CN102451350A - Formula of medicament for enhancing immunity - Google Patents
Formula of medicament for enhancing immunity Download PDFInfo
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- CN102451350A CN102451350A CN201010519497XA CN201010519497A CN102451350A CN 102451350 A CN102451350 A CN 102451350A CN 201010519497X A CN201010519497X A CN 201010519497XA CN 201010519497 A CN201010519497 A CN 201010519497A CN 102451350 A CN102451350 A CN 102451350A
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- carnitine
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Abstract
The invention discloses a formula of a medicament for enhancing immunity, relating to the field of medicaments. The medicament is prepared from 85.4-95.4g of a Chinese chive extract, 67-77g of a ginseng extract, 3.0-4.2g of octacosane, 135-145g of L-carnitine, 135-145g of beta-cyclodextrin, 230.6-250.8g of sorbitol and 3.5-6.5g of magnesium stearate. The medicament has the effects of enhancing the immunity of a person, resisting ambient temperature stress of symptoms such as a poor immunologic function and the like caused by radiation treatment and chemo-treatment on a cancer patient, enhancing the surface cell activity of a human body, resisting aging, and the like.
Description
Technical field:
The present invention relates to drug world, be specifically related to a kind of prescription of enhancing immunity medicine.
Background technology:
Hypoimmunity is a kind of complex physical phenomenon of human body, is the result of multifactor comprehensive function.A large amount of research makes people exhaust or the metabolite accumulation from simple material for the understanding of immunity, is deep into cell, subcellular fraction and even molecular level gradually.
Along with the quickening of modern life rhythm, the aggravation of social competition, hypoimmunity more and more becomes the health problem of puzzlement much human, causes that because of hypoimmunity the crowd of disease also increases gradually, and will be in ascendant trend always.Simultaneously, along with growth in the living standard, health perception also strengthens gradually, and the health product with enhancing immunity have the very big market space.
Summary of the invention:
The prescription that the purpose of this invention is to provide a kind of enhancing immunity medicine; It can improve people's immunity, and the treatment cancer patient because of the diseases such as immunologic hypofunction that radiation and chemotherapy causes, is had the cold-and-heat resistent stress; The vigor that has the enhances human body superficial cell simultaneously suppresses effects such as aging.
In order to solve the existing problem of background technology, the present invention adopts following technical scheme: it is to be prepared from leek extract 85.4g-95.4g, Radix Ginseng extract 67g-77g, octacosane 3.0g-4.2g, L-carnitine 135g-145g, beta-schardinger dextrin-135g-145g, Sorbitol 230.6g-250.8g, magnesium stearate 3.5g-6.5g.
The present invention can improve people's immunity, and the treatment cancer patient because of the diseases such as immunologic hypofunction that radiation and chemotherapy causes, is had the cold-and-heat resistent stress, has the vigor of enhances human body superficial cell simultaneously, suppresses effects such as aging.
The specific embodiment:
This specific embodiment adopts following technical scheme: it is to be prepared from leek extract 92.4g, Radix Ginseng extract 77g, octacosane 4.2g, L-carnitine 140g, beta-schardinger dextrin-140g, Sorbitol 240.8g, magnesium stearate 5.6g.
This specific embodiment can improve people's immunity, and the treatment cancer patient because of the diseases such as immunologic hypofunction that radiation and chemotherapy causes, is had the cold-and-heat resistent stress, has the vigor of enhances human body superficial cell simultaneously, suppresses effects such as aging.
Leek extract:
Folium Allii tuberosi seed and root all can be used as medicine, and seed is warm in nature, and acrid in the mouth, salty is gone into liver, kidney channel; That chews pungently has a Folium Allii tuberosi flavor, contains alkaloid and saponin, can invigorating the liver and kidney; Warm waist knee joint, Xing Yangdao controls sexual impotence controlling nocturnal emission with astringent drugs and married woman's YIN-cold; Lower abdomen pain is the strong waist medicine of excitement of the strong waist of the kidney invigorating, can be used for treating diseases such as seminal emission, premature ejaculation, sexual impotence and polyuria.According to the pharmacopeia record, the Folium Allii tuberosi seed has the effect of " temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs ", and the fragrant-flowered garlic seed is used as strengthening yang and invigorating kidney and is used as medicine in China's history among the people existing thousands of years.
Radix Ginseng extract:
Radix Ginseng is Araliaceae Radix Ginseng Panax ginseng C.Belong to traditional traditional tonic medicine, have effects such as qi-supplementing, blood-engendering, strengthening vital QI to eliminate pathogenic factors.Stem and leaf of Radix Ginseng total saponins is from its stem and leaf, to extract.
