CN101288754A - Huyuebao preparation - Google Patents
Huyuebao preparation Download PDFInfo
- Publication number
- CN101288754A CN101288754A CNA2008103021220A CN200810302122A CN101288754A CN 101288754 A CN101288754 A CN 101288754A CN A2008103021220 A CNA2008103021220 A CN A2008103021220A CN 200810302122 A CN200810302122 A CN 200810302122A CN 101288754 A CN101288754 A CN 101288754A
- Authority
- CN
- China
- Prior art keywords
- radix
- precious
- month
- preparation
- sophorae flavescentis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 56
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 28
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 27
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 27
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 27
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 27
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004327 boric acid Substances 0.000 claims abstract description 27
- 235000008434 ginseng Nutrition 0.000 claims abstract description 27
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 27
- 229930182490 saponin Natural products 0.000 claims abstract description 27
- 150000007949 saponins Chemical class 0.000 claims abstract description 27
- 206010061218 Inflammation Diseases 0.000 claims abstract description 19
- 230000004054 inflammatory process Effects 0.000 claims abstract description 17
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims description 32
- 241000746375 Andrographis Species 0.000 claims description 29
- 241000208340 Araliaceae Species 0.000 claims description 26
- 244000293323 Cosmos caudatus Species 0.000 claims description 26
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 21
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims description 16
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 claims description 16
- 239000004615 ingredient Substances 0.000 claims description 12
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims description 6
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims description 6
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 claims description 6
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 claims description 6
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 235000021050 feed intake Nutrition 0.000 claims description 6
- 229930014456 matrine Natural products 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 239000000829 suppository Substances 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000007796 conventional method Methods 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 244000080767 Areca catechu Species 0.000 claims 3
- 244000235603 Acacia catechu Species 0.000 abstract description 24
- -1 dried alum Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 11
- 239000003814 drug Substances 0.000 abstract description 9
- 208000003251 Pruritus Diseases 0.000 abstract description 7
- 206010046914 Vaginal infection Diseases 0.000 abstract description 7
- 238000001035 drying Methods 0.000 abstract description 7
- 230000003628 erosive effect Effects 0.000 abstract description 7
- 201000008100 Vaginitis Diseases 0.000 abstract description 6
- 244000045947 parasite Species 0.000 abstract description 6
- 208000006374 Uterine Cervicitis Diseases 0.000 abstract description 5
- 206010008323 cervicitis Diseases 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000007803 itching Effects 0.000 abstract description 4
- 208000025865 Ulcer Diseases 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 231100000397 ulcer Toxicity 0.000 abstract description 3
- 241001071917 Lithospermum Species 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 abstract description 2
- 230000036407 pain Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 244000118350 Andrographis paniculata Species 0.000 abstract 1
- 244000163122 Curcuma domestica Species 0.000 abstract 1
- 235000003392 Curcuma domestica Nutrition 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 229960002645 boric acid Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 235000013976 turmeric Nutrition 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 210000004877 mucosa Anatomy 0.000 description 7
- 238000010992 reflux Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 210000001215 vagina Anatomy 0.000 description 7
- 239000000341 volatile oil Substances 0.000 description 7
- 239000006071 cream Substances 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 241000222122 Candida albicans Species 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 210000003756 cervix mucus Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000000003 vaginal tablet Substances 0.000 description 3
- 229940044977 vaginal tablet Drugs 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 208000001387 Causalgia Diseases 0.000 description 2
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- WNFXUXZJJKTDOZ-HNNXBMFYSA-N [(1s)-1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] acetate Chemical compound C1=CC(O)=C2C(=O)C([C@@H](OC(C)=O)CC=C(C)C)=CC(=O)C2=C1O WNFXUXZJJKTDOZ-HNNXBMFYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000007938 effervescent tablet Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- WNFXUXZJJKTDOZ-UHFFFAOYSA-N shikonin acetate Natural products C1=CC(O)=C2C(=O)C(C(OC(C)=O)CC=C(C)C)=CC(=O)C2=C1O WNFXUXZJJKTDOZ-UHFFFAOYSA-N 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 description 1
- 206010002153 Anal fissure Diseases 0.000 description 1
- 208000016583 Anus disease Diseases 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- 208000009531 Fissure in Ano Diseases 0.000 description 1
- 241001528553 Malus asiatica Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a Huyuebao preparation which is made from cortex phellodendri, sophora, andrographis paniculata, lithospermum, zedoary turmeric, cortex<3> moutan, ginseng stem leaf saponin, catechu, dried alum, boric acid, borneol and nacre powder and has the effects of clearing away heat and toxic materials, drying dampness, destroying parasites and relieving itching, relieving inflammation and stopping pains, removing erosion and generating muscle. The preparation is obviously effective in treating vaginitis, vaginal ulcer, cervicitis, cervical erosion, multicoloured leukorrhagia, etc., and can rapidly and effectively control gynecological inflammation and can shorten the course without adverse reactions after the medications.
