CN102388308B - 单体和二聚形式的脂连蛋白受体片段和使用方法 - Google Patents
单体和二聚形式的脂连蛋白受体片段和使用方法 Download PDFInfo
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- CN102388308B CN102388308B CN201080016065.5A CN201080016065A CN102388308B CN 102388308 B CN102388308 B CN 102388308B CN 201080016065 A CN201080016065 A CN 201080016065A CN 102388308 B CN102388308 B CN 102388308B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
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- Hematology (AREA)
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- Urology & Nephrology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Pulmonology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17197909P | 2009-04-23 | 2009-04-23 | |
| US61/171979 | 2009-04-23 | ||
| PCT/US2010/030836 WO2010123720A1 (en) | 2009-04-23 | 2010-04-13 | Monomeric and dimeric forms of adiponectin receptor fragments and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102388308A CN102388308A (zh) | 2012-03-21 |
| CN102388308B true CN102388308B (zh) | 2015-08-19 |
Family
ID=43011406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080016065.5A Expired - Fee Related CN102388308B (zh) | 2009-04-23 | 2010-04-13 | 单体和二聚形式的脂连蛋白受体片段和使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8865648B2 (enExample) |
| EP (2) | EP2422199B1 (enExample) |
| JP (2) | JP5882196B2 (enExample) |
| CN (1) | CN102388308B (enExample) |
| ES (1) | ES2693165T3 (enExample) |
| WO (1) | WO2010123720A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20110565A1 (es) | 2008-08-12 | 2011-09-02 | Zinfandel Pharmaceuticals Inc | Metodo de identificacion de factores de riesgo de la enfermedad |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| EP2391377A2 (en) | 2009-02-02 | 2011-12-07 | Ramot at Tel-Aviv University Ltd. | Peptides, pharmaceutical compositions comprising same and uses thereof |
| EP2422199B1 (en) | 2009-04-23 | 2018-07-25 | Siemens Healthcare Diagnostics Inc. | Monomeric and dimeric forms of adiponectin receptor fragments and methods of use |
| US8901074B2 (en) | 2010-08-04 | 2014-12-02 | Ramot At Tel-Aviv University | Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases |
| EA201391017A1 (ru) | 2011-01-10 | 2014-04-30 | Зинфандел Фармасьютикалз, Инк. | Способы и готовые лекарственные формы для лечения болезни альцгеймера |
| US9291629B2 (en) | 2011-04-11 | 2016-03-22 | Siemens Healthcare Diagnostics Inc. | Adiponectin receptor C-terminal fragments (CTF)-immunoglobulin |
| DK2771364T3 (da) * | 2011-10-27 | 2019-08-19 | Genmab As | Fremstilling af heterodimere proteiner |
| DE102015201100B4 (de) * | 2015-01-22 | 2018-05-17 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Antivirale Mittel |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007120311A2 (en) * | 2005-12-07 | 2007-10-25 | Siemens Healthcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
| CN101932728A (zh) * | 2007-11-30 | 2010-12-29 | 西门子医疗保健诊断公司 | 脂连蛋白受体片段和使用方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| US20020173474A1 (en) | 1993-02-12 | 2002-11-21 | President And Fellows Of Harvard College | Methods & materials involving dimerization-mediated regulation of biological events |
| WO1994028418A1 (en) | 1993-05-28 | 1994-12-08 | Baylor College Of Medicine | Method and apparatus for desorption and ionization of analytes |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| EP1033134B8 (en) | 1997-10-29 | 2007-09-19 | Otsuka Pharmaceutical Co., Ltd. | Compositions inhibiting smooth muscle proliferation and method for the diagnosis of arteriosclerosis |
| EP1068356B8 (en) | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| WO2000056934A1 (en) | 1999-03-24 | 2000-09-28 | Packard Bioscience Company | Continuous porous matrix arrays |
| US20040067490A1 (en) | 2001-09-07 | 2004-04-08 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| CA2382015A1 (en) | 1999-08-17 | 2001-02-22 | Incyte Genomics, Inc. | Membrane associated proteins |
| AU2001274888A1 (en) | 2000-05-19 | 2001-12-03 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| US20020102617A1 (en) | 2000-08-03 | 2002-08-01 | Macbeath Gavin | Protein microarrays |
