CN102497909B - 中空微针阵列 - Google Patents
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- CN102497909B CN102497909B CN201080040166.6A CN201080040166A CN102497909B CN 102497909 B CN102497909 B CN 102497909B CN 201080040166 A CN201080040166 A CN 201080040166A CN 102497909 B CN102497909 B CN 102497909B
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Landscapes
- Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23034709P | 2009-07-31 | 2009-07-31 | |
| US61/230,347 | 2009-07-31 | ||
| PCT/US2010/043414 WO2011014514A1 (en) | 2009-07-31 | 2010-07-27 | Hollow microneedle arrays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102497909A CN102497909A (zh) | 2012-06-13 |
| CN102497909B true CN102497909B (zh) | 2014-10-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080040166.6A Expired - Fee Related CN102497909B (zh) | 2009-07-31 | 2010-07-27 | 中空微针阵列 |
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| Country | Link |
|---|---|
| US (2) | US10010706B2 (enExample) |
| EP (2) | EP3354312A1 (enExample) |
| JP (1) | JP5702384B2 (enExample) |
| KR (1) | KR101712226B1 (enExample) |
| CN (1) | CN102497909B (enExample) |
| AU (1) | AU2010276511B2 (enExample) |
| BR (1) | BR112012001685B8 (enExample) |
| CA (1) | CA2769102C (enExample) |
| ES (1) | ES2661063T3 (enExample) |
| RU (1) | RU2508135C2 (enExample) |
| WO (1) | WO2011014514A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107913460A (zh) * | 2016-10-10 | 2018-04-17 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送系统 |
| CN107913459A (zh) * | 2016-10-10 | 2018-04-17 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送装置 |
Families Citing this family (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| KR101440795B1 (ko) | 2006-06-30 | 2014-09-22 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| BRPI0817907B8 (pt) | 2007-10-02 | 2021-06-22 | Lamodel Ltd | aparelho para administrar uma substância a um indivíduo |
| SI3184136T1 (sl) | 2010-03-25 | 2021-11-30 | New Injection Systems Ltd | Injektor |
| CN104906656B (zh) | 2010-04-21 | 2020-01-10 | 艾伯维生物技术有限公司 | 用于治疗药剂的受控输送的可佩戴自动注射装置 |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| EP3520841B1 (en) | 2010-05-20 | 2021-03-10 | Becton, Dickinson and Company | Drug delivery device |
| AU2015203703B2 (en) * | 2010-05-20 | 2018-01-18 | Becton, Dickinson And Company | Drug delivery device |
| GB2483505B (en) * | 2010-09-13 | 2012-10-10 | Ndm Technologies Ltd | Devices for transdermal drug delivery |
| US8668675B2 (en) * | 2010-11-03 | 2014-03-11 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
| MY166835A (en) | 2011-01-24 | 2018-07-23 | Abbvie Biotechnology Ltd | Automatic injection devices having overmolded gripping surfaces |
| EP2686058A1 (en) * | 2011-03-18 | 2014-01-22 | Université Libre de Bruxelles | Devices for puncturing a human or animal body's membrane |
| CN102727992A (zh) * | 2011-03-31 | 2012-10-17 | 株式会社汉比特科技与创新 | 印章式针组件 |
| CA2832729A1 (en) * | 2011-04-21 | 2012-10-26 | Abbvie Inc. | Wearable automatic injection device for controlled administration of therapeutic agents |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| JP6411888B2 (ja) * | 2011-09-07 | 2018-10-24 | スリーエム イノベイティブ プロパティズ カンパニー | 中空マイクロニードルアレイのための送達システム |
| EP2731643B2 (en) | 2011-09-13 | 2019-06-05 | Unitract Syringe Pty Ltd | Sterile fluid pathway connection to drug containers for drug delivery pumps |
| JP6126105B2 (ja) * | 2011-10-12 | 2017-05-10 | スリーエム イノベイティブ プロパティズ カンパニー | 一体化されたマイクロニードル送達システム |
