CN100384447C - Medicine for treating gynecopathy and its preparing method - Google Patents
Medicine for treating gynecopathy and its preparing method Download PDFInfo
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Abstract
The present invention relates to medicine for treating gynecological diseases and a preparation method of the medicine. Bacterial vaginitis, trichomonal vaginitis and colpomycosis are gynecological common diseases; according to the relevant report, 'the morbidity of the gynecological common diseases occupies 10% to 23% of all women at present, ' which seriously damages the physical and mental health of women. The existing medicines for treating the gynecological common diseases, such as metronidazole, clindamycin, ampicillin, etc., have obvious action of killing bacteria and insect pests, but have certain side effect or toxicity; moreover, the recurrence rate is high after the medicines are not supplied. The present invention provided the medicine which is prepared from raw materials, such as Chinese gall, wild chrysanthemum, phellodendron, pomegranate rind, common cnidium fruit, red peony root, dried alum, borneol, sodium bicarbonate and citric acid. The medicine of the present invention has the advantages of no toxic or side effect, convenient use, obvious effect, strong action of killing pathogens, low recurrence rate after diseases are healed, unique formula and unique efficiency; the medicine of the present invention not only has the efficiency of clearing heat, removing moisture, killing insect pests and relieving itching, but also has the efficiency of dissipating blood stasis, eliminating swelling and alleviating pain.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of gynaecopathia and preparation method thereof.
Background technology
Bacillary, infusorian property, colpitis mycotica are the inflammation that connective tissue causes under cause of disease infringement vaginal mucosa by direct or indirect contact infection and the mucosa, are common gynecological diseases.Because the management of extensive use of antibiotic, immunosuppressant in recent years and public place, sterilization are not tight, make the sickness rate of above-mentioned vagina increase to some extent.According to relevant: " the present sickness rate of such disease accounts for women crowd's 10%-23%.In the morbidity crowd, bacterial vaginitis accounts for 41%, and trichomonal vaginitis accounts for 24%, and colpitis mycotica accounts for 27%." this is seriously endangering women's physical and mental health, so it is significant to be devoted to treat the research of above-mentioned disease.
" bacterial vaginitis is because ability of Lactobacillus in human vagina reduces, and other antibacterial breeds in a large number, mainly contains Gartner Salmonella, Streptococcus lactis (Lister) Lohnis 1909.554., escherichia coli, Bacillus proteus, reaches the mixed infection that mycoplasma causes." modern medicine is treated it, mainly is metronidazole for oral administration, Clindamicin, ampicillin, and is local with metronidazole, JIEERYIN XIYE." trichomonal vaginitis per vaginam trichomonacide causes, the propagated infectious disease of attribute, and trichomonal vaginitis can consume the vagina epithelium glycogen, makes vaginal wall acidity reduce the easier breeding of infusorian." modern medicine treats it; mainly make metronidazole for oral administration, piperanitrozole, tinidazole; local with ace-tarsoni, carbarsone, hachimycin, metronidazole, at the low acid environment of vagina, with 0.5% acetate solution, 10% lactate buffer solution, washing vagina as complementary therapy." colpitis mycotica is because the intravaginal glycogen of intravaginal dysbacteriosis or diabetes, pregnancy women increases, and ability of Lactobacillus in human vagina is suppressed, and mycete (mainly being Candida albicans) is easy to growth and breeding, causes a disease." modern medicine is treated it, mainly is nystatin for oral administration, ketoconazole, clotrimazole, econazole, hachimycin, imidazole, fluconazol, itraconazole use 2-4% soda solution washing vagina as complementary therapy at the high acid environment of vagina.
Above-mentioned at pathogenic former medicine, its effect of killing bacterium, worm is comparatively remarkable, but certain side effect or toxicity are arranged, and relapse rate is higher after the drug withdrawal.As metronidazole, Clindamicin, ammonia benzyl mycin, piperanitrozole, tinidazole, ace-tarsoni, carbarsone, hachimycin, nystatin, side effect such as that ketoconazole, clotrimazole, econazole, imidazole, fluconazol, itraconazole all have is nauseating, diarrhoea, erythra.Dizzy, insomnia that metronidazole can also cause, idol has leukopenia, or nervus centralis poisoning symptom (as movement disorder)." miconazole class medicine also has certain infringement to liver, renal function.”
