CN102416057A - Whitening Chinese medicinal composition - Google Patents
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- CN102416057A CN102416057A CN2011104097375A CN201110409737A CN102416057A CN 102416057 A CN102416057 A CN 102416057A CN 2011104097375 A CN2011104097375 A CN 2011104097375A CN 201110409737 A CN201110409737 A CN 201110409737A CN 102416057 A CN102416057 A CN 102416057A
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Abstract
The invention relates to a whitening Chinese medicinal composition, which is characterized by comprising the following Chinese medicinal materials in part by mass: 1 to 3 parts of circassian bean, 4 to 6 parts of angelica dahurica, 4 to 6 parts of euphorbia lathyris leaf, 4 to 6 parts of cherry leaf and 1 to 3 parts of jasmine flowers. The whitening Chinese medicinal composition is prepared by a method comprising: grinding the five Chinese medicinal materials, uniformly mixing the five Chinese medicinal materials, adding water in an amount which is 20 times the total mass of the five Chinese medicinal materials, soaking at 60 to 70 DEG C for 5 hours, separating medicinal liquid, concentrating, spray-drying and grinding.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially a kind of Chinese medicine composition of Pear Power effect.
Background technology
Along with the development and the growth in the living standard of society, cosmetics have become an indispensable part in people's life.Meanwhile, people are also increasingly high for the quality and the performance requirement of cosmetics.
Skin color is determined by three factors: the content of HbO2 Oxyhemoglobin and reduced hemoglobin in the content of various pigments and the distribution situation in the skin, skin blood, the thickness of skin and light are in the scattering phenomenon of skin surface.Wherein the melanocyte that melanocyte produced that contains of skin is the principal element of decision skin color, and tryrosinase then is the key enzyme of synthetic melanocyte, thereby so the active generation that suppresses melanocyte of restraint of tyrosinase be the critical path that finally reaches whitening effect.
The whitening agent that is used at present cosmetics both at home and abroad is mainly hydroquinone, kojic acid, fruit acid, arbutin and vitamin C derivatives etc., and the some of them material exists cytotoxicity stronger, weak and poor stability of percutaneous permeability or shortcoming such as cost an arm and a leg.
Advantages such as plant whitening is complied with its pure natural property, and the popularity in source is wide in variety, and is nontoxic, as to have no side effect, the increasing concern that receives consumers in general.
Semen adenantherae pavoninae is the leguminous plant Semen adenantherae pavoninae
Adenanthera pavoninaL. var.
MicrospermaThe seed of (Teijsm.et Binnend.) Nielsen.
The Radix Angelicae Dahuricae is the umbellate form section plant Radix Angelicae Dahuricae
Angelica dahurica(Fisch.ex Hoffm.) Benth. et Hook.f. or Radix angelicae dahuricae
Angelica dahurica(Fisch.ex Hoffm.) Benth. et Hook.f. var.
Formosana(Boiss.) dry root of Shan et Yuan.
Folium Euphorbiae lathyris is Radix Cirsii Japonici section plant Euphorbia lathyris
Euphorbia lathyrisL. leaf.
Folium Pruni pseudocerasi is the rosaceous plant Fructus Pruni pseudocerasi
Cerasus pseudocerasus(Lindl.) leaf of G.Don.
Flos Jasmini Sambac is Oleaceae plant jasmine
Jasminum sambac(L.) flower of Ait..
Summary of the invention
Problem to be solved by this invention provides a kind of compositions of Pear Power effect.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposals:
Chinese crude drug with following mass fraction is a raw material: Semen adenantherae pavoninae 1-3 part, Radix Angelicae Dahuricae 4-6 part, Folium Euphorbiae lathyris 4-6 part, Folium Pruni pseudocerasi 4-6 part, Flos Jasmini Sambac 1-3 part; Adopt following method to be prepared from: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got.
The mass fraction of Chinese crude drug is preferably: 2 parts of Semen adenantherae pavoninaes, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Folium Euphorbiae lathyris, 5 parts of Folium Pruni pseudocerasis, 2 parts of Flos Jasmini Sambacs.
The whitening function of the present composition proves through following efficacy test.
Tyrosinase activity and the synthetic influence of melanin in 1 couple of mice B16 of Test Example melanocyte.