| CN102327656B (zh) * | 2011-10-18 | 2013-05-08 | 清华大学 | 一次性阵列式微型注射针头 |
| AU2012345768B2 (en) | 2011-11-30 | 2016-05-12 | Kindeva Drug Delivery L.P. | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| CN104302349B (zh) * | 2012-03-16 | 2018-06-05 | 新加坡国立大学 | 制造聚合物微针的新方法 |
| JP5903016B2 (ja) | 2012-06-27 | 2016-04-13 | コスメディ製薬株式会社 | マイクロニードルパッチの保護離型シート |
| US9782574B2 (en) | 2012-10-10 | 2017-10-10 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
| EP2906285B1 (en) * | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
| WO2014062538A1 (en) | 2012-10-19 | 2014-04-24 | 3M Innovative Properties Company | Polysaccharide-containing hydrogels, compositions, articles, and methods |
| USD705422S1 (en) | 2012-10-26 | 2014-05-20 | 3M Innovative Properties Company | Microneedle applicator |
| USD693921S1 (en) | 2012-10-26 | 2013-11-19 | 3M Innovative Properties Company | Microneedle applicator |
| CN104797287B (zh) | 2012-11-16 | 2017-12-26 | 3M创新有限公司 | 力控施用装置 |
| EP3072548B1 (en) * | 2012-11-21 | 2019-03-06 | Amgen, Inc | Drug delivery device |
| DK2922588T3 (da) | 2012-11-23 | 2019-05-06 | New Injection Systems Ltd | Autoinjektorindretning |
| JP6865524B2 (ja) | 2012-12-21 | 2021-04-28 | コリウム, インコーポレイテッド | 治療剤を送達するためのマイクロアレイおよび使用方法 |
| EP3513833A1 (en) | 2012-12-21 | 2019-07-24 | 3M Innovative Properties Co. | Adhesive assemblies and microneedle injection apparatus comprising same |
| EP2938390A1 (en) | 2012-12-27 | 2015-11-04 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
| US20150352295A1 (en) * | 2013-01-08 | 2015-12-10 | 3M Innovative Properties Company | Application For Applying A Microneedle Device To Skin |
| US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
| BR112015020328B1 (pt) * | 2013-02-28 | 2022-05-31 | Sorrento Therapeutics, Inc | Dispositivo de aplicação transdérmica de droga |
| JP6487899B2 (ja) | 2013-03-12 | 2019-03-20 | コリウム インターナショナル, インコーポレイテッド | 微小突起アプリケータ |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| WO2014150285A2 (en) * | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| SG11201507885TA (en) | 2013-03-22 | 2015-11-27 | 3M Innovative Properties Co | Microneedle applicator comprising a counter assembly |
| BR112015026199B1 (pt) * | 2013-04-15 | 2022-03-22 | Becton, Dickinson And Company | Dispositivo de coleta de fluido biológico e sistema de separação de fluido biológico |
| EP3003459B1 (en) * | 2013-05-31 | 2018-06-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
| US9872975B2 (en) | 2013-05-31 | 2018-01-23 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
| JP6494602B2 (ja) * | 2013-05-31 | 2019-04-03 | スリーエム イノベイティブ プロパティズ カンパニー | 二重カバーを備えるマイクロニードル注射装置 |
| EP3020445A4 (en) | 2013-07-08 | 2017-03-08 | Toppan Printing Co., Ltd. | Hollow needle-like body device |
| SG11201600330XA (en) | 2013-07-16 | 2016-02-26 | 3M Innovative Properties Co | Article comprising a microneedle |
| US10384047B2 (en) | 2013-07-16 | 2019-08-20 | 3M Innovative Properties Company | Hollow microneedle with bevel opening |
| US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
| WO2015009524A1 (en) | 2013-07-16 | 2015-01-22 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| EP3763383A1 (en) | 2013-12-16 | 2021-01-13 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
| CN110141719B (zh) * | 2013-12-19 | 2022-05-27 | 美敦力迷你迈德公司 | 贴身注射器及其使用方法 |
| GB201401133D0 (en) * | 2014-01-23 | 2014-03-12 | Renephra Ltd | Fluid extraction device, applicator device and associated methods |