Chinese medicine is according to its unique theoretical system and drug resource, and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs female vagina is being brought into play important effect always.The critical treatment female vagina is not only evident in efficacy, and non-evident effect.Yet traditional Chinese traditional treatment mainly is with the oral or demibain of Chinese medicine decoction, flushing, and is very inconvenient when the patient uses.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of gynaecopathia and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of medicine for the treatment of gynaecopathia, it is the medicament that is prepared into by the following weight proportion raw material:
72～88 parts of 90～110 portions of Cortex Phellodendris of 180～220 parts of Flos Chrysanthemi Indicis of Galla Chinensis
16.2～19.8 parts of 36～44 parts of Radix Paeoniae Rubra of 45～55 parts of Fructus Cnidiis of Pericarpium Granati
67.5～82.5 parts of 1.8～2.2 parts of sodium bicarbonate of 9～11 parts of Borneolum Syntheticums of dried Alumen
81～99 parts of citric acid
Above-mentioned a kind of medicine for the treatment of gynaecopathia, wherein the weight proportion of each raw material is:
76～84 parts of 95～105 portions of Cortex Phellodendris of 190～210 parts of Flos Chrysanthemi Indicis of Galla Chinensis
17.1～18.9 parts of 38～42 parts of Radix Paeoniae Rubra of 47.5～52.5 parts of Fructus Cnidiis of Pericarpium Granati
71.25～78.75 parts of 1.9～2.1 parts of sodium bicarbonate of 9.5～10.5 parts of Borneolum Syntheticums of dried Alumen
81～99 parts of citric acid
Above-mentioned a kind of medicine for the treatment of gynaecopathia, wherein the weight proportion of each raw material is:
80 parts of 100 portions of Cortex Phellodendris of 200 parts of Flos Chrysanthemi Indicis of Galla Chinensis
18 parts of 40 parts of Radix Paeoniae Rubra of 50 parts of Fructus Cnidiis of Pericarpium Granati
75 parts of 2 parts of sodium bicarbonate of 10 parts of Borneolum Syntheticums of dried Alumen
90 parts of citric acid
Above-mentioned a kind of medicine for the treatment of gynaecopathia, its dosage form are that the processing step of preparation method of effervescent tablet is as follows:
A. concoct
Galla Chinensis: get crude drug, knock open, remove the debug dirt, impurity is smashed to pieces;
Cortex Phellodendri: remove impurity, the spray clear water runs through shredding, drying;
Pericarpium Granati: remove impurity, remove clean residual interior flesh and seed, smash to pieces after the cleaning, drying;
Radix Paeoniae Rubra: remove impurity, separately size is cleaned, and runs through shave, drying;
Dried Alumen: get clean Alumen, put the marmite internal heating and dissolve, take out, smash to pieces to the cellular blocks of solid of whole formation;
Citric acid: 70-75 ℃ of drying and dehydrating 24 hours, standby with preceding;
All the other each flavors clean standby;
B. pulverize
Alumen powder is broken into fine powder, crosses 100 mesh sieves, and is standby;
Borneolum Syntheticum is pulverized, and crosses 60 mesh sieves, and is standby;
All the other medicated powder of respectively distinguishing the flavor of are broken into the Semen Glycines bulky grain, and are standby;
C. extract, separate with concentrated
(1) gets the Fructus Cnidii medical material and put in the multi-function extractor, add 8 times of 95% alcohol dipping 2 hours, the hot reflux secondary, each 2 hours, filter, medicinal residues stay does decocting use, alcohol extract decompression recycling ethanol, evaporating temperature 50-60 ℃, vacuum 0.08-0.09MPa, heating steam pressure are 0.05-0.09MPa, get the alcohol extract thick paste, yield is about 9.5%, and is standby;
(2) medicinal residues of getting after Flos Chrysanthemi Indici, Cortex Phellodendri medical material and the Fructus Cnidii alcohol extraction are fried in shallow oil three times altogether, and amount of water is respectively 10,8,8 times of medical material, and the time respectively is 1.5 hours.Decoction liquor filters the back and merges, concentrating under reduced pressure, and vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, and heating steam pressure is 0.05-0.08Mpa, and becoming relative density is the thick paste of 1.30-1.35, and it is at 60 ℃, and heat is surveyed down, yield about 25%;
