CN102438645A - 阴道上皮界面润滑的治疗调节 - Google Patents

阴道上皮界面润滑的治疗调节 Download PDF

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Publication number
CN102438645A
CN102438645A CN2010800112543A CN201080011254A CN102438645A CN 102438645 A CN102438645 A CN 102438645A CN 2010800112543 A CN2010800112543 A CN 2010800112543A CN 201080011254 A CN201080011254 A CN 201080011254A CN 102438645 A CN102438645 A CN 102438645A
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CN
China
Prior art keywords
pharmaceutical composition
prg4
therapeutic agent
vaginal
purification
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Pending
Application number
CN2010800112543A
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English (en)
Chinese (zh)
Inventor
E.R.特瑞特三世
B.萨利文
D.萨利文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Schepens Eye Research Institute Inc
Lubris LLC
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The Schepens Eye Research Institute Inc
Lubris LLC
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Publication date
Application filed by The Schepens Eye Research Institute Inc, Lubris LLC filed Critical The Schepens Eye Research Institute Inc
Publication of CN102438645A publication Critical patent/CN102438645A/zh
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A—HUMAN NECESSITIES
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    • A61P5/30—Oestrogens

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  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
CN2010800112543A 2009-01-13 2010-01-13 阴道上皮界面润滑的治疗调节 Pending CN102438645A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14434409P 2009-01-13 2009-01-13
US61/144344 2009-01-13
US26040209P 2009-11-12 2009-11-12
US61/260402 2009-11-12
PCT/US2010/020929 WO2010083239A2 (en) 2009-01-13 2010-01-13 Therapeutic modulation of vaginal epithelium boundary lubrication

Publications (1)

Publication Number Publication Date
CN102438645A true CN102438645A (zh) 2012-05-02

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CN2010800112543A Pending CN102438645A (zh) 2009-01-13 2010-01-13 阴道上皮界面润滑的治疗调节

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US (1) US8980840B2 (cg-RX-API-DMAC10.html)
EP (1) EP2381957B1 (cg-RX-API-DMAC10.html)
JP (2) JP2012515170A (cg-RX-API-DMAC10.html)
CN (1) CN102438645A (cg-RX-API-DMAC10.html)
CA (1) CA2749480C (cg-RX-API-DMAC10.html)
ES (1) ES2534082T3 (cg-RX-API-DMAC10.html)
WO (1) WO2010083239A2 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107847556A (zh) * 2015-01-26 2018-03-27 卢布里斯有限责任公司 Prg4作为抗炎剂的应用