| US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| GB201402261D0 (en) | 2014-02-10 | 2014-03-26 | Owen Mumford Ltd | Injector apparatus |
| PT3122426T (pt) | 2014-03-28 | 2023-02-28 | Univ Duke | Tratamento de cancro da mama utilizando moduladores seletivos do recetor de estrogénio |
| KR20220026606A (ko) * | 2014-04-30 | 2022-03-04 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 경피 약물 전달 장치 및 방법의 수용기 부분 |
| BR112016023642A2 (pt) * | 2014-04-30 | 2017-08-22 | Kimberly Clark Co | Porção de cartucho do aparelho de distribuição transdérmica de droga e métodos |
| JP6566964B2 (ja) * | 2014-04-30 | 2019-08-28 | ソレント・セラピューティクス・インコーポレイテッド | 経皮的薬物送達装置および方法 |
| CN106512199B (zh) * | 2014-06-16 | 2019-07-16 | 游学秋 | 异平面微针阵列及其制作方法 |
| WO2016006409A1 (ja) | 2014-07-09 | 2016-01-14 | 凸版印刷株式会社 | 液剤注入装置 |
| CN104117138A (zh) * | 2014-07-24 | 2014-10-29 | 河南科技大学 | 一种超声微针复合经皮给药装置 |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| WO2016072060A1 (ja) | 2014-11-05 | 2016-05-12 | 凸版印刷株式会社 | マイクロニードルセット |
| US10010708B2 (en) * | 2014-12-20 | 2018-07-03 | Esthetic Education LLC | Microneedle cartridge and nosecone assembly |
| EP3037124A1 (en) | 2014-12-22 | 2016-06-29 | Universite Libre De Bruxelles | Drug delivery device with microneedles |
| AU2016209496B2 (en) | 2015-01-21 | 2018-06-28 | Kindeva Drug Delivery L.P. | Microneedle array and method of use |
| JP2018502927A (ja) | 2015-01-27 | 2018-02-01 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルワクチンパッチ用ミョウバン含有コーティング製剤 |
| CA2974324A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
| CN112386787B (zh) | 2015-02-16 | 2023-09-08 | 凸版印刷株式会社 | 微针 |
| KR102634489B1 (ko) | 2015-03-10 | 2024-02-07 | 리제너론 파아마슈티컬스, 인크. | 무균 관통 시스템 및 방법 |
| WO2016145373A1 (en) | 2015-03-12 | 2016-09-15 | Chrono Therapeutics Inc. | Craving input and support system |
| AU2016235138B2 (en) * | 2015-03-26 | 2018-07-26 | Enable Injections, Inc | Pressurized gas powered medicament transfer and re-suspension apparatus and method |
| WO2016168081A1 (en) * | 2015-04-13 | 2016-10-20 | Mayo Foundation For Medical Education And Research | Magnetic wound closure systems |
| EP3288383A4 (en) | 2015-04-29 | 2019-01-23 | Radius Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| EP4252798A3 (en) | 2015-06-04 | 2023-10-25 | Medimop Medical Projects Ltd. | Cartridge insertion for drug delivery device |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
| CN112972833B (zh) | 2015-10-09 | 2024-01-09 | 西医药服务以色列分公司 | 注射器针帽脱离器 |
| WO2017113011A1 (en) * | 2015-12-29 | 2017-07-06 | Gajanan Kulkarni | Transdermal microneedle drug delivery device and method |
| JP6542481B2 (ja) | 2016-01-21 | 2019-07-10 | ウェスト ファーマ サービシーズ イスラエル リミテッド | システム |
| JP6885960B2 (ja) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 視覚的インジケータを有する薬剤デリバリデバイス |
| CN109219456B (zh) * | 2016-01-21 | 2020-05-15 | 西医药服务以色列有限公司 | 自动注射器中的力牵制 |
| US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
| GB2552193A (en) * | 2016-07-13 | 2018-01-17 | Ndm Technologies Ltd | Improvements in or relating to transdermal delivery |
| CN109562229B (zh) | 2016-08-01 | 2021-07-13 | 西医药服务以色列有限公司 | 抗旋转药筒销 |
| EP3490635B1 (en) | 2016-08-01 | 2021-11-17 | West Pharma. Services Il, Ltd. | Partial door closure prevention spring |
| MX2019001580A (es) | 2016-08-08 | 2019-06-20 | Unl Holdings Llc | Dispositivo y metodo para conectar un canal de flujo de fluidos y dispositivos de administracion de farmacos que incorporan dichos dispositivos. |