(3) get Galla Chinensis, Pericarpium Granati, Radix Paeoniae Rubra decocting secondary, 2 hours for the first time, 1.5 hours for the second time, amount of water is respectively 10,8 times, after decoction liquor filters, merge concentrating under reduced pressure, vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, heating steam pressure is 0.05-0.08Mpa, and becoming relative density is the thick paste of 1.30-1.35, and it is at 60 ℃, heat is surveyed down, yield about 40%;
D. dry
(1) two thick pastes with (1), (2) gained among the step C mix, and add dry starch in 1: 1 ratio and mix thoroughly, and 60-70 ℃, heating steam pressure is 0.03MPa, vacuum 0.06-0.08Mpa, vacuum drying;
(2) with the thick paste 60-70 ℃ vacuum drying of (3) among a step C gained, heating steam pressure is 0.03MPa, vacuum 0.06-0.08MPa;
E. granulate
(1) dried cream powder with (1) among step D gained is broken into fine powder, crosses 100 mesh sieves, with sodium bicarbonate, and the dried Alumen fine powder, the appropriate amount of starch mixing is mixed thoroughly, with 50% ethanol moistening, makes soft material, and 18 mesh sieves are granulated, 60-65 ℃ of oven dry, standby behind the granulate, this pellet moisture should not be higher than 2%;
(2) dried cream powder with (2) among step D gained is broken into fine powder, crosses 100 mesh sieves, with 95% ethanol moistening, makes soft material, and 18 mesh sieves are granulated, 60-65 ℃ of oven dry, and standby behind the granulate, pellet moisture is not higher than 2%:
(3) citric acid after the dehydration is directly pulverized granulation, crosses 20 mesh sieves, gets final product;
F. three kinds of granules with the step e gained mix, and add Borneolum Syntheticum powder and an amount of Pulvis Talci, mix thoroughly, are pressed into special-shaped tablets, single dose plastic-aluminum cover blister package, promptly.
Medicine of the present invention is with respect to prior art, and its advantage is as follows:
1, have no side effect, easy to use;
2, rapid-action, general 24 hours take effect with interior, improve and to eliminate the symptom effect remarkable;
3, it is stronger to kill the former effect of causing a disease, and the relapse rate after curing is lower;
4, prescription uniqueness, the effect uniqueness possesses double effects, can removing damp-heat, killing parasites for relieving itching, again can the dissipating blood stasis for subsidence of swelling pain relieving.
The specific embodiment
The present invention is a kind of medicine for the treatment of gynaecopathia, and it is by Galla Chinensis, Flos Chrysanthemi Indici, and Cortex Phellodendri, Pericarpium Granati, Fructus Cnidii, Radix Paeoniae Rubra, dried Alumen, Borneolum Syntheticum, sodium bicarbonate, citric acid constitutes,
Main pharmacodynamics of the present invention can be reached a conclusion by following experiment:
One, the present invention is to the killing in vitro and the inhibitory action of trichomonal vaginitis
Set up experiment infusorian matched group (negative control), JIEERYIN XIYE matched group (positive control) and 12.5%, 25.0%, 50.0%, 100% 4 concentration solution experiments group in the experimentation.
Experimental result sees Table 1
Table 1 the present invention is to the average eradicative rate (%) of trichomonal vaginitis
By table 1 as seen, the present invention is external has significant killing action to pathogenic trichomonal vaginitis.The concentration of its minimum infusorian of effectively going out is: 12.5% (15min); The shortest time of killing infusorian is 5min (100% concentration).This medicine obviously is better than JIEERYIN in the effect of killing in vitro trichomonal vaginitis.
Two, the experimental result of the present invention's mice subcutaneous abscess model effect that trichomonal vaginitis is caused
After animal was weighed, normal control group and model control group normal saline, experimental group were used the solution of the present invention of 12.5%, 25.0%, 50.0% 3 concentration respectively, the positive controls JIEERYIN XIYE, smear inoculation position skin, every day twice, successive administration 7 days.Experimental result sees Table 2 and table 3.