| CA2440219A1 (en) | 2001-02-21 | 2002-10-17 | Curagen Corporation | Proteins, polynucleotides encoding them and methods of using the same |
| CA2440144A1 (en) | 2001-03-14 | 2002-09-19 | Oklahoma Medical Research Foundation | Methods for reducing fat by administration of adiponectin |
| US20030083261A1 (en) | 2001-04-30 | 2003-05-01 | Hongtao Yu | Class of 12mer peptides that inhibit the function of the mitotic check point protein Mad2 |
| CA2459489C (en) | 2001-08-17 | 2010-02-02 | Rebio Gen, Inc. | Method for diagnosing or monitoring carbohydrate metabolism disorders |
| WO2004022596A1 (en) | 2002-09-05 | 2004-03-18 | Komed Co., Ltd. | Monoclonal antibody against adiponectin, preparation method and use thereof |
| US20030153013A1 (en) | 2002-11-07 | 2003-08-14 | Ruo-Pan Huang | Antibody-based protein array system |
| JP4347874B2 (ja) * | 2002-12-29 | 2009-10-21 | 株式会社東京大学Tlo | アディポネクチン受容体及びそれをコードする遺伝子 |
| DE60335216D1 (de) | 2002-12-29 | 2011-01-13 | Nissan Chemical Ind Ltd | Adiponektin-rezeptor und dafür kodierendes gen |
| DE602004022632D1 (de) * | 2003-01-09 | 2009-10-01 | Beth Israel Hospital | Verwendung von adiponectin zur diagnose von krebs |
| EP1607742B1 (en) | 2003-03-24 | 2011-11-23 | Mitsubishi Chemical Medience Corporation | Latex reagent for adiponectin analysis and method of adiponectin analysis |
| EP1718327B1 (en) | 2003-06-20 | 2015-01-07 | University of Florida | Biomarkers for differentiating between type 1 and type 2 diabetes |
| US7435808B2 (en) * | 2003-06-25 | 2008-10-14 | Bristol-Myers Squibb Company | Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 |
| ES2347562T3 (es) * | 2003-09-27 | 2010-11-02 | Siemens Healthcare Diagnostics Inc. | Disagnosticos y terapias para enfermedades asociados con receptor emparejado de proteina g adipor1 (adipor1). |
| WO2005031345A2 (en) | 2003-09-27 | 2005-04-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2) |
| DE602004022575D1 (de) | 2003-10-15 | 2009-09-24 | Sekisui Medical Co Ltd | Verfahren zum selektiven testen von adiponectinmultimeren |
| JP4397934B2 (ja) | 2003-11-07 | 2010-01-13 | メルク エンド カムパニー インコーポレーテッド | インスリン感作薬での処置に対する反応者を識別する方法 |
| EP1733733A1 (en) * | 2004-03-04 | 2006-12-20 | Takashi Kadowaki | Regulator for adiponectin receptor expression |
| GB0426798D0 (en) | 2004-12-07 | 2005-01-12 | Emtelle Uk Ltd | Optical fibre tube and method of manufacturing same |
| EP2422199B1 (en) | 2009-04-23 | 2018-07-25 | Siemens Healthcare Diagnostics Inc. | Monomeric and dimeric forms of adiponectin receptor fragments and methods of use |
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2010
- 2010-04-13 EP EP10767527.4A patent/EP2422199B1/en not_active Not-in-force
- 2010-04-13 JP JP2012507255A patent/JP5882196B2/ja not_active Expired - Fee Related
- 2010-04-13 CN CN201080016065.5A patent/CN102388308B/zh not_active Expired - Fee Related
- 2010-04-13 US US13/265,968 patent/US8865648B2/en active Active
- 2010-04-13 EP EP18184946.4A patent/EP3444611A1/en not_active Withdrawn
- 2010-04-13 ES ES10767527.4T patent/ES2693165T3/es active Active
- 2010-04-13 WO PCT/US2010/030836 patent/WO2010123720A1/en not_active Ceased
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2014
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2015
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007120311A2 (en) * | 2005-12-07 | 2007-10-25 | Siemens Healthcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
| CN101932728A (zh) * | 2007-11-30 | 2010-12-29 | 西门子医疗保健诊断公司 | 脂连蛋白受体片段和使用方法 |
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| Publication number | Publication date |
|---|---|
| JP2012524902A (ja) | 2012-10-18 |
| US20150038426A1 (en) | 2015-02-05 |
| EP3444611A1 (en) | 2019-02-20 |
| CN102388308A (zh) | 2012-03-21 |
| EP2422199A1 (en) | 2012-02-29 |
| ES2693165T3 (es) | 2018-12-07 |
| EP2422199B1 (en) | 2018-07-25 |
| JP5882196B2 (ja) | 2016-03-09 |
| US20120135916A1 (en) | 2012-05-31 |
| WO2010123720A1 (en) | 2010-10-28 |
| US20180346540A1 (en) | 2018-12-06 |
| US8865648B2 (en) | 2014-10-21 |
| EP2422199A4 (en) | 2013-01-30 |
| JP2016035470A (ja) | 2016-03-17 |
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