Description
Technical field
The present invention relates to a kind of preparation, especially relate to a kind of month precious preparation that protects that is mainly used to gynecological inflammation.
Background technology
Gynecological inflammation such as vaginitis, cervicitis etc. are commonly encountered disease, frequently-occurring disease.This disease has the trend that sickness rate increases, age of onset shifts to an earlier date at present, strong, the easily recurrence of this disease transmission, serious threat women's physical and mental health.Washing liquid, suppository at present commonly used on the market as two azoles Thailand, easily can destroy the balance of intravaginal pH value, be unfavorable for the growth of normal physiological flora, cause vaginal dysbacteriosis, and easily produce Resistant strain, cause more virus breeding and grow, increase the weight of gynecological's inflammation, and recurrence easily.The name of disease of traditional Chinese medical science female virtues absence of vagina inflammation, cervicitis, because of clinical with leukorrhagia increase, the pudendum causalgia of scratching where it itches is main symptom, so belong to diseases such as damp invasion of lower energizer, leukorrheal diseases.The Chinese patent medicine of treatment gynecological inflammation, as FUKE QIANJIN PIAN, HUAHONG PIAN, JINJI JIAONANG etc., the effect that has heat-clearing and toxic substances removing mostly can be played and nurse one's health the endocrine effect preferably, can adjust women's body constitution, but onset is slow, specific aim is not strong, general auxiliary treatment as chronic gynecological inflammation can not be treated as first-selection, otherwise with Gou Yun county health Solely, the pathogen that causes inflammation can take advantage of the occasion to spread, development, thereby has delayed the state of an illness.Chinese medicine for external application has the advantage for the treatment of both the principal and secondary aspects of a disease, and few side effects directly acts on the affected part again, acts on characteristics rapidly, is subjected to patient's welcome.
Summary of the invention
The object of the present invention is to provide a kind of month precious preparation that protects, said preparation has heat-clearing and toxic substances removing, dampness leukorrhagia stopping, killing parasites for relieving itching, anti-inflammatory analgetic, the effect of putrefaction-removing granulation-promoting is clinical effective proved recipe, is used for that vaginitis, ulcer of vagina, cervicitis, cervical erosion, red and white leukorrhea due to the various pathogenic bacterias is inferior all a significant curative effect, can fast and effeciently control gynecological inflammation, shorten the course of disease, have no adverse reaction after the medication, be worth clinical expansion to use.
Protecting a month precious preparation is made by the raw material of following weight parts:
Cortex Phellodendri 250-2500, Radix Sophorae Flavescentis 250-2500, Herba Andrographis 250-2500, Radix Arnebiae (Radix Lithospermi) 200-2000, Rhizoma Curcumae 200-2000, Cortex Moutan 200-2000, stem and leaf of Radix Ginseng saponin 1-100, catechu 20-200, dried Alumen 20-200, boric acid 10-100, Borneolum Syntheticum 1-100, Margarita layer powder 1-100
The optimum ratio scope is:
Cortex Phellodendri 500-2000, Radix Sophorae Flavescentis 500-2000, Herba Andrographis 500-2000, Radix Arnebiae (Radix Lithospermi) 300-1200, Rhizoma Curcumae 300-1200, Cortex Moutan 3001-200, stem and leaf of Radix Ginseng saponin 10-50, catechu 30-100, dried Alumen 30-100, boric acid 30-80, Borneolum Syntheticum 5-50, Margarita layer powder 2-20
Optimal proportion is:
Cortex Phellodendri 1500, Radix Sophorae Flavescentis 1500, Herba Andrographis 1500, Radix Arnebiae (Radix Lithospermi) 800, Rhizoma Curcumae 800, Cortex Moutan 800, stem and leaf of Radix Ginseng saponin 25, catechu 50, dried Alumen 50, boric acid 50, Borneolum Syntheticum 10, Margarita layer powder 5
Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis heat-clearing and toxic substances removing, dampness are dispeled the wind, killing parasites for relieving itching is a principal agent, are aided with Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan removing heat from blood and promoting blood circulation, detoxifcation dissipating blood stasis, stem and leaf of Radix Ginseng saponin's QI invigorating and blood producing, strengthening vital QI to eliminate pathogenic factors, catechu, dried Alumen dampness removing to stop itchin, detoxifcation parasite killing, assistant is with boric acid, the antibacterial parasite killing of Borneolum Syntheticum, clearing away heat to alleviate pain granulation promoting, Margarita layer powder flavor promoting tissue regeneration and ulcer healing, leukorrhagia stoppingization is turbid, full side plays heat-clearing and toxic substances removing, dampness leukorrhagia stopping, killing parasites for relieving itching altogether, anti-inflammatory analgetic, the merit of putrefaction-removing granulation-promoting.