Table 2 the present invention is to the unit that influences of experiment mice body weight: g (X ± S)
Table 3 the present invention is to the influence of model mice subcutaneous abscess
Under the normal raising condition, all animal body weight averages increase gradually, and with after the administration of the present invention, the increase of body weight seemingly has the trend that slows down.The present invention is inhibited in the mice subcutaneous abscess that trichomonal vaginitis is caused, during its administration concentration 12.5%, the abscess of all laboratory animals is disappeared, but along with the increase of dosage, its inhibitory action to abscess weakens.Experimental result confirms that also the inhibition of the mice subcutaneous abscess that solution of the present invention causes trichomonal vaginitis is all obvious than JIEERYIN.
Three, the present invention's rabbit experiment bacterial vaginitis effect experimental result that mixed cell is caused
After animal was weighed, normal control group and model control group normal saline, experimental group were used five times of solution of the present invention of 12.5%, 25.0%, 50.0% 3 concentration respectively, the positive controls JIEERYIN XIYE, lavation laboratory animal vagina, every day twice, successive administration 7 days.Experimental result sees Table 4 and table 5.
Table 4 the present invention is to the unit that influences of experimental rabbit body weight: kg
Table 5 the present invention is to the therapeutical effect of rabbit bacterial vaginitis
Under the normal raising condition, the rabbit body weight increases gradually, and behind the bacterial infection, body weight obviously descends, and with after the Drug therapy of the present invention, body weight all begins to increase, and JIEERYIN group body weight does not increase.By the treatment experiment confirm, medicine of the present invention has the obvious treatment effect to the rabbit bacterial vaginitis, its administration concentration promptly had the obvious treatment effect at 12.5% o'clock, can see significantly that by the pathological examination result its restitution to bacterial infection is better than JIEERYIN.
Four, the experiment of the present invention's rabbit experiment colpitis mycotica therapeutical effect that Candida albicans is caused
After animal was weighed, normal control group and model control group normal saline, experimental group were used the solution of the present invention of 12.5%, 25.0%, 50.0% 3 concentration respectively, the positive controls JIEERYIN XIYE, lavation laboratory animal vagina, every day twice, successive administration 7 days.Experimental result sees Table 6 and table 7.
Table 6 the present invention is to the unit that influences of experimental rabbit body weight: kg
Table 7 the present invention is to the therapeutical effect of rabbit colpitis mycotica
Under the normal raising condition, except that normal control group rabbit body weight increased gradually, behind the infection Candida albicans, body weight slightly descended, and with after the Drug therapy of the present invention, body weight all continues to reduce.By the treatment experiment confirm, medicine of the present invention has the obvious treatment effect to the rabbit colpitis mycotica, its administration concentration promptly had the obvious treatment effect at 12.5% o'clock, can see significantly that by the pathological examination result its restitution to fungal infection is better than JIEERYIN.
Other drug effects of the present invention also can draw by experiment to draw a conclusion:
The rat paw edema that on Carrageenan of the present invention, Ovum Gallus domesticus album cause has antagonism, can alleviate the mice auricle swelling that dimethylbenzene causes, can alleviate rat agar granuloma weight, and showing has antiinflammatory action; Mice there is analgesic activity with the evidence that hot plate method and writhing method carry out; Have and improve the Cavia porcellus itch-threshold effect that histamine phosphate causes, showing has itching-relieving action; Can significantly expand the effect of mice arteriole caliber, show the effect that microcirculation improvement is arranged.
The present invention has also carried out long-term toxicity test for animals, does not see that outward appearance, body weight gain appear in animal, and the toxicity of hemogram, liver, renal function and 17 kinds of organs and tissues changes, and drug withdrawal recovers not see in 3 weeks that delayed toxicity takes place; Carried out animal acute toxicity test, the animals administer amount is equivalent to Coming-of-Age Day 180 times with dosage, does not cause animal dead; Carried out the local skin irritant test, breakage all has no stimulation to the Cavia porcellus complete sum; Carried out skin anaphylactic test, do not seen that skin has anaphylaxis.
