CN102369185A - 用于治疗神经退行性疾病的吲哚衍生物 - Google Patents

用于治疗神经退行性疾病的吲哚衍生物 Download PDF

Info

Publication number
CN102369185A
CN102369185A CN2010800147167A CN201080014716A CN102369185A CN 102369185 A CN102369185 A CN 102369185A CN 2010800147167 A CN2010800147167 A CN 2010800147167A CN 201080014716 A CN201080014716 A CN 201080014716A CN 102369185 A CN102369185 A CN 102369185A
Authority
CN
China
Prior art keywords
compound
general formula
group
compounds
following general
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800147167A
Other languages
English (en)
Chinese (zh)
Inventor
F·施密特
B·菲加代尔
R·雷斯曼-沃扎里
P·尚皮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Original Assignee
NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NATIONAL CENTER FOR SCIENTIFIC RESEARCH filed Critical NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Publication of CN102369185A publication Critical patent/CN102369185A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CN2010800147167A 2009-03-02 2010-03-02 用于治疗神经退行性疾病的吲哚衍生物 Pending CN102369185A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0951303 2009-03-02
FR0951303A FR2942625B1 (fr) 2009-03-02 2009-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives
PCT/EP2010/052596 WO2010100133A2 (fr) 2009-03-02 2010-03-02 Derives indoliques pour le traitement de maladies neurodegeneratives

Publications (1)

Publication Number Publication Date
CN102369185A true CN102369185A (zh) 2012-03-07

Family

ID=40688413

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800147167A Pending CN102369185A (zh) 2009-03-02 2010-03-02 用于治疗神经退行性疾病的吲哚衍生物

Country Status (7)

Country Link
US (1) US8614246B2 (https=)
EP (1) EP2403830A2 (https=)
JP (1) JP2012519202A (https=)
CN (1) CN102369185A (https=)
CA (1) CA2754283A1 (https=)
FR (1) FR2942625B1 (https=)
WO (1) WO2010100133A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN106565588A (zh) * 2016-11-10 2017-04-19 徐州工程学院 一种从坚果中提取食物源二十烷酸‑5‑羟色胺的方法
CN107118146A (zh) * 2017-04-13 2017-09-01 宁波大学 一种6‑溴色胺衍生物及其制备方法和用途
CN107814787A (zh) * 2017-11-13 2018-03-20 济南大学 一种他克林‑吲哚乙酸杂联体化合物及其制备方法和应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
KR101874594B1 (ko) * 2016-12-07 2018-07-05 한국한의학연구원 아떼모야 잎 추출물 또는 이의 분획물을 포함하는 인지기능 장애의 예방 또는 치료용 조성물
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
IL297869A (en) * 2020-05-04 2023-01-01 Tufts College Synthetic lipid-like agents for administration in the brain
CA3229361A1 (en) * 2021-08-20 2023-02-23 Abdelmalik Slassi 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto
WO2025137730A1 (en) * 2023-12-22 2025-06-26 Alexander Shulgin Research Institute, Inc. N-substituted tryptamines and n-substituted lysergamides and their use as therapeutic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition
CN102014897A (zh) * 2008-04-21 2011-04-13 西格纳姆生物科学公司 化合物、组合物和其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08239362A (ja) * 1994-12-28 1996-09-17 Sankyo Co Ltd インドール誘導体
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPH1077267A (ja) * 1996-09-03 1998-03-24 Sagami Chem Res Center ５−メトキシトリプタミン誘導体
JP4156825B2 (ja) * 2001-11-01 2008-09-24 株式会社ロッテ 抗鬱・抗ストレス剤及びそれを含有する組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition
CN102014897A (zh) * 2008-04-21 2011-04-13 西格纳姆生物科学公司 化合物、组合物和其制备方法

