CN102428931A - Bacteriocidal composition containing Boscalid and triazole bactericide - Google Patents

Bacteriocidal composition containing Boscalid and triazole bactericide Download PDF

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CN102428931A
CN102428931A CN2011104369098A CN201110436909A CN102428931A CN 102428931 A CN102428931 A CN 102428931A CN 2011104369098 A CN2011104369098 A CN 2011104369098A CN 201110436909 A CN201110436909 A CN 201110436909A CN 102428931 A CN102428931 A CN 102428931A
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boscalid
bactericidal composition
bactericidal
azoles
disease
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CN102428931B (en
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缪金凤
汪静莉
宋亚华
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JIANGYIN SULI CHEMICAL CO., LTD.
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JINGYIN SULI CHEMICAL CO Ltd
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Abstract

The invention relates to a bacteriocidal composition and an application thereof. The bacteriocidal composition is characterized by comprising Boscalid (A) and at least one (B) selected from the following active components of a triazole bactericide: difenoconazole, propiconazole, tebuconazole, hexaconazole, flutriafol, epoxiconazole, tetraconazole, flusilazole, myclobutanil, cyproconazole, triazolone and diniconazole, wherein the mass ratio of A to B is (1:50)-(50:1). The composition can be applied to preventing and treating diseases of crops such as cereal crops, melons, fruits, vegetables and the like.