For showing that medicine of the present invention to colpitic therapeutic effect, the invention provides the data of one group of clinical test results.Year November in October, 1999 to 1999, by the clinical staff of Shaanxi Chinese medicine academy Affiliated Hospital, (product batch number: 19990824) 50 examples (30 days courses of treatment) clinical preliminary test has been carried out in the curative effect and the safety that belong to traditional Chinese medical science syndrome of dampness-heat diffusing downward of bacillary, the infusorian property of treatment, colpitis mycotica to the effervescent tablet of the present invention of centering trial production.Result: bacterial vaginitis (14 example) recovery from illness 9 examples, produce effects 2 examples, effective 2 examples, invalid 1 example, trichomonal vaginitis (18 example) recovery from illness 5 examples, produce effects 7 examples, effective 5 examples, invalid 1 example, colpitis mycotica (18 example) recovery from illness 8 examples, produce effects 6 examples, effective 4 examples, invalid 0 example.Total obvious effective rate 74%, total effective rate 96%.Trial test is the result show: this medical instrument has rapid-action (in general 24 hours), improvement and elimination symptom effect are remarkable, it is stronger to kill the former effect of causing a disease, and lower (trichomonal vaginitis 1 example that clinical cure is only arranged of relapse rate after curing, 3 menstrual cycle are followed up a case by regular visits to after the drug withdrawal, recurrence is arranged, so the produce effects of being judged to be).
Embodiment 1:
The invention provides a kind of medicine for the treatment of gynaecopathia, the weight proportion of its each raw material is:
Galla Chinensis 200g Flos Chrysanthemi Indici 100g Cortex Phellodendri 80g
Pericarpium Granati 50g Fructus Cnidii 40g Radix Paeoniae Rubra 18g
Dried Alumen 10g Borneolum Syntheticum 2g sodium bicarbonate 75g
Citric acid 90g
The processing step of the preparation method of its effervescent tablet is as follows:
A. concoct
Galla Chinensis: get crude drug, knock open, remove the debug dirt, impurity is smashed to pieces;
Cortex Phellodendri: remove impurity, the spray clear water runs through shredding, drying;
Pericarpium Granati: remove impurity, remove clean residual interior flesh and seed, smash to pieces after the cleaning, drying;
Radix Paeoniae Rubra: remove impurity, separately size is cleaned, and runs through shave, drying;
Dried Alumen: get clean Alumen, put the marmite internal heating and dissolve, take out, smash to pieces to the cellular blocks of solid of whole formation;
Citric acid: 70-75 ℃ of drying and dehydrating 24 hours, standby with preceding;
All the other each flavors clean standby.
B. pulverize
Alumen powder is broken into fine powder, crosses 100 mesh sieves, and is standby;
Borneolum Syntheticum is pulverized, and crosses 60 mesh sieves, and is standby;
All the other medicated powder of respectively distinguishing the flavor of are broken into the Semen Glycines bulky grain, and are standby.
C. extract, separate with concentrated
(1) getting the Fructus Cnidii medical material puts in the multi-function extractor, add 8 times of 95% alcohol dipping 2 hours, hot reflux secondary, each 2 hours, filter, medicinal residues stay does decocting use, alcohol extract decompression recycling ethanol, evaporating temperature 50-60 ℃, vacuum 0.08-0.09MPa, heating steam pressure is 0.05-0.09MPa, gets alcohol extract thick paste (yield about 9.5%), and is standby;
(2) medicinal residues of getting after Flos Chrysanthemi Indici, Cortex Phellodendri medical material and the Fructus Cnidii alcohol extraction are fried in shallow oil three times altogether, and amount of water is respectively 10,8,8 times of medical material, and the time respectively is 1.5 hours.Decoction liquor filters the back and merges, and concentrating under reduced pressure (vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, heating steam pressure is 0.05-0.08MPa) one-tenths relative density is the thick paste (yield about 25%) of 1.30-1.35 (60 ℃, the heat survey);
(3) get Galla Chinensis, Pericarpium Granati, Radix Paeoniae Rubra decocting secondary, 2 hours for the first time, 1.5 hours for the second time, amount of water is respectively 10,8 times, after decoction liquor filters, and the merging concentrating under reduced pressure (vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, heating steam pressure is 0.05-0.08MPa) the one-tenth relative density is the thick paste (yield about 40%) of 1.30-1.35 (60 ℃, heat survey);
D. dry
(1) two thick pastes with (1), (2) gained among the step C mix, and add dry starch in 1: 1 ratio and mix 60-70 ℃ of (heating steam pressure is 0.03MPa, vacuum 0.06-0.08MPa) vacuum drying thoroughly;
(2) with the thick paste 60-70 ℃ vacuum drying (heating steam pressure is 0.03MPa, vacuum 0.06-0.08MPa) of (3) gained among the step C.
