CN103416425B - A kind of bactericidal composition containing tiadinil and triazole type - Google Patents
A kind of bactericidal composition containing tiadinil and triazole type Download PDFInfo
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- CN103416425B CN103416425B CN201210160355.8A CN201210160355A CN103416425B CN 103416425 B CN103416425 B CN 103416425B CN 201210160355 A CN201210160355 A CN 201210160355A CN 103416425 B CN103416425 B CN 103416425B
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- tiadinil
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- triazole
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- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical compound N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 title claims abstract description 142
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 150000003852 triazoles Chemical class 0.000 title claims abstract description 49
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 19
- 201000010099 disease Diseases 0.000 claims abstract description 47
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 47
- 239000003899 bactericide agent Substances 0.000 claims abstract description 40
- 150000003851 azoles Chemical class 0.000 claims abstract description 28
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims abstract description 17
- LQDARGUHUSPFNL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(COC(F)(F)C(F)F)CN1C=NC=N1 LQDARGUHUSPFNL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005839 Tebuconazole Substances 0.000 claims abstract description 17
- 239000005840 Tetraconazole Substances 0.000 claims abstract description 17
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 claims abstract description 15
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims abstract description 15
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 claims abstract description 15
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000005757 Cyproconazole Substances 0.000 claims abstract description 15
- 239000005760 Difenoconazole Substances 0.000 claims abstract description 15
- 239000005767 Epoxiconazole Substances 0.000 claims abstract description 15
- 239000005787 Flutriafol Substances 0.000 claims abstract description 15
- 239000005813 Penconazole Substances 0.000 claims abstract description 15
- 239000005822 Propiconazole Substances 0.000 claims abstract description 15
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 claims abstract description 15
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- DQJCHOQLCLEDLL-UHFFFAOYSA-N tricyclazole Chemical compound CC1=CC=CC2=C1N1C=NN=C1S2 DQJCHOQLCLEDLL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 241000894006 Bacteria Species 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000011737 fluorine Substances 0.000 claims abstract description 14
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 14
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 claims abstract description 13
- 241000221785 Erysiphales Species 0.000 claims description 19
- 235000007164 Oryza sativa Nutrition 0.000 claims description 17
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 17
- 235000009566 rice Nutrition 0.000 claims description 17
- 239000000375 suspending agent Substances 0.000 claims description 17
- 206010039509 Scab Diseases 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 11
- 239000003094 microcapsule Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 241000223218 Fusarium Species 0.000 claims description 5
- 206010027146 Melanoderma Diseases 0.000 claims description 5
- 241000233679 Peronosporaceae Species 0.000 claims description 5
- 241000221696 Sclerotinia sclerotiorum Species 0.000 claims description 5
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 5
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 5
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- 239000004562 water dispersible granule Substances 0.000 claims description 4
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 48
- 230000000694 effects Effects 0.000 abstract description 9
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 230000000855 fungicidal effect Effects 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 66
- 238000012360 testing method Methods 0.000 description 57
- 239000002131 composite material Substances 0.000 description 41
- 230000003449 preventive effect Effects 0.000 description 32
- 231100000820 toxicity test Toxicity 0.000 description 26
- 241000209140 Triticum Species 0.000 description 23
- 235000021307 Triticum Nutrition 0.000 description 23
- 239000000575 pesticide Substances 0.000 description 21
- 241000209094 Oryza Species 0.000 description 16
- 239000012071 phase Substances 0.000 description 15
- 230000005764 inhibitory process Effects 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 13
- 229940079593 drug Drugs 0.000 description 11
- 206010067482 No adverse event Diseases 0.000 description 9
- 238000011835 investigation Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000013530 defoamer Substances 0.000 description 8
- 239000002270 dispersing agent Substances 0.000 description 8
- 241000223600 Alternaria Species 0.000 description 7
- 240000008067 Cucumis sativus Species 0.000 description 7
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 7
- 241000510928 Erysiphe necator Species 0.000 description 7
- 235000014443 Pyrus communis Nutrition 0.000 description 7
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- 230000002528 anti-freeze Effects 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 230000010165 autogamy Effects 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- 241000219095 Vitis Species 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 206010011732 Cyst Diseases 0.000 description 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 3
- 240000003768 Solanum lycopersicum Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 208000031513 cyst Diseases 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- -1 propiconazole compound Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000004563 wettable powder Substances 0.000 description 2
- STMIIPIFODONDC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(O)(CCCC)CN1C=NC=N1 STMIIPIFODONDC-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000005858 Triflumizole Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 239000004557 technical material Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical compound O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 description 1
- HSMVPDGQOIQYSR-KGENOOAVSA-N triflumizole Chemical compound C1=CN=CN1C(/COCCC)=N/C1=CC=C(Cl)C=C1C(F)(F)F HSMVPDGQOIQYSR-KGENOOAVSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing tiadinil and triazole type, bactericidal composition contains active components A and active component B, active components A is tiadinil, active component B is triazole bactericidal agent, described triazole bactericidal agent is selected from any one compound following: Tebuconazole, tricyclazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole, and the weight ratio of active components A and active component B is 1 ︰ 60 ~ 80 ︰ 1.The present composition has greater activity to the multiple diseases in various crop, and has obvious synergistic effect, expands fungicidal spectrum.And have that dosage is little, resistance of rainwater washing against, the obvious feature of synergy.<!--1-->
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition in crop pest containing tiadinil and triazole type.
