CN102389391A - Natual cosmetic composition for beautifying and whitening - Google Patents
Natual cosmetic composition for beautifying and whitening Download PDFInfo
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- CN102389391A CN102389391A CN2011103704370A CN201110370437A CN102389391A CN 102389391 A CN102389391 A CN 102389391A CN 2011103704370 A CN2011103704370 A CN 2011103704370A CN 201110370437 A CN201110370437 A CN 201110370437A CN 102389391 A CN102389391 A CN 102389391A
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- quel
- whitening
- phellinus igniarius
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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- Engineering & Computer Science (AREA)
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- Cosmetics (AREA)
Abstract
The present invention discloses a natural cosmetic composition for beautifying and whitening, and particularly to a natural cosmetic composition for beautifying and whitening, wherein Sang Hwang mushroom extract is used as an active ingredient. As the cosmetic composition has a remarkable restriction effect for activating tyrosinase, the cosmetic composition can be used as an effective cosmetic composition for beautifying and whitening. Additionally, as a natural Korean material is adopted in the cosmetic composition, the cosmetic composition can replace the prior-art synthetic cosmetic composition for beautifying and whitening.
Description
Technical field
The present invention relates to whiten and use the natural cosmetics compositions, be specifically related to contain the compositions that applies some make up of whitening of the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract of remarkable whitening effect.
Background technology
Along with the increase of growth in the living standard and income, except that the Ms, the man also strengthens the care of skin beauty treatment gradually.People are concerned about because of UV-induced black speck, freckle more recently.Determine the factor of skin color that melanin, carotene, hemoglobin etc. are arranged in addition, what wherein have the greatest impact is melanin.Melanin is that (tyrosine (amino acid whose a kind of) is in the melanosome (melanosomes) of black cell through a series of oxidizing process; After the tryrosinase oxidation; Convert dihydroxyphenylalanine into), become brown (pheomelanin), black (eumelanin) polymer.This process is carried out in the brown organelle that is called " melanosome (melanosomes) ".This " melanosome (melanosomes) " (containing melanin granule) moves to the end of dendron around the nucleus, because of the phagocytic function of horn cell, is transplanted in the Cytoplasm, finally is accumulated in around the nucleus.
Melanic synthetic, melanosome (melanosomes) number, to the influence that all receives gene of moving of horn cell, also receive the influence of incretion interferents such as heavy metal, sandstorm, ozone, ultraviolet.Cytokine (cytokine in addition; The generation, melanic synthetic and transfer of tryrosinase is given in influence), metal ion, casein, prostaglandin, histamine such as copper, zinc, ferrum are also to melanic synthetic influential (Park soon am; Da Han cosmetics association newpapers and periodicals, 25:77-127,1999).Therefore to contain melanic synthetic and containment tryrosinase, can reach the skin whitening effect.
Before the present invention, adopt hydroquinone, ascorbic acid, kojic acid, glutathion etc. that tryrosinase is had the material that suppresses activation effect, prepare ointment, facial cream, the elite of skin external.The skin pigmentation that this has embodied whitening of skin and has treated skin black speck, freckle etc.But Benzodiazepines can stimulate skin, so use level is restricted to minute quantity.Ascorbic acid is because of having problem of oxidation, therefore adopts the easy variable color of cosmetics, spoiled of ascorbic acid, and the result can reduce product quality and reduce whitening effect.Like oral kojic acid, have the probability of bringing out cancer, need more deep its safety of inspection.Sulfhydryl compound such as glutathion, cysteine has specific peculiar smell, and is absorbed with problem, and in addition, the glycosides of these compositions and derivant have high polarity, are not suitable for as cosmetic material.
For seeking the composition of not only safety but also Pear Power effect, through the multiple natural materials of investigation, the result has found that activation has significant effect to the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract to restraint of tyrosinase.
Summary of the invention
The present invention adopts the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract to use the natural cosmetics material as whitening, to reach the activatory effect of restraint of tyrosinase.
The present invention contains whitening of Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract to use the natural cosmetics compositions.
This cosmetic composition has effective inhibit feature because of the activation to tryrosinase, so can be used as the compositions of the special-purpose cosmetics of whitening.These cosmetics are because of having adopted natural South Korea composition, so can substitute the existing synthetic special-purpose cosmetic ingredient of whitening.