Modern study shows that the main effective ingredient of Cortex Phellodendri is a berberine hydrochloride, and the main effective ingredient of Radix Sophorae Flavescentis is a matrine, and very strong antibacterial and anti-inflammation functions is all arranged.The main effective ingredient of Herba Andrographis is an andrographolide, and good antibiotic analgesic, resist inflammation on repercussive function is arranged.The main effective ingredient of Radix Arnebiae (Radix Lithospermi) is Acetyl-shikonin Acetylshikonin, shikonin etc., has that good antiinflammatory is antibacterial, the effect of blood activating and promoting tissue regeneration.The main effective ingredient of Rhizoma Curcumae is a volatile oil, have good antibacterial, the effect of enhance immunity.The main effective ingredient of Cortex Moutan is a paeonol, and the effect of anti-inflammation, antipyretic-antalgic, antiallergic, enhance immunity is arranged.
According to the achievement of modern study, the extract that Cortex Phellodendri in the prescription, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan can all or part of its effective ingredient of usefulness feeds intake, and can feed intake by all or part of its effective ingredient of direct usefulness.Cortex Phellodendri can substitute with berberine hydrochloride, and Radix Sophorae Flavescentis can substitute with matrine, and Herba Andrographis can substitute with andrographolide, and Radix Arnebiae (Radix Lithospermi) can substitute with Oleum Radix Arnebiae (Oleum Radix Lithospermi)/Radix Arnebiae extract, and Rhizoma Curcumae can substitute with Oleum Curcumae, and Cortex Moutan can substitute with paeonol.
The described month precious preparation that protects is characterized in that available conventional method is made any dosage form.Especially various exterior-applied formulations can be made into and comprise tablet, capsule, suppository, lotion, ointment, gel, membrane, powder, pill, tampon in interior any dosage form.
The described month precious preparation that protects, the application in treatment gynecological inflammation preparation, the application in preparations such as treatment hemorrhoid, anal fissure, and the application in other inflammation preparation of treatment.
Preparation method: stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Borneolum Syntheticum in (1) prescription, that Margarita layer powder is ground into fine powder is standby;
(2) Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan adopt suitable method to extract according to separately characteristics in the prescription, and methods such as water is carried as adopting, water extract-alcohol precipitation, alcohol extraction, oil are carried, distillation are extracted.Or adopt each the effective elements of the medicine/effective component extracts to feed intake.
(3) adopt conventional method to make the preparation of various dosage forms, as tablet, capsule, suppository, lotion, ointment, gel, membrane, powder, pill, tampon etc.
The pharmacological evaluation of protecting month precious preparation shows, protects the external energy of month precious preparation and suppresses kill staphylococcus aureus, bacillus pyocyaneus, Candida albicans, escherichia coli, trichomonas vaginitis; Experimental rabbit mycotic and bacterial vaginitis that the internal energy remarkable inhibition of body is formed by Candida albicans and escherichia coli.Show that protecting a month precious preparation has effects such as significantly antibiotic, antiinflammatory.Protect a month treasured and be clinical effective proved recipe, being used for hundreds of examples such as vaginitis, cervicitis, cervical erosion all has significant curative effect, can fast and effeciently control gynecological inflammation, shortens the course of disease, has no adverse reaction after the medication, is worth clinical expansion to use.
Pharmacological experimental data:
1, in-vitro antibacterial experiment
Get the dilution bacterium liquid streak inoculation of cultivating 24 hours in the containing on the medicine plating medium of a series of concentration (draw with suction pipe the infusorian liquid of cultivating 48 hours is one after another drop of goes in the culture medium), do blank antibacterial contrast simultaneously, minimum inhibitory concentration (MIC) sees Table 1.
Table 1 in-vitro antibacterial experimental result
Annotate: "+" expression has bacteria growing
As can be known from the results, protect a month treasured above-mentioned antibacterial and infusorian are had strong vitro inhibition killing action.