1.1 material
The strain of mice B16 MC, DMEM culture medium are purchased in the Chinese Academy of Medical Sciences.Trypsin, L-DOPA, tetramethyl azo azoles blue (MTT) are purchased in Nanjing and are built up biotech firm.Arbutin (98%) is purchased in Nanjing Zelang Pharmaceutical Technology Inc., and the present composition is pressed the self-control of embodiment 11 methods.
ELIASA, U.S. BIO-RAD company.
1.2 method
1.2.1 supply the preparation of reagent thing
Get Chinese medicine composition by embodiment 11 methods preparations, respectively with deionized water be made into 0.5,1, the solution of 10mg/mL, be designated as basic, normal, high dose groups.
1.2.2 mice B16 melanocyte is cultivated
Under the aseptic condition, with 1 * 10
5The mice B16 melanocyte of individual/mL is inoculated in the culture bottle of the DMEM culture medium that contains 10% (volume fraction) calf serum, at 37 ℃, 5%CO
2Cultivate in the incubator, went down to posterity once with 0.25% trypsinization in per 3 days.
1.2.3 intracellular tyrosine enzyme activity determination
Treat that cell grows into logarithmic (log) phase, use 0.25% trypsinization, adjust to cell 2 * 10
4Individual/mL, be inoculated in 96 orifice plates every hole 100 μ L.After placing incubator to cultivate 24h, abandon supernatant, add medicine to be measured.Each concentration is established 8 holes, and matched group does not add medicine, for it commensurability liquid of keeping.Hatched 3 days.Behind the drug effect 3 days, abandoning supernatant, with pH6.8 PBS flushing twice, every hole adds the PBS that 90 μ L contain 1%Triton X-100.Ultrasonication in the ice bath, every hole add the L-DOPA of 10 μ L 10mM, hatch 60min for 37 ℃, measure each hole absorbance of 490nm.
Suppression ratio=(1-drug group mean light absorbency value/matched group mean light absorbency value) * 100%.
1.2.4 melanin content is measured in the cell
With the B16 melanocyte with 1 * 10
5The density of individual/mL is inoculated in 6 orifice plates.Every hole 3mL, hatch 24h after, abandon supernatant, add medicine to be measured, behind the drug effect 3d, abandon supernatant, PBS washing, every hole adds 0.5mL trypsin digestion cell 3min, adds 2mL and keeps liquid and stop digestion, counts every group of cell respectively.The centrifugal supernatant of abandoning of cell suspension adds 1mol/L NaOH solution in the deposition, 80 ℃ of heating 30min.Spectrophotometer detects the absorbance of 475nm.
Melanin synthesizes suppression ratio=[1-(medicine hole absorbance/medicine porocyte number)/(control wells absorbance/control wells cell number)] * 100%
1.2.4 date processing
Data are represented with means standard deviation.
1.3 result
Because the growth of high concentration medicine pair cell has a significant effect, for fear of the interference of drug cell toxicity to the enzymatic activity effect, this experiment has adopted the pair cell normal physiological not have the drug level of influence.
Result of the test (seeing table 1) shows that the present composition significantly restraint of tyrosinase is active, and it is synthetic to suppress melanin.
Table 1 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 54.6±0.4 | 47.4±0.6 |
| Middle dose groups | 68.3±0.3 | 53.1±0.6 |
| High dose group | 89.6±0.4 | 78.3±0.5 |
| The arbutin group | 81.2±0.5 | 72.3±0.7 |
Test Example 2, human body skin experiment
2.1 material
The dermal melanin detector, German CK company.
2.2 method
2.2.1 supply the preparation of reagent thing
Specimen: get Chinese medicine composition, become solution by following formulation: the present composition, mass percent 20% by the preparation of embodiment 11 methods; Carboxymethyl cellulose, mass percent 1%; Deionized water, mass percent 79%.
Reference substance:, process by the substrate that does not contain Chinese medicine composition with reference to the specimen prescription.
2.2.2 test method
Select adult female 30 people of skin health, the inboard 2cm of left and right sides forearm * the 2cm zone is for being tried the position, and a side is the test block, smears sample; One side is the check plot, smears reference substance.Smear totally 28 days every day 1 time.Whenever checked melanin content in the skin at a distance from 7 days with the dermal melanin tester.And press following method and calculate the melanin suppression ratio:
Dermal melanin suppression ratio=(check plot dermal melanin content-test block dermal melanin content)/check plot dermal melanin content * 100%.