Description

A kind of bactericidal composition that contains Boscalid and triazole bactericidal agent
(1) technical field
The present invention relates to a kind of bactericidal composition and uses thereof, particularly, the present invention relates to a kind ofly contain Boscalid and at least a bactericidal composition that is selected from triazole bactericidal agent as active component, and this bactericidal composition is used for the purposes of controlling plant diseases.
(2) background technology
Boscalid
English common name: Boscalid
Chemical name: 2-chloro-N-(4-chlordiphenyl-2-yl) vitamin PP
Structural formula:
Figure BSA00000642512200011
Boscalid is a novel nicotinamide systemic fungicide newly developed in recent years; Fungicidal spectrum is wider; Almost all types of fungal diseases all there is activity; Very effective to preventing and treating powdery mildew, gray mold, stalk break and various rots etc., and also effective to the resistance bacterium of other medicaments, be mainly used in the control of diseases such as comprising rape, grape, fruit tree, vegetables and field crop.Because its distinctive mechanism of action is difficult for producing cross resistance, in addition to crop safety and favourable toxicity data and ecological effect, is the novel nicotinamide bactericide of significant.
Though Boscalid has above-mentioned advantage, because cost is too high, at present domestic almost not application.
(3) summary of the invention
One of the object of the invention is to overcome above-mentioned deficiency, but the low delaying drug resistance development of a kind of applied widely, effective, cost is provided contain Boscalid and a kind of bactericidal composition that is selected from triazole bactericidal agent as active component.
Two of the object of the invention is to provide a kind of Boscalid and at least a purposes that is selected from the bactericidal composition of triazole bactericidal agent of containing.
The objective of the invention is to realize like this:
A kind of bactericidal composition that contains Boscalid; Said composition contains active ingredient and is (A) Boscalid and at least a being selected from (B) triazole bactericidal agent: Difenoconazole, propiconazole, Tebuconazole, own azoles alcohol, Flutriafol, fluorine ring azoles, tetraconazole, Flusilazole, nitrile bacterium azoles, Cyproconazole, triazolone, alkene azoles alcohol, the weight ratio of said A and B is 1~50: 50~1.
The preferred weight ratio of said A and B is 3~40: 2~40.
Said combination dosage form is any one formulation that allows on the agricultural chemicals.For example wetting powder, water dispersible granules, suspending agent, aqueous emulsion, missible oil or the agent of kind clothing etc.
When concrete the application, said A and the mass percent of B component in above-mentioned formulation are 5~90%.
A kind of purposes that contains the bactericidal composition of Boscalid is used to prevent and treat the control of cereal crop or gourd, fruit and vegetable class plant disease.The for example control of the multiple cereal crop disease on paddy rice, the wheat; For example rice blast, banded sclerotial blight, false smut, glume blight, wheat rust, powdery mildew, full rot, wheat scab, barley leaf blotch, leaf rust, Gerlachia oryaae; Triticale powdery mildew, leaf rust; Corn northern and southern leaf blight, head smut etc., preferred, bactericidal composition of the present invention is used to prevent and treat rice sheath blight disease, leaf rust of barley, triticale leaf rust, wheat scab and the corn northern leaf blight.Gourd, fruit and vegetable class plant disease is for example cucumber downy mildew, alternaria leaf spot of apple, ring rot of apple, pear scab, Chinese cabbage rot, downy mildew of garpe, capsicum epidemic disease, watermelon anthrax, citrus scab, tomato late blight etc.; Preferably, bactericidal composition of the present invention is used to prevent and treat tomato late blight, pear scab.
Compared with prior art, the invention has the beneficial effects as follows:
(1) present composition synergistic effect of in certain ratio range, doing well, the bactericidal effect of composition have had than single agent and have significantly improved, and have reduced agricultural chemicals using dosage and cost simultaneously, have reduced residually, have also alleviated the harmful effect to environment;
(2) mechanism of action of two kinds of active components is different among the present invention, and the application of composition can delay or overcome the resistance of pathogen, prolongs the service life of product;
(3) present composition is applicable to control cereal crop disease, also can be used for the control of other crop pest in addition
(4) embodiment
Clearer in order to be the object of the invention, technical scheme and advantage, the present invention describes with following instantiation, but the present invention is not limited to these examples.
The present composition is an active ingredient with Boscalid and a kind of active component that is selected from triazole bactericidal agent; Find through the indoor bioassay test; Antagonistic drug venereal disease evil had obvious role in synergism after both were composite, specifically explained with following biologicall test instance.
The instance 1 of measuring in kind: Boscalid and the composite toxicity test of own azoles alcohol to Rhizoctonia solani Kuhn
1, subjects: rice sheath blight disease [Latin formal name used at school: Thanatephorus cucumeris (Frank) Donk.]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1156.5-2006 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1156.5-2006 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up Rhizoctonia solani Kuhn that is mixed of Boscalid, own azoles alcohol and the two different proportion thereof sees table 1, in the table 1 " pyridine: oneself " be writing a Chinese character in simplified form of " Boscalid: own azoles alcohol ".
Table 1 Boscalid and own azoles alcohol are mixed to the toxicity test result of Rhizoctonia solani Kuhn
Figure BSA00000642512200041
Indoor biometrics is the result show: Boscalid and own azoles alcohol are mixed with 1: 1,1: 3,1: 5,1: 7,3: 1,5: 1 and 7: 1 ratios; It shows addition or synergistic effect to Rhizoctonia solani Kuhn, and is wherein the most obvious with the ratio mixed synergies of 1: 1,1: 3,1: 5 and 3: 1.
The instance 2 of measuring in kind: the composite toxicity test of Boscalid and Difenoconazole to the leaf rust of barley bacterium
1, subjects: leaf rust of barley bacterium [Latin formal name used at school: Puccinia hordei Otth.]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1156.15-2008 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1156.15-2008 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up the leaf rust of barley bacterium that is mixed of Boscalid, Difenoconazole and the two different proportion thereof sees table 2, and " pyridine: benzene " is writing a Chinese character in simplified form of " Boscalid: Difenoconazole " in the table 2.
Table 2 Boscalid and Difenoconazole are mixed to the toxicity test result of leaf rust of barley bacterium
Figure BSA00000642512200051
Indoor biometrics is the result show: Boscalid and Difenoconazole are mixed with 1: 1,1: 2,1: 5,1: 8,2: 1,5: 1 and 8: 1 ratios; It shows addition or synergistic effect to leaf rust of barley, and is wherein the most obvious with the ratio mixed synergies of 1: 1,1: 2,2: 1 and 5: 1.