2, to the influence of experimental colpitis mycotica due to the rabbit Candida albicans
Get 24 of female rabbit, be divided into 3 groups at random, 8 every group, earlier Candida albicans bacterium liquid 1.0ml/kg is splashed into rabbit vagina, infected transvaginal administration then through 24 hours, matched group is given sterile distilled water, continuous 7 days, puts to death animal, dissect, observe its gradient of infection, mark, no change is 0 minute, and it is 1 minute that vaginal mucosa has exudate, and it is 2 parts that vaginal mucosa has the limitation microabscess, being dispersed in property of vaginal mucosa microabscess is 3 parts, and it is 4 parts that erosion appears in vagina, the results are shown in Table 2.
The influence of table 2 pair rabbit experiment colpitis mycotica
| Group | Number of animals (only) | Gradient of infection (X ± s) | Suppression ratio (%) |
| The blank group | 8 | 3.62±0.52 | -- |
| Protect a month precious group (low) | 8 | 0.62±0.74 | 82.87 |
| Protect a month precious group (height) | 8 | 0.25±0.46 | 93.09 |
As can be known from the results, the acute festering type vaginitis appears in the blank group, alleviates significantly and protect a month precious group inflammation, with the blank group significant difference (P＜0.01) is arranged relatively.
3, to the influence of experimental bacterial vaginitis due to the rabbit escherichia coli
Get 24 of female rabbit, be divided into 3 groups at random, 8 every group, earlier the continuous cut of escherichia coli be inoculated in rabbit vagina, inoculation back the 3rd heaven-made vaginal secretions inspection, vagina has phenomenons such as hyperemia, edema, erosion, after the moulding success, and vagina administration, matched group is given sterile distilled water, continuous 7 days, put to death animal, dissect, observe its gradient of infection, mark, no change is 0 minute, and it is 1 minute that vaginal mucosa has exudate, it is 2 parts that vaginal mucosa has the limitation microabscess, being dispersed in property of vaginal mucosa microabscess is 3 parts, and it is 4 parts that erosion appears in vagina, the results are shown in Table 3.
The influence of table 2 pair rabbit experiment bacterial vaginitis
| Group | Number of animals (only) | Gradient of infection (X ± s) | Suppression ratio (%) |
| The blank group | 8 | 3.50±0.53 | -- |
| Protect a month precious group (low) | 8 | 0.62±0.52 | 82.29 |
| Protect a month precious group (height) | 8 | 0.38±0.52 | 89.14 |
As can be known from the results, protecting a month precious group has significant inhibition of inflammation, with the blank group significant difference (P＜0.01) is arranged relatively.Illustrate that protecting a month treasured has remarkable inhibitory action to the rabbit experiment bacterial vaginitis.
Clinical model case:
1, pay certain, the woman, 36 years old, symptom regard sb. as an outsider cloudy pruritus, causalgia, the leucorrhea stiff bean dregs sample that is white in color with frequent micturition, dysurea, can be found Candida albicans in the secretions.Treat with protecting a month precious vaginal tablet, every day 1 time, medication is after 6 days, clinical symptom disappearance, and leucorrhea is normal, and vaginal secretions is checked negative.
2, Zheng, the woman, 51 years old, the symptom cloudy pruritus of regarding sb. as an outsider, leucorrhea canescence water from washing rice sample, frowziness, the vaginal mucosa color is light red mild hyperaemia, and posterior fornix has canescence water from washing rice water sample cystose leucorrhea to gather, and detects infusorian in the secretions.Treat with protecting a month precious vaginal tablet, every day 1 time, medication is after 7 days, clinical symptom disappearance, and leucorrhea is normal, and vaginal secretions is checked negative.
The specific embodiment
Below in conjunction with specific embodiment month precious preparation that protects among the present invention is further described.
