2 (en) * 2016-01-21 2020-04-07 West Pharma. Services IL, Ltd. Force containment in an automatic injector
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
GB2552193A (en) * 2016-07-13 2018-01-17 Ndm Technologies Ltd Improvements in or relating to transdermal delivery
CN109562229B (zh) 2016-08-01 2021-07-13 西医药服务以色列有限公司 抗旋转药筒销
CN109562220B (zh) 2016-08-01 2021-06-29 西医药服务以色列有限公司 部分门关闭防止弹簧
US11033676B2 (en) 2016-08-08 2021-06-15 Unl Holdings Llc Drug delivery device and method for connecting a fluid flowpath
CN106362250B (zh) * 2016-09-18 2021-03-05 电子科技大学 微型阵列注射器
US11666705B2 (en) 2016-09-27 2023-06-06 Sanofi-Aventis Deutschland Gmbh Medicament delivery device
EP3315156A1 (en) * 2016-11-01 2018-05-02 Sanofi-Aventis Deutschland GmbH Medicament delivery device
CA3045477A1 (en) * 2016-12-05 2018-06-14 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
JP7008709B2 (ja) 2016-12-16 2022-01-25 ソレント・セラピューティクス・インコーポレイテッド 制御アセンブリを有する流体送達装置及びその使用方法
JP7193458B2 (ja) 2016-12-16 2022-12-20 ソレント・セラピューティクス・インコーポレイテッド 流体送達装置用のアプリケーション装置及びその使用方法
USD819197S1 (en) 2016-12-16 2018-05-29 Kimberly-Clark Worldwide, Inc. Fluid delivery apparatus
USD836774S1 (en) 2016-12-16 2018-12-25 Sorrento Therapeutics, Inc. Cartridge for a fluid delivery apparatus
CA3047282A1 (en) 2016-12-16 2018-06-21 Sorrento Therapeutics, Inc. Method for administering a medicament suitable for treating a migraine or cluster headache
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
MX383786B (es) 2017-01-05 2025-03-14 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
JP6931217B2 (ja) * 2017-03-28 2021-09-01 コスメディ製薬株式会社 水溶性シート状製剤のアプリケータ
CN115025329B (zh) 2017-05-05 2024-05-14 里珍纳龙药品有限公司 自动注射器和相关使用方法
JP6921997B2 (ja) 2017-05-30 2021-08-18 ウェスト ファーマ サービシーズ イスラエル リミテッド ウェアラブル注射器のモジュラ駆動トレイン
CN111182931B (zh) * 2017-08-10 2022-06-24 西部制药服务有限公司(以色列) 注射器延迟药筒刺穿机构
JP7284748B2 (ja) 2017-10-17 2023-05-31 キンデーバ ドラッグ デリバリー リミティド パートナーシップ マイクロニードルアレイを皮膚に適用するためのアプリケータ
DE102017223505A1 (de) 2017-12-21 2019-06-27 Vetter Pharma-Fertigung GmbH & Co. KG Behälter für medizinische Flüssigkeiten und Verfahren zum Befüllen eines solchen Behälters
EP3727514B1 (en) 2017-12-22 2025-02-05 West Pharma Services IL, Ltd. Injector usable with different dimension cartridges
US11058605B2 (en) 2018-03-08 2021-07-13 Flex Ltd. Sterilization fluid path with barrier removal
CN118079142A (zh) * 2018-04-11 2024-05-28 赛诺菲 药物递送装置
WO2019197360A1 (en) * 2018-04-11 2019-10-17 Sanofi Drug delivery device
US11690799B2 (en) 2018-04-19 2023-07-04 Lts Lohmann Therapie-Systeme Ag Microneedle system for applying interferon
EP3793440A1 (en) 2018-05-16 2021-03-24 Kindeva Drug Delivery L.P. Microneedle biosensor
AU2019279884B2 (en) 2018-05-29 2025-01-30 Morningside Venture Investments Limited Drug delivery methods and systems
