CN105796713B - A kind of lenitive rose Chinese medicine composition and its preparation method and application - Google Patents
A kind of lenitive rose Chinese medicine composition and its preparation method and application Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to biomedicine field, and in particular to a kind of lenitive rose Chinese medicine composition and its preparation method and application.Rose Chinese medicine composition of the present invention contains rose, motherwort, safflower, Chinese cassia tree, evodia rutaecarpa, Radix Angelicae Sinensis and the root bark of tree peony.The present invention mixes rose wate decocting liquid with kinds of traditional Chinese medicines extract solution, starts with from promoting blood circulation, clearing and activating the channels and collaterals, conditioning analgesic, energy rapid recovery menstrual pain, mitigates patient suffering.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of lenitive rose Chinese medicine composition and its preparation side
Method and application.
Background technology
Dysmenorrhoea is one of most common gynaecology's symptom, refers to women and carrys out the lower abdomen pain through the appearance of forward and backward and its intermenstrual period
Bitterly, qualities of life are influenceed with the soreness of waist or other discomforts, serious symptom, the incidence of disease can be 35% or so in clinical statisticses.It is clinical
Symptom is：Underbelly or flank pain, there is pendant to keenly feel, with the soreness of waist, or even pain and waist sacrum；Severe patient can be cold with Nausea and vomiting
Dropping sweat, cold limbs, or even faint；Recurred with menstruation week.Dysmenorrhoea can bring many harm to women, such as：Pachylosis
It is nigrescence, long acne, poor appetite, stress, emotional instability, irritable, blahs aypnia, difficulty in walking, in poor health,
Fertility and heredity can be also influenceed simultaneously, so, timely treat or alleviation dysmenorrhoea is extremely important.Dysmenorrhoea is generally divided into two classes, and one
Kind is primary dysmenorrhea, refers to the stomachache occurred at the very start from menstruation, reproductive organs is without obvious lesion, mostly functional pain
Through accounting for dysmenorrhoea more than 90%；Another kind is acquired dysmenorrhea, the bellyache in menstrual period that the several years that refers to pass through just occurs, more secondary to basin
The lesions such as chamber inflammation, cervical stenosis.
For dysmenorrhoea the lighter, use hot compress or food therapy mostly, by expand blood vessel, it is clearing and activating the channels and collaterals, make smooth muscle relaxation
To relieve pain；For dysmenorrhoea compared with severe one, then generally require symptomatic treatment, based on analgesic, calmness, as aspirin, naproxen tablet,
Profit pain, prostaglandin inhibitor (brufen/Ketoprofen/Meclofenamic Acid etc.) are dissipated, reduces point of the inflammatory mediators such as prostaglandin
Secrete, it is desirable to the orally available contraceptive relief of symptoms of dysmenorrhoea women of birth control.But the Western medicine of these treatment dysmenorrhoeas, there is obvious secondary work
With.Chinese medicine class is then often using ginger brown sugar water, rose tea, ginger jujube tea, Radix Angelicae Sinensis tea etc..And above Chinese medicine class therapeutic effect
It is not notable.Therefore, it is always the problem of this area is to be solved to seek a kind of effective alleviation or medicine.
To solve the above problems, the present invention now provide a kind of lenitive rose Chinese medicine composition and preparation method thereof and
Using.The present invention mixes rose wate decocting liquid with kinds of traditional Chinese medicines extract solution, starts with from promoting blood circulation, clearing and activating the channels and collaterals, conditioning analgesic, energy
Rapid recovery menstrual pain, mitigate patient suffering.
The content of the invention
It is an object of the invention to provide a kind of lenitive rose Chinese medicine composition, the Chinese medicine composition energy rapid recovery
Menstrual pain, mitigate patient suffering.
It is a further object to provide the preparation method of above-mentioned rose Chinese medicine composition.
It is a further object to provide the application of above-mentioned rose Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of lenitive rose Chinese medicine composition, the rose Chinese medicine composition contain rose, and motherwort is red
Flower, Chinese cassia tree, evodia rutaecarpa, Radix Angelicae Sinensis, the root bark of tree peony.
A kind of lenitive rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than component：
15-20 part roses, 25-35 part motherworts, 8-10 part safflowers, 8-10 part Chinese cassia trees, 12-15 part evodia rutaecarpas, 9-12 part Radix Angelicae Sinensis,
15-20 part root barks of tree peony.
A kind of lenitive rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than component：
15 portions of roses, 25 portions of motherworts, 8 parts of safflowers, 8 portions of Chinese cassia trees, 12 portions of evodia rutaecarpas, 9 parts of Radix Angelicae Sinensis, 15 parts of root barks of tree peony.
The preparation method of above-mentioned lenitive rose Chinese medicine composition is as follows：Take rose, motherwort, safflower, Chinese cassia tree,
Evodia rutaecarpa, Radix Angelicae Sinensis and the root bark of tree peony, are proportionally mixed, and add distilled water 3L, 80 DEG C are decocted bubble half an hour, and concentration is after mixing in triplicate
.