Embodiment 1
Protecting a month precious preparation is made by the following weight proportion raw material:
Proportioning 1: Cortex Phellodendri 250g, Radix Sophorae Flavescentis 250g, Herba Andrographis 100g, Radix Arnebiae (Radix Lithospermi) 250g, Rhizoma Curcumae 250g, Cortex Moutan 100g, stem and leaf of Radix Ginseng saponin 5g, catechu 20g, dried Alumen 20g, boric acid 10g, Borneolum Syntheticum 1g, Margarita layer powder 1g
Proportioning 2: Cortex Phellodendri 2500g, Radix Sophorae Flavescentis 2500g, Herba Andrographis 2500g, Radix Arnebiae (Radix Lithospermi) 2000g, Rhizoma Curcumae 2000g, Cortex Moutan 2000g, stem and leaf of Radix Ginseng saponin 100g, catechu 200g, dried Alumen 200g, boric acid 200g, Borneolum Syntheticum 100g, Margarita layer powder 100g
Proportioning 3: Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g, Herba Andrographis 500g, Radix Arnebiae (Radix Lithospermi) 300g, Rhizoma Curcumae 300g, Cortex Moutan 300g, stem and leaf of Radix Ginseng saponin 10g, catechu 30g, dried Alumen 30g, boric acid 30g, Borneolum Syntheticum 5g, Margarita layer powder 2g
Proportioning 4: Cortex Phellodendri 2000g, Radix Sophorae Flavescentis 2000g, Herba Andrographis 2000g, Radix Arnebiae (Radix Lithospermi) 1200g, Rhizoma Curcumae 1200g, Cortex Moutan 1200g, stem and leaf of Radix Ginseng saponin 50g, catechu 100g, dried Alumen 100g, boric acid 80g, Borneolum Syntheticum 50g, Margarita layer powder 20g
Proportioning 5: Cortex Phellodendri 1500g, Radix Sophorae Flavescentis 1500g, Herba Andrographis 1500g, Radix Arnebiae (Radix Lithospermi) 800g, Rhizoma Curcumae 800g, Cortex Moutan 800g, stem and leaf of Radix Ginseng saponin 25g, catechu 50g, dried Alumen 50g, boric acid 50g, Borneolum Syntheticum 10g, Margarita layer powder 5g
Preparation method 1 (vaginal tablet):
Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, that Margarita layer powder is ground into fine powder is standby; Cortex Moutan distillation extraction paeonol is standby; It is standby that Rhizoma Curcumae extracts volatile oil; Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi) are with 50% alcohol reflux secondary, and each 2 hours, extracting solution merged, reclaim ethanol, concentrate drying, pulverize, gained dried cream powder and above-mentioned fine powder and appropriate amount of auxiliary materials mixing are granulated drying, add Borneolum Syntheticum, paeonol, Oleum Curcumae, mixing is pressed into 1000, promptly.
Preparation method 2 (effervescent tablet):
Cortex Phellodendri, Radix Sophorae Flavescentis decoct with water twice, and each 2 hours, collecting decoction was concentrated in right amount, adds ethanol to 60%, leaves standstill 24 hours, and supernatant reclaims ethanol, and it is standby to be condensed into thick paste; Cortex Moutan distillation extraction paeonol is standby; It is standby that Rhizoma Curcumae extracts volatile oil; Herba Andrographis, Radix Arnebiae (Radix Lithospermi) are with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, was condensed into thick paste, with above-mentioned thick paste mixing, drying, pulverize, and gained dried cream powder and an amount of sodium bicarbonate mixing, it is standby to make the alkali granule; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Borneolum Syntheticum, Margarita layer powder are ground into fine powder, and with an amount of citric acid mixing, it is standby to make granulates; With above-mentioned alkali granule, granulates and Borneolum Syntheticum, paeonol, Oleum Curcumae mixing, be pressed into 1000 effervescent tablets.
Preparation method 3 (suppository):
Cortex Phellodendri, Radix Sophorae Flavescentis decoct with water twice, and each 2 hours, collecting decoction was concentrated in right amount, adds ethanol to 60%, leaves standstill 24 hours, and supernatant reclaims ethanol, and it is standby to be condensed into thick paste; Herba Andrographis is with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, and it is standby to be condensed into thick paste; The oil immersion of Radix Arnebiae (Radix Lithospermi) perfuming is carried standby; It is standby that Rhizoma Curcumae extracts volatile oil; It is standby that Cortex Moutan extracts paeonol; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; Other gets the suppository base heating and dissolves, and adds above-mentioned each spares, mixes, and makes 1000 suppositorys.
Preparation method 4 (capsule):
Get Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan and decoct with water twice, each 2 hours, collecting decoction was concentrated in right amount, adds ethanol to 65%, leaves standstill 24 hours, and supernatant reclaims ethanol, concentrate, and drying, it is standby to be ground into dried cream powder; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, Borneolum Syntheticum powder are broken into fine powder, with above-mentioned dried cream powder mixing, incapsulate, and make 1000 capsules.
