CN105796713A - Rose traditional Chinese medicine composition capable of relieving pain and preparation method and application thereof - Google Patents
Rose traditional Chinese medicine composition capable of relieving pain and preparation method and application thereof Download PDFInfo
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- CN105796713A CN105796713A CN201610171533.5A CN201610171533A CN105796713A CN 105796713 A CN105796713 A CN 105796713A CN 201610171533 A CN201610171533 A CN 201610171533A CN 105796713 A CN105796713 A CN 105796713A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to the field of biological medicine, and particularly relates to a rose traditional Chinese medicine composition capable of relieving pain and a preparation method and application thereof. The rose traditional Chinese medicine composition is prepared from rose flowers, herba leonuri, flos carthami, cortex cinnamomi, fructus evodiae, radix angelicae sinensis and cortex moutan. According to the rose traditional Chinese medicine composition capable of relieving the pain and the preparation method and application thereof, a rose flower water decoction is mixed with multiple traditional Chinese medicine extracting solutions, by starting from activating the blood, clearing and activating the channels and collaterals, achieving conditioning and relieving the pain, menstrual pain can be relieved rapidly, and the pain of a patient is relieved.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of lenitive Flos Rosae Rugosae Chinese medicine composition and its preparation method and application.
Background technology
Dysmenorrhea is one of modal gynecological symptom, refers to that women carrys out the lower abdominal pain occurred through forward and backward and intermenstrual period, and with the soreness of waist or other discomforts, serious symptom affects quality of life, and in clinical statistics, sickness rate can about 35%.Clinical symptoms is: lower abdomen or flank pain, has pendant pain, with the soreness of waist, and even pain and waist sacrum；Severe patient can with Nausea and vomiting, dripping cold sweat, and deadly cold hand and foot is even fainted；Recur with menstruation week.Dysmenorrhea can bring much harm to women, as: pachylosis blackout, long acne, inappetence, psychentonia, emotional instability, irritable, blahs aypnia, difficulty in walking, physical weakness, also can affect fertility and heredity simultaneously, so, treatment or relieving dysmenorrhea are extremely important timely.Dysmenorrhea is generally divided into two classes, and one is primary dysmenorrhea, refers to that genitals, without obvious pathological changes, mostly is primary dysmenorrhea from the stomachache that menstruation occurs at the very start, accounts for dysmenorrhea more than 90%；Another kind is secondary dysmenorrhea, refers to the abdominal pain in menstruation that the several years of passing through just occurs, is secondary to the pathological changes such as pelvic inflammatory disease, cervical stenosis more.
For dysmenorrhea the lighter, mostly adopt hot compress or food therapy, by expanding blood vessel, dredge the meridian passage, making smooth muscle loosening carry out pain relieving；For dysmenorrhea relatively severe one, then generally require symptomatic treatment, based on pain relieving, calmness, such as aspirin, naproxen tablet, dissipate profit pain, prostaglandin inhibitor (ibuprofen/ketoprofen/meclofenamic acid etc.), reduce the secretion of the inflammatory mediators such as prostaglandin, it is desirable to the orally available contraceptive relief of symptoms of dysmenorrhea women of birth control.But the Western medicine of these treatment dysmenorrheas, has obvious side effect.Chinese medicine class then often adopts fresh ginger brown sugar water, rose tea, ginger jujube tea, Radix Angelicae Sinensis tea etc..And above Chinese medicine class therapeutic effect is not notable.Therefore, seek a kind of effective alleviation or medicine is always up the problem that this area is to be solved.
For solving the problems referred to above, the present invention now provides a kind of lenitive Flos Rosae Rugosae Chinese medicine composition and its preparation method and application.Rose wate decocting liquid is mixed by the present invention with kinds of traditional Chinese medicines extracting solution, from invigorating blood circulation, dredge the meridian passage, conditioning pain relieving start with, can rapid recovery menstrual pain, alleviate patient suffering.
Summary of the invention
It is an object of the invention to provide a kind of lenitive Flos Rosae Rugosae Chinese medicine composition, this Chinese medicine composition energy rapid recovery menstrual pain, alleviate patient suffering.
The preparation method that it is a further object to provide above-mentioned Flos Rosae Rugosae Chinese medicine composition.
