CN110801478A - Radix angelicae sinensis flower essential oil for treating dark eye circles - Google Patents
Radix angelicae sinensis flower essential oil for treating dark eye circles Download PDFInfo
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- CN110801478A CN110801478A CN201911305944.9A CN201911305944A CN110801478A CN 110801478 A CN110801478 A CN 110801478A CN 201911305944 A CN201911305944 A CN 201911305944A CN 110801478 A CN110801478 A CN 110801478A
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- essential oil
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- ginseng
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Abstract
The invention relates to radix angelicae sinensis flower essential oil for treating black eye circles, which can effectively solve the problem of treatment medication of the black eye circles and adopts the technical scheme that the essential oil comprises the following components: 4-6mL of ginseng essential oil, 5-7mL of angelica essential oil, 5-7mL of lemon essential oil, 5-7mL of cortex moutan essential oil, 5-7mL of salvia essential oil, 4-6mL of angelica essential oil, 5-7mL of rose essential oil, 4-6mL of safflower essential oil, 4-6mL of liquorice essential oil, 5-7mL of peach kernel essential oil and 4-6g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine; the invention has the advantages of rich raw materials, simple preparation method, easy production and preparation, convenient use and good effect, has the functions of promoting local blood circulation around eyes and relieving pigmentation, is an innovation of the medicine for treating dark circles, and has remarkable economic and social benefits.
Description
Technical Field
The invention relates to medicine, in particular to radix angelicae sinensis flower essential oil for treating black eye circles.
Background
The black eye circles are formed by the fact that blood flow speed of blood vessels of skin at eyes is too slow to form stagnant flow due to night stay, large emotion fluctuation, eye fatigue and aging; insufficient oxygen supply to tissues and excessive accumulation of metabolic waste in blood vessels can cause pigmentation of eyes. The older the person, the thinner the subcutaneous fat around the eye becomes, so the more visible the dark circles.
The traditional Chinese medicine holds that the black eye patients are mostly caused by liver yin deficiency and flaring up of deficient fire. Traditional Chinese medicine emphasizes that the essence and qi of five zang organs and six fu organs are both injected into eyes, while the liver opens into eyes, and if the eyes are kept up for a long time, pressure is large, or eyes are not enough, the liver-yin deficiency and deficient fire flaming, namely poor qi-blood circulation with flaming symptoms, can cause black eyes. For treating dark eye circles, the traditional Chinese medicine can regulate the disordered viscera functions and improve local blood circulation according to syndrome differentiation and observation of the states and colors of upper and lower eyelids, and can improve dark color around eyes. Although various medicines for treating the black eye are available, the use and the curative effect of the medicines are not satisfactory for various reasons, so that innovation of the medicines for treating the black eye is imperative.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention aims to provide the radix angelicae sinensis flower essential oil for treating black eye circles, which can effectively solve the problem of treatment medication of the black eye circles.
The invention solves the technical scheme that the radix angelicae sinensis flower essential oil for treating black eye circles comprises the following components: 4-6mL of ginseng essential oil, 5-7mL of angelica essential oil, 5-7mL of lemon essential oil, 5-7mL of cortex moutan essential oil, 5-7mL of salvia essential oil, 4-6mL of angelica essential oil, 5-7mL of rose essential oil, 4-6mL of safflower essential oil, 4-6mL of liquorice essential oil, 5-7mL of peach kernel essential oil and 4-6g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine; wherein:
the ginseng essential oil is prepared by crushing ginseng into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured in g, the liquid is measured in mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the ginseng essential oil;
the angelica essential oil is prepared by crushing angelica into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the angelica essential oil is obtained;
the lemon essential oil is prepared by pulverizing lemon into supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the lemon essential oil;
the cortex moutan essential oil is prepared by crushing cortex moutan into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the cortex moutan essential oil is obtained;
the salvia essential oil is prepared by crushing salvia into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the salvia essential oil;
the radix angelicae essential oil is prepared by crushing radix angelicae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the angelica essential oil is obtained;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the rose essential oil;
the safflower essential oil is prepared by crushing safflower into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain safflower essential oil;
the licorice essential oil is prepared by crushing licorice into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction with liquid-to-material weight-to-volume ratio of 1:10 ℃20, extracting at 42-50 ℃, under 20-25 MPa, at 50-60 ℃, under 4.5-5.5 MPa for 1.5-2.5 h to obtain licorice essential oil;
the peach kernel essential oil is prepared by crushing peach kernels into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Performing fluid extraction, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the peach kernel essential oil;
the borneol is borneol which meets the requirements specified in pharmacopoeia.
