CN102488763B - Composition with functions of treating dysmenorrhoea and beautifying - Google Patents
Composition with functions of treating dysmenorrhoea and beautifying Download PDFInfo
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- CN102488763B CN102488763B CN201110446099.4A CN201110446099A CN102488763B CN 102488763 B CN102488763 B CN 102488763B CN 201110446099 A CN201110446099 A CN 201110446099A CN 102488763 B CN102488763 B CN 102488763B
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Abstract
The invention provides a composition with functions of treating dysmenorrhoea and beautifying. The composition contains Chinese angelica, pseudo-ginseng, safflower and rose. The composition has a function of treating dysmenorrhoea as well as a beautifying function of treating chloasma, senile plaque expelling and skin wrinkles. The composition is a medicine with a plurality of effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, particularly relate to a kind of Chinese medicine composition with treatment dysmenorrhea effect and beautification function, belong to medical technical field.
Background technology
As common gynecological disease, dysmenorrhea affects women's orthobiosis, study and work to some extent, therefore the control of dysmenorrhea is paid close attention to for everybody always.The whole world approximately has 50% women to be perplexed by dysmenorrhea per month, and wherein over 50%, belongs to and can not find reason, the primary dysmenorrhea that also can't thoroughly effect a radical cure.In the U.S., dysmenorrhea is the main factor that causes that the schoolgirl is absent from school.Dysmenorrhea causes woman worker's absence rate between 5%-10%, and about 10% primary dysmenorrhea patient can seriously have within 1-3 days, can't work to every month.And at home, national sampling survey in 1980 finds that the prevalence of dysmenorrhea is 33.19%, wherein primary dysmenorrhea accounts for 53.2%, but in recent years, China's dysmenorrhea sickness rate is held ascendant trend.Carry out questionnaire survey to 7 ethnic universities in the whole nation from 15640 female student enrollment of 56 nationalitys in June, 2006, dysmenorrhea 10091 people are wherein arranged, the dysmenorrhea incidence rate is 65.6%, the ratio obtained far above national woman in menstrual period physical constants cooperative groups inquiry agency, more approaching with 68.2% and the Zhengzhou area 69.7% of in recent years reporting the area, Xi'an, the dysmenorrhea situation that the women is described is day by day serious, has become and has affected one of women's normal operation and common cause of quality of life.
Treatment for dysmenorrhea, doctor trained in Western medicine adopts spasmolytic, calmness and analgesics more, and oral contraceptive, prostate synthetase inhibitors, calcium ion channel blocker, the treatments such as adrenoceptor agonists, but effect is all not ideal, and side effect is comparatively obvious, the prolonged application said medicine can cause the system of defense miopragia of gastrointestinal mucosa, bring out stomach or duodenal ulcer and hemorrhage, more can cause the nervous function disorder, memory reduces, insomnia, also can cause the menstruation interruption, postpone menstrual period, or reduce the adverse consequences such as even amenorrhea through amount.
Theory of Chinese medical science thinks that primary dysmenorrhea pathogenesis complexity is various, and the factor body is weak, kidney qi owes to contain, or uterine hypoplasia, cause that menses are got rid of difficulty and stomachache or sense are coldly drenched with rain, greedy cool drink is cold, or occupy for a long time wetland, cold-damp is hindered in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the visitor causes the cold coagulation menses in uterus, and blood is lost smooth, stagnation of QI and blood may bring about pain.Its main pathogenesis is cold and stagnate, and the visitor appoints in punching, and the operation of uterus menses is not smooth, therefore that stagnation of QI and blood may bring about pain or uterus lose in moistening is foster, and Rong Ze pain.Its pattern of syndrome have deficiency and excess minute, real person has that stagnation of QI blood is tired, cold and stagnate, empty person is that yang deficiency endogenous cold, deficient qi and blood, Liver and kidney are deficient etc., current clinical primary dysmenorrhea is the most common with the QI stagnated by cold blood stasis type.Chinese medicine has extraordinary effect for dysmenorrhea treatment, and efficacy consolidation, toxic and side effects are little, and unique advantage is arranged.