Technical background
Tiadinil (Tiadinil) chemical name: 3'-chloro-4', 4'-dimethyl-1,2,3-thiadiazoles-5-formailide, molecular formula: C
11h
10clN
3oS.This medicament itself is poor to the inhibit activities of germ, and its effect machine buries and mainly stops disease mattress mycelia to invade contiguous healthy cell, and can induce generation disease-resistant gene.This medicament has absorption well, can pass through root absorption, and be transmitted to rapidly other positions, and be suitable for the water surface and use, the lasting period is long, has good control efficiency to leaf blast disease and fringe rice blast.
Triazole bactericidal agent broad-spectrum-have very high activity to the many kinds of disease funguses of sac fungi, basidiomycetes, imperfect fungus, but to oomycetes non-activity; Efficiently-drug effect is high, dosage reduces; Lasting period length-blade face 15-20 days, seed treatment about 80 days, soil treatment 100 days, all long than general bactericide, and extend with the increase of dosage; Uptake and transmission is good, and infiltration rate is fast, dispenser after 2 hours the absorbed amount of triazolone can suppress the growth of powdery mildew; There is strong preventive effect, good therapeutic action, stifling and eradicant action.The mechanism of action, for affect sterols biosynthesis, makes somatic cells film function be damaged.
But in the real process of agricultural production, the problem that controlling disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect clearly, very high composite just less of synergy ratio.Through inventor's research, find by tiadinil and triazole bactericidal agent mutually composite, have good synergistic effect within the specific limits, and relevant composite about tiadinil and triazole bactericidal agent, there is not yet relevant report at home and abroad at present.
Summary of the invention
The object of the invention is to propose a kind ofly have that synergistic function, use cost are low, preventive effect is good containing tiadinil with the bactericidal composition of triazole type.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing tiadinil and triazole type, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1 ︰ 60 ~ 80 ︰ 1, described active components A is selected from tiadinil, active component B is triazole bactericidal agent, and described triazole bactericidal agent is selected from: the one in Tebuconazole, tricyclazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole; Active components A and the preferred weight ratio of active component B are 1 ︰ 40 ~ 50 ︰ 1; The weight ratio being more preferably tiadinil and Tebuconazole, epoxiconazole, Difenoconazole or propiconazole is 1 ︰ 20 ~ 20 ︰ 1; The weight ratio of tiadinil and Flutriafol, cyproconazole, Flusilazole or fluorine bacterium azoles is 1 ︰ 20 ~ 30 ︰ 1; The weight ratio of tiadinil and tricyclazole is 1 ︰ 30 ~ 10 ︰ 1; The weight ratio of tiadinil and tetraconazole is 1 ︰ 10 ~ 25 ︰ 1; The weight ratio of tiadinil and penconazole is 1 ︰ 5 ~ 20 ︰ 1; The weight ratio of tiadinil and prothioconazoles is 1 ︰ 20 ~ 10 ︰ 1; The weight ratio of tiadinil and own azoles alcohol is 1 ︰ 5 ~ 25 ︰ 1.