Description of drawings
Fig. 1 illustrates and uses the mensuration result of Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract to the tryrosinase inhibit feature.
The specific embodiment
Through test, the material of having found to extract from Phellinus igniarius (L. ex Fr.) Quel. mushroom can the restraint of tyrosinase activation, embodies whitening effect.Detailed explanation relevant of the present invention is arranged as follows:
The English formal name used at school of the Phellinus igniarius (L. ex Fr.) Quel. mushroom of adopting among the present invention is Phellinus linteus, has another name called " phellinus igniarius ".In the soup piece of writing in " east doctor precious prison ", be record with " SANGMUER ".The diameter of cap is that 6-12cm, thickness are 2-10cm.It is perennial fungus.It is shaped as the hemispherical or the shape of a hoof.There is dark brown trickle fine hair at initial stage, and the back becomes does not have hair.Concentric dark brown ring rib is arranged.The edge is yellow, dark meat light coffee color.Downside does not have hymenium.Spore light yellowish brown, sphere.Be grown on the mulberry trunk.The initial stage shape is as the earth piece, and the later stage is shaped as the tongue as the people.Therefore be called again " Ganoderma applanatum (Pers. Ex Wallr) Pat. ".Have significant anticancer effect,, cultivate in a large number in Korea S as valuable medical material.For as medical material, when enduring Phellinus igniarius (L. ex Fr.) Quel., its decoction color can flavescence color or light yellow.There is not any fragrance.Taste is light.Be distributed in Korea S, Japan, Australia, North America etc.
Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract among the present invention's " cosmetic material compositions " carries out with super critical extraction, does not use the extract that obtains with hot water extraction method or organic solvent extraction method.Because super critical extraction can improve the purity of active ingredient, simultaneously, can remove residue and polluter.In addition in compounding substances, but the single composition of correct extraction.The extraction pressure of above-mentioned super critical extraction is 200-300bar, and extracting temperature is 40-60 ℃.With this understanding, when extracting, its extract is compared with the extract that under other condition, carries out, and has the activatory effect of restraint of tyrosinase better.
Adopt above-mentioned Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract,, can make cosmetic composition through the ordinary cosmetics manufacturing approach.For example, in the extract that obtains through said method, drop into glycerin, purify waste water, the ethylene glycol stearic acid mixes mutually, can make cosmetics such as skin cream or bath foam.
Input amount when not limiting above-mentioned Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract and being used in cosmetic material.But be as the criterion with dry weight, above-mentioned Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract accounts for the weight of cosmetic composition, preferably, is 0.5～15%.
When being less than 0.5% (weight ratio), might there be whitening effect like the content of Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract.As surpassing 15% (weight ratio), do not occur increasing ratio, the increase of whitening effect according to content.Safety can go wrong on going up or making in addition.
Under the prerequisite of the main effect that does not influence the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract, can in the present invention's " cosmetic composition ", can add other additive composition that helps to improve main effect.
Forms such as that the special-purpose natural South Korea cosmetic composition of whitening of the present invention can be made into is aqueous, paste, solid, shaped and Emulsion.Do not reduce under the situation of its effect, can be fabricated to any form.
Specific embodiment of the present invention is arranged as follows:
< embodiment >
1. obtain the method for Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract.
1) test material
In this test, the Phellinus igniarius (L. ex Fr.) Quel. of use mushroom is the mushroom that (strain) Liu chong hyuen medicinal mushroom farm (Korea S) provides.For being applicable to this test, utilize freeze drying plant (Freeze-dry, supplier: Samwon Freezing engineering Co., SFDTS 10K) to carry out lyophilization, after removing moisture, as reagent.