In the formula, the ginseng can be used for external application to nourish, smooth skin, prevent skin relaxation, reduce wrinkles, prevent ultraviolet rays and the like, and meanwhile, the ginseng active substance can also inhibit melanin formation to make the skin white and smooth. Peach kernel promotes blood circulation to remove blood stasis; the Chinese angelica has the functions of enriching the blood, promoting blood circulation and relieving pain, the cortex moutan has the functions of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, the rose has the functions of promoting qi circulation and relieving depression, regulating blood and relieving pain, the safflower has the functions of promoting blood circulation and stimulating the menstrual flow, removing blood stasis and relieving pain, the salvia miltiorrhiza has the functions of removing blood stasis and relieving pain; the lemon can remove old and dead cells, brighten skin color, compact capillaries, promote collagen production, lighten melanin and whiten skin around eyes; the angelica dahurica dispels wind and removes dampness, clears orifices and relieves pain, reduces swelling and expels pus, is white in color and enters the lung, and the lung mainly controls skin and fur, so that the problems on the skin are mostly solved from the lung channel; the liquorice harmonizes the medicine property, and the borneol has faint scent diffusing powder, and has the effects of inducing resuscitation, refreshing mind, clearing heat, removing toxicity, improving eyesight and removing nebula. The medicines of the whole formula are externally applied to the periphery of eyes, and can activate blood circulation to dissipate blood stasis, improve eyesight and remove nebula, improve circulation, promote pigment metabolism and whiten skin, thereby achieving the effect of eliminating black eye.
The invention has the advantages of rich raw materials, simple preparation method, easy production and preparation, convenient use and good effect, has the functions of promoting local blood circulation around eyes and relieving pigmentation, is an innovation of the medicine for treating dark circles, and has remarkable economic and social benefits.
Detailed Description
The following examples are provided to explain the present invention in detail.
The invention may be embodied in the form of the following examples.
Example 1
In the specific implementation of the invention, the radix angelicae sinensis flower essential oil for treating black eye circles comprises the following components: 5mL of ginseng essential oil, 6mL of angelica essential oil, 6mL of lemon essential oil, 6mL of cortex moutan essential oil, 6mL of salvia essential oil, 5mL of angelica essential oil, 6mL of rose essential oil, 5mL of safflower essential oil, 5mL of liquorice essential oil, 6mL of peach kernel essential oil and 5g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine; wherein:
the ginseng essential oil is prepared by crushing ginseng into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured in g, the liquid is measured in mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the ginseng essential oil;
the angelica essential oil is prepared by crushing angelica into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the angelica essential oil is obtained;
the lemon essential oil is prepared by pulverizing lemon, and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the lemon essential oil;
the cortex moutan essential oil is prepared by crushing cortex moutan into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the cortex moutan essential oil is obtained;
the salvia essential oil is prepared by crushing salvia into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the productEssential oil of red sage root;
the radix angelicae essential oil is prepared by crushing radix angelicae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the angelica essential oil is obtained;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the rose essential oil;
the safflower essential oil is prepared by crushing safflower into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain safflower essential oil;
the licorice essential oil is prepared by crushing licorice into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that licorice essential oil is obtained;
the peach kernel essential oil is prepared by crushing peach kernels into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Performing fluid extraction, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the peach kernel essential oil;
the borneol is borneol which meets the requirements specified in pharmacopoeia.
Example 2
In the specific implementation of the invention, the radix angelicae sinensis flower essential oil for treating black eye circles comprises the following components: 4.5mL of ginseng essential oil, 6.5mL of angelica essential oil, 5.5mL of lemon essential oil, 6.5mL of cortex moutan essential oil, 5.5mL of salvia essential oil, 5.5mL of angelica essential oil, 5.5mL of rose essential oil, 5.5mL of safflower essential oil, 4.5mL of liquorice essential oil, 6.5mL of peach kernel essential oil and 4.5g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine composition, and the preparation method is the same as that of example 1.