| CN106362250B (zh) * | 2016-09-18 | 2021-03-05 | 电子科技大学 | 微型阵列注射器 |
| WO2018060024A1 (en) | 2016-09-27 | 2018-04-05 | Sanofi-Aventis Deutschland Gmbh | A medicament delivery device |
| EP3315156A1 (en) * | 2016-11-01 | 2018-05-02 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
| CA3045477A1 (en) * | 2016-12-05 | 2018-06-14 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| USD819197S1 (en) | 2016-12-16 | 2018-05-29 | Kimberly-Clark Worldwide, Inc. | Fluid delivery apparatus |
| KR20190088077A (ko) | 2016-12-16 | 2019-07-25 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 편두통 또는 군발두통을 치료하기에 적합한 투약 방법 |
| USD836774S1 (en) | 2016-12-16 | 2018-12-25 | Sorrento Therapeutics, Inc. | Cartridge for a fluid delivery apparatus |
| CN110300612B (zh) | 2016-12-16 | 2022-04-22 | 索伦托治疗有限公司 | 具有控制器组件的流体递送装置及其使用方法 |
| AU2017378040B2 (en) | 2016-12-16 | 2023-06-08 | Vivasor, Inc. | Application device for a fluid delivery apparatus and method of use |
| EP3338832A1 (en) * | 2016-12-23 | 2018-06-27 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device |
| ES2981967T3 (es) | 2017-01-05 | 2024-10-14 | Radius Pharmaceuticals Inc | Formas polimórficas de RAD1901-2HCl |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| JP6931217B2 (ja) * | 2017-03-28 | 2021-09-01 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ |
| ES2919934T3 (es) | 2017-05-05 | 2022-07-29 | Regeneron Pharma | Autoinyector y procedimientos de uso relacionados |
| JP6921997B2 (ja) | 2017-05-30 | 2021-08-18 | ウェスト ファーマ サービシーズ イスラエル リミテッド | ウェアラブル注射器のモジュラ駆動トレイン |
| EP3664864B1 (en) * | 2017-08-10 | 2022-06-29 | West Pharma. Services Il, Ltd. | Injector with delayed cartridge piercing mechanism |
| AU2018352317B2 (en) | 2017-10-17 | 2021-04-01 | Kindeva Drug Delivery L.P. | Applicator for applying a microneedle array to skin |
| DE102017223505A1 (de) * | 2017-12-21 | 2019-06-27 | Vetter Pharma-Fertigung GmbH & Co. KG | Behälter für medizinische Flüssigkeiten und Verfahren zum Befüllen eines solchen Behälters |
| WO2019126421A1 (en) | 2017-12-22 | 2019-06-27 | West Pharma. Services Il., Ltd. | Injector usable with different dimension cartridges |
| US11058605B2 (en) | 2018-03-08 | 2021-07-13 | Flex Ltd. | Sterilization fluid path with barrier removal |
| US20210196892A1 (en) * | 2018-04-11 | 2021-07-01 | Sanofi | Drug Delivery Device |
| WO2019197360A1 (en) * | 2018-04-11 | 2019-10-17 | Sanofi | Drug delivery device |
| US11690799B2 (en) | 2018-04-19 | 2023-07-04 | Lts Lohmann Therapie-Systeme Ag | Microneedle system for applying interferon |
| JP2021526431A (ja) | 2018-05-16 | 2021-10-07 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | マイクロニードルバイオセンサ |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| JP7473486B2 (ja) | 2018-07-04 | 2024-04-23 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形形態 |
| CN109568711B (zh) * | 2018-11-01 | 2021-01-01 | 江苏爱朋医疗科技股份有限公司 | 输液管的自锁装置 |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| EP3908348B1 (en) * | 2019-01-07 | 2025-06-04 | SHL Medical AG | Medicament delivery device |
| DE102019200557A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
| WO2020219388A1 (en) * | 2019-04-20 | 2020-10-29 | Biolark. Inc. | An infusion set with full insertion and removal action |
| WO2020219393A2 (en) * | 2019-04-20 | 2020-10-29 | Biolark, Inc. | An infusion set having reduced patient pain |
| CN115835856A (zh) | 2020-05-13 | 2023-03-21 | 麻省理工学院 | 聚合物微装置的组合物以及其在癌症免疫疗法中的用途 |