2) method for distilling
The A supercritical extraction
The supercritical extraction device that uses in this test be SFE company extraction element (SFE-Extractor,, Natex: Australia; Max:1000bar)).When the carbon dioxide of saturation pressure state moved from the cylinder to the coolant, the bubble in the carbon dioxide was removed.Because the effect of high-pressure metering pump, carbon dioxide flows in system and flow into till the setting pressure with stable flow rate.According to extracting temperature, use temperature chamber, come the preheating carbon dioxide (carbon dioxide is to flow out from high-pressure pump, flow into extraction tank before, as extracting solvent).Thermocouple is with the temperature in the sensing extraction tank and regulate the extraction temperature.For keeping the extraction tank internal temperature, extraction tank has been installed heating sheath (Heat jacket) outward.So that back pressure adjustment valve to be installed, prevent to change the extraction conditions variation that causes in the system because of the pressure of moment.For preventing when extracting, positive because of solvent and solid reagent block system program at high-pressure pump and pressure regulator, 7 microns filter is installed.For removing intrasystem over pressure, safety-valve has been installed.
The supercritical extraction condition:
Because of in any document, all do not mention the extraction conditions of relevant Phellinus igniarius (L. ex Fr.) Quel. mushroom, therefore be suitable for common natural materials extraction conditions.This test is set and is extracted pressure: 150bar～300bar, extracts 40 ℃～60 ℃ of temperature.The above supercritical of 300bar is equipped because of cost of use height and the low reason of volume of production, has therefore set above-mentioned specified scope.After in extractor, putting into the Phellinus igniarius (L. ex Fr.) Quel. mushroom powder of 50g, make an experiment according to pressure in the experimental condition and temperature.The carbon dioxide flow that is suitable for during according to common supercritical extraction with the flow of 150ml/min, has carried out 80 minutes extraction.For extracting the functional materials of Phellinus igniarius (L. ex Fr.) Quel. mushroom, the ethanol that has added 3% (v/v) is as entrainer (entrainer, separation solvent).When only using the supercritical extraction of carbon dioxide, almost do not find extract.Predict that this causes because of the insufficient reason of Phellinus igniarius (L. ex Fr.) Quel. mushroom content of crude fat.So ethanol as complementary solvent, is extracted.According to the flow of carbon dioxide, set alcoholic acid addition.The visible table 1 of employed supercritical extraction condition during this test.
Table 1
When utilizing the functional materials of supercritical extraction Phellinus igniarius (L. ex Fr.) Quel. mushroom, as not using secondary solvent, because of the fat content in the Phellinus igniarius (L. ex Fr.) Quel. mushroom is low, so the amount of actual acquisition (material of in high-voltage tube, pasting) seldom.Therefore current test uses secondary solvent to carry out.The secondary solvent that uses is an ethanol, and quantity delivered is 3% (v/v) of carbon dioxide.
Other method for distilling of B
For measuring the physiological activation performance of Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract, except that the supercritical extraction condition, compare with ethanol, pure water extraction conditions, set 12 kinds of conditions altogether.We predict in the Phellinus igniarius (L. ex Fr.) Quel. mushroom in addition, should contain with super critical extraction, and the physiological activation material that can't extract has comprised the condition with the hot water extraction residue in this condition.
With pure water or ethanol, extract the reagent (40 ℃ extract down 2 hours) of 5g, carry out the filtering and concentrating drying with 0.2 μ m filter paper after, with the volumetric flask standardize solution of 100mL.
For guaranteeing optimum condition, as having represented the reagent extraction conditions in the following table 2:
Table 2
Annotate: reagent 1～10: supercritical extraction; Reagent 11: ethanol extraction; Reagent 12: pure water extracts; Reagent 13～22: after the supercritical extraction of reagent 1～10, use the hot water extraction residue.
2. measure the activation of whitening
Restraint of tyrosinase activation test
Tryrosinase (EC 1.14.18.1) has another name called polyphenol oxidase (PPO), is the oxidation ferment that contains ferrum, finds in plant, animal and microorganism etc.This ferment converts the O-quinone into after converting single phenol into O-phenol once more.It is the synthetic key enzyme of melanocyte.
The tryrosinase that this test use is extracted from mushroom (supplier: Sigma Chemical Co., USA), measured the activatory effect of extract restraint of tyrosinase that above the whole bag of tricks obtains.Promptly; With the dry dissolving of the reagent extract of above numbering 1-22; Get the extract solution of 30 μ L, be placed in 96 holes (96-well) microwell plate after, (concentration is: the 90units/mL phosphate buffer in microwell plate, to add the tryrosinase solution of 30 μ L; PH is 6.5), carried out phase reaction in following 10 minutes at 37 ℃.Afterwards, in this solution, add 110 μ L 2mM L-tyrosine two sodium solutions (supplier: Sigma Chemical Co., USA), carried out phase reaction in following 25 minutes at 37 ℃.In 492nm, measure the optical density of this reaction solution, thereby obtained tryrosinase activation suppression ratio.The active mensuration result of restraint of tyrosinase representes to see table 3 and Fig. 1.
