CN102441180B - 一种胃肠b超显像剂 - Google Patents
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Abstract
本发明涉及一种显像剂，特别涉及一种胃肠B超显像剂，是由以下重量份原料药制备而成：白术20g、木香20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g，分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g的吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶即得。本发明具有行气消胀、理气和胃的功能，快速消除胃肠内气泡，促进胃肠蠕动，清除胃肠粘液，使胃腔内无回声暗区，排除声波阻抗对胃肠B超诊断的干扰，提高胃肠B超的清晰度，胃壁各层结构清晰，病灶显示突出，减少漏诊、错诊的几率。
Description
技术领域
本发明涉及一种显像剂，特别是涉及一种胃肠B超显像剂。
背景技术
在临床检测中，B超检测可以清晰的显示腹部实质性脏器以及各脏器周围组织的各种断面图像，从而使早期的疾病得到明确的诊断，B超检测已成为临床医学中不可或缺的诊断方法；但是，胃肠B超检测也有其局限性，由于胃肠道内壁的特殊结构、腔内多有粘液和气体残存，而超声检查对于气体干扰的影响较大，腹部胃肠道等空腔脏器病变因空腔脏器内气体干扰，致使超声波被反射，使胃肠道病变部位模糊不清，从而影响图像质量，容易发生漏诊、误诊等现象。
发明内容
为了解决胃肠B超检测过程中因胃内壁气体残留而引起的诊断不准确的问题，本发明提供了一种作用快速，行气消胀、对胃病患者兼有治疗作用的胃肠B超显像剂。
本发明的胃肠B超显像剂，是由以下重量原料药制备而成：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g 、液体石蜡5g、脂肪酸甲酯聚氧乙烯醚2g、吐温80 2g、癸甲氯铵1g、甘油5g、尿囊素1g。
制备方法
（1）分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml；
（2）取步聚（1）的浓缩液，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶。
上述本发明的原料中，所述的脂肪酸甲酯聚氧乙烯醚为乳化剂，吐温80是表面活性剂，它们相互配合可以乳化油脂。由于人体胃肠内存在大量的油性物，造成现有的显像剂不能去除油脂，使显像剂不能彻底到达胃内的细小缝隙，加入脂肪酸甲酯聚氧乙烯醚和吐温80后，便可使胃肠壁内的油脂乳化，从而达到乳化油脂，充分充盈的目的。
上述原料中，所述的癸甲氯铵为杀菌剂，可以起到杀菌消毒的作用。
上述原料中，甘油和尿囊素可以起到滋润胃壁细胞，修复皮肤内壁，降低药剂对胃肠内壁的刺激的作用。
本发明的胃肠B超显像剂，通过加入一定量的中药提取物，起到行气消胀、理气和胃的功能，能够快速消除胃肠内气泡，促进胃肠蠕动，清除胃肠内粘液，使胃腔内无回声暗区，排除声波阻抗对胃肠B超诊断的干扰，提高胃肠B超的清晰度，胃壁各层结构清晰，病灶显示突出，减少漏诊、错诊的几率。
药效观察试验
检测标准：
优良：显像剂充盈良好，胃壁内无气泡和粘液干扰，胃粘膜面显示清晰，胃壁五层结构清晰可辨。
一般：显像剂充盈良好，胃壁内有少量气泡和粘液干扰，粘膜面显示较清晰，胃壁五层结构尚清晰，但不影响检测。
不良：胃腔内有大量气泡和粘液，粘膜面显示不清，胃壁层次无法辨认，影响检测。
药效观察结果:
通过对医院来诊胃炎病人4280例进行统计，其中优良2123例，一般1732例，总有效率为90.07%，具有统计学意义。
具体实施方式：
下面结合实施例对本发明做进一步的说明。
取原料药：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g；分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml；加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g的吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶，即得。
Claims (2)
1.一种胃肠B超显像剂，其特征是由下列重量原料药制备而成：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g、液体石蜡5g、脂肪酸甲酯聚氧乙烯醚2g、吐温80 2g、癸甲氯铵1g、甘油5g、尿囊素1g。
2.如权利要求1所述的胃肠B超显像剂，其特征在于所述显像剂采用以下方法制备而成：
（1）取白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g分别加10倍量和8倍量水，提取两次，过滤，合并滤液，浓缩至100ml；
（2）取步骤 （1）的浓缩液，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，搅拌均匀，装瓶，即得。
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103611173B (zh) * | 2013-12-02 | 2015-05-13 | 刘叶 | 胃肠b超显像剂 |
| CN104189926A (zh) * | 2014-08-06 | 2014-12-10 | 丁艳 | 胃b超快速显像剂 |
| CN104758957A (zh) * | 2015-02-12 | 2015-07-08 | 郝爱华 | 胃肠b超显像剂 |
| CN104667305A (zh) * | 2015-02-12 | 2015-06-03 | 郝爱华 | 一种胃肠b超显像剂 |
| CN104800864A (zh) * | 2015-04-24 | 2015-07-29 | 郑敏 | 一种胃b超显像剂 |
| CN105664189A (zh) * | 2016-03-09 | 2016-06-15 | 于春英 | 一种胃b超显像剂及其制备工艺 |
| CN115300643B (zh) | 2022-10-12 | 2022-12-09 | 山东百多安医疗器械股份有限公司 | 一种胃肠道超声检查助显剂及其制备方法 |
| CN115317629B (zh) | 2022-10-13 | 2022-12-20 | 山东百多安医疗器械股份有限公司 | 一种双组份胃部超声检查助显剂及其制备方法 |
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