The Chinese patent medicine product commonly used for the treatment of dysmenorrhea has at present: YUANHU ZHITONG PIAN, FUKE QIANJIN PIAN, Tongjing oral liquid, the flat soft gelatin capsule of Radix Angelicae Sinensis dysmenorrhea, TONGJINGBAO KELI etc.Although above-mentioned preparation has certain curative effect on the treatment dysmenorrhea, is mainly relief of symptoms, can not effect a radical cure, and need to often take medicine.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition with treatment dysmenorrhea effect and beautification function.
For the foregoing invention purpose, the invention provides following technical scheme:
Compositions with treatment dysmenorrhea effect and beautification function of the present invention is characterized in that a kind of the making in following prescription:
Prescription one: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10;
Prescription two: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10;
Prescription three: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10, Flos Rosae Chinensis 1～10;
Prescription four: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10, Herba Leonuri 1～10;
Prescription five: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10, Herba Leonuri 1～10;
Prescription six: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10, Herba Leonuri 1～10, Cortex Cinnamomi 1～10;
Prescription seven: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10, Herba Leonuri 1～10, Cortex Cinnamomi 1～10;
Prescription eight: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10, Herba Leonuri 1～10, Cortex Cinnamomi 1～10, Rhizoma Corydalis 1～10;
Prescription nine: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10, Herba Leonuri 1～10, Cortex Cinnamomi 1～10, Rhizoma Corydalis 1～10;
Compositions of the present invention is preferably made by the medical material of following weight portion:
Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Rugosae 1～10 or Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10.
Compositions of the present invention is more preferably made by the medical material of following weight portion:
Radix Angelicae Sinensis 2～5, Radix Notoginseng 2～5, Flos Carthami 2～5, Flos Rosae Rugosae 2～5 or Radix Angelicae Sinensis 2～5, Radix Notoginseng 2～5, Flos Carthami 2～5, Flos Rosae Chinensis 2～5.
The preparation method of compositions of the present invention comprises: after pulverizing medicinal materials or extraction, add pharmaceutic adjuvant to be prepared into granule, powder, tablet, capsule, pill, oral liquid, drop pill, external preparation.
The preparation method of compositions of the present invention more preferably comprises: after medicinal material extract, add pharmaceutic adjuvant to be prepared into granule.
Compositions of the present invention, its purposes is the medicine of preparation treatment dysmenorrhea, chloasma, senile plaque, wrinkle of skin.
Beneficial effect of the present invention is mainly:
Combination treatment dysmenorrhea of the present invention has the effect of highly significant, and not only relief of symptoms is rapid, and can effect a radical cure, and does not need often to take medicine.Clinical treatment primary dysmenorrhea case 635 examples, cure 513 examples, produce effects 109 examples, effective 13 examples.Combination treatment chloasma of the present invention, senile plaque, wrinkle of skin produce effects are rapid, without any untoward reaction.In the time of compositions flower treatment dysmenorrhea of the present invention, can also improve looks, a medicine multiple-effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but should notice that scope of the present invention is not subject to any restriction of these examples.
Embodiment 1
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Above-mentioned medical material is added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, obtain.
Embodiment 2
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Chinensis 15g
Above-mentioned medical material is added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, obtain.
Embodiment 3
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 2g, Flos Rosae Chinensis 10g, Herba Leonuri 10g, Cortex Cinnamomi 6g, Rhizoma Corydalis 6g
Above-mentioned medical material is added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, obtain.
Embodiment 4
Radix Angelicae Sinensis 6g, Radix Notoginseng 6g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Flos Carthami, Flos Rosae Rugosae are added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, add the Radix Notoginseng that is ground into fine powder, obtain.
Embodiment 5
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Flos Carthami, Flos Rosae Rugosae are added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, concentrated, add the Radix Notoginseng and the dextrin that are ground into fine powder, dry, pulverize into fine powder, granulate, incapsulate, obtain capsule.
