CN102462767A - Vagina effervescent tablets and preparation method thereof - Google Patents
Vagina effervescent tablets and preparation method thereof Download PDFInfo
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- CN102462767A CN102462767A CN2010105372303A CN201010537230A CN102462767A CN 102462767 A CN102462767 A CN 102462767A CN 2010105372303 A CN2010105372303 A CN 2010105372303A CN 201010537230 A CN201010537230 A CN 201010537230A CN 102462767 A CN102462767 A CN 102462767A
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Abstract
The invention discloses a female vagina effervescent tablets and a preparation method thereof. The drug solutions of the following traditional Chinese drugs are extracted by supercritical CO2 extraction to prepare the vaginal effervescent tablets, wherein the traditional Chinese drugs comprise, by weight, 2-6 parts of common cnidium fruit, 2-6 parts of Chinese mosla herb, 1-5 parts of flatspine pricklyash, and 1-3 parts of Chinese pulsatilla. The pH value of the care solution of the present invention is 6-7, and the vagina effervescent tablets of the present invention have significant effects of bacteriostasis, insect disinfestation, antiinflammatory, itching alleviating, regio pudendalis cleaning, and odor removing.
Description
Technical field
The present invention relates to feminine care products, be specifically related to vagina effervescence and preparation method thereof.
Background technology
Gynecological's pudendum, colpitis are a kind of commonly encountered diseases, frequently-occurring disease.Investigation shows, adult female's infection in various degree in the whole world about 87% gynecological inflammation, clinical common gynecologic inflammation has vaginitis, cervicitis, endometritis etc.Symptom such as gynecological inflammation mainly shows as pudendal pruritus, scorching hotly swells and ache clinically, leucorrhoea grow in quantity, frequent micturition, urgent micturition, dysurea, abnormal smells from the patient are unusual; Outbreak repeatedly; Prolongedly do not heal, have influence on routine work and with people's contacts, bring serious physiology and psychological burden to the patient.At present feminine care products on function or with antibacterial be main, or be main with the cleaning external genital, act on comparatively single; From nursing is main with conditioning liquid in form, and use is run off easily, impact effect.
The vagina effervescence of the present invention's preparation; Not only have broad-spectrum antibacterial, parasite killing, antiinflammatory, antipruritic, cleaning external genital, remove multi-function actions such as abnormal flavour; And can rapid disintegrate under a small amount of body fluid, being distributed in tract more fast than common vaginal tablet and some vaginal suppositories, effect is rapidly; Producing a large amount of foams has simultaneously increased the contacting and make the medicine can infiltrate mucosal fold of gauffer position of medicine and vagina, cervix uteri mucosa; Thereby help drug absorption, give full play to the curative effect of medicine, and effervescent tablet also can overcome the shortcoming that affects the treatment together with drug wastage after suppository is dissolved by the body temperature effect.
Summary of the invention
The technical problem that the present invention will solve provides a kind of vagina effervescent tablet; Can not only effectively suppress Candida albicans, staphylococcus aureus; And have the trichomonas vaginitis of killing, antiinflammatory, itching relieving and significantly act on; And reach the effect of cleaning external genital, thereby reach the purpose of treating both the principal and secondary aspects of a disease through reducing secretions.Another technical problem that the present invention will solve provides the method for preparing of vagina effervescent tablet.
The present invention realizes through following technical scheme:
This vagina effervescence is characterized in that: by following weight portion Chinese medicine, through CO
2Make vagina effervescence behind its medicinal liquid of supercritical extraction:
2～6 parts of Fructus Cnidiis, 2～6 parts of Herba Moslaes, 1～5 part in Pericarpium Zanthoxyli, 1～3 part of the Radix Pulsatillae.
