CN102397461A - 一种妇康宁片的制备方法 - Google Patents
一种妇康宁片的制备方法 Download PDFInfo
- Publication number
- CN102397461A CN102397461A CN2011103814169A CN201110381416A CN102397461A CN 102397461 A CN102397461 A CN 102397461A CN 2011103814169 A CN2011103814169 A CN 2011103814169A CN 201110381416 A CN201110381416 A CN 201110381416A CN 102397461 A CN102397461 A CN 102397461A
- Authority
- CN
- China
- Prior art keywords
- extract
- radix
- tablet
- ethanol
- tranquilness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005186 women's health Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 84
- 239000000284 extract Substances 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 34
- 235000021419 vinegar Nutrition 0.000 claims abstract description 14
- 239000000052 vinegar Substances 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 12
- 239000011347 resin Substances 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 12
- 239000008187 granular material Substances 0.000 claims abstract description 7
- 239000004375 Dextrin Substances 0.000 claims abstract description 6
- 229920001353 Dextrin Polymers 0.000 claims abstract description 6
- 235000019425 dextrin Nutrition 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 24
- 239000012141 concentrate Substances 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 20
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 18
- 230000006837 decompression Effects 0.000 claims description 15
- 238000004064 recycling Methods 0.000 claims description 15
- 235000010894 Artemisia argyi Nutrition 0.000 claims description 12
- 244000030166 artemisia Species 0.000 claims description 12
- 239000003610 charcoal Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 230000000274 adsorptive effect Effects 0.000 claims description 10
- 239000003480 eluent Substances 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 9
- 241000756943 Codonopsis Species 0.000 claims description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 7
- 241000180649 Panax notoginseng Species 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 4
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 3
- 241000207925 Leonurus Species 0.000 abstract 3
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 3
- 241000736199 Paeonia Species 0.000 abstract 3
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 2
- 239000001569 carbon dioxide Substances 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 229930195210 Ophiopogon Natural products 0.000 abstract 1
- 244000248557 Ophiopogon japonicus Species 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 12
- 206010013935 Dysmenorrhoea Diseases 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 241000700159 Rattus Species 0.000 description 12
- 210000005075 mammary gland Anatomy 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 206010020880 Hypertrophy Diseases 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 8
- 229960001723 oxytocin Drugs 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 7
- 101800000989 Oxytocin Proteins 0.000 description 7
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 7
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 7
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 6
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 229960005309 estradiol Drugs 0.000 description 4
- 229930182833 estradiol Natural products 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 3
- 229960000452 diethylstilbestrol Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229950002007 estradiol benzoate Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000556 factor analysis Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 229960003454 tamoxifen citrate Drugs 0.000 description 2