Preparation method 5 (lotion):
Get Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan and decoct with water twice, each 2 hours, collecting decoction, be concentrated in right amount, add ethanol to 65%, left standstill 24 hours, supernatant reclaims ethanol, is concentrated in right amount, and adding stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, Borneolum Syntheticum and tween 80 are an amount of, stir evenly, the adding antiseptic is an amount of, adds water to requirement, stir evenly, filter, fill, promptly.
Preparation method 6 (membrane):
Get Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi) and use 70% ethanol percolate extraction, diacolation liquid recycling ethanol, it is standby to be concentrated into thick paste; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; It is standby that Rhizoma Curcumae extracts volatile oil; It is standby that Cortex Moutan extracts paeonol; It is water-soluble that other gets filmogen, adds above-mentioned each spares and appropriate amount of auxiliary materials, and heat de-airing is made membrane, promptly.
Preparation method 7 (ointment):
Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis are with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, and it is standby to be condensed into thick paste; The oil immersion of Radix Arnebiae (Radix Lithospermi) perfuming is carried standby; It is standby that Rhizoma Curcumae extracts volatile oil; It is standby that Cortex Moutan extracts paeonol; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; Other gets ointment base and adds above-mentioned each spares, and stirring stirs, and makes ointment, promptly.
Preparation method 8 (gel):
Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi) are with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, and it is standby to be condensed into thick paste; It is standby that Rhizoma Curcumae extracts volatile oil; It is standby that Cortex Moutan extracts paeonol; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; Other gets gel-type vehicle and adds above-mentioned each spares, and stirring stirs, and makes gel, promptly.
Preparation method 9 (powder):
Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae are with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, concentrate, and drying pulverizes that to make dried cream powder standby; It is standby that Cortex Moutan extracts paeonol; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; With the abundant mixing of above-mentioned each spares, promptly.
Preparation method 10 (pill):
Cortex Phellodendri, Radix Sophorae Flavescentis decoct with water twice, and each 2 hours, decocting liquid merged, and it is standby to be condensed into thick paste; Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae are with 75% alcohol reflux secondary, and each 1 hour, extracting solution merged, and reclaimed ethanol, was concentrated into thick paste, with above-mentioned thick paste mixing, drying, pulverize that to make dried cream powder standby; It is standby that Cortex Moutan extracts paeonol; Stem and leaf of Radix Ginseng saponin, catechu, dried Alumen, boric acid, Margarita layer powder, that Borneolum Syntheticum powder is broken into fine powder is standby; With the abundant mixing of above-mentioned each spares, make pill, promptly.
Embodiment 2
Protect the extract that Cortex Phellodendri in month precious preparation, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan can all or part of its effective ingredient of usefulness and feed intake, can feed intake by all or part of its effective ingredient of direct usefulness.Now describe (making 1000 unit formulations) for example.
Proportioning 1:
Berberine hydrochloride 45g, matrine 20g, andrographolide 15g, Radix Arnebiae extract 20g, Oleum Curcumae 12g, paeonol 10g, stem and leaf of Radix Ginseng saponin 25g, catechu 50g, dried Alumen 50g, boric acid 50g, Borneolum Syntheticum 10g, Margarita layer powder 5g
Proportioning 2:
Berberine hydrochloride 25g, matrine 10g, andrographolide 10g, Radix Arnebiae extract 10g, Oleum Curcumae 5g, paeonol 5g, stem and leaf of Radix Ginseng saponin 12g, catechu 25g, dried Alumen 25g, boric acid 25g, Borneolum Syntheticum 5g, Margarita layer powder 3g
Proportioning 3:
Berberine hydrochloride 100g, matrine 30g, andrographolide 25g, Radix Arnebiae extract 30g, Oleum Curcumae 20g, paeonol 20g, stem and leaf of Radix Ginseng saponin 50g, catechu 100g, dried Alumen 100g, boric acid 50g, Borneolum Syntheticum 20g, Margarita layer powder 10g
Adopt conventional method to make the preparation of various dosage forms, as lotion, suppository, capsule, tablet, ointment, gel, membrane, powder etc.
Claims (8)
1. one kind is protected a month precious preparation, it is characterized in that, make: Cortex Phellodendri 250-2500, Radix Sophorae Flavescentis 250-2500, Herba Andrographis 250-2500, Radix Arnebiae (Radix Lithospermi) 200-2000, Rhizoma Curcumae 200-2000, Cortex Moutan 200-2000, stem and leaf of Radix Ginseng saponin 1-100, catechu 20-200, dried Alumen 20-200, boric acid 10-100, Borneolum Syntheticum 1-100, Margarita layer powder 1-100 by the raw material of following weight parts.