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2626337C (en) 2005-10-19 2015-12-29 Chavah Pty Ltd Reduction of side effects from aromatase inhibitors used for treating breast cancer
ES2534082T3 (es) * 2009-01-13 2015-04-17 Lubris Llc Modulación terapéutica de la lubricación del límite del epitelio vaginal
WO2010135736A2 (en) 2009-05-22 2010-11-25 Singularis Inc. Application and uses of prg4 and therapeutic modulation thereof
CA2771110C (en) * 2009-08-13 2019-02-26 Singularis, Inc. Prg4 treatment for interstitial cystitis
CN102552996A (zh) * 2010-12-07 2012-07-11 宁小静 人体润滑剂
ES2395801B1 (es) * 2011-06-23 2014-06-06 María Carmen PARDINA PALLEJÀ "pentoxifilina por vía transvaginal para el tratamiento de la infertilidad"
EP2782584B1 (en) 2011-11-23 2021-06-09 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
US10500250B2 (en) 2013-11-26 2019-12-10 Lubris Llc Compositions and methods for inhibiting intercellular interactions
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
KR20170040209A (ko) 2014-07-29 2017-04-12 쎄러퓨틱스엠디, 인코퍼레이티드 경피 크림
CA2965372C (en) 2014-10-22 2023-09-05 Havah Therapeutics Pty Ltd Methods of reducing mammographic breast density and/or breast cancer risk
LT3300482T (lt) 2015-05-19 2021-10-25 Lubris Llc Prg4 panaudojimas dinaminio regos aštrumo pagerinimui ir aukštesnės eilės aberacijų sumažinimui
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CA3002562A1 (en) 2015-10-22 2017-04-27 Havah Therapeutics Pty Ltd Methods of reducing mammographic breast density and/or breast cancer risk
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
CN114599369B (zh) 2019-06-03 2026-02-10 哈瓦赫治疗有限公司 用于递送雄激素剂和芳香酶抑制剂的药物制剂和系统以及使用方法
US20240408128A1 (en) * 2021-09-15 2024-12-12 Chemex Global Topical pharmaceutical compositions for treatment of infertility
CN118976097B (zh) * 2024-10-22 2025-01-24 北京岷德生物科技有限公司 一种治疗妇科疾病的组合物及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7000A (en) * 1850-01-08 Smut-machine
US7027A (en) * 1850-01-15 Circulak
US3005A (en) * 1843-03-17 Power-loom
US6433142B1 (en) 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
AU740758B2 (en) * 1997-10-28 2001-11-15 Vivus, Inc. Treatment of female sexual dysfunction
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US6960562B2 (en) 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6335023B1 (en) 1999-06-30 2002-01-01 Ruey J. Yu Oligosaccharide aldonic acids and their topical use
US7452545B2 (en) 2001-11-13 2008-11-18 Yu Ruey J Oligosaccharide aldonic acids and their topical use
US20030059489A1 (en) * 2001-09-24 2003-03-27 Canolio Inc. Genital lubricating compositions and uses thereof
US7005408B2 (en) * 2002-05-01 2006-02-28 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
US20060240037A1 (en) * 2003-06-04 2006-10-26 Edward Fey Methods and compositions for the treatment and prevention of degenerative joint disorders
WO2005016130A2 (en) 2003-08-14 2005-02-24 Wyeth Recombinant lubricin molecules and uses thereof
WO2005082857A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Substituted quinoline compounds for use as selective estrogen receptor modulator
CA2558497A1 (en) * 2004-03-05 2005-09-15 Synthes (U.S.A.) Use of a mixture for the production of an agent for treating defective or degenerated cartilage in the production of natural cartilage replacement in vitro
US8703198B2 (en) * 2005-03-02 2014-04-22 Aquatrove Biosciences Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof
CA2612380C (en) * 2005-06-16 2017-06-06 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
EP1890704A1 (en) * 2005-12-16 2008-02-27 Lyle Corporate Development, Inc. Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen
WO2007085020A2 (en) * 2006-01-20 2007-07-26 Pear Tree Pharmaceuticals, Inc. Method of treating atrophic vaginitis
WO2008133928A2 (en) * 2007-04-27 2008-11-06 The Gi Company, Inc. Mucin glycoproteins and their use for treatment of epithelial lesions and mucin dependent disorders
WO2008143816A1 (en) * 2007-05-15 2008-11-27 Mucosal Therapeutics Compositions and methods for reducing friction between the surface of tendons or other soft tissues
GB0722507D0 (en) * 2007-11-19 2007-12-27 Zhao Xiaobin Hyaluronic acid personal lubricant
ES2534082T3 (es) * 2009-01-13 2015-04-17 Lubris Llc Modulación terapéutica de la lubricación del límite del epitelio vaginal

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107847556A (zh) * 2015-01-26 2018-03-27 卢布里斯有限责任公司 Prg4作为抗炎剂的应用
CN107847556B (zh) * 2015-01-26 2021-09-24 卢布里斯有限责任公司 Prg4作为抗炎剂的应用

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ES2534082T3 (es) 2015-04-17
JP2012515170A (ja) 2012-07-05
WO2010083239A3 (en) 2010-12-09
US20120052077A1 (en) 2012-03-01
EP2381957A4 (en) 2013-12-25
EP2381957B1 (en) 2015-01-07
JP2015180620A (ja) 2015-10-15
WO2010083239A2 (en) 2010-07-22
CA2749480A1 (en) 2010-07-22
US8980840B2 (en) 2015-03-17
JP6039723B2 (ja) 2016-12-07
EP2381957A2 (en) 2011-11-02
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Application publication date: 20120502