CN102365270B - 新的氧肟酸衍生物、其制备方法以及包含它的药物组合物 - Google Patents
新的氧肟酸衍生物、其制备方法以及包含它的药物组合物 Download PDFInfo
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- CN102365270B CN102365270B CN201080013979.6A CN201080013979A CN102365270B CN 102365270 B CN102365270 B CN 102365270B CN 201080013979 A CN201080013979 A CN 201080013979A CN 102365270 B CN102365270 B CN 102365270B
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- phenyl
- indoles
- hydroxyl
- compound
- heptamide
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Abstract
Description
Claims (11)
Applications Claiming Priority (3)
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KR10-2009-0026578 | 2009-03-27 | ||
KR20090026578 | 2009-03-27 | ||
PCT/KR2010/001656 WO2010110545A2 (ko) | 2009-03-27 | 2010-03-18 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
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CN102365270A CN102365270A (zh) | 2012-02-29 |
CN102365270B true CN102365270B (zh) | 2014-07-30 |
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CN (1) | CN102365270B (zh) |
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CA (1) | CA2754085C (zh) |
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US20140315889A1 (en) * | 2011-10-28 | 2014-10-23 | Chong Kun Dang Pharmaceutical Corp. | Hydroxamate derivatives for hdac inhibitor, and the pharmaceutical composition comprising thereof |
ES2684396T3 (es) * | 2012-08-31 | 2018-10-02 | Novadrug, Llc | Heterociclil carboxamidas para tratar enfermedades víricas |
HUE041881T2 (hu) | 2013-04-29 | 2019-06-28 | Chong Kun Dang Pharmaceutical Corp | Új vegyületek mint szelektív hiszton dezacetiláz inhibitorok és az ezeket tartalmazó gyógyszerkészítmények |
EP3080125B1 (en) | 2013-12-12 | 2018-10-10 | Chong Kun Dang Pharmaceutical Corp. | Novel azaindole derivatives as selective histone deacetylase (hdac) inhibitors and pharmaceutical compositions comprising the same |
BR112016026518A2 (pt) * | 2014-05-14 | 2017-08-15 | Univ Colorado Regents | Ácidos hidroxâmicos heterocíclicos como inibidores da proteína desacetilase e inibidores duais de proteína desacetilase-proteína cinase e métodos de uso dos mesmos |
MX2017014953A (es) | 2015-05-22 | 2018-08-15 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de alquilos heterociclicos como inhibidores de histona desacetilasa selectivos y composiciones farmaceuticas que los comprenden. |
KR102002581B1 (ko) * | 2016-10-04 | 2019-07-22 | 주식회사 종근당 | 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 |
WO2018102261A2 (en) * | 2016-11-29 | 2018-06-07 | Xavier University Of Louisiana | Boronic derivatives hydroxamates as anticancer agents |
US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
WO2019079369A1 (en) | 2017-10-19 | 2019-04-25 | Effector Therapeutics, Inc. | BENZIMIDAZOLE INDOLE INHIBITORS OF MNK1 AND MNK2 |
KR102236356B1 (ko) * | 2017-11-24 | 2021-04-05 | 주식회사 종근당 | 루푸스의 예방 또는 치료를 위한 조성물 |
CN109096272B (zh) * | 2018-09-27 | 2021-04-02 | 沈阳药科大学 | 一种具有抗肿瘤活性的吲哚异羟肟酸类化合物及其应用 |
US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
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US771760A (en) | 1902-07-12 | 1904-10-04 | David M Balch | Process of treating seaweed. |
US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
IT1283637B1 (it) | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
WO2002030879A2 (en) | 2000-09-29 | 2002-04-18 | Prolifix Limited | Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US20070060614A1 (en) | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
US7135493B2 (en) * | 2003-01-13 | 2006-11-14 | Astellas Pharma Inc. | HDAC inhibitor |
WO2004110989A1 (en) * | 2003-05-14 | 2004-12-23 | Bayer Pharmaceuticals Corporation | N-hydroxy-7-(arylamino)heptanamide derivatives useful for treating hyper-proliferative disorders |
BRPI0615690B8 (pt) * | 2005-09-08 | 2021-05-25 | Mei Pharma Inc | compostos heterocíclicos de hidroxamato, seus usos e composição farmacêutica |
CA2662937A1 (en) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
KR100814098B1 (ko) * | 2006-11-03 | 2008-03-14 | 한국화학연구원 | 히스톤 디아세틸라제 저해활성을 갖는 알킬아미노나프탈렌일옥시 메틸옥트 n-하이드록시엔아마이드 유도체,이의 제조방법 및 이를 유효성분으로 하는 항암제용 약학조성물 |
US20090005374A1 (en) * | 2007-06-26 | 2009-01-01 | Melvin Jr Lawrence S | Imidazopyridinyl thiazolyl histone deacetylase inhibitors |
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Publication number | Publication date |
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CA2754085A1 (en) | 2010-09-30 |
WO2010110545A3 (ko) | 2011-03-24 |
BRPI1007092A2 (pt) | 2015-08-18 |
WO2010110545A2 (ko) | 2010-09-30 |
EP2412706B1 (en) | 2014-10-29 |
CA2754085C (en) | 2014-03-18 |
US20120028963A1 (en) | 2012-02-02 |
EP2412706A2 (en) | 2012-02-01 |
KR20100108220A (ko) | 2010-10-06 |
AU2010229591A1 (en) | 2011-10-20 |
AU2010229591B2 (en) | 2013-01-31 |
US8466161B2 (en) | 2013-06-18 |
MX2011010065A (es) | 2011-10-10 |
ES2525566T3 (es) | 2014-12-26 |
CN102365270A (zh) | 2012-02-29 |
BRPI1007092B8 (pt) | 2022-07-26 |
KR101168801B1 (ko) | 2012-07-25 |
EP2412706A4 (en) | 2012-05-09 |
JP5555868B2 (ja) | 2014-07-23 |
JP2012521982A (ja) | 2012-09-20 |
BRPI1007092B1 (pt) | 2022-07-12 |
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