Example 3
In the specific implementation of the invention, the radix angelicae sinensis flower essential oil for treating black eye circles comprises the following components: 5.5mL of ginseng essential oil, 5.5mL of angelica essential oil, 6.5mL of lemon essential oil, 5.5mL of cortex moutan essential oil, 6.5mL of salvia essential oil, 4.5mL of angelica essential oil, 6.5mL of rose essential oil, 4.5mL of safflower essential oil, 5.5mL of liquorice essential oil, 5.5mL of peach kernel essential oil and 5.5g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine composition, and the preparation method is the same as that of example 1.
The invention has scientific and reasonable compatibility and mutual support of components, has the functions of promoting local blood circulation around eyes and reducing pigmentation, is effectively used for treating dark circles, has very good experimental effect, and has the following relevant data:
firstly, animal experiments:
1 materials of the experiment
1.1 pharmaceutical Agents
2-chlorophenylalanine, shanghai ye biotechnology limited, lot No. S42561; adrenaline hydrochloride injection, distal medicine (china) ltd, lot No. 180406; the product of example 1 of the invention. Mouse TYR ELISA detection kit, Karlvin, Suzhou, Biotech Co., Ltd
1.2 Experimental instruments
Speckle full frame real time scanning imager, PERIMEDA, model,. star/pericam psi system; cutomer Dual MPA580 skin elasticity tester, Germany Coutage + Khazaka company; JM 1000 electronic scale, yuyao inscription weighing and checking equipment limited; AL204 electronic balance, mettler-toledo instruments (shanghai) ltd; batch number: JB1T 5374; high speed refrigerated centrifuge, Hunan instruments laboratory Instrument development Inc.; batch number: H2050R.
1.3 Experimental animals
Name of experimental animal: KM mice, 18-21 g, female grade: SPF; providing a unit: qualification number of the Ji nan Pengye experimental animal breeding company Limited: no. 37009200017330; providing a unit license number: SCXY (lu) 20140007 laboratory certification: SYXK 2015-.
2 method of experiment
60 KM female mice are taken, after fasting for 12 hours, the mice are anesthetized by intraperitoneal injection of chloral hydrate, hair around the eye parts of the mice is removed by depilatory cream, the melanin value of the eyelid parts of the mice is measured by a skin elastometer, the melanin value of the same part is measured for 3 times, the average value is taken, animals with overlarge melanin values are excluded, and 40 selected mice are divided into 4 groups according to the melanin value, wherein the groups are respectively a blank group, a model group, a large dose group of angelica sinensis flower essential oil and a small dose group of angelica sinensis flower essential oil.
Except for the blank group, mice in other groups were injected with adrenaline hydrochloride injection (0.8 ml/Kg) subcutaneously, then were injected with 2-chlorophenylalanine suspension 450mg/Kg intraperitoneally, and after 2h adrenaline injection, the mice were placed in cold water at 0 ℃ for swimming, and immediately taken out when they were immobile, wiped to dry hair, and placed beside the warm air to prevent frozen stiffness. After the mouse normally moves, the essential oil is sucked by a pipette gun and smeared on the lower eyelid of the mouse, and the dosage is respectively 10ul for the large dosage group of the angelica sinensis flower essential oil and 5ul for the small dosage group of the angelica sinensis flower essential oil. Continuously molding and administering for 7 days. After the essential oil is smeared on the day 7, the blood perfusion total amount of the lower eyelid of the mouse is measured by a speckle full-frame real-time scanning imager, and the melanin value of the eyelid of the mouse is measured by a skin elasticity instrument. Weighing, taking blood from the left eyeball, centrifuging to obtain serum, and detecting the level of Tyrosinase (TYR) in the serum. Taking the right lower eyelid skin, fixing with 10% formaldehyde solution to make pathological tissue section, HE staining, and observing the total number of melanin granule cells and the percentage of melanin-containing hair follicles in each 5 high-power visual fields under the optical lens visual field.