Described bactericidal composition can be made into wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
Described bactericidal composition is for preventing and treating the disease of crop, and described crop comprises cereal crop, fruit tree, vegetables, fiber crop, ornamental plants.
Described disease comprises rice blast, false smut, brown spot, bacterial leaf-blight, banded sclerotial blight, powdery mildew, rust, late blight, downy mildew, leaf spot, black spot, scab, ring spot, spot defoliation, smut, glume blight, moire disease, epidemic disease, white rot, anthracnose, anthrachose of grape, rust, leaf mold, fusarium wilt, stalk break, net blotch, gray mold, balck shank, spot blight, shot hole.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, simultaneously also relevant with target disease.In usual composition, the weight percentage of active component is 2% ~ 90% of gross weight, is preferably 5% ~ 80%.According to different preparation types, active component content scope is different.Usually, liquid preparation contains the active substance of by weight 1% ~ 60%, is preferably 5% ~ 50%; Solid pharmaceutical preparation contains the active substance of by weight 5% ~ 80%, is preferably 10% ~ 80%.
At least containing a kind of surfactant in bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 2% ~ 30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, stabilizing agent known in those skilled in the art, antifreeze etc. can also be contained.
Bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc. by active component with liquid flux or solid carrier.
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) pesticide usage amount reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) fungicidal spectrum is expanded, to multiple diseases as rice blast, false smut, brown spot, bacterial leaf-blight, banded sclerotial blight, powdery mildew, rust, late blight, downy mildew, leaf spot, black spot, scab, ring spot, spot defoliation, smut, glume blight, moire disease, epidemic disease, white rot, anthracnose, anthrachose of grape, rust, leaf mold, fusarium wilt, stalk break, net blotch, gray mold, balck shank, spot blight, shot hole have greater activity.
Embodiment
Below in conjunction with embodiment to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 ~ 17 wetting powder
By tiadinil, active component B, dispersant, wetting agent, filler mixing, mix in mixed cylinder, mix again after airslide disintegrating mill is pulverized, namely can be made into wetting powder product of the present invention.Specifically in table 1,2.
The each component of table 1 example 1 ~ 12 and content
The each component of table 2 example 13 ~ 17 and content
Example 18 ~ 32 water dispersible granules
Tiadinil, active component B, dispersant, wetting agent, binding agent (can add and can not add), disintegrant, filler are obtained together the particle diameter of needs through air-flow crushing, obtain granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and after drying, obtaining water dispersible granules product of the present invention.Specifically in table 3,4.
The each component of table 3 example 18 ~ 27 and content
The each component of table 4 example 28 ~ 32 and content
Example 33 ~ 47 suspending agent
Dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add tiadinil, active component B, surplus is supplied by deionized water, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent product of the present invention.Specifically in table 5,6.
The each component of table 5 example 33 ~ 42 and content
The each component of table 6 example 43 ~ 47 and content
Example 48 ~ 64 suspension emulsion
By dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), stabilizing agent (can add and can not add), mix through high speed shear, add tiadinil, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained tiadinil suspending agent, then by active component B, solvent (can add and can not add), emulsifier and the direct emulsification of various auxiliary agent high speed agitators in suspending agent, surplus is supplied, obtained suspension emulsion product of the present invention by deionized water.Specifically in table 7,8,9.
The each component of table 7 example 48 ~ 53 and content
The each component of table 8 example 54 ~ 59 and content
The each component of table 9 example 60 ~ 64 and content
Example 65 ~ 81 aqueous emulsion
Tiadinil, active component B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, obtained aqueous emulsion product of the present invention.Specifically in table 10,11.
The each component of table 10 example 65 ~ 76 and content
The each component of table 11 example 77 ~ 81 and content
Tebuconazole, tricyclazole, tetraconazole in table 1,3,5,7,8,10 are exchanged as other triazole bactericidal agent in active component B, also can obtain novel formulation.
