CN102335388A - Chinese medicine composition for soothing liver, removing stagnation, stimulating appetite, and promoting digestion and preparation method thereof - Google Patents
Chinese medicine composition for soothing liver, removing stagnation, stimulating appetite, and promoting digestion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for soothing liver, removing stagnation, stimulating appetite, and promoting digestion and a preparation method thereof, belonging to the field of modernization of traditional Chinese medicine. The active components of the Chinese medicine composition comprise the following ingredients: 150 weight portions of Cyperus rotundus prepared with vinegar, 35 weight portions of corydalis tuber prepared with vinegar, 50 weight portions of bitter organe fried with wheat bran, 35 weight portions of sandalwood, 35 weight portions of common aucklandia root, 15 weight portions of rhizoma wenyujin concisum, 35 weight portions of radix bupleuri, 75 weight portions of cortex magnolia officinalis prepared with ginger, 35 weight portions of clove, 35 weight portions of aquilaria wood, 25 weight portions of rhizoma galangae, 35 weight portions of green tangerine peel prepared with vinegar, 100 weight portions of dried orange peel, 35 weight portions of licorice, 35 weight portions of cardamom, 25 weight portions of curcuma zedoary prepared with vinegar, 35 weight portions of villous amomum fruit, and 15 weight portions of cinnamomum cassia. The invention has the advantages of stable and controllable quality, remarkably improved curative effect compared with present saled preparation on the market, small dosage needed by patients, and increased bioavailability, and has remarkable economic and social benefits.
Description
Technical field
The present invention relates to that a kind of soothing liver-QIization is strongly fragrant, the Chinese medicine composition of appetite-stimulating indigestion-relieving and method for preparing, belong to modern Chinese traditional medicine field.
Background technology
Piao's heavyization strongly fragrant ball is the Chinese medicine of the present commercially available strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization, and it is processed by Rhizoma Cyperi (vinegar system), Rhizoma Corydalis (vinegar system), Fructus Aurantii (parched with bran), Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Radix Bupleuri, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae Viride (vinegar system), Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Fructus Amomi Rotundus, Rhizoma Curcumae (vinegar system), Fructus Amomi, Cortex Cinnamomi.But Piao's heavyization strongly fragrant ball soothing liver-QI, change be strongly fragrant, whet the appetite, help digestion.Be used for distension and fullness of the chest and abdomen, dyspepsia, vomiting is felt sick, and stops eating and cuts off the water, and the stagnation of QI is gloomy, the gastral cavilty twinge.Rhizoma Cyperi soothing liver-QI for relieving depression in the side, regulating QI to relieve pain, the circulation of qi promoting of Cortex Magnoliae Officinalis row dampness, alleviating distention in middle-JIAO removes full, closes with the soothing liver-QI stomach function regulating, and the therapeutic method to keep the adverse QI flowing downwards is removed full. be monarch drug.The Radix Aucklandiae, Fructus Aurantii, Lignum Santali Albi, Pericarpium Citri Reticulatae regulating qi-flowing for harmonizing stomach, pain relieving in the accent, Lignum Aquilariae Resinatum, Radix Bupleuri, Pericarpium Citri Reticulatae Viride dispersing the stagnated live-QI to relieve the stagnation of QI, stopping nausea and vomiting by lowering the adverse flow of QI is ministerial drug altogether.Rhizoma Corydalis, Rhizoma Wenyujin Concisum, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, Flos Caryophylli, Rhizoma Alpiniae Officinarum, the pain relieving of Cortex Cinnamomi warming spleen and stomach for dispelling cold, Fructus Amomi Rotundus, Fructus Amomi removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting is adjuvant drug.The Radix Glycyrrhizae mediation property of medicine is messenger drug.Full side's compatibility is received dispersing the stagnated live-QI to relieve the stagnation of QI altogether, opens the merit that helmet helps digestion.The clinical hypochondriac pain that is used for, feelings will is not smooth, and liver is lost bar and reaches, and two side of body distensions that vapour lock is coerced due to the network are scurried pain, increase and decrease with the change of feelings will.Sighing frequently uncomfortable in chest, thin fur, stringy pulse; Chronic hepatitis, cholecystitis are seen above-mentioned patient.Stomachache, not catharsis of liver, gastral cavilty is had a pain due to the horizontal criminal's taste, abnormal ascending-descending of QI, and pain connects two sides of body, and belch is done frequently, noisy acid regurgitation, it is not smooth defecate, anorexia, tongue is greasy in vain, and stringy pulse delays; Digestive tract ulcer, chronic gastritis are seen above-mentioned patient.Singultus, depressed angry, irritability is taken advantage of stomach, due to the stomach adverse QI rushing upwards singultus repeatedly, fullness in the chest and hypochondrium is vexed, the time have nauseating, inappetence, greasy and thin fur, stringy pulse is slow; Gastrointestinal function of nervous system disease is seen above-mentioned patient.
In current high-tech, fast pace, society with keen competition, though material life is very abundant, psychentonia, anxiety ubiquity.These Nervous and Mental Factors usually are the reasons of morbidity.Except speech therapy, Chinese traditional treatment feelings will is hindered the disease that causes has a lot of methods, and the most frequently used is the dispersing the stagnated live-QI to relieve the stagnation of QI method.