E. granulate
(1) dried cream powder with (1) among step D gained is broken into fine powder (crossing 100 mesh sieves) and sodium bicarbonate, the dried Alumen fine powder, and the appropriate amount of starch mixing is mixed thoroughly, with 50% ethanol moistening, make soft material, 18 mesh sieves are granulated, 60-65 ℃ of oven dry, standby behind the granulate, this pellet moisture should not be higher than 2%;
(2) dried cream powder with (2) among step D gained is broken into fine powder (crossing 100 mesh sieves), with 95% ethanol moistening, makes soft material, and 18 mesh sieves are granulated, 60-65 ℃ of oven dry, and standby behind the granulate, pellet moisture is not higher than 2%.
(3) citric acid after the dehydration is directly pulverized granulation, crosses 20 mesh sieves, gets final product.
F. three kinds of granules with the step e gained mix, and add Borneolum Syntheticum powder and an amount of Pulvis Talci, mix thoroughly, are pressed into special-shaped tablets, and single dose plastic-aluminum cover blister package get final product.
Using method:
External behind the clean vagina, is sent 2 tablets of medicines into the vagina deep, and is clogged vaginal orifice with aseptic cotton balls before sleeping every day 1 time, in case the medicinal liquid outflow affects the treatment and pollution clothes.
Embodiment 2:
The invention provides a kind of medicine for the treatment of gynaecopathia, the weight proportion of its each raw material is:
Galla Chinensis 180g Flos Chrysanthemi Indici 90g Cortex Phellodendri 72g
Pericarpium Granati 45g Fructus Cnidii 36g Radix Paeoniae Rubra 16.2g
Dried Alumen 9g Borneolum Syntheticum 1.8g sodium bicarbonate 67.5g
Citric acid 81g
Its preparation method is identical with embodiment 1;
Embodiment 3:
The invention provides a kind of medicine for the treatment of gynaecopathia, the weight proportion of its each raw material is:
Galla Chinensis 220g Flos Chrysanthemi Indici 110g Cortex Phellodendri 88g
Pericarpium Granati 55g Fructus Cnidii 44g Radix Paeoniae Rubra 19.8g
Dried Alumen 11g Borneolum Syntheticum 2.2g sodium bicarbonate 82.5g
Citric acid 99g
Its preparation method is identical with embodiment 1.
Claims (3)
1. treat medicine for gynecopathy for one kind, it is characterized in that: it is according to the following raw materials by weight proportions proportioning:
72～88 parts of 90～110 portions of Cortex Phellodendris of 180～220 parts of Flos Chrysanthemi Indicis of Galla Chinensis
16.2～19.8 parts of 36～44 parts of Radix Paeoniae Rubra of 45～55 parts of Fructus Cnidiis of Pericarpium Granati
67.5～82.5 parts of 1.8～2.2 parts of sodium bicarbonate of 9～11 parts of Borneolum Syntheticums of dried Alumen
81～99 parts of citric acid;
Its pharmaceutical dosage form is that the processing step of preparation method of effervescent tablet is as follows:
A. concoct
Galla Chinensis: get crude drug, knock open, remove the debug dirt, impurity is smashed to pieces;
Cortex Phellodendri: remove impurity, the spray clear water runs through shredding, drying;
Pericarpium Granati: remove impurity, remove clean residual interior flesh and seed, smash to pieces after the cleaning, drying;
Radix Paeoniae Rubra: remove impurity, separately size is cleaned, and runs through shave, drying;
Dried Alumen: get clean Alumen, put the marmite internal heating and dissolve, take out, smash to pieces to the cellular blocks of solid of whole formation;
Citric acid: 70-75 ℃ of drying and dehydrating 24 hours, standby with preceding;
All the other each flavors clean standby;
B. pulverize
Alumen powder is broken into fine powder, crosses 100 mesh sieves, and is standby;
Borneolum Syntheticum is pulverized, and crosses 60 mesh sieves, and is standby;
All the other medicated powder of respectively distinguishing the flavor of are broken into the Semen Glycines bulky grain, and are standby;
C. extract, separate with concentrated
(1) gets the Fructus Cnidii medical material and put in the multi-function extractor, add 8 times of 95% alcohol dipping 2 hours, the hot reflux secondary, each 2 hours, filter, medicinal residues stay does decocting use, alcohol extract decompression recycling ethanol, evaporating temperature 50-60 ℃, vacuum 0.08-0.09MPa, heating steam pressure are 0.05-0.09MPa, get the alcohol extract thick paste, yield is about 9.5%, and is standby;