It is a further object to provide the application of above-mentioned Flos Rosae Rugosae Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of lenitive Flos Rosae Rugosae Chinese medicine composition, described Flos Rosae Rugosae Chinese medicine composition contains Flos Rosae Rugosae, Herba Leonuri, Flos Carthami, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Cortex Moutan.
A kind of lenitive Flos Rosae Rugosae Chinese medicine composition, described Flos Rosae Rugosae Chinese medicine composition contains the component of following weight ratio: 15-20 part Flos Rosae Rugosae, 25-35 part Herba Leonuri, 8-10 part Flos Carthami, 8-10 part Cortex Cinnamomi, 12-15 part Fructus Evodiae, 9-12 part Radix Angelicae Sinensis, 15-20 part Cortex Moutan.
A kind of lenitive Flos Rosae Rugosae Chinese medicine composition, described Flos Rosae Rugosae Chinese medicine composition contains the component of following weight ratio: 15 portions of Flos Rosae Rugosaes, 25 parts of Herba Leonuris, 8 parts of Flos Carthamis, 8 portions of Cortex Cinnamomis, 12 parts of Fructus Evodiaes, 9 parts of Radix Angelicae Sinensis, 15 parts of Cortex Moutans.
The preparation method of above-mentioned lenitive Flos Rosae Rugosae Chinese medicine composition is as follows: takes Flos Rosae Rugosae, Herba Leonuri, Flos Carthami, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis and Cortex Moutan, proportionally mixes, adds distilled water 3L, decocts for 80 DEG C and steeps half an hour, concentrates and get final product in triplicate after mixing.
Described Flos Rosae Rugosae Chinese medicine composition can be applied in preparing lenitive medicine.Wherein, described pain is caused by menstruation.
Above-mentioned Flos Rosae Rugosae Chinese medicine composition is tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, unguentum, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder, ejection preparation as the pharmaceutical dosage form of active ingredient.
Described Flos Rosae Rugosae Chinese medicine composition is as prepared into pharmaceutical preparation, during use, and oral Flos Rosae Rugosae Chinese medicinal composition preparation 15-30g or 15-30ml every time, every day 2 times, menstrual period and non-menstrual period all can take, and start to take best results with first 3 days of menstrual period, general three days take effect, it is possible to take continuously to menstruation and terminate.
The medicament composing prescription of Flos Rosae Rugosae Chinese medicine composition of the present invention with reference to plurality of medical pharmacopeia, the problem overcoming taboo combination, and the pharmacological basis of concrete selection Chinese herbal medicine is:
Flos Rosae Rugosae: Flos Rosae Rugosae sweet and slightly bitter taste, slightly warm in nature, returns liver, spleen, stomach warp.Flos Rosae Rugosae contains abundant natural complex C, protein, mineral etc..There is the beautifying skin-protection function of highly significant, energy whitening effect, soft skin, smooth microgroove, prevent wrinkle, skin regeneration can be promoted, make skin keep elastic and gloss.It is suitable for various skin quality, xerosis cutis, mottle, cicatrix, wound, burn and scald, sunburn, eczema, aging skin are all had splendid effect.
Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic；Enter the heart, liver, bladder warp；Function: invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Curing mainly: menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, and hematuria rushes down blood, carbuncle skin infection.
Flos Carthami: nature and flavor are pungent, warm.Enter the heart, Liver Channel.Function: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Curing mainly: amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Cortex Cinnamomi: acrid in the mouth, sweet, extremely hot in nature, there is benefit fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, effect of promoting the flow of QI-blood by warming the meridian, for sexual impotence cold womb, chills and pain of the waist and kness, to suffer from a deficiency of the kidney and breathe heavily, upward floating of YANG in deficiency condition, dizziness conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, and colic of cold type is suffered from abdominal pain, dysmenorrhea amenorrhea.
Fructus Evodiae: acrid in the mouth, hardship, hot in nature.Return liver, spleen, stomach, kidney channel.There are dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, effect of supporing yang antidiarrheal.Curing mainly: headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomits acid regurgitation, Diarrhoea.
Radix Angelicae Sinensis: nature and flavor are sweet, temperature.Return liver, the heart, spleen channel.Enrich blood；Invigorate blood circulation；Cure mainly: menstruction regulating and pain relieving；Moisturize laxation.The all cards of main blood deficiency；Menoxenia；Amenorrhea；Dysmenorrhea；Lump in the abdomen knot is poly-；Metrorrhagia；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness of the skin；Dryness of the intestine dyschezia；Weight after bloody dysentery；Ulcer sores；Injury from falling down.