Theory of Chinese medical science thinks that secular psychentonia, pessimal stimulation, depressed uneasiness all can cause depression of liver-QI.Stagnation of liver-QI is not dredged, and various symptoms can appear in functional activity of QI being not smooth, and often follows the unusual of the mental status.Treating different diseases with the same therapeutic principle, in medical dispersing the stagnated live-QI to relieve the stagnation of QI method can treat multiple various disease.
The prescription and the method for making of the strongly fragrant ball of heavyization of Piao are: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g.With 18 flavor medical materials, be ground into fine powder, sieve mixing.Every 100g powder adds refined honey 160～180g and processes big honeyed pills, promptly gets.
This medicine method for making is simple, evident in efficacy.But former prescription type is a honeyed pill, goes mouldy easily and microbiological contamination, and is unfavorable for quality control.Take and carry inconvenience, mouthfeel is not good, and every ball weighs 9 grams, and every dose of dose is excessive, and children's, old man and pharyngolaryngitis patient dysphagia are taken inconvenience, and patient's acceptance level is poor.And from oral slow to the gastrointestinal absorption process.These factors directly influence the Piao's strongly fragrant ball of heavyization application clinically, these factor affecting this medicine applying clinically.
Summary of the invention
First technical problem that the present invention will solve provides the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
The Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization, its active component is processed by the raw material of following parts by weight: 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts in Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts on Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts in Radix Glycyrrhizae, 35 parts in Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials: Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil obtain volatile oil A; All the other flavour of a drug water are carried, and concentrate, and drying obtains dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Dry thing II is the active component of medicine of the present invention.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6～10 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extract 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6～10 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extract 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2 times, extract 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II, dry thing II is active component of the present invention.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of soothing liver-QIization is strongly fragrant, the method for preparing of the Chinese medicine composition of appetite-stimulating indigestion-relieving, takes by weighing 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts in Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts on Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts in Radix Glycyrrhizae, 35 parts in Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extracts 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
In the said medical material,, obtain volatile oil A with Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6～10 hours; All the other flavour of a drug water are carried, and water is carried 2-3 time, extracts 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
In the said medical material,, obtain volatile oil A with Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
Chinese medicine composition that technical scheme of the present invention is related and preparation thereof have all that good soothing liver-QIization is strongly fragrant, the appetite-stimulating indigestion-relieving effect.Can be used for treating distension and fullness of the chest and abdomen, dyspepsia, vomiting is felt sick, and stops eating and cuts off the water, and the stagnation of QI is gloomy, the gastral cavilty twinge.Through zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention is compared with former dosage form, have excellent promotion gastrointestinal motility effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6 hours, obtain volatile oil A5.5ml; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 205 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 1500g, Rhizoma Corydalis (vinegar system) 350g, Fructus Aurantii (parched with bran) 500g, Lignum Santali Albi 350g, Radix Aucklandiae 350g, Rhizoma Wenyujin Concisum 150g, Radix Bupleuri 350g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 750g, Flos Caryophylli 350g, Lignum Aquilariae Resinatum 350g, Rhizoma Alpiniae Officinarum 250g, Pericarpium Citri Reticulatae Viride (vinegar system) 350g, Pericarpium Citri Reticulatae 1000g, Radix Glycyrrhizae 350g, Fructus Amomi Rotundus 350g, Rhizoma Curcumae (vinegar system) 250g, Fructus Amomi 350g, Cortex Cinnamomi 150g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours, obtain volatile oil A62ml; All the other flavour of a drug water are carried, and water is carried 3 times, extracts 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 3667 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours, obtain volatile oil A5.2ml; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 197 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 10 hours, obtain volatile oil A6.8ml; All the other flavour of a drug water are carried, and water is carried 3 times, extracts 2 hours with 8 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 209 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; Just Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil are 8 hours, obtain volatile oil A5ml; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 2 hours with 12 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 196 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 10 hours, obtain volatile oil A6.3ml; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 2 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 209 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Rhizoma Cyperi (vinegar system) 150g, Rhizoma Corydalis (vinegar system) 35g, Fructus Aurantii (parched with bran) 50g, Lignum Santali Albi 35g, Radix Aucklandiae 35g, Rhizoma Wenyujin Concisum 15g, Radix Bupleuri 35g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 75g, Flos Caryophylli 35g, Lignum Aquilariae Resinatum 35g, Rhizoma Alpiniae Officinarum 25g, Pericarpium Citri Reticulatae Viride (vinegar system) 35g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae 35g, Fructus Amomi Rotundus 35g, Rhizoma Curcumae (vinegar system) 25g, Fructus Amomi 35g, Cortex Cinnamomi 15g
Two. method for making:
Take by weighing each raw material by proportioning raw materials, subsequent use; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6 hours, obtain volatile oil A5.1ml; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 1 hour with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.Be active component 213 grams of the present invention.