- FQZYTYWMLGAPFJ-OQKDUQJOSA-N tamoxifen citrate Chemical compound [H+].[H+].[H+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 FQZYTYWMLGAPFJ-OQKDUQJOSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical class CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 1
- 101000874172 Rattus norvegicus Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Proteins 0.000 description 1
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical compound [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 210000002264 animal mammary gland Anatomy 0.000 description 1
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 1
- 229960003321 baicalin Drugs 0.000 description 1
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
样品 | 含量(mg/片) |
F-LJ | 10.1 |
F-CT | 2.4 |
组别 | 剂量(g/Kg) | 血栓干重(mg) |
正常对照 | — | 14.3±10.2** |
模型对照 | — | 36.5±14.7 |
F-CT | 0.16 | 18.5±11.6** |
F-LJ低 | 0.02 | 22.3±12.7* |
F-LJ中 | 0.04 | 18.6±12.1** |
F-LJ高 | 0.08 | 17.4±13.4** |
组别 | 剂量(g/Kg) | 乳头直径 (mm) | 雌二醇(pg/ml) | 乳腺增生评分 |
正常对照组 | - | 0.96±0.25** | 36.3±13.9** | 1.0±0.0** |
模型组 | - | 1.61±0.31 | 97.2±22.8 | 4.3±0.5 |
阳性对照组 | 4.0×10-3 | 1.15±0.27** | 55.4±29.2** | 2.1±0.3** |
F-LJ低 | 0.02 | 1.44±0.23 | 76.2±15.5* | 3.2±0.1 |
F-LJ中 | 0.04 | 1.18±0.19* | 57.9±27.8** | 2.3±0.2* |
F-LJ高 | 0.08 | 0.97±0.36** | 49.5±13.3** | 1.7±0.2** |
F-CT | 0.16 | 1.42±0.29 △ | 86.3±24.4 △ | 4.0±0.4 △ |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110381416 CN102397461B (zh) | 2011-11-27 | 2011-11-27 | 一种妇康宁片的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110381416 CN102397461B (zh) | 2011-11-27 | 2011-11-27 | 一种妇康宁片的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102397461A true CN102397461A (zh) | 2012-04-04 |
CN102397461B CN102397461B (zh) | 2013-03-20 |
Family
ID=45880359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110381416 Active CN102397461B (zh) | 2011-11-27 | 2011-11-27 | 一种妇康宁片的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102397461B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102973749A (zh) * | 2012-10-08 | 2013-03-20 | 卞毓平 | 一种防芷鼻炎片的制备方法及应用 |
CN102988667A (zh) * | 2012-10-15 | 2013-03-27 | 李正梅 | 一种调经活血片的制备方法及应用 |
CN102988479A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种清眩片的制备方法及应用 |
CN102988611A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种降压片的制备方法及应用 |
CN102988748A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种养阴降糖片的制备方法及应用 |
CN102988489A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种利鼻片的制备方法及应用 |
CN102988665A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种妇科调经片的制备方法及应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1522728A (zh) * | 2003-02-18 | 2004-08-25 | 毛友昌 | 妇康宁颗粒的制备方法 |
CN1660250A (zh) * | 2004-12-20 | 2005-08-31 | 叶耀良 | 一种治疗妇女痛经的中药制剂和制备方法 |
-
2011
- 2011-11-27 CN CN 201110381416 patent/CN102397461B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1522728A (zh) * | 2003-02-18 | 2004-08-25 | 毛友昌 | 妇康宁颗粒的制备方法 |
CN1660250A (zh) * | 2004-12-20 | 2005-08-31 | 叶耀良 | 一种治疗妇女痛经的中药制剂和制备方法 |
Non-Patent Citations (1)
Title |
---|
宋前流,等: "妇康宁片药物成分的定性鉴定与芍药苷含量测定", 《现代实用医学》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102973749A (zh) * | 2012-10-08 | 2013-03-20 | 卞毓平 | 一种防芷鼻炎片的制备方法及应用 |
CN102988479A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种清眩片的制备方法及应用 |
CN102988611A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种降压片的制备方法及应用 |
CN102988748A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种养阴降糖片的制备方法及应用 |
CN102988489A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种利鼻片的制备方法及应用 |
CN102988665A (zh) * | 2012-10-08 | 2013-03-27 | 卞毓平 | 一种妇科调经片的制备方法及应用 |
CN102988665B (zh) * | 2012-10-08 | 2014-01-08 | 章丘市妇幼保健院 | 一种妇科调经片的制备方法及应用 |
CN102988611B (zh) * | 2012-10-08 | 2014-02-05 | 陶利 | 一种降压片的制备方法及应用 |
CN102988748B (zh) * | 2012-10-08 | 2014-02-26 | 深圳市三也生物科技有限公司 | 一种养阴降糖片的制备方法及应用 |