AU2019297421B2 (en) 2018-07-04 2024-08-29 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD 1901-2HCL
CN109568711B (zh) * 2018-11-01 2021-01-01 江苏爱朋医疗科技股份有限公司 输液管的自锁装置
CA3119992A1 (en) 2018-11-16 2020-05-22 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
US12427246B2 (en) * 2019-01-07 2025-09-30 Shl Medical Ag Medicament delivery device
DE102019200557A1 (de) * 2019-01-17 2020-07-23 Lts Lohmann Therapie-Systeme Ag Applikator
MX2021009569A (es) 2019-02-12 2021-09-08 Radius Pharmaceuticals Inc Procesos y compuestos.
US20210030951A1 (en) * 2019-04-20 2021-02-04 Leif Bowman Infusion Set Having Reduced Patient Pain
EP3958945A4 (en) * 2019-04-20 2023-04-12 Biolark, Inc. FULL ACTION INSERTION AND WITHDRAWAL INFUSION SET
US12390537B2 (en) 2020-05-13 2025-08-19 Massachusetts Institute Of Technology Compositions of polymeric microdevices and methods of use thereof in cancer immunotherapy
CN116390688A (zh) * 2020-06-17 2023-07-04 比奥林股份有限公司 用于施用微针阵列的装置和方法
KR20230096963A (ko) * 2020-08-03 2023-06-30 큐랩 메디컬 엘티디. 최소 침습 모니터링 패치
EP4247457B1 (en) * 2020-11-19 2025-12-24 Becton, Dickinson and Company Drug delivery device with container holder
USD920500S1 (en) * 2020-12-14 2021-05-25 Xianlin He Microneedle instrument
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
JP7734362B2 (ja) * 2021-01-16 2025-09-05 シンクランド株式会社 アプリケータ及びアプリケータ用カートリッジ
US12161832B2 (en) 2021-03-01 2024-12-10 Deka Products Limited Partnership Medical agent dispensing systems, methods, and apparatuses
US12357804B2 (en) 2021-03-01 2025-07-15 Deka Products Limited Partnership Medical agent dispensing systems, methods, and apparatuses
CA3210642A1 (en) * 2021-03-01 2022-09-09 Dean Kamen Medical agent dispensing apparatuses, systems, and methods
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
JP7569586B2 (ja) 2021-09-28 2024-10-18 バイオリンク インコーポレイテッド 微小針アレイベースの持続的分析物監視デバイスのための微小針エンクロージャおよびアプリケータデバイス
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
USD1033641S1 (en) 2021-12-17 2024-07-02 Biolinq Incorporated Microneedle array sensor applicator device
USD1057153S1 (en) 2022-04-29 2025-01-07 Biolinq Incorporated Microneedle array sensor applicator device
EP4543529A1 (en) * 2022-06-27 2025-04-30 Nutromics Technology Pty Ltd Extended wear microneedle apparatus
WO2024097385A1 (en) 2022-11-05 2024-05-10 Kindeva Drug Delivery L.P. Microneedle array applicator and system
AU2023395786A1 (en) 2022-12-16 2025-07-31 Kindeva Drug Delivery L.P. Drug delivery device
WO2024145424A1 (en) * 2022-12-28 2024-07-04 Satio, Inc. Dermal patch for delivering a pharmaceutical
WO2025164446A1 (ja) * 2024-01-29 2025-08-07 久光製薬株式会社 アプリケータ
WO2025164447A1 (ja) * 2024-01-29 2025-08-07 久光製薬株式会社 アプリケータ
JP7738215B1 (ja) * 2024-01-29 2025-09-11 久光製薬株式会社 アプリケータ