The ginsenoside is one of main effective ingredient of Radix Ginseng, and is different by the chemical constitution of its aglycon, can be divided into panoxadiol's type saponin, protopanaxatriol ginsenoside, oleanolic acid type saponin; By the size of its RF value on thin layer chromatography, be called kind of monomer surplus in the of 20 altogether such as Ra class (Ra1-6), Rb class (Rb1-3), arsenic class and Rg class (Rg1-3) respectively
[6]
The experiment in vivo and vitro result of study shows that the ginsenoside has immunoregulation effect; Comprise and strengthen cytophagous activity in the body; Stimulate body that various antigens are produced corresponding antibody; Promote T lymphocyte and bone-marrow-derived lymphocyte to transform various ways such as propagation, can improve the nonspecific immunity and the specific immune function (comprising cellular immunization and humoral immunization) of laboratory animal.
Influence to reticuloendothelial system (RES) phagocytic function
[7]: the ginsenoside has facilitation to the phagocytic function of intact animal RES.With ginsenoside or Flos Ginseng's saponin 1.0mg/d subcutaneous injection 7d; Can significantly strengthen the activate the phagocytic capacity of mouse peritoneal emigrated cell to chicken red blood cell; The also corresponding raising of the serum lysozyme level of mice explains that ginsenoside or Flos Ginseng's saponin can both strengthen the phagocytic activity of macrophage.The stem and leaf of Radix Ginseng saponin also has similar function, the anti-infection ability of its ability stimulation in rats and mice.It has been generally acknowledged that; It is the content through RAS positive material, acetic acid alpha-Naphthol esterase, acid phosphatase and adenosinetriphosphataes in the increase macrophage that the ginsenoside stimulates the phagocytic function of mouse macrophage, thereby improves phagocytic rate, phagocytic index and the cytophagy area of macrophage.
Influence to specific antibody formation
[7,8]: the ginsenoside is a kind of immunostimulant, also is immunomodulator, and the people can not only promote Cavia porcellus leptospira production of antibodies, also can promote the generation of influenza virus specific antibody.With direct hemolysis plaque cell (HPFC) number of anti-sheep red blood cell (SRBC) is index, observes the Radix Ginseng Rubra decoct and irritates stomach forms cell (bone-marrow-derived lymphocyte) to mouse antibodies influence.The ginsenoside can obviously promote mice specific anti SRBC antibody forming cell reaction, but the splenocyte sum is not had obviously influence.
To LT influence
[9]: the T lymphocyte of normal body receives specific antigen or mitosis primary stimuli in the In vitro culture process, can be converted into lymphoblast, and this conversion capability has reflected the cellular immune level of body.Mouse subcutaneous injection ginsenoside (GS) 1.0mg/d, continuous 7d, can be observed GS in the mice body to be that the pouring commentaries on classics of mitogen stimulation has significant potentiation (P＜0.01) with concanavalin A (ConA) and bacteria lipopolysaccharide antigen (LPS).Because ConA and LPA are respectively the mitogen of T, bone-marrow-derived lymphocyte, so the ginsenoside can put forward mice T, the bone-marrow-derived lymphocyte reactivity to corresponding mitogen.The GS that the in vitro tests result has also confirmed variable concentrations has different facilitations to the mitogen IR of T, bone-marrow-derived lymphocyte, but too high or too low GS concentration all can reduce this facilitation.In addition, GS also has more weak facilitation to lymphocytic spontaneous nuclear transformation.
NK-IFN-IL-2 is regulated the influence of net
[9]: natural killer cell (NK) has immunoloregulation function widely.The ginsenoside can directly promote the activity of isolated mouse or intravital mouse spleen NK, also can produce indirect promotion NK cell activity through stimulating interferon (IFN) and interleukin-2 (IL-2), because IFN and IL-2 can improve the NK cell activity.Induce down at ConAR, the ginsenoside can optionally strengthen the activity of IL-2 in the old Mus splenocyte culture supernatant, and this possibly be the result that the ginsenoside promotes IL-2 gene expression process.IL-2 also is a kind of physiological IFN inducer, can the NK cell activity strengthened through stimulating IFN to produce.This shows that the ginsenoside regulates net to NK-IFN-IL-2 and played the forward regulating action.
Plain-2 acceptor effect between pair cell
[10]: solubility interleukin-2 receptor (sIL-2R) content in human serum and the animal cultured cell supernatant can raise with the increase at age; The ginsenoside Rg1 optionally strengthens the spleen lymphocyte proliferation ability of old Mus and suppresses formation and the release of sIL-2R, thereby improves the immunity of old Mus.