| CA3182778A1 (en) * | 2020-06-17 | 2021-12-23 | Biolinq, Inc. | Devices and methods for application of microneedle arrays |
| CN116367770A (zh) * | 2020-08-03 | 2023-06-30 | 曲莱博医疗有限公司 | 微创监测贴片 |
| CN116547026A (zh) * | 2020-11-19 | 2023-08-04 | 贝克顿·迪金森公司 | 具有容器保持件的药物输送装置 |
| USD920500S1 (en) * | 2020-12-14 | 2021-05-25 | Xianlin He | Microneedle instrument |
| US11389632B2 (en) | 2020-12-21 | 2022-07-19 | Mediccene Inc. | Intradermal drug delivery device |
| JP7734362B2 (ja) * | 2021-01-16 | 2025-09-05 | シンクランド株式会社 | アプリケータ及びアプリケータ用カートリッジ |
| IL322176A (en) | 2021-03-01 | 2025-09-01 | Deka Products Lp | Medical material dispensing device, system and method |
| US12161832B2 (en) | 2021-03-01 | 2024-12-10 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| US12357804B2 (en) | 2021-03-01 | 2025-07-15 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| EP4301225B1 (en) | 2021-09-28 | 2025-08-27 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
| USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
| USD1033641S1 (en) | 2021-12-17 | 2024-07-02 | Biolinq Incorporated | Microneedle array sensor applicator device |
| USD1057153S1 (en) | 2022-04-29 | 2025-01-07 | Biolinq Incorporated | Microneedle array sensor applicator device |
| CN119998004A (zh) * | 2022-06-27 | 2025-05-13 | 营养医学科技有限公司 | 延伸穿戴微针装置 |
| AU2023371939A1 (en) | 2022-11-05 | 2025-05-22 | Kindeva Drug Delivery L.P. | Microneedle array applicator and system |
| WO2024129424A1 (en) | 2022-12-16 | 2024-06-20 | Kindeva Drug Delivery L.P. | Drug delivery device |
| WO2024145424A1 (en) * | 2022-12-28 | 2024-07-04 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| WO2025164446A1 (ja) * | 2024-01-29 | 2025-08-07 | 久光製薬株式会社 | アプリケータ |
| WO2025164447A1 (ja) * | 2024-01-29 | 2025-08-07 | 久光製薬株式会社 | アプリケータ |
| JP7738215B1 (ja) * | 2024-01-29 | 2025-09-11 | 久光製薬株式会社 | アプリケータ |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671430A (zh) * | 2002-07-22 | 2005-09-21 | 贝克顿·迪金森公司 | 贴片状注射装置 |
| CN1723053A (zh) * | 2002-09-12 | 2006-01-18 | 儿童医院医疗中心 | 无痛药物注射的方法和设备 |
| CN101208130A (zh) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | 微针阵列施放器装置 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2814987C2 (de) * | 1978-04-07 | 1980-02-14 | Erwin Noll | Tätowierzange zum Kennzeichnen der Ohren von Tieren |
| US4755173A (en) | 1986-02-25 | 1988-07-05 | Pacesetter Infusion, Ltd. | Soft cannula subcutaneous injection set |
| US5176662A (en) | 1990-08-23 | 1993-01-05 | Minimed Technologies, Ltd. | Subcutaneous injection set with improved cannula mounting arrangement |
| US5257980A (en) | 1993-04-05 | 1993-11-02 | Minimed Technologies, Ltd. | Subcutaneous injection set with crimp-free soft cannula |
| CA2132277C (en) * | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
| EP1341442B1 (en) | 2000-10-13 | 2005-06-29 | Alza Corporation | Microblade array impact applicator |
| RU2275871C2 (ru) | 2000-10-13 | 2006-05-10 | Алза Корпорейшн | Устройство и способ для прокалывания кожи микровыступами |
| JP4383168B2 (ja) | 2001-09-12 | 2009-12-16 | ベクトン・ディキンソン・アンド・カンパニー | マイクロ針投与デバイスおよび薬物投与デバイス |
| US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| US7097634B2 (en) | 2002-07-31 | 2006-08-29 | Alza Corporation | Injection device providing automatic needle retraction |
| EP1539279B1 (en) * | 2002-08-29 | 2006-06-28 | Novo Nordisk A/S | Frontloaded injection device |
| US6896666B2 (en) | 2002-11-08 | 2005-05-24 | Kochamba Family Trust | Cutaneous injection delivery under suction |