(2) medicinal residues of getting after Flos Chrysanthemi Indici, Cortex Phellodendri medical material and the Fructus Cnidii alcohol extraction are fried in shallow oil three times altogether, and amount of water is respectively 10,8,8 times of medical material, and the time respectively is 1.5 hours; Decoction liquor filters the back and merges, concentrating under reduced pressure, and vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, and heating steam pressure is 0.05-0.08Mpa, and becoming relative density is the thick paste of 1.30-1.35, and it is at 60 ℃, and heat is surveyed down, yield about 25%;
(3) get Galla Chinensis, Pericarpium Granati, Radix Paeoniae Rubra decocting secondary, 2 hours for the first time, 1.5 hours for the second time, amount of water is respectively 10,8 times, after decoction liquor filters, merge concentrating under reduced pressure, vacuum 0.06-0.08MPa, evaporating temperature is 60-70 ℃, heating steam pressure is 0.05-0.08Mpa, and becoming relative density is the thick paste of 1.30-1.35, and it is at 60 ℃, heat is surveyed down, yield about 40%;
D. dry
(1) two thick pastes with (1), (2) gained among the step C mix, and add dry starch in 1: 1 ratio and mix thoroughly, and 60-70 ℃, heating steam pressure is 0.03MPa, vacuum 0.06-0.08Mpa, vacuum drying;
(2) with the thick paste 60-70 ℃ vacuum drying of (3) among a step C gained, heating steam pressure is 0.03MPa, vacuum 0.06-0.08MPa;
E. granulate
(1) dried cream powder with (1) among step D gained is broken into fine powder, crosses 100 mesh sieves, with sodium bicarbonate, and the dried Alumen fine powder, the appropriate amount of starch mixing is mixed thoroughly, with 50% ethanol moistening, makes soft material, and 18 mesh sieves are granulated, 60-65 ℃ of oven dry, standby behind the granulate, this pellet moisture should not be higher than 2%;
(2) dried cream powder with (2) among step D gained is broken into fine powder, crosses 100 mesh sieves, with 95% ethanol moistening, makes soft material, and 18 mesh sieves are granulated, 60-65 ℃ of oven dry, and standby behind the granulate, pellet moisture is not higher than 2%;
(3) citric acid after the dehydration is directly pulverized granulation, crosses 20 mesh sieves, gets final product;
F. three kinds of granules with the step e gained mix, and add Borneolum Syntheticum powder and an amount of Pulvis Talci, mix thoroughly, are pressed into special-shaped tablets, single dose plastic-aluminum cover blister package, promptly.
2. a kind of medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that wherein the weight proportion of each crude drug is:
76～84 parts of 95～105 portions of Cortex Phellodendris of 190～210 parts of Flos Chrysanthemi Indicis of Galla Chinensis
17.1～18.9 parts of 38～42 parts of Radix Paeoniae Rubra of 47.5～52.5 parts of Fructus Cnidiis of Pericarpium Granati
71.25～78.75 parts of 1.9～2.1 parts of sodium bicarbonate of 9.5～10.5 parts of Borneolum Syntheticums of dried Alumen
81～99 parts of citric acid.
3. a kind of medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that wherein the weight proportion of each crude drug is:
80 parts of 100 portions of Cortex Phellodendris of 200 parts of Flos Chrysanthemi Indicis of Galla Chinensis
18 parts of 40 parts of Radix Paeoniae Rubra of 50 parts of Fructus Cnidiis of Pericarpium Granati
75 parts of 2 parts of sodium bicarbonate of 10 parts of Borneolum Syntheticums of dried Alumen
90 parts of citric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100419383A CN100384447C (en) | 2006-03-15 | 2006-03-15 | Medicine for treating gynecopathy and its preparing method |
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| CN102861116B (en) * | 2012-10-18 | 2015-02-25 | 中国科学院新疆理化技术研究所 | Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1097604A (en) * | 1993-07-21 | 1995-01-25 | 黄勇 | Fumigating and washing hemorrhoid curing powder and preparation method thereof |
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| CN1097604A (en) * | 1993-07-21 | 1995-01-25 | 黄勇 | Fumigating and washing hemorrhoid curing powder and preparation method thereof |
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