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ASHER KALIR ET AL.: ""Synthesis and Pharmacological Activity of Alkylated Tryptamines"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
B.E.LEONARD ET AL.: ""The effects of some tryptamine derivatives on brain monoamines and their precursor amino acids"", 《NEUROPHARMACOLOGY》 *
CHRISTOPHER J. FOWLER ET AL.: ""Inhibition of Fatty Acid Amidohydrolase, the Enzyme Responsible for the Metabolism of the Endocannabinoid Anandamide, by Analogues of Arachidonoyl-serotonin"", 《JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY》 *
D AMATO R J ET AL.: ""Aminergic systems in Alzheimer"s disease and Parkinson"s disease"", 《ANNALS OF NEUROLOGY》 *
DANIEL CHA´VEZ,ET AL.: ""Tryptamine Derived Amides and Acetogenins from the Seeds of Rolliniamucosa"", 《JOURNAL OF NATURAL PRODUCTS》 *
DJALIL COOWAR,ET AL.: ""Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
GLENNON R A ET AL.: ""BINDING OF O-ALKYL DERIVATIVES OF SEROTONIN AT HUMAN 5-HT1DBETA RECEPTORS"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
NICHOLSON S L ET AL.: ""5-Hydroxytryptamine (5-HT, serotonin) and Parkinson"s disease: Opportunities for novel therapeutics to reduce the problems of levodopa therapy"", 《EUROPEAN JOURNAL OF NEUROLOGY》 *
R.W.BRIMBLECOMBE: ""Hyperthermic effects of some tryptamine derivatives in relation to their behavioural activity"", 《NEUROPHARMACOLOGY》 *
SUCKLING C J ET AL.: ""Non-selective inhibition of GABA and 5-HT uptake systems in rat brain by N-n-alkyl hydroxybenzylamine and N-n-alkyl phenylethylamine derivatives "", 《BIOCHEMICAL PHARMACOLOGY》 *
YANG-CHANG WU, ET AL.: ""Tryptamine-Derived Amides and Alkaloids from the Seeds of Annona atemoya"", 《JOURNAL OF NATURAL PRODUCTS》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN106565588A (zh) * 2016-11-10 2017-04-19 徐州工程学院 一种从坚果中提取食物源二十烷酸‑5‑羟色胺的方法
CN107118146A (zh) * 2017-04-13 2017-09-01 宁波大学 一种6‑溴色胺衍生物及其制备方法和用途
CN107118146B (zh) * 2017-04-13 2019-09-03 宁波大学 一种6-溴色胺衍生物及其制备方法和用途
CN107814787A (zh) * 2017-11-13 2018-03-20 济南大学 一种他克林‑吲哚乙酸杂联体化合物及其制备方法和应用

Also Published As

Publication number Publication date
US20110319387A1 (en) 2011-12-29
US8614246B2 (en) 2013-12-24
WO2010100133A2 (fr) 2010-09-10
EP2403830A2 (fr) 2012-01-11
FR2942625A1 (fr) 2010-09-03
FR2942625B1 (fr) 2013-11-22
JP2012519202A (ja) 2012-08-23
WO2010100133A3 (fr) 2010-11-18
CA2754283A1 (fr) 2010-09-10

Similar Documents

Publication Publication Date Title
CN102369185A (zh) 用于治疗神经退行性疾病的吲哚衍生物
EP2964223B1 (en) Compounds inhibiting leucine-rich repeat kinase enzyme activity
US6251923B1 (en) Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
EP0950047B1 (fr) Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1385825B1 (de) Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate
EP1560823B1 (de) 4-substituierte 1-aminocyclohexan-derivate zur verwendung als orl1-rezeptor- und mu-opiat-rezeptor-liganden
RS59056B1 (sr) Derivati benzimidazola kao inhibitori bromodomena
EP0873309A1 (fr) Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine
EP0995743A1 (fr) Dérivés de dihydro- et tétrahydroquinoléine en tant qu'antioxydant médical
JPH0329069B2 (https=)
WO2017211272A1 (zh) 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
KR20080042098A (ko) 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산: 제조 방법 및신경 정신 질환 치료를 위한 용도
JP2010536771A5 (https=)
AU2008286919A1 (en) Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
JP5926365B2 (ja) 神経変性疾患の処置用のアミノキノキサリン誘導体
DE69411143T2 (de) Tryptamin analoge mit 5-ht1d selektivität
US8901317B2 (en) Tryptamine derivatives, their preparation and their use in gastropathy
EP0533516A2 (fr) Nouveaux composés amidiques des 1-(alcoxybenzyl) pipérazines, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent
EP0970080B1 (en) Imino-aza-anthracyclinone derivatives for the treatment of amyloidosis
AU2004232482A1 (en) 4-, 6- o 7-hydroxyindoles having N-oxide groups and the use thereof as therapeutic agents
CN116554050A (zh) 酰胺苯酚类衍生物及其用途
IT202300002109A1 (it) Derivati indolilacetici da utilizzare nel trattamento di malattie neurodegenerative
CN117957211A (zh) 氟化色胺化合物、其类似物及其使用方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120307