Embodiment 6
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Radix Notoginseng, Flos Carthami, Flos Rosae Rugosae are added to 10 times of amount soak with ethanol of 50% 0.5 hour, reflux, extract, 2 times, each 1 hour, merge extracting solution 2 times, reclaim ethanol, concentrated, add starch, dry, pulverize into fine powder, granulate, mix homogeneously with Pulvis Talci and magnesium stearate, tabletting, obtain tablet.
Embodiment 7
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Radix Notoginseng, Flos Carthami, Flos Rosae Rugosae are added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, concentrated, add dextrin, granulate, drying, packing, obtain granule.
Embodiment 8
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Above-mentioned pulverizing medicinal materials is become to fine powder, and packing, obtain powder.
Embodiment 9
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Radix Notoginseng, Flos Carthami, Flos Rosae Rugosae are added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, concentrated, with the Macrogol 4000 melted, to mix homogeneously, dripping becomes drop pill, obtains drop pill.
Embodiment 10
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Above-mentioned pulverizing medicinal materials is become to fine powder, be rolled onto the watered pill; Or add Mel, make honeyed pill.
Embodiment 10
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Radix Angelicae Sinensis, Flos Carthami, Flos Rosae Rugosae are added to 10 times of water gagings and soak 0.5 hour, decoct 2 times, each 1 hour, merge decocting liquid 2 times, add the Radix Notoginseng that is ground into fine powder, mix homogeneously, twist into concentrated pill.
Embodiment 11
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g
Above-mentioned medical material is added to 10 times of water gagings and soak 0.5 hour, decoct each 1 hour 2 times, merge 2 times decocting liquid, concentrated, add ethanol to ethanol content and reach 60%, precipitate with ethanol 48 hours, get supernatant and reclaim ethanol, add suitable quantity of water, activated carbon decolorizing, filter, divide and be filled in oral liquid bottle, sterilizing, obtain oral liquid.
Embodiment 12
Differentiation of symptoms and signs for classification of syndrome standard and the diagnostic criteria of doctor trained in Western medicine dysmenorrhea with reference to five editions teaching materials of New Century higher institutions of Chinese medicine planning teaching material " Gynecology of Chinese Medicine " about dysmenorrhea, treatment case 87 examples:
(1) patient age distributes
Table 1 age distribution table
(2) dysmenorrhea degree
With reference to " practical gynecology " standards of grading, formulate: menstrual period and front and back lower abdomen pain thereof 5 minutes (basis minute); Stomachache 1 minute unbearably; Suffer from abdominal pain obvious 0.5 minute; Feel restless 1 minute; Suffer a shock 2 minutes; Pale complexion 0.5 minute; Dripping cold sweat 1 minute; Extreme cold of the limbs 1 minute; Need lie up 1 minute; Affect work and study 1 minute; Do not alleviate 1 minute with general pain relieving measure; By general pain relieving measure pain, postpone 0.5 minute; Companion's waist is ached 0.5 minute; Companion's nausea and vomiting 0.5 minute; Companion's rectal tenesmus 0.5 minute; Pain at one day with interior 0.5 minute: every increase of pain phase 1 day 0.5 minute.
(3) dysmenorrhea weight grade scale
Slightly: integration is that 5-7.9 divides
Moderate: integration is that 8-12.9 divides
Severe: integration is that 13-15 divides
(4) Therapeutic Method
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g, add 20 times of water gagings by above-mentioned medical material and soak 0.5 hour, decoct 2 times, and each 1 hour, merge decocting liquid 2 times, day take 2～3 times, every day, potion, each premenstrually serve on 5 days, serve on 2-3 cycle.
(5) efficacy determination
" People's Republic of China's Chinese medicine industry standard one TCM Gynecology disease criterion of therapeutical effect " relevant criterion with reference to State Administration of Traditional Chinese Medicine's issue in 1994.Cure: the rear stomachache of taking medicine and other transference cure, 3 menstrual cycle of drug withdrawal do not recur, and pain degree recovers " 0 " minute person.Produce effects: take medicine and obviously alleviate, all the other transference cures or alleviate, refuse to obey that analgesic can adhere to work, pain degree for the treatment integration be down to before the treatment integration below 1/2.Effectively: suffer from abdominal pain and alleviate, all the other symptoms take a turn for the better, and take analgesic and can adhere to work, and pain degree is reduced to front below 1/3 of integration for the treatment of for the treatment integration.Invalid: stomachache and other symptom are without the changer.