Example 82 ~ 86 microemulsion
Tiadinil, active component B are dissolved in and are equipped with in the homogenizer of solvent, emulsifier, antifreeze (can add and can not add), defoamer, stabilizing agent (can add and can not add) are joined in the homogenizer that above-mentioned solution is housed, deionized water gives strong mixing and homogenize after supplying surplus, finally obtain the microemulsion product of the present invention that clear appearance is transparent.Specifically in table 12.
The each component of table 12 example 82 ~ 86 and content
Example 87 ~ 91 microcapsule suspending agent
By tiadinil, active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, pH adjusting agent, dispersant, defoamer, surplus deionized water is supplied, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 13.
The each component of table 13 example 87 ~ 91 and content
Example 92 ~ 96 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition in the aqueous phase solution containing emulsifier, pH adjusting agent, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add tiadinil, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μm, obtained suspending agent, then join in the aqueous phase solution of micro-capsule suspension by suspending agent, deionized water supplies surplus, makes the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition.Specifically in table 14.
The each component of table 14 example 92 ~ 96 and content
The embodiment of the present invention is the method adopting Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: determine that after the effective inhibition concentration scope of each medicament, medicament establishes 5 dosage process respectively by active constituent content through prerun, if clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter by right-angled intersection method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx), and calculate the EC of often kind of medicament thus with method of least squares
50value.Calculate two medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and the ratio of active component B shared by combination;
A is tiadinil;
B choosing is to the one in Tebuconazole, tricyclazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole.
Application Example two
For examination disease: alternaria leaf spot of apple; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and Original Tebuconazole and the two different ratio mixture.
Toxicity test result
Table 15 tiadinil and the composite toxicity test analysis of results table to alternaria leaf spot of apple of Tebuconazole
As shown in Table 15, tiadinil and Tebuconazole to alternaria leaf spot of apple proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and Tebuconazole is at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Optimum ratio through test discovery tiadinil and Tebuconazole is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20, especially when tiadinil and tebuconazole weight are more maximum than synergy ratio when being 1:1, synergistic effect is the most obvious.
Application Example three
For examination disease: rice blast; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and Mensurating Tricyclazole Technical and the two different ratio mixture.
Toxicity test result
Table 16 tiadinil and the composite toxicity test analysis of results table to rice blast of tricyclazole
As shown in Table 16, tiadinil and tricyclazole to rice blast proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and tricyclazole is at 1 ︰ 30 ~ 10 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Optimum ratio through test discovery tiadinil and tricyclazole is 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,2:5,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, especially when tiadinil and tricyclazole weight ratio are 1:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four
For examination disease: wheat powdery mildew; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of tetraconazole and the two different ratio mixture.
Toxicity test result
Table 17 tiadinil and the composite toxicity test analysis of results table to wheat powdery mildew of tetraconazole
As shown in Table 17, tiadinil and tetraconazole to the sick proportioning of wheat powdery mildew when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and tetraconazole is at 1 ︰ 10 ~ 25 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Optimum ratio through test discovery tiadinil and tetraconazole is 25:1,20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,5:2,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10, especially when tiadinil and tetraconazole weight ratio are 5:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example five
For examination disease: wheat rust; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of Flutriafol and the two different ratio mixture.
Toxicity test result
Table 18 tiadinil and the composite toxicity test analysis of results table to wheat rust of Flutriafol
As shown in Table 18, tiadinil and Flutriafol to wheat rust proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and Flutriafol is at 1 ︰ 20 ~ 30 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Especially when tiadinil and Flutriafol weight ratio are 3:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example six
For examination disease: ring rot of apple; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of cyproconazole and the two different ratio mixture.
Toxicity test result
Table 19 tiadinil and the composite toxicity test analysis of results table to ring rot of apple of cyproconazole
As shown in Table 19, tiadinil and cyproconazole to ring rot of apple proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and cyproconazole is at 1 ︰ 20 ~ 30 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Especially when tiadinil and cyproconazole weight ratio are 3:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example seven
For examination disease: grape powdery mildew; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of penconazole and the two different ratio mixture.
Toxicity test result
Table 20 tiadinil and the composite toxicity test analysis of results table to grape powdery mildew of penconazole
As shown in Table 20, tiadinil and penconazole to grape powdery mildew proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and penconazole is at 1 ︰ 5 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Especially when tiadinil and penconazole weight ratio are 4:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example eight
For examination disease: pear scab; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and flusilazole and the two different ratio mixture.