The instance 3 of measuring in kind: the composite toxicity test of Boscalid and Flutriafol to triticale leaf rust bacterium
1, subjects: triticale leaf rust bacterium [Latin formal name used at school: ccinia recondita=P.Recondita Roberge ex Desmaz.f.tritici]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1156.15-2008 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1156.15-2008 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up triticale leaf rust bacterium that is mixed of Boscalid, Flutriafol and the two different proportion thereof sees table 3, and " pyridine: powder " is writing a Chinese character in simplified form of " Boscalid: Flutriafol " in the table 3.
Table 3 Boscalid and Flutriafol are mixed to the toxicity test result of triticale leaf rust bacterium
Indoor biometrics is the result show: Boscalid and Flutriafol are mixed with 1: 1,1: 2,1: 4,1: 8,2: 1,4: 1 and 8: 1 ratios; It shows addition or synergistic effect to triticale leaf rust bacterium, and is wherein the most obvious with the ratio mixed synergies of 1: 1,2: 1 and 2: 1.
The instance 4 of measuring in kind: the composite toxicity test of Boscalid and Cyproconazole to fusarium graminearum
1, subjects: fusarium graminearum [Latin formal name used at school: FusaHum graminearum Sehw.]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1156.2-2006 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1156.2-2006 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up fusarium graminearum that is mixed of Boscalid, Cyproconazole and the two different proportion thereof sees table 4, and " pyridine: ring " is writing a Chinese character in simplified form of " Boscalid: Cyproconazole " in the table 4.
Table 4 Boscalid and Cyproconazole are mixed to the toxicity test result of fusarium graminearum
Figure BSA00000642512200071
Indoor biometrics is the result show: Boscalid and Cyproconazole are mixed with 1: 1,1: 3,1: 5,1: 7,3: 1,5: 1 and 7: 1 ratios; It shows addition or synergistic effect to fusarium graminearum, and is wherein the most obvious with the ratio mixed synergies of 1: 1,1: 3,1: 5 and 3: 1.
The instance 5 of measuring in kind: the composite toxicity test of Boscalid and fluorine ring azoles to Exserohilum turcicum
1, subjects: the corn northern leaf blight [Latin formal name used at school: Leonard et Suggs Exserohilum turcicum (Pass.))]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1464.15-2007 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1464.15-2007 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up Exserohilum turcicum that is mixed of Boscalid, fluorine ring azoles and the two different proportion thereof sees table 5, and " pyridine: fluorine " is writing a Chinese character in simplified form of " Boscalid: fluorine ring azoles " in the table 5.
Table 5 Boscalid and fluorine ring azoles are mixed to the toxicity test result of Exserohilum turcicum
Figure BSA00000642512200081
Indoor biometrics is the result show: Boscalid and fluorine ring azoles are mixed with 1: 1,1: 3,1: 5,1: 9,3: 1,5: 1 and 9: 1 ratios; It shows addition or synergistic effect to Exserohilum turcicum, and is wherein the most obvious with the ratio mixed synergies of 1: 1,1: 3,1: 5 and 3: 1.
The instance 6 of measuring in kind: the composite toxicity test of Boscalid and Flusilazole to the tomato late blight bacterium
1, subjects: tomato late blight bacterium [Latin formal name used at school: Phytophthora infestans (Mont.) deBary.]
2, test method:, adopt the pastille medium therapy with reference to " pesticide bioassay test rule NY/T 1156.2-2006 ".
3, data statistic analysis: analyze with the SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC 50And co-toxicity coefficient.
4, evaluation method: with reference to " pesticide bioassay test rule NY/T 1156.2-2006 "; Estimate the synergistic effect of pharmacy mix according to the co-toxicity coefficient method (CTC) of Sun&Johnson (1960); Be that CTC≤80 are antagonism; 80<CTC<120 are summation action, and CTC>=120 are synergistic effect.
5, result and analysis
The toxicity test result who makes up the tomato late blight bacterium that is mixed of Boscalid, Flusilazole and the two different proportion thereof sees table 5, and " pyridine: silicon " is writing a Chinese character in simplified form of " Boscalid: Flusilazole " in the table 5.
Table 5 Boscalid and Flusilazole are mixed to the toxicity test result of tomato late blight bacterium
Figure BSA00000642512200091
Indoor biometrics is the result show: Boscalid and fluorine ring azoles are mixed with 1: 1,1: 3,1: 5,1: 9,3: 1,5: 1 and 9: 1 ratios; It shows addition or synergistic effect to the tomato late blight bacterium, and is wherein the most obvious with the ratio mixed synergies of 1: 1,1: 3,3: 1 and 5: 1.
The present composition can be with known auxiliary agent and assistant agent, with known method preparation and be fit to agricultural and go up any one formulation of using; Wherein reasonable formulation has missible oil, water dispersible granules, aqueous emulsion, suspending agent, the agent of kind clothing and wetting powder, and these known auxiliary agents, assistant agent have dispersant, diffusant, antifoaming agent, wetting agent, disintegrant, filler etc.
Below describe with instantiation.
Embodiment 1:
Boscalid 10g, own azoles alcohol 30g, cyclohexanone 15g, phenethyl phenol polyethenoxy ether 3g, castor oil are added to 100g, be mixed to even liquid phase, make the present composition 40% missible oil.
Embodiment 2:
Boscalid 30g, Difenoconazole 10g, sodium methylene bis-naphthalene sulfonate 5g, sodium lignin sulfonate 8g, urea 3g, polyvinyl alcohol 1.5g, bentonite are added to 100g,, make the present composition 40% water dispersible granules through comminution by gas stream, granulation.
Embodiment 3:
With Boscalid 10g, Flutriafol 20g, dodecyl sodium sulfate 5g, NPE 3g, naphthalene sulfonic acid-formaldehyde condensation product 2g, xanthans 0.2g, propane diols 5g, suitable quantity of water; Mixing is through wet grinding; Homogenizing makes the present composition 30% suspending agent.
Embodiment 4:
Boscalid 20g, Cyproconazole 20g, dispersing agent NNO 4.5g, sodium lignin sulfonate 3g, white carbon 5g, kaolin are added to 100g, mix making the present composition 40% wetting powder through comminution by gas stream.
Embodiment 5:
With Boscalid 5g, fluorine ring azoles 15g, pyrrolidones 20g, alkylaryl formaldehyde resin APEO 10g, APES phosphate 1g, ethylene glycol 4g and suitable quantity of water; The preparation oil phase; The preparation water; Under high shear, the even aqueous phase of oil phase is perhaps added water in the oil phase, shear and make the present composition 20% aqueous emulsion.
Embodiment 6:
Boscalid 30g, fluorine ring azoles 45g, sodium alkyl sulfate 8g, alkyl naphthalene sulfonic acid formaldehyde condensation products 3g, glauber salt 3g, polyvinyl alcohol 1.5g, bentonite are added to 100g,, make the present composition 75% water dispersible granules through comminution by gas stream, granulation.
Embodiment 7:
With Boscalid 30g, Flusilazole 10g, dodecyl sodium sulfonate calcium 5g, NPE 3g, naphthalene sulfonic acid-formaldehyde condensation product 2g, xanthans 0.1g, ethylene glycol 5g, organic silicone 0.3g, suitable quantity of water; Mixing is through wet grinding; Homogenizing makes the present composition 40% suspending agent.