2.2.3 date processing
Data are represented with means standard deviation.
2.3 result
Result of the test (seeing table 2) shows that the present composition can obviously reduce dermal melanin content, and along with the time progressively reduces.
Melanic influence in the table 2 pair human body skin.
| The 1st week | The 2nd week | The 3rd week | The 4th week | |
| Melanin suppression ratio (%) | 10.3±4.6 | 12.8±6.4 | 15.3±5.2 | 19.5±9.4 |
Above-mentioned test shows that the present composition has very strong whitening function, can be used as the preparation that whitening additive is used for cosmetics, and according to different preparation methods, its mass percent in cosmetics can be 1-50%.
For technical scheme of the present invention better is described, hereinafter will be done further statement to its specific embodiment, but the scope that the present invention requires to protect is not limited to following embodiment.
The specific embodiment
Embodiment 1
Prescription: Semen adenantherae pavoninae 100g, Radix Angelicae Dahuricae 600g, Folium Euphorbiae lathyris 600g, Folium Pruni pseudocerasi 600g, Flos Jasmini Sambac 300g (being equivalent to 1:6:6:6:3).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 380g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 3 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 54.4±0.3 | 44.3±0.6 |
| Middle dose groups | 62.7±0.4 | 53.7±0.6 |
| High dose group | 84.3±0.5 | 72.5±0.7 |
Embodiment 2
Prescription: Semen adenantherae pavoninae 300g, Radix Angelicae Dahuricae 400g, Folium Euphorbiae lathyris 400g, Folium Pruni pseudocerasi 400g, Flos Jasmini Sambac 100g (being equivalent to 3:4:4:4:1).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 279g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 4 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 52.3±0.5 | 42.3±0.5 |
| Middle dose groups | 61.2±0.4 | 51.2±0.4 |
| High dose group | 80.1±0.4 | 64.7±0.5 |
Embodiment 3
Prescription: Semen adenantherae pavoninae 300g, Radix Angelicae Dahuricae 400g, Folium Euphorbiae lathyris 600g, Folium Pruni pseudocerasi 600g, Flos Jasmini Sambac 300g (being equivalent to 3:4:6:6:3).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 383g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 5 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 52.3±0.4 | 42.3±0.6 |
| Middle dose groups | 64.5±0.3 | 52.6±0.5 |
| High dose group | 81.2±0.5 | 61.3±0.5 |
Embodiment 4
Prescription: Semen adenantherae pavoninae 100g, Radix Angelicae Dahuricae 600g, Folium Euphorbiae lathyris 400g, Folium Pruni pseudocerasi 400g, Flos Jasmini Sambac 100g (being equivalent to 1:6:4:4:1).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 281g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 6 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 50.7±0.5 | 41.2±0.5 |
| Middle dose groups | 61.5±0.4 | 50.6±0.6 |
| High dose group | 77.2±0.5 | 61.7±0.5 |
Embodiment 5
Prescription: Semen adenantherae pavoninae 300g, Radix Angelicae Dahuricae 600g, Folium Euphorbiae lathyris 400g, Folium Pruni pseudocerasi 600g, Flos Jasmini Sambac 300g (being equivalent to 3:6:4:6:3).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 385g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 7 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 55.2±0.5 | 41.7±0.6 |
| Middle dose groups | 66.3±0.5 | 53.2±0.7 |
| High dose group | 82.3±0.4 | 62.7±0.5 |
Embodiment 6
Prescription: Semen adenantherae pavoninae 100g, Radix Angelicae Dahuricae 400g, Folium Euphorbiae lathyris 600g, Folium Pruni pseudocerasi 400g, Flos Jasmini Sambac 100g (being equivalent to 1:4:6:4:1).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 283g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 8 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 51.3±0.6 | 42.3±0.5 |
| Middle dose groups | 62.7±0.5 | 51.4±0.4 |
| High dose group | 76.5±0.5 | 62.7±0.6 |
Embodiment 7