The method for preparing of this vagina effervescence is characterized in that comprising the following steps:
(1) gets Fructus Cnidii, Pericarpium Zanthoxyli, Herba Moslae, the Radix Pulsatillae, mix by the described weight proportion of claim 1 and pulverize, add 1～3 times of ethanol of above-mentioned Chinese medicine weight, under the control temperature is 35 ℃～55 ℃, the condition of pressure 30Mpa～40Mpa, carry out CO
2Supercritical extraction 2 hours～4 hours obtains Chinese medicine extraction medicinal liquid;
(2) get the Chinese medicine extract that step (1) obtains, add the lactose and the starch of 1～2 times of weight, drying is ground into fine powder, is divided into 2 parts, and is subsequent use;
(3) get 1 part of the fine powder that step (1) obtains, add the citric acid of 0.5～1.5 times of weight, the starch slurry with 10%～15% is a binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the acid grain;
(4) get 1 part of the fine powder that step (1) obtains, add the sodium bicarbonate of 0.5～1.5 times of weight, the starch slurry with 10%～15% is a binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the alkali grain;
(5) drying is sour completely, alkali granule mix homogeneously is crossed 20 mesh sieve granulate, adds the magnesium stearate mix homogeneously of doing particle weight 0.1%～1%, and tabletting promptly gets.
Advantage of the present invention:
One, has broad-spectrum antibacterial, antiinflammatory and itching-relieving action
This vagina effervescence all has bacteriostasis to Candida albicans, staphylococcus aureus, escherichia coli and Pseudomonas aeruginosa, especially Candida albicans is had strong inhibitory action, and minimal inhibitory concentration is 2mg/ml.This vagina effervescence antiinflammatory action is remarkable, and antipruritic suppression ratio reaches 72%.
Two, have and significantly kill the trichomonas vaginitis effect
Use this vagina effervescence after 24 hours mirror observe down infusorian mortality rate in the vaginal secretions BIAO and BEN, will not move, the edge is not put in order, include a large amount of particulate circular polypides is judged to be dead infusorian, the infusorian killing rate can reach more than 80%.
Three, safe in utilization
This vagina effervescence has no stimulation to vaginal mucosa, local skin anaphylaxis or systemic anaphylaxis also do not occur, and is safe in utilization.
Four, dosage form is suitable
This vagina effervescence; Can rapid disintegrate under a small amount of body fluid, be distributed in tract more fast than common vaginal tablet and some vaginal suppositories, effect is rapidly; Producing a large amount of foams has simultaneously increased the contacting and make the medicine can infiltrate mucosal fold of gauffer position of medicine and vagina, cervix uteri mucosa; Thereby help drug absorption, give full play to the curative effect of medicine, and effervescent tablet also can overcome the shortcoming that affects the treatment together with drug wastage after suppository is dissolved by the body temperature effect.
The major function of each medicine among the present invention:
One, Fructus Cnidii: the effect of tool warming the kidney to invigorate YANG, expelling wind and cold, parasite killing pain relieving, clinical its dampness wind dispelling insecticide effect of getting is used to treat gynecological and all diseases of skin outward.
Two, Pericarpium Zanthoxyli: medication is with a long history, and its pain relieving insecticidal action is used widely in clinical after the Qing Dynasty.Pericarpium Zanthoxyli has inhibitory action in various degree to antibacterial, fungus, has to kill the infusorian effect significantly.
Three, Herba Moslae: expelling insect and relieving itching has significant broad-spectrum antiseptic and pharmacological actions such as antiinflammatory, enhance immunity, and can effectively eliminate stink.
Four, the Radix Pulsatillae: having the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, clinically be usually used in treating bacillary dysentery, amebic dysentery and gynecology colpitis etc., is early to find to have one of Chinese medicine of obviously killing the trichomonal vaginitis effect.
To sum up, vagina effervescence has broad-spectrum antibacterial, parasite killing, inflammation-resisting itch-stopping and the effect of cleaning external genital, thereby reaches the multi-functional effect of treating both the principal and secondary aspects of a disease; Effect is paid in non-stimulated, allergy etc.; Dosage form is reasonable, and is rapid-action, and effect is the desirable dosage form of treatment gynecology colpitis rapidly fully.
