CN102406593A - 制备可压制的磷酸三钙团聚体及口服制剂的方法 - Google Patents

制备可压制的磷酸三钙团聚体及口服制剂的方法 Download PDF

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Publication number
CN102406593A
CN102406593A CN2011103374578A CN201110337457A CN102406593A CN 102406593 A CN102406593 A CN 102406593A CN 2011103374578 A CN2011103374578 A CN 2011103374578A CN 201110337457 A CN201110337457 A CN 201110337457A CN 102406593 A CN102406593 A CN 102406593A
Authority
CN
China
Prior art keywords
pbw
tricalcium phosphate
guar gum
aqueous slurry
binder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011103374578A
Other languages
English (en)
Chinese (zh)
Inventor
刘易斯·罗·亨德里克斯
吉尔·玛丽·乔宾斯
韦恩·卡马科
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syensqo USA LLC
Original Assignee
Rhodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia Inc filed Critical Rhodia Inc
Publication of CN102406593A publication Critical patent/CN102406593A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
CN2011103374578A 2004-05-04 2005-05-04 制备可压制的磷酸三钙团聚体及口服制剂的方法 Pending CN102406593A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56792604P 2004-05-04 2004-05-04
US60/567,926 2004-05-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800144628A Division CN1964701A (zh) 2004-05-04 2005-05-04 可直接压制的磷酸三钙

Publications (1)

Publication Number Publication Date
CN102406593A true CN102406593A (zh) 2012-04-11

Family

ID=35320719

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011103374578A Pending CN102406593A (zh) 2004-05-04 2005-05-04 制备可压制的磷酸三钙团聚体及口服制剂的方法
CNA2005800144628A Pending CN1964701A (zh) 2004-05-04 2005-05-04 可直接压制的磷酸三钙

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005800144628A Pending CN1964701A (zh) 2004-05-04 2005-05-04 可直接压制的磷酸三钙

Country Status (11)

Country Link
US (1) US7226620B2 (https=)
EP (2) EP1755556A4 (https=)
JP (1) JP5038130B2 (https=)
CN (2) CN102406593A (https=)
AU (1) AU2005240137B2 (https=)
CA (1) CA2565667C (https=)
ES (1) ES2606149T3 (https=)
HU (1) HUE033015T2 (https=)
MX (1) MXPA06012788A (https=)
NZ (1) NZ550942A (https=)
WO (1) WO2005107722A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
SI2719378T1 (sl) 2006-06-19 2016-11-30 Alpharma Pharmaceuticals Llc Farmacevtski sestavki
FR2919191B1 (fr) * 2007-07-25 2010-01-01 Teknimed Sas Composition adhesive pour comblement osseux a base de phosphatede calcium.
US8409538B2 (en) * 2008-12-04 2013-04-02 Skeletal Kinetics Llc Tricalcium phosphate coarse particle compositions and methods for making the same
US8673364B2 (en) 2009-09-28 2014-03-18 Skeletal Kinetics, Llc Rapid setting high strength calcium phosphate cements comprising cyclodextrins
KR20180027641A (ko) 2011-02-02 2018-03-14 알파마 파머슈티컬스 엘엘씨 오피오이드 효능제 및 격리된 길항제를 포함하는 제약 조성물
CN107281216B (zh) * 2017-06-16 2020-05-05 北京济美堂医药研究有限公司 含钙化合物的药物制剂

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB748402A (en) * 1951-11-08 1956-05-02 Avoset Company Improvements in or relating to methods of making gel-forming composition and resulting product
US3134719A (en) 1962-04-05 1964-05-26 American Cyanamid Co Calcium phosphates in tablet compressing
DE1228029C2 (de) 1964-05-09 1973-05-17 Merck Ag E Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation
US3639169A (en) 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles and method therefor
US3639168A (en) 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles
US3821414A (en) * 1969-12-17 1974-06-28 Sucrest Corp Direct compression vehicle
CA1183328A (en) * 1980-12-12 1985-03-05 Thomas W. Gerard Compacting calcium phosphate
CA1325707C (en) * 1986-10-31 1994-01-04 Chihang Raymond Chu Granular tricalcium phosphate compositions suitable for direct compression tableting
JP3034592B2 (ja) * 1990-11-20 2000-04-17 わかもと製薬株式会社 経口用固形製剤及びその製造法
JP2521612B2 (ja) * 1992-05-20 1996-08-07 ウエイ・ミン・フアーマシユーテイカル・マニユフアクチヤリング・カンパニー・リミテツド 直接錠剤形成助剤
DE4220782A1 (de) * 1992-06-25 1994-01-05 Basf Ag Verfahren zur Herstellung von festen pharmazeutischen Retardformen
JPH07267850A (ja) * 1994-03-28 1995-10-17 Eisai Co Ltd 不快味を防止した医薬組成物及びその製造方法
US5766330A (en) * 1996-12-24 1998-06-16 Knights; Ralph J. Method of suspending insoluble calcium in protein composition
AR017512A1 (es) * 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
GB9825033D0 (en) * 1998-11-13 1999-01-13 Nycomed Pharma As Process
US6235322B1 (en) 1999-03-09 2001-05-22 Mintech, Inc. Highly soluble and stable mineral supplements containing calcium and magnesium
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
US6599544B2 (en) 2000-01-26 2003-07-29 American Micronutrients, Inc. Calcium enrichment composition and method for producing the same
WO2003013270A2 (en) * 2001-08-09 2003-02-20 Rhodia Inc. Calcium dietary supplement

Also Published As

Publication number Publication date
WO2005107722A3 (en) 2006-07-27
AU2005240137A1 (en) 2005-11-17
WO2005107722A2 (en) 2005-11-17
MXPA06012788A (es) 2007-04-02
JP5038130B2 (ja) 2012-10-03
EP2455067B1 (en) 2016-10-12
CA2565667C (en) 2013-10-29
JP2007536248A (ja) 2007-12-13
EP1755556A2 (en) 2007-02-28
US20050249813A1 (en) 2005-11-10
EP2455067A1 (en) 2012-05-23
ES2606149T3 (es) 2017-03-22
EP1755556A4 (en) 2009-09-30
HUE033015T2 (en) 2017-11-28
US7226620B2 (en) 2007-06-05
CN1964701A (zh) 2007-05-16
CA2565667A1 (en) 2005-11-17
AU2005240137B2 (en) 2010-04-15
NZ550942A (en) 2011-02-25

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20120411

RJ01 Rejection of invention patent application after publication