| US7252651B2 (en) * | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
| CA2820537C (en) | 2003-04-23 | 2015-10-20 | Valeritas, Inc. | Hydraulically actuated pump for fluid administration |
| US6926694B2 (en) | 2003-05-09 | 2005-08-09 | Medsolve Technologies, Llc | Apparatus and method for delivery of therapeutic and/or diagnostic agents |
| BRPI0413538B8 (pt) * | 2003-08-12 | 2021-06-22 | Becton Dickison And Company | dispositivo para fornecer um medicamento para o corpo de um paciente por injeção |
| WO2005044333A2 (en) | 2003-10-31 | 2005-05-19 | Alza Corporation | Self-actuating applicator for microprojection array |
| US7753879B2 (en) | 2004-01-29 | 2010-07-13 | M2 Group Holdings, Inc. | Disposable medicine dispensing device |
| WO2005123173A1 (en) | 2004-06-10 | 2005-12-29 | 3M Innovative Properties Company | Patch application device and kit |
| WO2007002523A2 (en) * | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
| JP4963849B2 (ja) | 2006-03-13 | 2012-06-27 | シスメックス株式会社 | 微細孔形成システム |
| JP2008154849A (ja) * | 2006-12-25 | 2008-07-10 | Ritsumeikan | 注入装置 |
| WO2008133702A1 (en) * | 2007-04-30 | 2008-11-06 | Medtronic Minimed, Inc. | Needle inserting and fluid flow connection for infusion medium delivery system |
| CN105999538A (zh) | 2008-11-18 | 2016-10-12 | 3M创新有限公司 | 空心微针阵列和方法 |
| US8668675B2 (en) | 2010-11-03 | 2014-03-11 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
| US10800040B1 (en) | 2017-12-14 | 2020-10-13 | Amazon Technologies, Inc. | Simulation-real world feedback loop for learning robotic control policies |
-
2010
- 2010-07-27 US US13/386,937 patent/US10010706B2/en active Active
- 2010-07-27 CN CN201080040166.6A patent/CN102497909B/zh not_active Expired - Fee Related
- 2010-07-27 AU AU2010276511A patent/AU2010276511B2/en not_active Ceased
- 2010-07-27 WO PCT/US2010/043414 patent/WO2011014514A1/en not_active Ceased
- 2010-07-27 JP JP2012522974A patent/JP5702384B2/ja not_active Expired - Fee Related
- 2010-07-27 BR BR112012001685A patent/BR112012001685B8/pt not_active IP Right Cessation
- 2010-07-27 EP EP17206068.3A patent/EP3354312A1/en not_active Withdrawn
- 2010-07-27 KR KR1020127004830A patent/KR101712226B1/ko not_active Expired - Fee Related
- 2010-07-27 CA CA2769102A patent/CA2769102C/en not_active Expired - Fee Related
- 2010-07-27 EP EP10739791.1A patent/EP2459267B1/en not_active Not-in-force
- 2010-07-27 ES ES10739791.1T patent/ES2661063T3/es active Active
- 2010-07-27 RU RU2012102688/14A patent/RU2508135C2/ru active
-
2018
- 2018-07-02 US US16/025,141 patent/US11103685B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671430A (zh) * | 2002-07-22 | 2005-09-21 | 贝克顿·迪金森公司 | 贴片状注射装置 |
| CN1723053A (zh) * | 2002-09-12 | 2006-01-18 | 儿童医院医疗中心 | 无痛药物注射的方法和设备 |
| CN101208130A (zh) * | 2005-06-27 | 2008-06-25 | 3M创新有限公司 | 微针阵列施放器装置 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107913460A (zh) * | 2016-10-10 | 2018-04-17 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送系统 |
| CN107913459A (zh) * | 2016-10-10 | 2018-04-17 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送装置 |
| CN107913460B (zh) * | 2016-10-10 | 2021-06-22 | 苏州纳通生物纳米技术有限公司 | 一种液体定量输送系统 |
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| US20120123387A1 (en) | 2012-05-17 |
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| BR112012001685B8 (pt) | 2021-06-22 |
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| WO2011014514A8 (en) | 2011-09-15 |
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