2. month precious preparation that protects according to claim 1, it is characterized in that, make: Cortex Phellodendri 500-2000, Radix Sophorae Flavescentis 500-2000, Herba Andrographis 500-2000, Radix Arnebiae (Radix Lithospermi) 300-1200, Rhizoma Curcumae 300-1200, Cortex Moutan 300-1200, stem and leaf of Radix Ginseng saponin 10-50, catechu 30-100, dried Alumen 30-100, boric acid 30-80, Borneolum Syntheticum 5-50, Margarita layer powder 2-20 by the raw material of following weight parts.
3. month precious preparation that protects according to claim 1, it is characterized in that, make: Cortex Phellodendri 1500, Radix Sophorae Flavescentis 1500, Herba Andrographis 1500, Radix Arnebiae (Radix Lithospermi) 800, Rhizoma Curcumae 800, Cortex Moutan 800, stem and leaf of Radix Ginseng saponin 25, catechu 50, dried Alumen 50, boric acid 50, Borneolum Syntheticum 10, Margarita layer powder 5 by the raw material of following weight parts.
4. according to claim 1,2, the 3 described month precious preparations that protect, it is characterized in that, Cortex Phellodendri described in the prescription, Radix Sophorae Flavescentis, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae, Cortex Moutan can all or part of its effective ingredient of usefulness extract feed intake, can feed intake by all or part of its effective ingredient of direct usefulness.
5. according to claim 1,2, the 3 described month precious preparations that protect, it is characterized in that, Cortex Phellodendri can substitute with berberine hydrochloride in the prescription, Radix Sophorae Flavescentis can substitute with matrine, Herba Andrographis can substitute with andrographolide, Radix Arnebiae (Radix Lithospermi) can substitute with Oleum Radix Arnebiae (Oleum Radix Lithospermi)/Radix Arnebiae extract, and Rhizoma Curcumae can substitute with Oleum Curcumae, and Cortex Moutan can substitute with paeonol.
6. according to claim 1,2, the 3 described month precious preparations that protect, it is characterized in that available conventional method is made any dosage form.
7. according to claim 1,2, the 3 described month precious preparations of protecting, it is characterized in that, can be made into and comprise tablet, capsule, suppository, lotion, ointment, gel, membrane, powder, pill, tampon in interior any dosage form.
8. according to claim 1,2, the 3 described month precious preparations that protect, it is characterized in that the application in treatment gynecological inflammation and other inflammation preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008103021220A CN101288754B (en) | 2008-06-13 | 2008-06-13 | Huyuebao preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008103021220A CN101288754B (en) | 2008-06-13 | 2008-06-13 | Huyuebao preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101288754A true CN101288754A (en) | 2008-10-22 |
| CN101288754B CN101288754B (en) | 2011-04-20 |
Family
ID=40033313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008103021220A Active CN101288754B (en) | 2008-06-13 | 2008-06-13 | Huyuebao preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101288754B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579654A (en) * | 2012-03-26 | 2012-07-18 | 杨长辉 | Anti-bacteria medicine for protecting and cleaning human body vagina and preparation method thereof |
| CN103041283A (en) * | 2011-10-12 | 2013-04-17 | 薛晓鸥 | Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof |
| CN103393756A (en) * | 2010-06-30 | 2013-11-20 | 杨红宇 | Externally-applied hemorrhoid drug |
| EP2842543A1 (en) * | 2013-08-23 | 2015-03-04 | S & V Technologies GmbH | Composition with cooling effect for topical application |
| CN104721417A (en) * | 2013-12-24 | 2015-06-24 | 葵花药业集团（伊春）有限公司 | External-administration inflammation-diminishing pharmaceutical composition |
-
2008
- 2008-06-13 CN CN2008103021220A patent/CN101288754B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393756A (en) * | 2010-06-30 | 2013-11-20 | 杨红宇 | Externally-applied hemorrhoid drug |
| CN103041283A (en) * | 2011-10-12 | 2013-04-17 | 薛晓鸥 | Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof |
| CN103041283B (en) * | 2011-10-12 | 2014-10-22 | 薛晓鸥 | Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof |
| CN102579654A (en) * | 2012-03-26 | 2012-07-18 | 杨长辉 | Anti-bacteria medicine for protecting and cleaning human body vagina and preparation method thereof |
| EP2842543A1 (en) * | 2013-08-23 | 2015-03-04 | S & V Technologies GmbH | Composition with cooling effect for topical application |
| CN104721417A (en) * | 2013-12-24 | 2015-06-24 | 葵花药业集团（伊春）有限公司 | External-administration inflammation-diminishing pharmaceutical composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101288754B (en) | 2011-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103721131B (en) | A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease | |
