CN102459239A - 丙型肝炎病毒抑制剂 - Google Patents
丙型肝炎病毒抑制剂 Download PDFInfo
- Publication number
- CN102459239A CN102459239A CN2010800335147A CN201080033514A CN102459239A CN 102459239 A CN102459239 A CN 102459239A CN 2010800335147 A CN2010800335147 A CN 2010800335147A CN 201080033514 A CN201080033514 A CN 201080033514A CN 102459239 A CN102459239 A CN 102459239A
- Authority
- CN
- China
- Prior art keywords
- cap
- mmol
- hcv
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(C1)(C1[n]1nccc1)C(O)=O Chemical compound *C(C1)(C1[n]1nccc1)C(O)=O 0.000 description 1
- CEIWJQQRQQULIF-IMJVUQEBSA-N C(C1C2)[C@H]1N[C@@H]2c1ncc(-c(cc2)ccc2-c(cc2)ccc2-c2cnc([C@H]3N[C@@H]4[IH]#CC4C3)[nH]2)[nH]1 Chemical compound C(C1C2)[C@H]1N[C@@H]2c1ncc(-c(cc2)ccc2-c(cc2)ccc2-c2cnc([C@H]3N[C@@H]4[IH]#CC4C3)[nH]2)[nH]1 CEIWJQQRQQULIF-IMJVUQEBSA-N 0.000 description 1
- SONAICBCXXXQKU-NSOVKSMOSA-N CC(C)(C)OC(N(CCC1)[C@@H]1C(OCC(c(cc1)ccc1-c(cc1)ccc1C(COC([C@H](CCC1)N1C(OC(C)(C)C)=O)=O)=O)=O)=O)=O Chemical compound CC(C)(C)OC(N(CCC1)[C@@H]1C(OCC(c(cc1)ccc1-c(cc1)ccc1C(COC([C@H](CCC1)N1C(OC(C)(C)C)=O)=O)=O)=O)=O)=O SONAICBCXXXQKU-NSOVKSMOSA-N 0.000 description 1
- RRDCSHFAYROYMG-AWEZNQCLSA-N CC(C)(C)OC(N[C@@H](CC=C)C(OCc1ccccc1)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CC=C)C(OCc1ccccc1)=O)=O RRDCSHFAYROYMG-AWEZNQCLSA-N 0.000 description 1
- CZPYIONABGXNGD-UHFFFAOYSA-N CCC(CC)C(C1)(C1NC(OC)=O)C(O)=O Chemical compound CCC(CC)C(C1)(C1NC(OC)=O)C(O)=O CZPYIONABGXNGD-UHFFFAOYSA-N 0.000 description 1
- AXFCHHYYQFKZQR-GFCCVEGCSA-N CCN([C@@H](C(O)=O)c1ccccc1)C1CC1 Chemical compound CCN([C@@H](C(O)=O)c1ccccc1)C1CC1 AXFCHHYYQFKZQR-GFCCVEGCSA-N 0.000 description 1
- ZWVBAHITHMYEMS-SECBINFHSA-N CCNC(N[C@@H](C(O)=O)c1ccccc1)=O Chemical compound CCNC(N[C@@H](C(O)=O)c1ccccc1)=O ZWVBAHITHMYEMS-SECBINFHSA-N 0.000 description 1
- RVBBBKNEWQFTQF-UHFFFAOYSA-N CCc([s]1)c(C(O)=O)nc1Cl Chemical compound CCc([s]1)c(C(O)=O)nc1Cl RVBBBKNEWQFTQF-UHFFFAOYSA-N 0.000 description 1
- WFNCZUIGZZVNKH-UHFFFAOYSA-N CCc1c(C(OC)=O)nccc1 Chemical compound CCc1c(C(OC)=O)nccc1 WFNCZUIGZZVNKH-UHFFFAOYSA-N 0.000 description 1
- MLOBRLOZPSSKKO-SECBINFHSA-N CN(C)[C@@H](C(O)=O)c1ccccc1 Chemical compound CN(C)[C@@H](C(O)=O)c1ccccc1 MLOBRLOZPSSKKO-SECBINFHSA-N 0.000 description 1
- GKJACXUIWWDMBO-UHFFFAOYSA-N CN(C)c1c(cc(nc2C(O)=O)Cl)c2ccc1 Chemical compound CN(C)c1c(cc(nc2C(O)=O)Cl)c2ccc1 GKJACXUIWWDMBO-UHFFFAOYSA-N 0.000 description 1
- JPCXGAHSWZKCCO-UHFFFAOYSA-N COC(NC(C1COC1)C(O)=O)=O Chemical compound COC(NC(C1COC1)C(O)=O)=O JPCXGAHSWZKCCO-UHFFFAOYSA-N 0.000 description 1
- GTUZXWNEKXNDOE-MRVPVSSYSA-N COC(N[C@@H](C(O)=O)c(cccc1)c1Cl)=O Chemical compound COC(N[C@@H](C(O)=O)c(cccc1)c1Cl)=O GTUZXWNEKXNDOE-MRVPVSSYSA-N 0.000 description 1
- NWTVZVFJYVHLQS-QMMMGPOBSA-N COC([C@H](C(CC1)CCC1(F)F)NC(OC)=O)=O Chemical compound COC([C@H](C(CC1)CCC1(F)F)NC(OC)=O)=O NWTVZVFJYVHLQS-QMMMGPOBSA-N 0.000 description 1
- HKWKVZRIFSAVLQ-UHFFFAOYSA-N COc1ccc2c(C(O)=O)nccc2c1 Chemical compound COc1ccc2c(C(O)=O)nccc2c1 HKWKVZRIFSAVLQ-UHFFFAOYSA-N 0.000 description 1
- QEIFWXUIJHFGPI-DMTCNVIQSA-N C[C@H]([C@@H](C(O)=O)NC(OC)=O)O Chemical compound C[C@H]([C@@H](C(O)=O)NC(OC)=O)O QEIFWXUIJHFGPI-DMTCNVIQSA-N 0.000 description 1
- OEPLXFQYVFZKPJ-UHFFFAOYSA-N N#Cc1nc(-c2ccc[o]2)c(cccc2)c2c1 Chemical compound N#Cc1nc(-c2ccc[o]2)c(cccc2)c2c1 OEPLXFQYVFZKPJ-UHFFFAOYSA-N 0.000 description 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N N[C@@H](C(O)=O)c1ccccc1 Chemical compound N[C@@H](C(O)=O)c1ccccc1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 description 1
- LMIZLNPFTRQPSF-SSDOTTSWSA-N N[C@@H](C(O)=O)c1ccccc1Cl Chemical compound N[C@@H](C(O)=O)c1ccccc1Cl LMIZLNPFTRQPSF-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18240309P | 2009-05-29 | 2009-05-29 | |
| US61/182,403 | 2009-05-29 | ||
| PCT/US2010/035527 WO2010138368A1 (en) | 2009-05-29 | 2010-05-20 | Hepatitis c virus inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102459239A true CN102459239A (zh) | 2012-05-16 |
Family
ID=42312822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800335147A Pending CN102459239A (zh) | 2009-05-29 | 2010-05-20 | 丙型肝炎病毒抑制剂 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8138215B2 (https=) |
| EP (1) | EP2435425B1 (https=) |