Cortex Moutan: cold in nature, bitter in the mouth；Cool；It is slightly cold.GUIXIN；Liver；Kidney；Lung meridian.Clearing away heat and cooling blood；Promoting blood circulation to remove blood stasis.Cure mainly: amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle sore tumefacting virus；Fall and flutter the pain of injury；Beriberoid pyretic arthralgia.
Beneficial effects of the present invention:
1. Flos Rosae Rugosae Chinese medicine composition of the present invention chooses kinds of traditional Chinese medicines, and from invigorating blood circulation, dredge the meridian passage, conditioning pain relieving start with, it is possible to prevention or alleviate the psychentonia caused by dysmenorrhes and dysmenorrhea, alleviates patient suffering, has no side effect, treating both the principal and secondary aspects of a disease.
2. Flos Rosae Rugosae Chinese medicine composition reasonable mixture ratio of components of the present invention, is the Chinese herbal medicine of Clinical practice, takes safety.
Detailed description of the invention
The preparation method of embodiment 1 Flos Rosae Rugosae Chinese medicine composition
Taking 20g Flos Rosae Rugosae, 35g Herba Leonuri, 10g Flos Carthami, 10g Cortex Cinnamomi, 15g Fructus Evodiae, 12g Radix Angelicae Sinensis and 20g Cortex Moutan, proportionally mix, add distilled water 3L, decoct bubble half an hour and filter for 80 DEG C, in triplicate, mix filtrate, concentration is settled to 200ml.
The preparation method of embodiment 2 Flos Rosae Rugosae Chinese medicine composition
Taking 15g Flos Rosae Rugosae, 25g Herba Leonuri, 8g Flos Carthami, 8g Cortex Cinnamomi, 12g Fructus Evodiae, 9g Radix Angelicae Sinensis and 15g Cortex Moutan, proportionally mix, add distilled water 3L, decoct bubble half an hour and filter for 80 DEG C, in triplicate, mix filtrate, concentration is settled to 200ml.
The foundation of embodiment 3 rat primary dysmenorrhea model
Take Kunming kind female mice, totally 72, combine duplication primary dysmenorrhea model with estrogen and oxytocin.With 10mg kg d-1To mice continuous subcutaneous injection estradiol benzoate 8d, make Mouse Uterus synchronization.8th day, oxytocin lumbar injection 100u kg-1Manufacture rat primary dysmenorrhea animal model.
The compliance test result of embodiment 4 Flos Rosae Rugosae Chinese medicine composition relieving dysmenorrhea
1, experimental group is arranged
Model control group: normal saline.
Rose wate decocting liquid matched group: take Flos Rosae Rugosae 15g, adds distilled water 3L, and 80 DEG C decoct distillation, are concentrated by distillate, are settled to 100ml and get final product.
Chinese medicine composition matched group: take 25g Herba Leonuri, 8g Flos Carthami, 8g Cortex Cinnamomi, 12g Fructus Evodiae, 9g Radix Angelicae Sinensis and 15g Cortex Moutan, proportionally mix, add distilled water 3L, decocts for 80 DEG C and steeps half an hour, be concentrated into 100ml in triplicate and get final product after mixing.
Flos Rosae Rugosae Chinese medicine composition high dose group: preparation is such as embodiment 1.
Flos Rosae Rugosae Chinese medicine composition low dose group: preparation is such as embodiment 2.
2, experimental procedure
72 Kunming kind female mices are divided into 6 groups, often group 12, Method Modeling described in embodiment 4, from the 6th day, the morning every day dorsal sc injection estradiol benzoate 10mg kg d-1, afternoon, administration was intervened: model control group only gives normal saline gavage 0.4ml/, and all the other only respectively organize gavage relative medicine 0.4ml/, for three days on end, after being administered in the 8th day, and lumbar injection oxytocin 100u kg-1, mouse writhing number of times in 40min after record injection, and calculate writhing response suppression ratio.