The ginsenoside is to the relation of Immune Effects and levels of cyclic nucleotides
[10,11,12]: cyclic nucleotide is the important adjusting material of life; Physiological functions such as the formation of body lymphocyte transformation, antibody and release, cellular immunization all there is important regulatory role, can thinks that therefore the variation of levels of cyclic nucleotides is that body is regulated a kind of performance of immunologic function on molecular level in the cell.Discover that cyclic adenosine monophosphate of old Mus spleen lymphocyte (cAMP) and cyclic guanosine monophosphate (cGMP) level all are starkly lower than young Mus, wherein the level with cAMP descends greatlyyer, and the more young Mus of ratio that shows as cAMP/cGMP is low.And the ginsenoside of doses can make that cAMP and cGMP level obviously raise in the old Mus spleen tissue, and wherein the rising level of cAMP is more obvious, makes the ratio of cAMP/cGMP return to young Mus level, shows as old Mus lymphocyte transformation function and strengthens.
This shows that the ginsenoside is comprehensive to animal and human immune system's regulatory function.
The L-carnitine:
Zoopery proves; The L-carnitine has the function that improves endurance, resisting fatigue, enhancing explosive force; The right grade of Wang Shu carried out anti-fatigue test to the L-carnitine, and the lactic acid that the result is illustrated in after obviously prolonging the mice swimming with a load attached to the body time under the condition that the L-carnitine doses is 150mg/kg BW and 50mg/kgBW and reducing mice swimming fatigue raises.There are some researches prove simultaneously, can take the L-carnitine in the human motion training, can improve tired elimination speed, promote antisecosis.Discoveries such as Marconi are carried
Before oral L-carnitine 2-3 week, every day, 2-3g can significantly improve athletic maximum aerobic capacity.And the trickle growth (5%) of maximum aerobic capacity can improve athletic motor capacity greatly.Discoveries such as Cerretelli, take carnitine after, in given submaximal exercise or maximal exercise, the heart rate of experimental subject slightly descends, this side light carnitine can improve maximum aerobic capacity.Discoveries such as angelini, behind the additional L-carnitine, the adenines compounds translocase suppresses to be disengaged, and the adenylic acid that passes mitochondrial inner membrane increases, and causes the G-T of muscle and phosphagen concentration to raise, and the peak power of muscle raises.Think that at present the antifatigue effect of L-carnitine is realized through following approach.Reduce the ratio of S-acetyl-coenzyme-A/coenzyme A, promote the activity of pyruvic dehydrogenase, promote the oxidation utilization of glucose.In maximum dose and ultra maximum dose metabolic process, not only glycolytic cycle is excited, and lipolysis is also very active; The acidylate coenzyme A that produces in the steatolysis process if especially S-acetyl-coenzyme-A is too much, surpasses the limit with the oxaloacetic acid reaction; Be deposited in Cytoplasm and the mitochondrion; Make the ratio of S-acetyl-coenzyme-A/coenzyme A raise, suppress pyruvic dehydrogenase, suppress the oxidation utilization of glucose.Carnitine-coenzyme A acetyltransferase catalysis the S-acetyl-coenzyme-A that is positioned at the mitochondrial inner membrane medial surface is transformed into acetylcarnitine, reduces S-acetyl-coenzyme-A/coenzyme A ratio, activates pyruvic dehydrogenase, promotes the oxidation of acetone acid, and then promotes the oxidation utilization of glucose.Practice thrift free coenzyme A; The amount .L-carnitine that increases tricarboxylic acid cycle is accepted the acyl group on the acyl-CoA; The a-ketoglutaric acid that more free coenzyme A can be participated in the tricarboxylic acid cycle is converted into this step reaction of S-(3-carboxy-propionyl)-coenzyme-A; Promote the metabolism stream in the circulation, promote fat combustion indirectly, promote aerobic metabolism.Promote the oxidation utilization of branched-chain amino acid, improve exercise tolerance.The catabolism of branched-chain amino acid mainly carries out in skeletal muscle.In motion and the training process; Branched-amino acid decarboxylase and branched-chain amino acid dehydrogenase activity increase; Branched-chain amino acid oxidative deamination dehydrogenation in the skeletal muscle generates the side chain acyl-CoA; Generate side chain fatty acyl carnitine and free coenzyme A with the reaction of L-carnitine, reduce of the inhibition of excessive acyl-CoA, promote the oxidation utilization of branched-chain amino acid the BCKA dehydrogenase.The side chain fatty acyl carnitine