(6) observed result
In the case of all observations, 3 menstrual cycle of mean treatment heal, and follow up a case by regular visits to and within 3-6 month, have no recurrence.After the patient generally takes 5 doses before menstrual cycle, pain can alleviate, and taking continuously 2-3 cycle pain can disappear fully or alleviate.If notice that menstrual period and menstruation front and back are warming, generally do not recur.By statistics, this is organized 87 examples and cures altogether 82 examples, produce effects 5 examples.Before and after the check treatment, remarkable statistical significance is arranged.During treatment, all patients have no the obvious adverse reaction report, show that we's treatment dysmenorrhea is safe and effective.
Integral distribution before and after table 2 dysmenorrhea treatment
Embodiment 13
Differentiation of symptoms and signs for classification of syndrome standard and the diagnostic criteria of doctor trained in Western medicine dysmenorrhea with reference to five editions teaching materials of New Century higher institutions of Chinese medicine planning teaching material " Gynecology of Chinese Medicine " about dysmenorrhea, treatment case 76 examples:
(1) patient age distributes
Table 3 age distribution table
(2) dysmenorrhea degree
With reference to " practical gynecology " standards of grading, formulate: menstrual period and front and back lower abdomen pain thereof 5 minutes (basis minute); Stomachache 1 minute unbearably; Suffer from abdominal pain obvious 0.5 minute; Feel restless 1 minute; Suffer a shock 2 minutes; Pale complexion 0.5 minute; Dripping cold sweat 1 minute; Extreme cold of the limbs 1 minute; Need lie up 1 minute; Affect work and study 1 minute; Do not alleviate 1 minute with general pain relieving measure; By general pain relieving measure pain, postpone 0.5 minute; Companion's waist is ached 0.5 minute; Companion's nausea and vomiting 0.5 minute; Companion's rectal tenesmus 0.5 minute; Pain at one day with interior 0.5 minute: every increase of pain phase 1 day 0.5 minute.
(3) dysmenorrhea weight grade scale
Longitude: integration is that 5-7.9 divides
Moderate: integration is that 8-12.9 divides
Severe: integration is that 13-15 divides
(4) Therapeutic Method
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Chinensis 10g, Herba Leonuri 10g, Cortex Cinnamomi 6g, Rhizoma Corydalis 6g, add 10 times of water gagings by above-mentioned medical material and soak 0.5 hour, decocts 2 times, each 1 hour, merge decocting liquid 2 times, day takes 2～3 times, every day, potion, each premenstrually serve on 3 days, serve on 2-3 cycle.
(5) efficacy determination
" People's Republic of China's Chinese medicine industry standard one TCM Gynecology disease criterion of therapeutical effect " relevant criterion with reference to State Administration of Traditional Chinese Medicine's issue in 1994.Cure: the rear stomachache of taking medicine and other transference cure, 3 menstrual cycle of drug withdrawal do not recur, and pain degree recovers " 0 " minute person.Produce effects: take medicine and obviously alleviate, all the other transference cures or alleviate, refuse to obey that analgesic can adhere to work, pain degree for the treatment integration be down to before the treatment integration below 1/2.Effectively: suffer from abdominal pain and alleviate, all the other symptoms take a turn for the better, and take analgesic and can adhere to work, and pain degree is reduced to front below 1/3 of integration for the treatment of for the treatment integration.Invalid: stomachache and other symptom are without the changer.
(6) observed result
In the case of all observations, 3 menstrual cycle of mean treatment heal, and follow up a case by regular visits to and within 3-6 month, have no recurrence.After the patient generally takes 3 doses before menstrual cycle, pain can alleviate, and taking continuously 2-3 cycle pain can disappear fully or alleviate.If notice that menstrual period and menstruation front and back are warming, generally do not recur.By statistics, this is organized 76 examples and cures altogether 73 examples, produce effects 3 examples.Before and after the check treatment, remarkable statistical significance is arranged.During treatment, all patients have no the obvious adverse reaction report, show that we's treatment dysmenorrhea is safe and effective.
