CN102348714B - 甾族化合物 - Google Patents

甾族化合物 Download PDF

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Publication number
CN102348714B
CN102348714B CN201080011406.XA CN201080011406A CN102348714B CN 102348714 B CN102348714 B CN 102348714B CN 201080011406 A CN201080011406 A CN 201080011406A CN 102348714 B CN102348714 B CN 102348714B
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CN
China
Prior art keywords
compound
skin
compound according
chloroform
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080011406.XA
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English (en)
Chinese (zh)
Other versions
CN102348714A (zh
Inventor
石井隆幸
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mikasa Seiyaku Co Ltd
Original Assignee
Mikasa Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mikasa Seiyaku Co Ltd filed Critical Mikasa Seiyaku Co Ltd
Publication of CN102348714A publication Critical patent/CN102348714A/zh
Application granted granted Critical
Publication of CN102348714B publication Critical patent/CN102348714B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201080011406.XA 2009-03-09 2010-03-08 甾族化合物 Expired - Fee Related CN102348714B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009055172 2009-03-09
JP2009-055172 2009-03-09
PCT/JP2010/054269 WO2010104187A1 (ja) 2009-03-09 2010-03-08 ステロイド化合物

Publications (2)

Publication Number Publication Date
CN102348714A CN102348714A (zh) 2012-02-08
CN102348714B true CN102348714B (zh) 2015-01-07

Family

ID=42728470

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080011406.XA Expired - Fee Related CN102348714B (zh) 2009-03-09 2010-03-08 甾族化合物

Country Status (9)

Country Link
US (1) US8765696B2 (ja)
EP (1) EP2407476B1 (ja)
JP (1) JP5412622B2 (ja)
CN (1) CN102348714B (ja)
AU (1) AU2010221972B2 (ja)
CA (1) CA2754589C (ja)
ES (1) ES2471145T3 (ja)
TW (1) TWI465459B (ja)
WO (1) WO2010104187A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6326645B2 (ja) * 2014-03-31 2018-05-23 三笠製薬株式会社 アレルギー性皮膚炎治療用貼付剤
CN104402964B (zh) * 2014-12-10 2016-06-15 南京大学 闭花木酮的o-(咪唑基)乙基衍生物、制备方法及其用途
CN104744556B (zh) * 2015-04-15 2016-06-29 马修尧 闭花木酮的o-(1h-四氮唑基)乙基衍生物、制备方法及其用途
US20180126000A1 (en) 2016-06-02 2018-05-10 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
WO2018089373A2 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
JP7364471B2 (ja) 2017-05-18 2023-10-18 レゲネロン ファーマシューティカルス，インコーポレーテッド シクロデキストリンタンパク質薬物コンジュゲート
KR20200095477A (ko) 2017-12-01 2020-08-10 애브비 인코포레이티드 글루코코르티코이드 수용체 작용제 및 이의 면역접합체
KR20200108002A (ko) * 2018-01-08 2020-09-16 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 항체-접합체
US11377502B2 (en) 2018-05-09 2022-07-05 Regeneron Pharmaceuticals, Inc. Anti-MSR1 antibodies and methods of use thereof
NL2029599B1 (en) * 2021-11-02 2023-06-01 Univ Leiden Glycosylated Prodrugs

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721956A1 (en) * 1993-09-29 1996-07-17 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
WO1999047542A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Medicaments contenant en tant que principe actif des composes steroides glycosyles substitues en position 21
WO1999047541A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Composes steroides glycosyles a substitution en position 21
WO2005025577A1 (en) * 2003-09-15 2005-03-24 Altana Pharma Ag Use of ciclesonide for the treatment of inflammatory bowel diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185682A (en) * 1961-10-04 1965-05-25 Merck & Co Inc Steroid glucuronides and processes for preparing the same
US3206359A (en) * 1963-02-18 1965-09-14 Merck & Co Inc Galacturonides of the anti-inflammatory pregnane series
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
EP0701565B1 (de) * 1993-04-02 1998-10-28 Byk Gulden Lomberg Chemische Fabrik GmbH Neue prednisolonderivate
US6120752A (en) * 1997-05-21 2000-09-19 3M Innovative Properties Company Medicinal aerosol products containing formulations of ciclesonide and related steroids
ES2452691T5 (es) * 2003-09-16 2022-09-14 Covis Pharma Gmbh Uso de ciclesonida para el tratamiento de enfermedades respiratorias
JP5661985B2 (ja) * 2006-12-27 2015-01-28 帝人ファーマ株式会社 無菌性水性懸濁製剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721956A1 (en) * 1993-09-29 1996-07-17 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
WO1999047542A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Medicaments contenant en tant que principe actif des composes steroides glycosyles substitues en position 21
WO1999047541A1 (fr) * 1998-03-19 1999-09-23 Nissin Food Products Co., Ltd. Composes steroides glycosyles a substitution en position 21
WO2005025577A1 (en) * 2003-09-15 2005-03-24 Altana Pharma Ag Use of ciclesonide for the treatment of inflammatory bowel diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Inhaled corticosteroids in the treatment of respiratory allergy: safety vs. efficacy;Maria Cândida V. Rizzo 等;《Jornal de Pediatria》;20061231;第82卷(第5期);第198-205页 *
The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue;Elaine Mutch 等;《Biochemical Pharmacology》;20070131;第73卷(第10期);第1657-1664页 *

Also Published As

Publication number Publication date
EP2407476A1 (en) 2012-01-18
TWI465459B (zh) 2014-12-21
AU2010221972B2 (en) 2012-07-05
EP2407476A4 (en) 2012-09-12
CA2754589A1 (en) 2010-09-16
JPWO2010104187A1 (ja) 2012-09-13
WO2010104187A1 (ja) 2010-09-16
TW201043637A (en) 2010-12-16
AU2010221972A1 (en) 2011-09-29
JP5412622B2 (ja) 2014-02-12
EP2407476B1 (en) 2014-05-07
US20120059158A1 (en) 2012-03-08
CN102348714A (zh) 2012-02-08
ES2471145T3 (es) 2014-06-25
US8765696B2 (en) 2014-07-01
CA2754589C (en) 2013-07-16

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Granted publication date: 20150107

Termination date: 20180308

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