also can be absorbed by liver, carries out further oxidation produce power, or carries out gluconeogenesis and become glucose.Remove too much lactic acid, improve motor capacity, promote fatigue recovery.In maximal exercise and ultra maximal exercise, when surpassing so-called " anaerobic threshold ", muscle begins to utilize the energy that obtains under the anaerobic situation, produces lactic acid.Lactic acid too much can increase the acidity of blood and tissue fluid, reduces the generation of ATP, causes fatigue.In fact, the too much acetone acid of part is not transformed into lactic acid, but the form deposit with acetylcarnitine gets up after the decarboxylation.Acetylcarnitine becomes the warehouse of " activatory acetyl group ", at any time acetyl group is transformed to coenzyme A, supplies with tricarboxylic acid cycle.Simultaneously, reduce lactic oxygen debt, make people's physical ability bear more oxygen debt.Promote the ammonia Degradation, recover mobility's labor.Ammonia is protein degradation products, also is the recognition marks of sports fatigue, even lower content also has bigger toxicity.Discover that carnitine has the toxic protective effect of anti-ammonia.Discover that carnitine has the effect of similar arginine, ornithine, promote ornithine cycle, make ammonia be degraded to carbamide, remove the toxicity of ammonia.Transport activatory LCFA and pass mitochondrial inner membrane, get into the active mitochondrial matrix of tryptophan side-chain alpha system.The activation of fatty acid occurs in the endochylema part, and further oxidation occurs in mitochondrion inside.Long acyl coenzyme G can not pass mitochondrial inner membrane, must generate fatty acyl carnitine by the carnitine acyltransferase I catalysis of mitochondrial inner membrane lateral surface, just possibly pass mitochondrial inner membrane.Carnitine+fatty acyl carnitine translocase is transported the L-carnitine and is passed mitochondrial inner membrane from mitochondrial matrix, fatty acyl carnitine is transported outside mitochondrion penetrated mitochondrial inner membrane, keeps the constant basis in carnitine pond in the mitochondrion.By the carnitine acyltransferase II catalysis that is positioned at the mitochondrial inner membrane medial surface, make the fatty acyl carnitine and the coenzyme A reaction that get into inner membrance again, the acyl-CoA of generation gets in the mitochondrial matrix, and the carnitine that generates supplies carnitine-acyl group translocase exchange to use once more.
Claims (1)
1. the prescription of an enhancing immunity medicine is characterized in that it is to be prepared from leek extract 85.4g-95.4g, Radix Ginseng extract 67g-77g, octacosane 3.0g-4.2g, L-carnitine 135g-145g, beta-schardinger dextrin-135g-145g, Sorbitol 230.6g-250.8g, magnesium stearate 3.5g-6.5g.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106690307A (en) * | 2016-12-07 | 2017-05-24 | 珠海联邦制药股份有限公司 | Immunity enhancing and physical fatigue alleviating health-care capsules and preparation method thereof |
| CN110438078A (en) * | 2019-09-12 | 2019-11-12 | 李保平 | A kind of purposes that Radix Codonopsis alkynol promotes NK cell Proliferation in vitro, enhances its killing activity |
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| CN1830293A (en) * | 2006-01-13 | 2006-09-13 | 天津天隆农业科技有限公司 | Aquatic feedstuff containing octocosoic alcohol and L-carnitine and its production method |
| CN1871948A (en) * | 2005-08-11 | 2006-12-06 | 黄恒燊 | Sport beverage and preparation method |
| CN101524100A (en) * | 2009-04-03 | 2009-09-09 | 邹平三星油脂工业有限公司 | Edible oil and preparation method thereof |
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2010
- 2010-10-26 CN CN201010519497XA patent/CN102451350A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1871948A (en) * | 2005-08-11 | 2006-12-06 | 黄恒燊 | Sport beverage and preparation method |
| CN1830293A (en) * | 2006-01-13 | 2006-09-13 | 天津天隆农业科技有限公司 | Aquatic feedstuff containing octocosoic alcohol and L-carnitine and its production method |
| CN101524100A (en) * | 2009-04-03 | 2009-09-09 | 邹平三星油脂工业有限公司 | Edible oil and preparation method thereof |
Non-Patent Citations (1)
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| 赵洪静等: "中国保健（功能）饮料分析", 《中国食品学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106690307A (en) * | 2016-12-07 | 2017-05-24 | 珠海联邦制药股份有限公司 | Immunity enhancing and physical fatigue alleviating health-care capsules and preparation method thereof |
| CN110438078A (en) * | 2019-09-12 | 2019-11-12 | 李保平 | A kind of purposes that Radix Codonopsis alkynol promotes NK cell Proliferation in vitro, enhances its killing activity |
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Application publication date: 20120516 |