The rose Chinese medicine composition can be applied in medicine for relieving pain is prepared.Wherein, the pain is by menstruation
It is caused.
Above-mentioned rose Chinese medicine composition as effective component pharmaceutical dosage form for tablet, capsule, powder, soft capsule,
Dripping pill, honeyed bolus, pill, granule, paste, sustained release preparation, quick releasing formulation, controlled release preparation, oral liquid, freeze-dried powder
Agent, ejection preparation.
The rose Chinese medicine composition is such as prepared into pharmaceutical preparation, in use, oral rose Chinese medicinal composition preparation every time
15-30g or 15-30ml, 2 times a day, menstrual period and non-menstrual period can take, to start within 3 days before menstrual period to take best results, one
As take effect within three days, can continuously take to menstruation and terminate.
The medicament composing prescription of rose Chinese medicine composition of the present invention with reference to plurality of medical pharmacopeia, overcome taboo combination
Problem, the specific pharmacological basis from Chinese herbal medicine are：
Rose：Rose sweet and slightly bitter taste, slightly warm in nature, Return liver, spleen, stomach.Rose contains abundant natural complex
C, protein, mineral matter etc..Beautifying skin-protection function with highly significant, energy whitening effect, soft skin, smooths microgroove, in advance
Anti-wrinkle, skin regeneration can be promoted, make skin keep elasticity and gloss.Be adapted to various skin quality, to dry skin, color spot, scar,
Wound, burn and scald, sunburn, eczema, aging skin all have splendid effect.
Motherwort：Acrid-sweet flavor, gas tepor are nontoxic；Enter the heart, liver, bladder warp；Function：Promoting blood circulation, dissolving stasis, menstruation regulating, disappear water.It is main
Control：Irregular menstruation, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle swells sore.
Safflower：Nature and flavor are pungent, warm.Enter the heart, Liver Channel.Function：Invigorate blood circulation, stasis eliminatings analgesic.Cure mainly：Amenorrhea, abdominal mass, difficult labour,
Stillborn foetus, disease that postpartum lochia can't go, hemostasis are had a pain, carbuncle swells, injury from falling down.
Chinese cassia tree：Acrid flavour, sweet, extremely hot in nature, there is a mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, the effect of warming meridian, are used for
Impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia stomachache, dysmenorrhoea
Amenorrhea.
Evodia rutaecarpa：Acrid flavour, hardship, property heat.Return liver, spleen, stomach, kidney channel.There are eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, the work(of supporing yang antidiarrheal
Effect.Cure mainly：Jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention, vomit acid regurgitation, Diarrhoea.
Radix Angelicae Sinensis：Nature and flavor are sweet, temperature.Return liver, the heart, the spleen channel.Enrich blood；Promoting blood circulation；Cure mainly：Menstruction regulating and pain relieving；Moisturize laxation.The main deficiency of blood is all
Card；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Abdominal mass knot gathers；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Numbness；Intestines are dry and shit is difficult；Weight after dysentery characterized by blood in the stool；
Ulcer sores；Injury from falling down.
The root bark of tree peony：It is cold in nature, bitter；It is cool；It is slightly cold.The thoughts of returning home；Liver；Kidney；Lung channel.Clearing heat and cooling blood；Promoting blood circulation to remove blood stasis.Cure mainly：Stasis passes through
Close；Dysmenorrhoea；Carbuncle sore tumefacting virus；The pain of injury caused by falling and tumbling；Beriberoid pyretic arthralgia.
Beneficial effects of the present invention：
1. rose Chinese medicine composition of the present invention chooses kinds of traditional Chinese medicines, start with from promoting blood circulation, clearing and activating the channels and collaterals, conditioning analgesic,
It can prevent or alleviate the stress caused by dysmenorrhes and dysmenorrhoea, mitigate patient suffering, have no side effect, treat both principal and secondary aspect of disease.
2. rose Chinese medicine composition reasonable mixture ratio of components of the present invention, it is the Chinese herbal medicine of Clinical practice, takes safety.
Embodiment
The preparation method of the rose Chinese medicine composition of embodiment 1
20g roses, 35g motherworts, 10g safflowers, 10g Chinese cassia trees, 15g evodia rutaecarpas, 12g Radix Angelicae Sinensis and the 20g root barks of tree peony are taken, according to
Ratio is mixed, and adds distilled water 3L, and 80 DEG C are decocted bubble half an hour and filtered, and in triplicate, mix filtrate, concentration is settled to 200ml.
The preparation method of the rose Chinese medicine composition of embodiment 2
Take 15g roses, 25g motherworts, 8g safflowers, 8g Chinese cassia trees, 12g evodia rutaecarpas, 9g Radix Angelicae Sinensis and the 15g root barks of tree peony, according to than
Example is mixed, and adds distilled water 3L, and 80 DEG C are decocted bubble half an hour and filtered, and in triplicate, mix filtrate, concentration is settled to 200ml.