Writhing response suppression ratio (%)=(model control group average writhing number of times-administration group average writhing number of times) average writhing number of times × 100% of ÷ model control group
3, experimental result
Compared with model control group, the writhing number of times of all the other each administration groups significantly reduces, it was shown that rat primary dysmenorrhea model is successfully established.Compared with rose wate decocting liquid matched group, Chinese medicine composition matched group, the high and low dose group of Flos Rosae Rugosae Chinese medicine composition all can substantially reduce the writhing number of times (P < 0.05) of mice, the writhing response suppression ratio of mice is respectively reached 26.0% and 36.1% by Flos Rosae Rugosae Chinese medicine composition high and low dose, wherein, the most pronounced effects (table 1) of Flos Rosae Rugosae Chinese medicine composition low dose group relieving dysmenorrhea.
The table 1 Flos Rosae Rugosae Chinese medicine composition writhing inhibitory action to rat primary dysmenorrhea model
Note: compare with model control group:*P<0.05；With rose wate decocting liquid group:△P<0.05；Compare with Chinese medicine composition matched group:◇P<0.05。
Proved by above-described embodiment, the lenitive Flos Rosae Rugosae Chinese medicine composition of one provided by the invention from invigorating blood circulation, dredge the meridian passage, conditioning pain relieving start with, can rapid recovery menstrual pain, alleviate patient suffering, can application in the medicine preparing relief of menstrual pain.
Claims (7)
1. a lenitive Flos Rosae Rugosae Chinese medicine composition, it is characterised in that described Flos Rosae Rugosae Chinese medicine composition contains Flos Rosae Rugosae, Herba Leonuri, Flos Carthami, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Cortex Moutan.
2. a kind of lenitive Flos Rosae Rugosae Chinese medicine composition as claimed in claim 1, it is characterized in that, described Flos Rosae Rugosae Chinese medicine composition contains the component of following weight ratio: 15-20 part Flos Rosae Rugosae, 25-35 part Herba Leonuri, 8-10 part Flos Carthami, 8-10 part Cortex Cinnamomi, 12-15 part Fructus Evodiae, 9-12 part Radix Angelicae Sinensis, 15-20 part Cortex Moutan.
3. a kind of lenitive Flos Rosae Rugosae Chinese medicine composition as claimed in claim 1, it is characterised in that described Flos Rosae Rugosae Chinese medicine composition contains the component of following weight ratio: 15 portions of Flos Rosae Rugosaes, 25 parts of Herba Leonuris, 8 parts of Flos Carthamis, 8 portions of Cortex Cinnamomis, 12 parts of Fructus Evodiaes, 9 parts of Radix Angelicae Sinensis, 15 parts of Cortex Moutans.
4. the preparation method of the lenitive Flos Rosae Rugosae Chinese medicine composition as described in any one of claim 1-3, it is characterized in that, described preparation method is as follows: take Flos Rosae Rugosae, Herba Leonuri, Flos Carthami, Cortex Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis and Cortex Moutan, proportionally mix, add distilled water 3L, decoct for 80 DEG C and steep half an hour, concentrate and get final product after mixing in triplicate.
5. the application in preparing lenitive medicine of the Flos Rosae Rugosae Chinese medicine composition as described in any one of claim 1-3.
6. apply as claimed in claim 5, it is characterised in that described pain is caused by menstruation.
7. apply as claimed in claim 5, it is characterized in that, described Flos Rosae Rugosae Chinese medicine composition is tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, unguentum, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder, ejection preparation as the pharmaceutical dosage form of active ingredient.
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| CN111713593A (en) * | 2020-07-02 | 2020-09-29 | 北京中医药大学 | A kind of soft candy for dysmenorrhea based on homologous substance of medicine and food, preparation method and application thereof |
| CN115581731A (en) * | 2022-10-20 | 2023-01-10 | 武汉森澜生物科技有限公司 | Traditional Chinese medicine composition for relieving yang deficiency and internal cold type dysmenorrhea |
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| CN102488763A (en) * | 2011-12-28 | 2012-06-13 | 吕慧侠 | Composition with functions of treating dysmenorrhoea and beautifying |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111713593A (en) * | 2020-07-02 | 2020-09-29 | 北京中医药大学 | A kind of soft candy for dysmenorrhea based on homologous substance of medicine and food, preparation method and application thereof |
| CN115581731A (en) * | 2022-10-20 | 2023-01-10 | 武汉森澜生物科技有限公司 | Traditional Chinese medicine composition for relieving yang deficiency and internal cold type dysmenorrhea |
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