Toxicity test result
Table 21 tiadinil and the composite toxicity test analysis of results table to pear scab of Flusilazole
As shown in Table 21, tiadinil and Flusilazole to pear scab proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and Flusilazole is at 1 ︰ 20 ~ 30 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Especially when tiadinil and Flusilazole weight ratio are 3:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example nine
For examination disease: wheat leaf blight; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of prothioconazoles and the two different ratio mixture.
Toxicity test result
Table 22 tiadinil and the composite toxicity test analysis of results table to wheat leaf blight of prothioconazoles
As shown in Table 22, tiadinil and prothioconazoles to wheat leaf blight proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and prothioconazoles is at 1 ︰ 20 ~ 10 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Especially when tiadinil and prothioconazoles weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example ten
For examination disease: wheat powdery mildew; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of own azoles alcohol and the two different ratio mixture.
Toxicity test result
Table 23 tiadinil and the composite toxicity test analysis of results table to wheat powdery mildew of own azoles alcohol
As shown in Table 23, tiadinil and own azoles alcohol to wheat powdery mildew proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and own azoles alcohol is at 1 ︰ 5 ~ 25 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Especially when tiadinil and own azoles alcohol weight ratio are 5:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example 11
For examination disease: sigatoka; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and epoxiconazole raw drug and the two different ratio mixture.
Toxicity test result
Table 24 tiadinil and the composite toxicity test analysis of results table to sigatoka of epoxiconazole
As shown in Table 24, tiadinil and epoxiconazole to sigatoka proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and epoxiconazole is at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.Especially when tiadinil and epoxiconazole weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example 12
For examination disease: tomato blight; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and difenoconazole technical material and the two different ratio mixture.
Toxicity test result
Table 25 tiadinil and the composite toxicity test analysis of results table to tomato blight of Difenoconazole
As shown in Table 25, tiadinil and Difenoconazole to tomato blight proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and Difenoconazole is at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Especially when tiadinil and Difenoconazole weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example 13
For examination disease: powdery mildew of cucumber; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and the former medicine of fluorine bacterium azoles and the two different ratio mixture.
Toxicity test result
Table 26 tiadinil and the composite toxicity test analysis of results table to powdery mildew of cucumber of fluorine bacterium azoles
As shown in Table 26, tiadinil and fluorine bacterium azoles to powdery mildew of cucumber proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and fluorine bacterium azoles is at 1 ︰ 20 ~ 30 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Especially when tiadinil and fluorine bacterium azoles weight ratio are 3:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example 14
For examination disease: wheat sharp eyespot; Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd.; Experimental scheme: through effective inhibition concentration scope of preliminary experiment determination tiadinil and propiconazole and the two different ratio mixture.
Toxicity test result
Table 27 tiadinil and propiconazole compound are to the toxicity test analysis of results table of wheat sharp eyespot
As shown in Table 27, tiadinil and propiconazole to wheat sharp eyespot proportioning when 1 ︰ 60 ~ 80 ︰ 1, synergy ratio SR is all greater than 1.5, both explanations mixture in 1 ︰ 60 ~ 80 ︰ 1 scope all shows synergistic effect, when the proportioning of tiadinil and propiconazole is at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Especially when tiadinil and propiconazole weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Find through test: tiadinil and Tebuconazole, tricyclazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, to rice blast in various crop after propiconazole compound, false smut, brown spot, bacterial leaf-blight, banded sclerotial blight, powdery mildew, rust, late blight, downy mildew, leaf spot, black spot, scab, ring spot, spot defoliation, smut, glume blight, moire disease, epidemic disease, white rot, anthracnose, anthrachose of grape, rust, leaf mold, fusarium wilt, stalk break, net blotch, gray mold, balck shank, spot blight, the control of shot hole has obvious synergistic effect, synergy ratio is all more than 1.50.
Test of pesticide effectiveness part: test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., provided.