The specific embodiment
Embodiment one:
(1) get 2 parts of Fructus Cnidiis, 3 parts of Herba Moslaes, 4 parts in Pericarpium Zanthoxyli, 2 parts of the Radix Pulsatillaes mix to be pulverized, and add 2 times of ethanol of above-mentioned Chinese medicine weight, under the control temperature is 45 ℃, the condition of pressure 40Mpa, carry out CO
2Supercritical extraction 2 hours obtains Chinese medicine extraction medicinal liquid;
(2) get the Chinese medicine extract that step (1) obtains, adding waits weight lactose and starch, and drying is ground into fine powder, is divided into 2 parts, and is subsequent use;
(3) get 1 part of the fine powder that step (1) obtains, weight citric acids such as adding, the starch slurry with 15% are binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the acid grain;
(4) get 1 part of the fine powder that step (1) obtains, weight sodium bicarbonate such as adding, the starch slurry with 15% are binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the alkali grain;
(5) drying is sour completely, alkali granule mix homogeneously is crossed 20 mesh sieve granulate, adds the magnesium stearate mix homogeneously of doing particle weight 1%, and tabletting promptly gets.
Claims (2)
1. a vagina effervescence is characterized in that: by following weight portion Chinese medicine, through CO
2Process behind its medicinal liquid of supercritical extraction: 2～6 parts of Fructus Cnidiis, 2～6 parts of Herba Moslaes, 1～5 part in Pericarpium Zanthoxyli, 1～3 part of the Radix Pulsatillae.
2. the method for preparing of a vagina effervescence is characterized in that comprising the following steps:
(1) gets Fructus Cnidii, Pericarpium Zanthoxyli, Herba Moslae, the Radix Pulsatillae, mix by the described weight proportion of claim 1 and pulverize, add 1～3 times of ethanol of above-mentioned Chinese medicine weight, under the control temperature is 35 ℃～55 ℃, the condition of pressure 30Mpa～40Mpa, carry out CO
2Supercritical extraction 2 hours～4 hours obtains Chinese medicine extraction medicinal liquid;
(2) get the Chinese medicine extract that step (1) obtains, add the lactose and the starch of 1～2 times of weight, drying is ground into fine powder, is divided into 2 parts, and is subsequent use;
(3) get 1 part of the fine powder that step (1) obtains, add the citric acid of 0.5～1.5 times of weight, the starch slurry with 10%～15% is a binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the acid grain;
(4) get 1 part of the fine powder that step (1) obtains, add the sodium bicarbonate of 0.5～1.5 times of weight, the starch slurry with 10%～15% is a binding agent, and 18 orders are granulated, and 50 ℃～55 ℃ dryings make the alkali grain;
(5) drying is sour completely, alkali granule mix homogeneously is crossed 20 mesh sieve granulate, adds the magnesium stearate mix homogeneously of doing particle weight 0.1%～1%, and tabletting promptly gets.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105372303A CN102462767A (en) | 2010-11-09 | 2010-11-09 | Vagina effervescent tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105372303A CN102462767A (en) | 2010-11-09 | 2010-11-09 | Vagina effervescent tablets and preparation method thereof |
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| CN102462767A true CN102462767A (en) | 2012-05-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208482A (en) * | 2014-09-16 | 2014-12-17 | 孙霞 | Traditional Chinese medicine preparation for treating bacterial vaginitis and preparation method of traditional Chinese medicine preparation |
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2010
- 2010-11-09 CN CN2010105372303A patent/CN102462767A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208482A (en) * | 2014-09-16 | 2014-12-17 | 孙霞 | Traditional Chinese medicine preparation for treating bacterial vaginitis and preparation method of traditional Chinese medicine preparation |
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Application publication date: 20120523 |