Table 3
Table 3 is found out up, and activation has significant effect to the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract to restraint of tyrosinase.In addition, under the supercritical extraction condition, tryrosinase activation suppression ratio is minimum under 150bar/40 ℃ condition, under the condition of 300bar/60 ℃ (pressure and temperature are the highest), shows the highest.
Claims (6)
1. the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract is in the application of skin-lightening cosmetic.
2. whiten and use the natural cosmetics compositions for one kind, it is characterized in that, comprise the Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract as effective ingredient.
3. a kind of whitening according to claim 2 used the natural cosmetics compositions; It is characterized in that: said Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract is as the criterion with dry weight; Whiten with the gross weight contrast of natural cosmetics compositions with said, Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract content is 0.5～15%.
4. a kind of whitening according to claim 2 used the natural cosmetics compositions, it is characterized in that: said Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract obtains with super critical extraction.
5. a kind of whitening according to claim 3 used the natural cosmetics compositions, it is characterized in that: with under the extraction temperature of the extraction pressure of 200-300bar, 40-60 ℃, use super critical extraction to obtain said Phellinus igniarius (L. ex Fr.) Quel. Agaricus campestris extract.
6. a kind of whitening according to claim 2 used the natural cosmetics compositions, it is characterized in that: above-mentioned whitening can be made into aqueous, paste, solid, shaped or Emulsion form with the natural cosmetics compositions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0082170 | 2011-08-18 | ||
| KR1020110082170A KR20130019887A (en) | 2011-08-18 | 2011-08-18 | Cosmetic composition for whitening by using oriental natural materials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102389391A true CN102389391A (en) | 2012-03-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103704370A Pending CN102389391A (en) | 2011-08-18 | 2011-11-18 | Natual cosmetic composition for beautifying and whitening |
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| Country | Link |
|---|---|
| KR (1) | KR20130019887A (en) |
| CN (1) | CN102389391A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102513584B1 (en) * | 2020-11-20 | 2023-03-24 | 상황미인(주) | Composition for UV and fine dust protecting and method for preparing the same |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020068154A (en) * | 2001-02-20 | 2002-08-27 | 나드리화장품주식회사 | Niosome containing natural phellinus linteus extract and cosmetic composition containing it |
| KR20040102766A (en) * | 2003-05-29 | 2004-12-08 | 나드리화장품주식회사 | Cosmetic composition containing niosome with tranexamic acid and supercritical fluid extract of phellinus linteus |
| KR20050113033A (en) * | 2004-05-28 | 2005-12-01 | 신영상 | Cosmetics containing phellinus linteus extracts |
| JP2007031303A (en) * | 2005-07-25 | 2007-02-08 | Sansho Seiyaku Co Ltd | Beautifying cosmetic |
-
2011
- 2011-08-18 KR KR1020110082170A patent/KR20130019887A/en not_active Application Discontinuation
- 2011-11-18 CN CN2011103704370A patent/CN102389391A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020068154A (en) * | 2001-02-20 | 2002-08-27 | 나드리화장품주식회사 | Niosome containing natural phellinus linteus extract and cosmetic composition containing it |
| KR20040102766A (en) * | 2003-05-29 | 2004-12-08 | 나드리화장품주식회사 | Cosmetic composition containing niosome with tranexamic acid and supercritical fluid extract of phellinus linteus |
| KR20050113033A (en) * | 2004-05-28 | 2005-12-01 | 신영상 | Cosmetics containing phellinus linteus extracts |
| JP2007031303A (en) * | 2005-07-25 | 2007-02-08 | Sansho Seiyaku Co Ltd | Beautifying cosmetic |
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| Publication number | Publication date |
|---|---|
| KR20130019887A (en) | 2013-02-27 |
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Application publication date: 20120328 |