JP2012515170A - 膣上皮境界潤滑の治療的調節 - Google Patents
膣上皮境界潤滑の治療的調節 Download PDFInfo
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| PCT/US2010/020929 WO2010083239A2 (en) | 2009-01-13 | 2010-01-13 | Therapeutic modulation of vaginal epithelium boundary lubrication |
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| JP2015062261A Expired - Fee Related JP6039723B2 (ja) | 2009-01-13 | 2015-03-25 | 膣上皮境界潤滑の治療的調節 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015180620A (ja) * | 2009-01-13 | 2015-10-15 | ルブリス，エルエルシー． | 膣上皮境界潤滑の治療的調節 |
| JP2018505867A (ja) * | 2015-01-26 | 2018-03-01 | ルブリス，エルエルシー． | 抗炎症剤としてのｐｒｇ４の使用 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2626337C (en) | 2005-10-19 | 2015-12-29 | Chavah Pty Ltd | Reduction of side effects from aromatase inhibitors used for treating breast cancer |
| WO2010135736A2 (en) | 2009-05-22 | 2010-11-25 | Singularis Inc. | Application and uses of prg4 and therapeutic modulation thereof |
| CA2771110C (en) * | 2009-08-13 | 2019-02-26 | Singularis, Inc. | Prg4 treatment for interstitial cystitis |
| CN102552996A (zh) * | 2010-12-07 | 2012-07-11 | 宁小静 | 人体润滑剂 |
| ES2395801B1 (es) * | 2011-06-23 | 2014-06-06 | María Carmen PARDINA PALLEJÀ | "pentoxifilina por vía transvaginal para el tratamiento de la infertilidad" |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| US10500250B2 (en) | 2013-11-26 | 2019-12-10 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| KR20170040209A (ko) | 2014-07-29 | 2017-04-12 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 경피 크림 |
| CA2965372C (en) | 2014-10-22 | 2023-09-05 | Havah Therapeutics Pty Ltd | Methods of reducing mammographic breast density and/or breast cancer risk |
| LT3300482T (lt) | 2015-05-19 | 2021-10-25 | Lubris Llc | Prg4 panaudojimas dinaminio regos aštrumo pagerinimui ir aukštesnės eilės aberacijų sumažinimui |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| CA3002562A1 (en) | 2015-10-22 | 2017-04-27 | Havah Therapeutics Pty Ltd | Methods of reducing mammographic breast density and/or breast cancer risk |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| CN114599369B (zh) | 2019-06-03 | 2026-02-10 | 哈瓦赫治疗有限公司 | 用于递送雄激素剂和芳香酶抑制剂的药物制剂和系统以及使用方法 |
| US20240408128A1 (en) * | 2021-09-15 | 2024-12-12 | Chemex Global | Topical pharmaceutical compositions for treatment of infertility |
| CN118976097B (zh) * | 2024-10-22 | 2025-01-24 | 北京岷德生物科技有限公司 | 一种治疗妇科疾病的组合物及其制备方法和应用 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3005A (en) * | 1843-03-17 | Power-loom | ||
| US7000A (en) * | 1850-01-08 | Smut-machine | ||
| US7027A (en) * | 1850-01-15 | Circulak | ||
| JP2001520999A (ja) * | 1997-10-28 | 2001-11-06 | アシビ， エルエルシー | 女性の性的機能不全の処置 |
| WO2005000331A2 (en) * | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
| JP2005531541A (ja) * | 2002-05-01 | 2005-10-20 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の無水の潤滑性組成物 |
| JP2007502122A (ja) * | 2003-08-14 | 2007-02-08 | ワイス | 組換えルブリシン分子およびその使用 |
| WO2007070067A1 (en) * | 2005-12-16 | 2007-06-21 | Lyle Corporate Development, Inc. | Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen |
| WO2007085020A2 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
| WO2007103194A2 (en) * | 2006-03-01 | 2007-09-13 | Aquatrove Biosciences, Inc. | Aqueous moisturizers and lubricants and uses thereof |
| WO2008143816A1 (en) * | 2007-05-15 | 2008-11-27 | Mucosal Therapeutics | Compositions and methods for reducing friction between the surface of tendons or other soft tissues |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6433142B1 (en) | 1989-08-08 | 2002-08-13 | Genetics Institute, Llc | Megakaryocyte stimulating factors |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
| US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
| US6335023B1 (en) | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