The foundation of the rat primary dysmenorrhea model of embodiment 3
Kunming kind female mice is taken, totally 72, primary dysmenorrhea model is replicated with estrogen and oxytocin joint.With
10mg·kg·d-1Mouse continuous subcutaneous injection oestradiol benzoate 8d is given, synchronizes Mouse Uterus.8th day, oxytocin abdomen
Chamber injects 100ukg-1Manufacture rat primary dysmenorrhoea animal model.
The rose Chinese medicine composition of embodiment 4 alleviates the compliance test result of dysmenorrhoea
1st, experimental group is set
Model control group：Physiological saline.
Rose wate decocting liquid control group：Rose 15g is taken, adds distilled water 3L, 80 DEG C decoct distillation, and distillate is concentrated,
100ml is settled to produce.
Chinese medicine composition control group：25g motherworts, 8g safflowers, 8g Chinese cassia trees, 12g evodia rutaecarpas, 9g Radix Angelicae Sinensis and the 15g root barks of tree peony are taken,
Proportionally mix, add distilled water 3L, 80 DEG C are decocted bubble half an hour, and being concentrated into 100ml after mixing in triplicate produces.
Rose Chinese medicine composition high dose group：Prepare such as embodiment 1.
Rose Chinese medicine composition low dose group：Prepare such as embodiment 2.
2nd, experimental procedure
72 Kunming kind female mices are divided into 6 groups, every group 12, according to Method Modeling described in embodiment 4, from the 6th
It rises, daily morning dorsal sc injection oestradiol benzoate 10mgkgd-1, afternoon, administration was intervened：Model control group is given
Physiological saline gavage 0.4ml/, remaining each group gavage relative medicine 0.4ml/, for three days on end, and after administration in the 8th day, abdominal cavity
Inject oxytocin 100ukg-1, mouse writhing number in 40min after record injection, and calculate writhing response inhibiting rate.
Writhing response inhibiting rate (%)=(the average writhing number of the average writhing number-administration group of model control group) ÷ models
Average writhing number × 100% of control group
3rd, experimental result
Compared with model control group, the writhing number of remaining each administration group significantly reduces, and shows rat primary dysmenorrhoea mould
Type is successfully established.Compared with rose wate decocting liquid control group, Chinese medicine composition control group, high and low dose of rose Chinese medicine composition
Amount group can substantially reduce the writhing number (P of mouse<0.05), rose Chinese medicine composition high and low dose is anti-to the writhing of mouse
Inhibiting rate is answered to respectively reach 26.0% and 36.1%, wherein, the effect that rose Chinese medicine composition low dose group alleviates dysmenorrhoea is most aobvious
Write (table 1).
Writhing inhibitory action of the rose Chinese medicine composition of table 1 to rat primary dysmenorrhea model
Note：Compared with model control group：*P<0.05；With rose wate decocting liquid group：△P<0.05；Compareed with Chinese medicine composition
Group compares：◇P<0.05。
Proved by above-described embodiment, a kind of lenitive rose Chinese medicine composition provided by the invention is from promoting blood circulation, logical
Channels and activating collaterals, conditioning analgesic are started with, and energy rapid recovery menstrual pain, mitigate patient suffering, can prepare the medicine of alleviation menstrual pain
Application in thing.
Claims (5)
1. a kind of rose Chinese medicine composition for alleviating dysmenorrhoea, it is characterised in that the bulk drug of the rose Chinese medicine composition is under
State weight than component：15-20 part roses, 25-35 part motherworts, 8-10 part safflowers, 8-10 part Chinese cassia trees, 12-15 part Wus Zhu
Cornel, 9-12 part Radix Angelicae Sinensis, 15-20 parts root bark of tree peony composition.
A kind of 2. rose Chinese medicine composition for alleviating dysmenorrhoea as claimed in claim 1, it is characterised in that the rose Chinese medicine group
The bulk drug of compound by following weight than component：15 portions of roses, 25 portions of motherworts, 8 parts of safflowers, 8 portions of Chinese cassia trees, 12 parts of Wu Zhu
Cornel, 9 parts of Radix Angelicae Sinensis, 15 parts of root bark of tree peony compositions.
3. a kind of preparation method of the rose Chinese medicine composition of alleviation dysmenorrhoea as described in claim any one of 1-2, its feature
It is, the preparation method is as follows：Rose, motherwort, safflower, Chinese cassia tree, evodia rutaecarpa, Radix Angelicae Sinensis and the root bark of tree peony are taken, is proportionally mixed
It is even, add distilled water 3L, 80 DEG C are decocted bubble half an hour and filtered, and in triplicate, are mixed filtrate, are concentrated and produce.
4. application of the rose Chinese medicine composition in the medicine for alleviating dysmenorrhoea is prepared as described in claim any one of 1-2.
5. application as claimed in claim 4, it is characterised in that medicine agent of the rose Chinese medicine composition as effective component
Type is tablet, capsule, powder, pill, granule, paste, controlled release preparation, oral liquid, ejection preparation.
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