Prescription: Semen adenantherae pavoninae 300g, Radix Angelicae Dahuricae 600g, Folium Euphorbiae lathyris 600g, Folium Pruni pseudocerasi 400g, Flos Jasmini Sambac 300g (being equivalent to 3:6:6:4:3).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 384g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 9 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 53.7±0.5 | 44.2±0.4 |
| Middle dose groups | 64.2±0.6 | 52.8±0.5 |
| High dose group | 86.7±0.6 | 64.4±0.4 |
Embodiment 8
Prescription: Semen adenantherae pavoninae 100g, Radix Angelicae Dahuricae 400g, Folium Euphorbiae lathyris 400g, Folium Pruni pseudocerasi 600g, Flos Jasmini Sambac 100g (being equivalent to 1:4:4:6:1).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 277g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 10 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 51.3±0.6 | 41.2±0.5 |
| Middle dose groups | 62.4±0.5 | 51.4±0.6 |
| High dose group | 75.3±0.5 | 62.6±0.4 |
Embodiment 9
Prescription: Semen adenantherae pavoninae 300g, Radix Angelicae Dahuricae 600g, Folium Euphorbiae lathyris 600g, Folium Pruni pseudocerasi 600g, Flos Jasmini Sambac 100g (being equivalent to 3:6:6:6:1).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 391g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 11 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 56.6±0.6 | 47.3±0.5 |
| Middle dose groups | 67.3±0.7 | 56.4±0.4 |
| High dose group | 82.9±0.5 | 67.8±0.4 |
Embodiment 10
Prescription: Semen adenantherae pavoninae 100g, Radix Angelicae Dahuricae 400g, Folium Euphorbiae lathyris 400g, Folium Pruni pseudocerasi 400g, Flos Jasmini Sambac 300g (being equivalent to 1:4:4:4:3).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 250g.
Whitening function test: get the present composition, respectively with deionized water be made into 0.5,1,10mg/mL, be designated as basic, normal, high dose groups, test method is with reference to Test Example 1, result of the test (seeing table 3) shows that the present composition has stronger whitening function.
Table 12 present composition is to tryrosinase and melanic influence.
| Tyrosinase inhibition rate (%) | Melanin synthesizes suppression ratio (%) | |
| Low dose group | 49.3±0.5 | 42.3±0.5 |
| Middle dose groups | 56.7±0.4 | 44.6±0.5 |
| High dose group | 74.3±0.6 | 53.7±0.6 |
Embodiment 11
Prescription: Semen adenantherae pavoninae 200g, Radix Angelicae Dahuricae 500g, Folium Euphorbiae lathyris 500, Folium Pruni pseudocerasi 500g, Flos Jasmini Sambac 200g (being equivalent to 2:5:5:5:2).
Method for making: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got 380g.
Claims (2)
1. plant the Chinese medicine composition of Pear Power effect, it is characterized in that described compositions is a raw material with the Chinese crude drug of following mass fraction: Semen adenantherae pavoninae 1-3 part, Radix Angelicae Dahuricae 4-6 part, Folium Euphorbiae lathyris 4-6 part, Folium Pruni pseudocerasi 4-6 part, Flos Jasmini Sambac 1-3 part; Adopt following method to be prepared from: get above-mentioned 5 flavor Chinese crude drugs, pulverize, mixing adds the water of 20 times of amounts of its gross mass quality, and 60-70 ℃ of warm macerating 5 hours separates medicinal liquid, concentrates, and spray drying is pulverized and promptly got.
2. according to the Chinese medicine composition of the said a kind of Pear Power effect of claim 1, it is characterized in that the mass fraction of said Chinese crude drug is following: 2 parts of Semen adenantherae pavoninaes, 5 parts of the Radixs Angelicae Dahuricae, 5 parts of Folium Euphorbiae lathyris, 5 parts of Folium Pruni pseudocerasis, 2 parts of Flos Jasmini Sambacs.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411681A (en) * | 2008-11-21 | 2009-04-22 | 赵献民 | Chinese medicine whitening and spot-removing facemask powder and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411681A (en) * | 2008-11-21 | 2009-04-22 | 赵献民 | Chinese medicine whitening and spot-removing facemask powder and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 石青等: "古代中药外用美容探讨", 《江西中医药》 * |
| 邵俊丽等: "《本草纲目》美容药物探析", 《中国美容医学》 * |
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Application publication date: 20120418 |