CN102459347A - 双重可变结构域免疫球蛋白及其用途 - Google Patents

双重可变结构域免疫球蛋白及其用途 Download PDF

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Publication number
CN102459347A
CN102459347A CN2010800293337A CN201080029333A CN102459347A CN 102459347 A CN102459347 A CN 102459347A CN 2010800293337 A CN2010800293337 A CN 2010800293337A CN 201080029333 A CN201080029333 A CN 201080029333A CN 102459347 A CN102459347 A CN 102459347A
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seq
binding
antigen
antibody
amino acid
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Chinese (zh)
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T.哈于尔
J.刘
G.A.金斯伯里
E.B.雷利
S.E.摩根-拉普
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AbbVie Inc
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Abbott GmbH and Co KG
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CN2010800293337A 2009-05-01 2010-04-30 双重可变结构域免疫球蛋白及其用途 Pending CN102459347A (zh)

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Application Number Priority Date Filing Date Title
US17471109P 2009-05-01 2009-05-01
US61/174711 2009-05-01
PCT/US2010/033231 WO2010127284A2 (en) 2009-05-01 2010-04-30 Dual variable domain immunoglobulins and uses thereof

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CN102459347A true CN102459347A (zh) 2012-05-16

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US (3) US20110263827A1 (https=)
EP (1) EP2425010A4 (https=)
JP (1) JP2012525155A (https=)
KR (1) KR20120044294A (https=)
CN (1) CN102459347A (https=)
AR (1) AR076508A1 (https=)
AU (1) AU2010242830C1 (https=)
BR (1) BRPI1012193A2 (https=)
CA (1) CA2760213A1 (https=)
CL (1) CL2011002702A1 (https=)
CO (1) CO6470824A2 (https=)
CR (1) CR20110631A (https=)
DO (1) DOP2011000333A (https=)
EC (1) ECSP11011496A (https=)
IL (1) IL215928A0 (https=)
MX (1) MX2011011669A (https=)
NZ (1) NZ596711A (https=)
PE (1) PE20120813A1 (https=)
RU (1) RU2011148913A (https=)
SG (2) SG175427A1 (https=)
TW (1) TW201042040A (https=)
UY (1) UY32603A (https=)
WO (1) WO2010127284A2 (https=)
ZA (1) ZA201108704B (https=)

Cited By (3)

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CN105209076A (zh) * 2013-03-15 2015-12-30 阿布维公司 抗体药物偶联物(adc)纯化
CN113234165A (zh) * 2021-05-07 2021-08-10 暨南大学 EpCAM的改造的结合蛋白及其应用
CN113354715A (zh) * 2021-05-07 2021-09-07 暨南大学 Egfr的改造的结合蛋白及其应用

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CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
BRPI0910482A2 (pt) 2008-04-29 2019-09-24 Abbott Lab imunoglobinas de domínio variável duplo e usos das mesmas
PE20100092A1 (es) 2008-06-03 2010-03-12 Abbott Lab Inmunoglobulina con dominio variable dual y usos de la misma
BRPI0913366A8 (pt) 2008-06-03 2017-07-11 Abbott Lab Imunoglobulinas de domínio variável duplo e seus usos
NZ603698A (en) 2008-07-08 2014-03-28 Abbvie Inc Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
MX2011010166A (es) * 2009-04-07 2011-10-11 Roche Glycart Ag Anticuerpos biespecificos anti-erbb-3/anti-c-met.
WO2011025964A2 (en) 2009-08-29 2011-03-03 Abbott Laboratories Therapeutic dll4 binding proteins
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AU2010306677B2 (en) * 2009-10-15 2013-05-23 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CN102656190A (zh) 2009-12-08 2012-09-05 雅培股份有限两合公司 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体
BR112012021941A2 (pt) 2010-03-02 2022-02-01 Abbvie Inc Proteínas terapêuticas de ligação a dll4
US8735546B2 (en) 2010-08-03 2014-05-27 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
PE20140229A1 (es) 2010-08-26 2014-03-27 Abbvie Inc Inmunoglobulinas con dominio variable dual y usos de las mismas
EP2681242B1 (en) 2011-03-01 2018-01-24 Amgen Inc. Sclerostin and dkk-1 bispecific binding agents
MX2013014789A (es) 2011-06-16 2014-01-20 Novartis Ag Proteinas solubles para utilizarse como productos terapeuticos.
BR112014016299A8 (pt) * 2011-12-30 2017-07-04 Abbvie Inc imunoglobulinas de domínio variável e usos das mesmas
AR089529A1 (es) 2011-12-30 2014-08-27 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
NZ714482A (en) 2012-01-27 2017-08-25 Abbvie Inc Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
CN103382223B (zh) 2012-04-01 2015-06-10 上海益杰生物技术有限公司 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽
WO2013169382A1 (en) * 2012-05-07 2013-11-14 DePuy Synthes Products, LLC Methods and devices for treating intervertebral disc disease
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