3 statistical treatment
Statistical processing of data using SPSS 21.0 statistical software package for data analysis, mean ± SD for data measurement: (
S) is expressed by adopting one-factor analysis of variance, the Least Significant Difference (LSD) method is adopted for the uniform variance testers, the Games-Howell method is adopted for the non-uniform variance testers, and the grade data is adoptedRaditExamination of。
4 results of the experiment
4.1 Effect on local melanin content in mouse Black eye model
TABLE 1 Effect of Angelica sinensis flower essential oil on local melanin content in mouse Black eye model ((
±s）
| Group of | Dosage form | Melanin value |
| Blank space | 217.37±4.38 | |
| Model (model) | 247.46±16.32## | |
| Radix Angelicae sinensis flower essential oil large dose | 10ul per eye circumference | 231.33±16.04* |
| Small dose of radix Angelicae sinensis flower essential oil | 5ul per eye circumference | 229.03±17.46* |
And model groupBy comparison, the process of the first and second steps,*P<0.05，**P<0.01; in comparison with the blank set, the results,# P<0.05，## P<0.01
as can be seen from Table 1, the model group showed a clear black eye and the mouse had a significantly increased melanin value at the eyelid, compared to the blank group (seeP<0.01), which indicates that the black eye model is successfully established. Compared with the model group, the values of melanin of the eyelid parts of mice in large and small dose groups of the radix angelicae sinensis flower essential oil are obviously reduced (P<0.05）。
4.2 Change in Total perfusion of eyelid microcirculation after different treatments in groups of animals
Table 2 influence of radix angelicae sinensis flower essential oil on total perfusion of eyelid microcirculation in mouse black eye model: (±s）
| Group of | Dosage form | Microcirculation total Perfusion (PU) |
| Blank space | 114.95±14.02 | |
| Model (model) | 128.96±14.51# | |
| Radix Angelicae sinensis flower essential oil large dose | 10ul per eye circumference | 97.47±12.15** |
| Small dose of radix Angelicae sinensis flower essential oil | 5ul per eye circumference | 107.58±17.53** |
In comparison with the set of models,*P<0.05，**P<0.01; in comparison with the blank set, the results,# P<0.05，## P<0.01
the blood vessels around the eyes are more, so that the eyelids cannot rest after staying up, the blood vessels continuously tense and contract, the blood flow is increased for a long time, and blood stasis and edema of the blood vessels of the subcutaneous tissues around the eyes are caused, and shadows are left. As can be seen from Table 2, the total perfusion rate of eyelid microcirculation was significantly increased in the model group compared to the blank group: (P<0.05); compared with the model group, the large and small dosage of the radix angelicae sinensis flower essential oil can obviously reduce the blood flow perfusion of the eyelid part of the mouse (P<0.01）。
4.3 Change in the level of Tyrosinase (TYR) in serum after different treatments of the animals of each group
Table 4 effect of angelica sinensis flower essential oil on Tyrosinase (TYR) levels in mouse black eye model serum ((r))
±s）
| Group of | Dosage form | TYR(umol/L) |
| Blank space | 51.57±4.08 | |
| Model (model) | 60.44±8.23## | |
| Radix Angelicae sinensis flower essential oil large dose | 10ul per eye circumference | 53.1±6.4* |
| Small dose of radix Angelicae sinensis flower essential oil | 5ul per eye circumference | 51.37±4.51** |
In comparison with the set of models,*P<0.05，**P<0.01; in comparison with the blank set, the results,# P<0.05，## P<0.01
as can be seen from Table 4, the tyrosinase levels in the serum of the model mice were significantly increased compared to the blank group (P<0.01) the group with a small dose of radix Angelicae sinensis flower essential oil significantly reduced tyrosinase levels in serum compared to the model group (P<0.01) the radix Angelicae sinensis flower essential oil can obviously reduce the level of tyrosinase in serumP<0.05）。
Second, clinical application
Under the condition of ensuring safety in animal experiments, clinical trials prove that the effect is very good, and the related data are as follows (taking example 1 as an example):
the traditional Chinese medicine holds that the black eye patients are mostly caused by liver yin deficiency and flaring up of deficient fire. Traditional Chinese medicine emphasizes that the essence and qi of five zang organs and six fu organs are both injected into eyes, while the liver opens into eyes, and if the eyes are kept up for a long time, pressure is large, or eyes are not enough, the liver-yin deficiency and deficient fire flaming, namely poor qi-blood circulation with flaming symptoms, can cause black eyes. For treating dark eye circles, the traditional Chinese medicine can regulate the disordered viscera functions and improve local blood circulation according to syndrome differentiation and observation of the states and colors of upper and lower eyelids, and can improve dark color around eyes.