CN102988489B (zh) * | 2012-10-08 | 2014-07-16 | 卞毓平 | 一种利鼻片在制备抑制人黑色素瘤细胞m14细胞增殖药物中的应用 |
CN102988667A (zh) * | 2012-10-15 | 2013-03-27 | 李正梅 | 一种调经活血片的制备方法及应用 |
Also Published As
Publication number | Publication date |
---|---|
CN102397461B (zh) | 2013-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102397461B (zh) | 一种妇康宁片的制备方法 | |
Tam et al. | The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action | |
CN102397451B (zh) | 一种利胆片的制备方法 | |
CN102008533B (zh) | 一种淫羊藿提取物的药用用途及制备方法 | |
CN101002847A (zh) | 治疗乳腺增生的药物及其制备方法 | |
CN105148258A (zh) | 组合物及其应用,含有该组合物的制剂 | |
CN102397522A (zh) | 一种新生化颗粒的制备方法 | |
CN101011545A (zh) | 一种制备菝葜有效部位群的方法 | |
CN101966325B (zh) | 用于治疗湿热瘀阻型子宫内膜异位症的药物及其制备方法 | |
CN103908631A (zh) | 一种具有抗乳腺增生作用的中药复方提取物及其制备方法 | |
CN103432420A (zh) | 一种治疗糖尿病的中药组合物及其制备方法和检测方法 | |
CN106266343A (zh) | 一种脑血疏的制备方法 | |
CN105287474A (zh) | 茴香酸对羟基苯乙酯的应用 | |
CN102716424B (zh) | 一种治疗乳癖的药物组合物及其制备方法和用途 | |
CN109528917B (zh) | 一种治疗类风湿性关节炎的朝医方组合物及其乳膏剂的制备方法 | |
CN101991568B (zh) | 洋川芎内酯i在制备抗抑郁症药物、偏头痛药物及其他5-羟色胺能系统相关疾病药物中的应用 | |
CN111375030A (zh) | 一种治疗皮肤瘙痒的中药凝胶剂 | |
CN100998783B (zh) | 一种治疗胃肠疾病中药组合物胶囊剂及其制备方法 | |
CN100998784B (zh) | 一种治疗胃肠疾病中药组合物的制备方法 | |
CN102805768A (zh) | 一种猫爪草提取物在制备抗肺癌的药物中的应用 | |
CN100998788B (zh) | 一种治疗胃肠疾病中药组合物滴丸及其制备方法 | |
CN105535039A (zh) | 一种幼油草提取物及其治疗痛风性关节炎的医药用途 | |
CN1296083C (zh) | 一种乌鸡白凤泡腾片及其制备方法 | |
CN105708873A (zh) | 落新妇超微粉饮片及其制备方法 | |
CN1250266C (zh) | 一种治疗妇科疾病的中药制剂的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI BOCIMED PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SUZHOU PAITENG BIOPHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20140703 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 215011 SUZHOU, JIANGSU PROVINCE TO: 201203 PUDONG NEW AREA, SHANGHAI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140703 Address after: 201203 Shanghai Zhangjiang hi tech Park Cailun Road, room 1006 No. 781 Patentee after: Shanghai Bozhi Yanxin Pharmaceutical Technology Co.,Ltd. Address before: 215011 Jiangsu high tech Zone Suzhou City Binhe Road, No. 1326 Patentee before: Suzhou Paiteng Biopharmaceutical Technology Co., Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI MABCT MEDICINE TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHANGHAI BOCIMED PHARMACEUTICAL CO., LTD. Effective date: 20150729 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150729 Address after: 201203 Shanghai Zhangjiang hi tech park, No. 150, No. 9 Cailun Road, building 3 floor Patentee after: SHANGHAI MABCT MEDICINE TECHNOLOGY CO., LTD. Address before: 201203 Shanghai Zhangjiang hi tech Park Cailun Road, room 1006 No. 781 Patentee before: Shanghai Bozhi Yanxin Pharmaceutical Technology Co.,Ltd. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20170314 Address after: 850000 Lhasa, Tibet autonomous region, Liu Wu District, Liu Wu building, room 1202 Patentee after: Lhasa Pharmaceutical Technology Co., Ltd. Address before: 201203 Shanghai Zhangjiang hi tech park, No. 150, No. 9 Cailun Road, building 3 floor Patentee before: SHANGHAI MABCT MEDICINE TECHNOLOGY CO., LTD. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170802 Address after: 850000 Lhasa, Tibet autonomous region, Liu Wu District, Liu Wu building, room 1202 Patentee after: Lhasa Pharmaceutical Technology Co., Ltd. Address before: 201203 Shanghai Zhangjiang hi tech park, No. 150, No. 9 Cailun Road, building 3 floor Patentee before: SHANGHAI MABCT MEDICINE TECHNOLOGY CO., LTD. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171108 Address after: 570100 Haikou, Meilan District, Hainan Province Shunda Road, No. 6 Patentee after: Hainan sailike Pharmaceutical Co., Ltd. Address before: 850000 Lhasa, Tibet autonomous region, Liu Wu District, Liu Wu building, room 1202 Patentee before: Lhasa Pharmaceutical Technology Co., Ltd. |
|
TR01 | Transfer of patent right |