| US7452545B2 (en) | 2001-11-13 | 2008-11-18 | Yu Ruey J | Oligosaccharide aldonic acids and their topical use |
| US20030059489A1 (en) * | 2001-09-24 | 2003-03-27 | Canolio Inc. | Genital lubricating compositions and uses thereof |
| WO2005082857A1 (en) * | 2004-02-25 | 2005-09-09 | Smithkline Beecham Corporation | Substituted quinoline compounds for use as selective estrogen receptor modulator |
| CA2558497A1 (en) * | 2004-03-05 | 2005-09-15 | Synthes (U.S.A.) | Use of a mixture for the production of an agent for treating defective or degenerated cartilage in the production of natural cartilage replacement in vitro |
| CA2612380C (en) * | 2005-06-16 | 2017-06-06 | Warner Chilcott Company, Inc. | Estrogen compositions for vaginal administration |
| WO2008133928A2 (en) * | 2007-04-27 | 2008-11-06 | The Gi Company, Inc. | Mucin glycoproteins and their use for treatment of epithelial lesions and mucin dependent disorders |
| GB0722507D0 (en) * | 2007-11-19 | 2007-12-27 | Zhao Xiaobin | Hyaluronic acid personal lubricant |
| ES2534082T3 (es) * | 2009-01-13 | 2015-04-17 | Lubris Llc | Modulación terapéutica de la lubricación del límite del epitelio vaginal |
-
2010
- 2010-01-13 ES ES10732051.7T patent/ES2534082T3/es active Active
- 2010-01-13 US US13/144,203 patent/US8980840B2/en active Active
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- 2010-01-13 CN CN2010800112543A patent/CN102438645A/zh active Pending
- 2010-01-13 WO PCT/US2010/020929 patent/WO2010083239A2/en not_active Ceased
- 2010-01-13 EP EP10732051.7A patent/EP2381957B1/en not_active Not-in-force
- 2010-01-13 JP JP2011545542A patent/JP2012515170A/ja active Pending
-
2015
- 2015-03-25 JP JP2015062261A patent/JP6039723B2/ja not_active Expired - Fee Related
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3005A (en) * | 1843-03-17 | Power-loom | ||
| US7000A (en) * | 1850-01-08 | Smut-machine | ||
| US7027A (en) * | 1850-01-15 | Circulak | ||
| JP2001520999A (ja) * | 1997-10-28 | 2001-11-06 | アシビ， エルエルシー | 女性の性的機能不全の処置 |
| JP2005531541A (ja) * | 2002-05-01 | 2005-10-20 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の無水の潤滑性組成物 |
| WO2005000331A2 (en) * | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
| JP2007502122A (ja) * | 2003-08-14 | 2007-02-08 | ワイス | 組換えルブリシン分子およびその使用 |
| WO2007070067A1 (en) * | 2005-12-16 | 2007-06-21 | Lyle Corporate Development, Inc. | Regeneration of vaginal tissue with non-systemic vaginal administration of estrogen |
| WO2007085020A2 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
| WO2007103194A2 (en) * | 2006-03-01 | 2007-09-13 | Aquatrove Biosciences, Inc. | Aqueous moisturizers and lubricants and uses thereof |
| WO2008143816A1 (en) * | 2007-05-15 | 2008-11-27 | Mucosal Therapeutics | Compositions and methods for reducing friction between the surface of tendons or other soft tissues |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015180620A (ja) * | 2009-01-13 | 2015-10-15 | ルブリス，エルエルシー． | 膣上皮境界潤滑の治療的調節 |
| JP2018505867A (ja) * | 2015-01-26 | 2018-03-01 | ルブリス，エルエルシー． | 抗炎症剤としてのｐｒｇ４の使用 |
| JP2020189878A (ja) * | 2015-01-26 | 2020-11-26 | ルブリス，エルエルシー． | 抗炎症剤としてのｐｒｇ４の使用 |
| JP7212653B2 (ja) | 2015-01-26 | 2023-01-25 | ルブリス，エルエルシー． | 抗炎症剤としてのｐｒｇ４の使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2534082T3 (es) | 2015-04-17 |
| WO2010083239A3 (en) | 2010-12-09 |
| US20120052077A1 (en) | 2012-03-01 |
| EP2381957A4 (en) | 2013-12-25 |
| EP2381957B1 (en) | 2015-01-07 |
| JP2015180620A (ja) | 2015-10-15 |
| WO2010083239A2 (en) | 2010-07-22 |
| CA2749480A1 (en) | 2010-07-22 |
| US8980840B2 (en) | 2015-03-17 |
| JP6039723B2 (ja) | 2016-12-07 |
| EP2381957A2 (en) | 2011-11-02 |
| CN102438645A (zh) | 2012-05-02 |
| CA2749480C (en) | 2015-03-31 |
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