Claims (8)

1. bactericidal composition that contains Boscalid; It is characterized in that: said composition contains Boscalid (A) and at least a (B) triazole bactericidal agent that is selected from as follows: Difenoconazole, propiconazole, Tebuconazole, own azoles alcohol, Flutriafol, fluorine ring azoles, tetraconazole, Flusilazole, nitrile bacterium azoles, Cyproconazole, triazolone, alkene azoles alcohol, the weight ratio of A and B is 1~50: 50~1.
2. bactericidal composition according to claim 1 is characterized in that: the weight ratio of said A and B is 3~40: 2~40.
3. bactericidal composition according to claim 1 and 2 is characterized in that: said combination dosage form is any one formulation that allows on the agricultural chemicals.
4. bactericidal composition according to claim 3 is characterized in that: said combination dosage form is wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
5. bactericidal composition according to claim 4 is characterized in that: said Boscalid and the triazole bactericidal agent mass percent in formulation is 5~90%.
6. claim 1 or 2 bactericidal composition are used to prevent and treat the purposes of cereal crop or gourd, fruit and vegetable class plant disease.
7. according to the purposes of claim 6, cereal crop disease wherein is rice sheath blight disease, leaf rust of barley, triticale leaf rust, wheat scab and the corn northern leaf blight.
8. according to the purposes of claim 6, wherein gourd, fruit and vegetable class plant disease is tomato late blight, pear scab.
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Cited By (11)