| JP (1) | JP5632910B2 (https=) |
| CN (1) | CN102459239A (https=) |
| AR (1) | AR076900A1 (https=) |
| TW (1) | TW201100401A (https=) |
| WO (1) | WO2010138368A1 (https=) |
Families Citing this family (72)
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|---|---|---|---|---|
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8546405B2 (en) | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
| SG172352A1 (en) | 2008-12-23 | 2011-07-28 | Abbott Lab | Anti-viral compounds |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9278922B2 (en) | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
| HUE030465T2 (hu) | 2009-05-13 | 2017-05-29 | Antivirális vegyületek | |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| EA020031B1 (ru) | 2009-06-11 | 2014-08-29 | Эббви Бахамаз Лтд. | Противовирусные соединения |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| CN102480971B (zh) | 2009-09-04 | 2014-11-26 | 杨森制药公司 | 化合物 |
| US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8759332B2 (en) | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
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| US9156818B2 (en) | 2009-09-11 | 2015-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| TWI429645B (en) * | 2009-12-04 | 2014-03-11 | Proline derivatives | |
| US8653070B2 (en) | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20110152246A1 (en) * | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| PE20130244A1 (es) | 2010-01-25 | 2013-03-10 | Enanta Pharm Inc | Inhibidores del virus de la hepatitis c |
| US8178531B2 (en) | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| CN102858157A (zh) | 2010-03-04 | 2013-01-02 | 埃南塔制药公司 | 作为hcv复制的抑制剂的组合药物活性剂 |
| EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| US20110312996A1 (en) * | 2010-05-17 | 2011-12-22 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US8778938B2 (en) | 2010-06-04 | 2014-07-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| WO2012021704A1 (en) | 2010-08-12 | 2012-02-16 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
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| NZ710567A (en) * | 2010-11-17 | 2017-01-27 | Gilead Sciences Inc | Antiviral compounds |
| EP2651928A4 (en) * | 2010-12-15 | 2014-06-18 | Abbvie Inc | ANTI-VIRAL COMPOUNDS |
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| EP2950786B1 (en) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
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| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
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| US12037340B2 (en) | 2021-05-21 | 2024-07-16 | Gilead Sciences, Inc. | Pentacyclic derivatives as Zika virus inhibitors |
| US12497408B2 (en) | 2021-05-21 | 2025-12-16 | Gilead Sciences, Inc. | Tetracyclic compounds and methods for the treatment of Zika virus infection |
Citations (2)
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| WO2008021927A2 (en) * | 2006-08-11 | 2008-02-21 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
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- 2010-05-20 EP EP10724195.2A patent/EP2435425B1/en not_active Not-in-force
- 2010-05-20 WO PCT/US2010/035527 patent/WO2010138368A1/en not_active Ceased
- 2010-05-20 JP JP2012513137A patent/JP5632910B2/ja not_active Expired - Fee Related
- 2010-05-20 CN CN2010800335147A patent/CN102459239A/zh active Pending
- 2010-05-28 TW TW099117294A patent/TW201100401A/zh unknown
- 2010-05-31 AR ARP100101886A patent/AR076900A1/es unknown
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| WO2008021927A2 (en) * | 2006-08-11 | 2008-02-21 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US20090068140A1 (en) * | 2006-08-11 | 2009-03-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
Also Published As
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|---|---|
| TW201100401A (en) | 2011-01-01 |
| WO2010138368A1 (en) | 2010-12-02 |
| JP2012528161A (ja) | 2012-11-12 |
| EP2435425A1 (en) | 2012-04-04 |
| US8138215B2 (en) | 2012-03-20 |
| AR076900A1 (es) | 2011-07-13 |
| JP5632910B2 (ja) | 2014-11-26 |
| EP2435425B1 (en) | 2014-10-15 |
| US20100303755A1 (en) | 2010-12-02 |
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