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040024367A1 (en) * 2002-07-31 2004-02-05 Scott Gilbert Injection device providing automatic needle retraction
CN1671430A (zh) * 2002-07-22 2005-09-21 贝克顿·迪金森公司 贴片状注射装置
CN1723053A (zh) * 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
CN101208130A (zh) * 2005-06-27 2008-06-25 3M创新有限公司 微针阵列施放器装置

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2814987C2 (de) 1978-04-07 1980-02-14 Erwin Noll Tätowierzange zum Kennzeichnen der Ohren von Tieren
US4755173A (en) 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US5176662A (en) 1990-08-23 1993-01-05 Minimed Technologies, Ltd. Subcutaneous injection set with improved cannula mounting arrangement
US5257980A (en) 1993-04-05 1993-11-02 Minimed Technologies, Ltd. Subcutaneous injection set with crimp-free soft cannula
CA2132277C (en) * 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US6607509B2 (en) 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
ATE428357T1 (de) 2000-10-13 2009-05-15 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
AU9682701A (en) 2000-10-13 2002-04-22 Alza Corp Microblade array impact applicator
CN100349629C (zh) 2001-09-12 2007-11-21 贝克顿迪肯森公司 用于药物传送的微针为基础的笔装置和使用该装置的方法
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
ATE331542T1 (de) * 2002-08-29 2006-07-15 Novo Nordisk As Injektionsvorrichtung mit frontladung
US6896666B2 (en) * 2002-11-08 2005-05-24 Kochamba Family Trust Cutaneous injection delivery under suction
US7252651B2 (en) * 2003-01-07 2007-08-07 Becton, Dickinson And Company Disposable injection device
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US6926694B2 (en) 2003-05-09 2005-08-09 Medsolve Technologies, Llc Apparatus and method for delivery of therapeutic and/or diagnostic agents
WO2005018705A2 (en) * 2003-08-12 2005-03-03 Becton, Dickinson And Company Patch-like infusion device
US7097631B2 (en) 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
WO2005072794A2 (en) 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
EP3329960A1 (en) 2004-06-10 2018-06-06 3M Innovative Properties Company Patch application device and kit
WO2007002523A2 (en) * 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
JP4963849B2 (ja) 2006-03-13 2012-06-27 シスメックス株式会社 微細孔形成システム
JP2008154849A (ja) * 2006-12-25 2008-07-10 Ritsumeikan 注入装置
US20100152674A1 (en) * 2007-04-30 2010-06-17 Medtronic Minimed, Inc Needle inserting and fluid flow connection for infusion medium delivery system
JP2012509106A (ja) 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US10800040B1 (en) 2017-12-14 2020-10-13 Amazon Technologies, Inc. Simulation-real world feedback loop for learning robotic control policies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1671430A (zh) * 2002-07-22 2005-09-21 贝克顿·迪金森公司 贴片状注射装置
US20040024367A1 (en) * 2002-07-31 2004-02-05 Scott Gilbert Injection device providing automatic needle retraction
CN1723053A (zh) * 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
CN101208130A (zh) * 2005-06-27 2008-06-25 3M创新有限公司 微针阵列施放器装置

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107913460A (zh) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 一种液体定量输送系统
CN107913459A (zh) * 2016-10-10 2018-04-17 苏州纳通生物纳米技术有限公司 一种液体定量输送装置
CN107913460B (zh) * 2016-10-10 2021-06-22 苏州纳通生物纳米技术有限公司 一种液体定量输送系统

Also Published As

Publication number Publication date
BR112012001685B1 (pt) 2020-11-03
CA2769102A1 (en) 2011-02-03
CA2769102C (en) 2017-09-19
BR112012001685A2 (pt) 2017-06-13
US10010706B2 (en) 2018-07-03
BR112012001685B8 (pt) 2021-06-22
US20120123387A1 (en) 2012-05-17
EP3354312A1 (en) 2018-08-01
JP2013500773A (ja) 2013-01-10
CN102497909A (zh) 2012-06-13
EP2459267B1 (en) 2017-12-20
RU2508135C2 (ru) 2014-02-27
US20180304063A1 (en) 2018-10-25
AU2010276511B2 (en) 2013-09-19
WO2011014514A8 (en) 2011-09-15
AU2010276511A1 (en) 2012-02-16
KR20120039733A (ko) 2012-04-25
RU2012102688A (ru) 2013-09-10
ES2661063T3 (es) 2018-03-27
WO2011014514A1 (en) 2011-02-03
US11103685B2 (en) 2021-08-31
JP5702384B2 (ja) 2015-04-15
EP2459267A1 (en) 2012-06-06
KR101712226B1 (ko) 2017-03-03

Similar Documents

Publication Publication Date Title
CN102497909B (zh) 中空微针阵列
KR102105500B1 (ko) 중공형 미세침 어레이용 전달 시스템
CN104870049B (zh) 粘合剂组件和包括该粘合剂组件的微针注入设备
JP5450568B2 (ja) パッチ様注入装置
CN110958893B (zh) 药物输送装置
CN105833395A (zh) 自注射装置

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141029

CF01 Termination of patent right due to non-payment of annual fee