Table 28 contrasts the table of comparisons of medicament
| Numbering | Contrast medicament | Numbering | Contrast medicament |
| Medicament 1 | 10% tiadinil suspending agent (autogamy) | Medicament 8 | 10% Flusilazole aqueous emulsion (commercial) |
| Medicament 2 | 25% Tebuconazole wetting powder (commercial) | Medicament 9 | 5% prothioconazoles suspending agent (autogamy) |
| Medicament 3 | 20% tricyclazole wettable powder (commercial) | Medicament 10 | 5% hexaconazole suspending agent (commercial) |
| Medicament 4 | 4% tetraconazole aqueous emulsion (commercial) | Medicament 11 | 12.5% epoxiconazole suspension concentrate (commercial) |
| Medicament 5 | 12.5% Flutriafol suspending agent (autogamy) | Medicament 12 | 10% difenoconazole water emulsion (commercial) |
| Medicament 6 | 10% cyproconazole wetting powder (autogamy) | Medicament 13 | 30% triflumizole wettable powder (commercial) |
| Medicament 7 | 10% penconazole missible oil (autogamy) | Medicament 14 | 25% propiconazole emulsifiable concentrate (commercial) |
Application Example 15 tiadinil and triazole bactericidal agent and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and the investigation rice blast state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 29 tiadinil and triazole bactericidal agent and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 29, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat rice blast, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 16 tiadinil and triazole bactericidal agent and compositely prevent and treat the wheat smut test of pesticide effectiveness
This test arrangement is at Shaanxi Province's Weinan City, and the investigation wheat smut state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 30 tiadinil and triazole bactericidal agent and compositely prevent and treat the wheat smut test of pesticide effectiveness
As can be seen from Table 30, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat wheat smut, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 17 tiadinil and triazole bactericidal agent and the composite control pear scab test of pesticide effectiveness thereof
This test arrangement is in Xianyang, Shanxi province city, and the investigation pear scab state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after third time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 31 tiadinil and triazole bactericidal agent and the composite control pear scab test of pesticide effectiveness thereof
As can be seen from Table 31, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 18 tiadinil and triazole bactericidal agent and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This test arrangement is in Xianyang, Shanxi province city, and the investigation alternaria leaf spot of apple state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 32 tiadinil and triazole bactericidal agent and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 32, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 19 tiadinil and triazole bactericidal agent and the composite control grape powdery mildew test of pesticide effectiveness thereof
This test arrangement is in Weinan City suburb, Shaanxi Province, and the investigation grape powdery mildew state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after third time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 33 tiadinil and triazole bactericidal agent and the composite control grape powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 33, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat grape powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 20 tiadinil and triazole bactericidal agent and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City, and the investigation rice sheath blight disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 34 tiadinil and triazole bactericidal agent and the composite water prevention rice sheath blight test of pesticide effectiveness thereof
As can be seen from Table 34, tiadinil and triazole bactericidal agent composite after can the effective water prevention rice sheath blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 21 tiadinil and triazole bactericidal agent and compositely prevent and treat the powdery mildew of cucumber test of pesticide effectiveness
This test arrangement is in Jingyang County, Shaanxi Province, and the investigation powdery mildew of cucumber state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 35 tiadinil and triazole bactericidal agent and compositely prevent and treat the powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 35, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 22 tiadinil and triazole bactericidal agent and compositely prevent and treat the wheat rust test of pesticide effectiveness
This test arrangement is at Shaanxi Province's Weinan City, and the investigation wheat rust state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 36 tiadinil and triazole bactericidal agent and compositely prevent and treat the wheat rust test of pesticide effectiveness
As can be seen from Table 36, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat wheat rust, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 23 tiadinil and triazole bactericidal agent and compositely prevent and treat the sigatoka test of pesticide effectiveness
This test arrangement is in Nanning, and the investigation sigatoka state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 3 days, 10 days, 20 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 37 tiadinil and triazole bactericidal agent and compositely prevent and treat the sigatoka test of pesticide effectiveness
As can be seen from Table 37, tiadinil and triazole bactericidal agent composite after effectively can prevent and treat sigatoka, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Draw by all parts of the country test, tiadinil and triazole bactericidal agent composite rear to the rice blast in various crop, false smut, brown spot, bacterial leaf-blight, banded sclerotial blight, powdery mildew, rust, late blight, downy mildew, leaf spot, black spot, scab, ring spot, spot defoliation, smut, glume blight, moire disease, epidemic disease, white rot, anthracnose, anthrachose of grape, rust, leaf mold, fusarium wilt, stalk break, net blotch, gray mold, balck shank, spot blight, the preventive effect of the Common Diseases such as shot hole is all greater than 95%, be better than single dose preventive effect, synergy is obvious.