The radix angelicae sinensis flower essential oil is used for treating 15 dark eye circles (obvious black deposition appears around eyes, and clear inducement is long-term staying up night, large pressure or insufficient sleeping eyes and the like).
The treatment scheme comprises the following steps: applying the radix Angelicae sinensis flower essential oil on the black part around eyes, closing eyes and resting for 20-30 minutes. The dosage is 0.2mL/cm2. The medicine is used for 7 days. During the administration period, the patient takes a rest on schedule and is light in diet.
The therapeutic effect judgment standard is as follows: the effect is shown: black fading of black eye is larger than or equal to 70%; the method has the following advantages: black fading of black eye is larger than or equal to 40%; and (4) invalidation: dark circles fade < 40%.
Statistical treatment: among 15 cases, 8 cases are effective, 6 cases are effective, 1 case is ineffective, the total effective rate is 93.3%, and the using effect is very good.
The same experiment is carried out on the example 1 and the examples 2 and 3 at the same time, and the same and similar results are obtained, which shows that the product has good quality and stable and reliable curative effect, and are not listed any more.
The experiments show that the traditional Chinese medicine composition has the functions of promoting local blood circulation around eyes and relieving pigmentation, is effectively used for treating black eye circles, has the advantages of simple preparation method, abundant raw materials, easy production and preparation and definite curative effect, is an innovation of medicines for treating black eye circles, and has remarkable economic and social benefits.
Claims (4)
1. The radix angelicae sinensis flower essential oil for treating dark eye circles is characterized by comprising the following components: 4-6mL of ginseng essential oil, 5-7mL of angelica essential oil, 5-7mL of lemon essential oil, 5-7mL of cortex moutan essential oil, 5-7mL of salvia essential oil, 4-6mL of angelica essential oil, 5-7mL of rose essential oil, 4-6mL of safflower essential oil, 4-6mL of liquorice essential oil, 5-7mL of peach kernel essential oil and 4-6g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine; wherein:
the ginseng essential oil is prepared by crushing ginseng into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction, wherein the weight volume ratio of liquid to material is 1:10-20, wherein the weight volume ratio is that the solid is counted by g, the liquid is counted by mL, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the ginseng essential oil is obtained;
the preparation methods of the angelica essential oil, the lemon essential oil, the cortex moutan essential oil, the salvia essential oil, the angelica essential oil, the rose essential oil, the safflower essential oil, the liquorice essential oil and the peach kernel essential oil are the same as the ginseng essential oil.
2. The radix angelicae sinensis flower essential oil for treating black eye circles as claimed in claim 1, is prepared from the following components: 5mL of ginseng essential oil, 6mL of angelica essential oil, 6mL of lemon essential oil, 6mL of cortex moutan essential oil, 6mL of salvia essential oil, 5mL of angelica essential oil, 6mL of rose essential oil, 5mL of safflower essential oil, 5mL of liquorice essential oil, 6mL of peach kernel essential oil and 5g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine.
3. The radix angelicae sinensis flower essential oil for treating black eye circles as claimed in claim 1, is prepared from the following components: 4.5mL of ginseng essential oil, 6.5mL of angelica essential oil, 5.5mL of lemon essential oil, 6.5mL of cortex moutan essential oil, 5.5mL of salvia essential oil, 5.5mL of angelica essential oil, 5.5mL of rose essential oil, 5.5mL of safflower essential oil, 4.5mL of liquorice essential oil, 6.5mL of peach kernel essential oil and 4.5g of borneol are dissolved and mixed evenly to prepare the traditional Chinese medicine.
4. The radix angelicae sinensis flower essential oil for treating black eye circles as claimed in claim 1, is prepared from the following components: 5.5mL of ginseng essential oil, 5.5mL of angelica essential oil, 6.5mL of lemon essential oil, 5.5mL of cortex moutan essential oil, 6.5mL of salvia essential oil, 4.5mL of angelica essential oil, 6.5mL of rose essential oil, 4.5mL of safflower essential oil, 5.5mL of liquorice essential oil, 5.5mL of peach kernel essential oil and 5.5g of borneol are dissolved and mixed evenly to prepare the traditional Chinese medicine.
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Application publication date: 20200218 |