Integral distribution before and after table 4 dysmenorrhea treatment
Embodiment 14
The present invention treats the effect observation of chloasma and senile plaque
(1) clinical case
Age 25 is to the women of 60 years old, chloasma case 123 examples, senile plaque case 61 examples.
(2) Therapeutic Method
Radix Angelicae Sinensis 6g, Radix Notoginseng 3g, Flos Carthami 6g, Flos Rosae Rugosae 10g, add 20 times of water gagings by above-mentioned medical material and soak 0.5 hour, decoct 2 times, and each 1 hour, merge decocting liquid 2 times, day takes 1 time, and every day, potion, serve on 3040 days.
(3) observed result
By statistics, all significantly desalinations of skin splash after the 123 example treatments of chloasma case.All significantly desalinations of skin splash after the 61 example treatments of senile plaque case.During treatment, all patients have no the obvious adverse reaction report, show that we's treatment chloasma and senile plaque are safe and effective.
Embodiment 15
The observation of speckle dispelling of the present invention and crease-resistant effect
(1) test friendly method
This experiment adopts controllable double-blind method, 24 weeks by a definite date, the skin expert is divided into two groups according to the feature of pigmented spots by the tester, chloasma group and senile plaque group, every group through random assortment, be divided into again experimental group and matched group and carry out Comparison of therapeutic, experimental group is taken the granule of the present invention according to embodiment 7 preparations, and matched group is taken fruit juice.The tester requires to avoid Exposure to Sunlight, before experiment and subsequent different times carry out clinical observation, digital picture and selftest.And do the detection of the aspects such as blood, urine before and after experiment, to observe the safety of oral liquid of the present invention.
(2) observed result
Granule of the present invention is after taking 8 weeks, and chloasma group and senile plaque group mottle are all desalinated and alleviated, and skin exquisiteness, gloss, ruddy, have remarkable result, and through the clinical verification of 6 months, curative effect was lasting.Before and after the treatment of fruit juice group, mottle is not seen significant change.The digital picture demonstration, after taking granule of the present invention, area of chloasma dwindles, and the pigmentation degree alleviates, skin smooth, ruddy; Senile plaque be improved significantly, decreased number, color alleviates, skin is taken front fine and smooth gloss, high resilience; Whole skin be improved significantly, more pale, be rich in gloss, have obvious whitening effect: wrinkle of skin obviously reduces, degree of depth wrinkle shoals, tiny wrinkle disappears.During treatment, all patients have no the obvious adverse reaction report, and blood and urine detection are all in normal range.
Claims (3)
1. the compositions with the effect for the treatment of dysmenorrhea, is characterized in that it is made by following prescription: Radix Angelicae Sinensis 1～10, Radix Notoginseng 1～10, Flos Carthami 1～10, Flos Rosae Chinensis 1～10, Herba Leonuri 1～10, Cortex Cinnamomi 1～10, Rhizoma Corydalis 1～10.
2. the preparation method of the described compositions of claim 1, comprising: after pulverizing medicinal materials or extraction, add pharmaceutic adjuvant to be prepared into granule, powder, tablet, capsule, pill, oral liquid, drop pill.
3. the application of compositions claimed in claim 1 in preparation treatment dysmenorrhea medicine.
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| CN110801478A (en) * | 2019-12-18 | 2020-02-18 | 河南中医药大学 | Radix angelicae sinensis flower essential oil for treating dark eye circles |
| CN112022988B (en) * | 2020-09-04 | 2022-04-19 | 赵瑞华 | Traditional Chinese medicine composition with effect of preventing and/or treating dysmenorrhea and preparation method and application thereof |
| CN112336794A (en) * | 2020-12-02 | 2021-02-09 | 曾凡伟 | A Chinese medicinal composition for treating gynecological diseases and caring skin |
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