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CN102972408A (en) * 2012-11-21 2013-03-20 青岛文创科技有限公司 Bactericidal composition containing triazolone and fluopicolide
CN103416425A (en) * 2012-05-22 2013-12-04 陕西韦尔奇作物保护有限公司 Fungicidal composition containing tiadinil and triazole fungicide
CN103518725A (en) * 2013-10-14 2014-01-22 安徽丰乐农化有限责任公司 Bactericide taking boscalid as effective component and for rice field, wheat field and corn field
CN104322501A (en) * 2012-08-15 2015-02-04 陕西美邦农药有限公司 Chesulfamide-containing efficient sterilization composition
CN104855413A (en) * 2015-05-12 2015-08-26 柳州市耕青科技有限公司 Special rot resistant agent for succulent stone flower
CN106135265A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of containing Boscalid and the bactericidal composition of bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silane and application
CN106135225A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of bactericidal composition containing Boscalid and Difenoconazole and application thereof
CN106135223A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of containing Boscalid and the bactericidal composition of prothioconazoles and application
CN106857532A (en) * 2017-04-28 2017-06-20 陕西上格之路生物科学有限公司 Application of the bactericidal composition containing Boscalid on rot is prevented and treated
CN109561688A (en) * 2016-08-04 2019-04-02 江苏龙灯化学有限公司 Synergistic fungicidal composition
CN111491511A (en) * 2017-12-20 2020-08-04 Upl有限公司 Co-crystal of boscalid and triazole

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CN103416425A (en) * 2012-05-22 2013-12-04 陕西韦尔奇作物保护有限公司 Fungicidal composition containing tiadinil and triazole fungicide
CN103416425B (en) * 2012-05-22 2016-02-17 陕西韦尔奇作物保护有限公司 A kind of bactericidal composition containing tiadinil and triazole type
CN104322501A (en) * 2012-08-15 2015-02-04 陕西美邦农药有限公司 Chesulfamide-containing efficient sterilization composition
CN102972408B (en) * 2012-11-21 2015-01-07 青岛文创科技有限公司 Bactericidal composition containing triazolone and fluopicolide
CN102972408A (en) * 2012-11-21 2013-03-20 青岛文创科技有限公司 Bactericidal composition containing triazolone and fluopicolide
CN103518725A (en) * 2013-10-14 2014-01-22 安徽丰乐农化有限责任公司 Bactericide taking boscalid as effective component and for rice field, wheat field and corn field
CN106135265A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of containing Boscalid and the bactericidal composition of bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silane and application
CN106135225A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of bactericidal composition containing Boscalid and Difenoconazole and application thereof
CN106135223A (en) * 2015-04-13 2016-11-23 南京华洲药业有限公司 A kind of containing Boscalid and the bactericidal composition of prothioconazoles and application
CN104855413A (en) * 2015-05-12 2015-08-26 柳州市耕青科技有限公司 Special rot resistant agent for succulent stone flower
CN109561688A (en) * 2016-08-04 2019-04-02 江苏龙灯化学有限公司 Synergistic fungicidal composition
GB2552695B (en) * 2016-08-04 2020-03-04 Rotam Agrochem Int Co Ltd A synergistic fungicidal composition
CN106857532A (en) * 2017-04-28 2017-06-20 陕西上格之路生物科学有限公司 Application of the bactericidal composition containing Boscalid on rot is prevented and treated
CN111491511A (en) * 2017-12-20 2020-08-04 Upl有限公司 Co-crystal of boscalid and triazole
US11632956B2 (en) 2017-12-20 2023-04-25 Upl Ltd Co-crystals of boscalid and triazoles

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