Claims (6)
1. contain a bactericidal composition for tiadinil and triazole type, it is characterized in that: effective active composition is active components A and active component B, and described active components A is tiadinil, and active component B is triazole bactericidal agent; Described triazole bactericidal agent is selected from the one in Tebuconazole, tricyclazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole, wherein the weight ratio of tiadinil and Tebuconazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole is 1 ︰ 60 ~ 80 ︰ 1, and the weight ratio of tiadinil and tricyclazole is 4:1 ~ 2:1 or 1:2 ~ 1:4.
2. the bactericidal composition containing tiadinil and triazole type according to claim 1, is characterized in that: the weight ratio of tiadinil and Tebuconazole, tetraconazole, Flutriafol, cyproconazole, penconazole, Flusilazole, prothioconazoles, own azoles alcohol, epoxiconazole, Difenoconazole, fluorine bacterium azoles, propiconazole is 1 ︰ 40 ~ 50 ︰ 1.
3. the bactericidal composition containing tiadinil and triazole type according to claim 2, is characterized in that:
The weight ratio of tiadinil and Tebuconazole, epoxiconazole, Difenoconazole or propiconazole is 1 ︰ 20 ~ 20 ︰ 1;
The weight ratio of tiadinil and Flutriafol, cyproconazole, Flusilazole or fluorine bacterium azoles is 1 ︰ 20 ~ 30 ︰ 1;
The weight ratio of tiadinil and tetraconazole is 1 ︰ 10 ~ 25 ︰ 1;
The weight ratio of tiadinil and penconazole is 1 ︰ 5 ~ 20 ︰ 1;
The weight ratio of tiadinil and prothioconazoles is 1 ︰ 20 ~ 10 ︰ 1;
The weight ratio of tiadinil and own azoles alcohol is 1 ︰ 5 ~ 25 ︰ 1.
4. the bactericidal composition containing tiadinil and triazole type as claimed in any of claims 1 to 3, is characterized in that: composition makes wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the bactericidal composition containing tiadinil and triazole type according to claim 4 is for preventing and treating the application of crop pest.
6. application according to claim 5, is characterized in that: described disease is rice blast, false smut, brown spot, bacterial leaf-blight, banded sclerotial blight, powdery mildew, rust, downy mildew, leaf spot, black spot, scab, ring spot, spot defoliation, smut, glume blight, moire disease, epidemic disease, white rot, anthracnose, anthrachose of grape, rust, leaf mold, fusarium wilt, stalk break, net blotch, gray mold, balck shank, spot blight, shot hole.
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| CN101647433A (en) * | 2009-07-21 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilization composition based on zoxamide |
| CN101617671A (en) * | 2009-08-01 | 2010-01-06 | 深圳诺普信农化股份有限公司 | Combination sterilization composition |
| CN102388911A (en) * | 2011-09-28 | 2012-03-28 | 联保作物科技有限公司 | Suspension seed coating formulation |
| CN103125504A (en) * | 2011-11-28 | 2013-06-05 | 深圳诺普信农化股份有限公司 | Sterilizing composition containing Tiadinil |
| CN102428931A (en) * | 2011-12-23 | 2012-05-02 | 江阴苏利化学有限公司 | Bacteriocidal composition containing Boscalid and triazole bactericide |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017178407A1 (en) * | 2016-04-13 | 2017-10-19 | Bayer Cropscience Aktiengesellschaft | Fungicidal combinations |
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|---|---|
| CN103416425A (en) | 2013-12-04 |
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Address after: 715500 Pucheng Shaanxi chemical base industrial park, Shaanxi, Weinan Patentee after: Shaanxi yitianfeng crop Technology Co.,Ltd. Address before: 715500 Pucheng Shaanxi chemical base industrial park, Shaanxi, Weinan Patentee before: Shaanxi Welch Crop Protection Co.,Ltd. |
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