| CN102145111B (en) | Traditional Chinese medicine composition for treating colpitis mycotica and preparation method thereof | |
| CN101049415A (en) | Preparation of Chinese traditional medicine for treating inflammation of department of gynecology | |
| CN102526441B (en) | Traditional Chinese medicine flushing liquor special for gynecological inflammation treatment | |
| CN102178814B (en) | Chinese medicinal composition for treating trichomonas vaginitis and preparation method thereof | |
| CN103800772A (en) | Gynecological external lotion for preventing and treating vagina inflammatory diseases and preparation method thereof | |
| CN101288754B (en) | Huyuebao preparation | |
| CN104721418B (en) | It is a kind of to be used to treat pharmaceutical composition of gynaecological imflammation and preparation method thereof and purposes | |
| CN101015578A (en) | Medicine for treating women's genital system disease | |
| CN101856475B (en) | Chinese medicinal composition for treating gynecological inflammation and preparation method thereof | |
| CN101391065B (en) | Compound momordica seed pepper soup for treating urgent chronic pelvic inflammatory disease | |
| CN103041247A (en) | Traditional Chinese medicine suppository for curing colpitis and preparation method thereof | |
| CN105477490A (en) | Pharmaceutical preparation for treating gynecological vulvae itching and application of pharmaceutical preparation | |
| CN102895610A (en) | Medicine for treating edema | |
| CN103768478B (en) | One is treated prostatitic Chinese medicine composition and its production and use | |
| CN103751532A (en) | Traditional Chinese medicine composition for treating gynecological inflammation and preparation method thereof | |
| CN100348241C (en) | Medicine for treating chronic prostatitis and its preparation method | |
| CN103070995A (en) | Traditional Chinese medicine for curing prostatitis | |
| CN102526620A (en) | Traditional Chinese medicinal composition for treating gynecological inflammation and application of same | |
| CN103263614B (en) | Pharmaceutical composition for preventing or treating vaginitis | |
| CN102743686B (en) | The scorching clearing capsule of a kind of basin | |
| CN101322771A (en) | Capsules for treating gynecology inflammation | |
| CN1970020B (en) | A pharmaceutical composition, preparation process and application thereof | |
| CN103550510A (en) | Lotion for treating various vaginitis | |
| CN104887906A (en) | Bitch pyometra treatment traditional Chinese tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIANGXI HANHE BIOLOGICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: MAO XIAOMIN Effective date: 20150902 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150902 Address after: 330069 high tech Industrial Development Zone, Jiangxi, Nanchang high tech Road, D group Patentee after: Jiangxi harworld Biotechnology Co.,Ltd. Address before: 330006 Jiangxi province Nanchang City Road Garden residential district Magi Magi 34 building 3 unit 301 room Patentee before: Mao Xiaomin |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20170420 Address after: 510000 Guangdong province Guangzhou Science City skim Springs Road No. 3, Guangzhou International Business Incubator in A District of Guangzhou maxspace moon people office Card No. 14 Patentee after: GUANGZHOU OUR MU BIOLOGICAL TECHNOLOGY CO.,LTD. Address before: 330069 high tech Industrial Development Zone, Jiangxi, Nanchang high tech Road, D group Patentee before: Jiangxi harworld Biotechnology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CP03 | Change of name, title or address |
Address after: 510700 Room 401, 402, 404, 406 and 408, building 1, No. 10, Keke Road, Huangpu District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU DREAM BIO-TECH Co.,Ltd. Address before: 510000 Guangzhou Science City, Guangzhou City, Guangdong Province, No. 3 Zhuquan Road, Guangzhou International Business Incubator Area A, Guangzhou Luyue Ren Chuangke Space Office Card No. 14 Patentee before: GUANGZHOU OUR MU BIOLOGICAL TECHNOLOGY CO.,LTD. |
|
| CP03 | Change of name, title or address | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211216 Address after: 511458 room 1501, No. 18, Jinmao East 1st Street, Nansha District, Guangzhou City, Guangdong Province (Location: c036) (office only) Patentee after: Guangdong qiaocraftsman new drug research Co.,Ltd. Address before: 510700 Room 401, 402, 404, 406 and 408, building 1, No. 10, Keke Road, Huangpu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU DREAM BIO-TECH Co.,Ltd. |
|
| TR01 | Transfer of patent right |