Embodiment 8: the preparation tablet
The active component 100g that embodiment 1 obtains adds microcrystalline Cellulose 10g, lactose 10g, and cross-linked pvp 5g, tabletting gets tablet, and every is 0.25g.
Embodiment 9: the preparation granule
The active component 500g that embodiment 2 obtains adds dextrin 100g, xylitol 400g, and citric acid 1g, aspartame 1g granulates, and gets granule, and every bag is 5g.
Embodiment 10: zoopery one: extract of the present invention is to the influence of mouse small intestine progradation
One. material and method
The strongly fragrant ball of heavyization of Piao (lot number: 090867), reach core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin and produce
Animal: the ICR mice is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK (capital) 2002-0003.
Cisapride is produced by Xian-Janssen Pharmaceutical Ltd., and carbon powder is produced by northization glass purchase and sale center, Tianjin
Arabic gum is produced by Tianjin pharmaceuticals
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, i.e. blank control group, cisapride positive controls, basic, normal, high group of the strongly fragrant ball group of Piao's heavyization, the strongly fragrant extract of plain heavyization.Dosage is: blank control group is irritated with purified water; Cisapride positive drug group is irritated with 10mg/kg cisapride medicinal liquid; The strongly fragrant ball group of heavyization of Piao is irritated with 8g crude drug/strongly fragrant ball medicinal liquid of kg heavyization of Piao; The Piao's strongly fragrant extract of heavyization (preparation of embodiment 3 methods) basic, normal, high group irritated with 2,4 respectively, the strongly fragrant extract medicinal liquid of plain heavyization of 8g crude drug/kg, and the administration volume is 20ml/kg, continuous gastric infusion 7 days; Fasting is 16 hours before the last administration, and 60 minutes every mouse stomaches only give 5% carbon powder (10% arabic gum) suspension 0.3ml/ after the administration, take off cervical vertebra after 15 minutes and put to death animal; Cut open the belly immediately, separate mesentery, the clip upper end is to pylorus; Lower end to ileocecal intestinal tube; Be tiled on the glass plate, draw gently linearly, measuring intestinal tube length is " small intestinal total length "; From the distance conduct " carbon powder is at the enteral advance distance " in pylorus to carbon powder forward position, calculate and advance percentage rate.
Two. result: see table 1.
Table 1 extract administration seven days is to the propulsive influence of mouse small intestine
Compare * P＜0.05 with the blank group, * * P＜0.01
The result shows: the strongly fragrant extract of plain heavyization of the propulsive length specification of promotion small intestinal carbon powder has the good propulsive function of promotion mouse small intestine 2,4, under the dosage of 8g crude drug/kg to Piao's heavyization strongly fragrant extract 2,4, under the dosage of 8g crude drug/kg.
Embodiment 11: zoopery two: extract of the present invention is to the influence of mice gastric emptying
One. method:
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random, i.e. blank control group, cisapride positive controls, basic, normal, high group of the strongly fragrant ball group of Piao's heavyization, the strongly fragrant extract of plain heavyization.Dosage is: blank control group is irritated with purified water; Cisapride positive drug group is irritated with 10mg/kg cisapride medicinal liquid; The strongly fragrant ball group of heavyization of Piao is irritated with 8g crude drug/strongly fragrant ball medicinal liquid of kg heavyization of Piao; The Piao's strongly fragrant extract of heavyization (preparation of embodiment 3 methods) basic, normal, high group irritated with 2,4 respectively, the strongly fragrant extract medicinal liquid of plain heavyization of 8g crude drug/kg; The administration volume is 20ml/kg, and gastric infusion is 7 days continuously, and fasting is 16 hours before the last administration; 60 minutes every mouse stomaches give the semi-solid paste of trophism (by milk powder after the administration; Sugar, starch is formed) 0.8ml/ only, take off cervical vertebra after 20 minutes and put to death mice.Open abdomen and get stomach, claim stomach full weight and net weight, calculate the gastric residue and account for institute to irritate the percentage by weight of semisolid paste be the gastric residual rate.
Two. result: see table 2.
The table 2 extract successive administration influence to the mice gastric emptying in seven days
Compare with the blank group, * P＜0.05, △ P＜0.05 is compared with the strongly fragrant ball of heavyization of Piao in * * P＜0.01
The result shows: the result shows: Piao's heavyization strongly fragrant extract is minimizing mice gastric residual quantity 2,4, under the dosage of 8g crude drug/kg, explains that the strongly fragrant extract of plain heavyization has the function of good promotion mice gastric emptying 2,4, under the dosage of 8g crude drug/kg.And the gastric emptying of the strongly fragrant extract of heavyization of Piao is better than the strongly fragrant ball of heavyization of Piao with dosage.
Claims (10)
1. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of soothing liver-QIization, it is characterized in that: its active component is processed by the raw material of following parts by weight: 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts in Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts on Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts in Radix Glycyrrhizae, 35 parts in Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis.
2. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 1; It is characterized in that said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil, obtain volatile oil A; All the other flavour of a drug water are carried, concentrated, obtain concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
3. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 2 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Just Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil are 6～10 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extracts 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
4. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 3 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extracts 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
5. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 4 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
6. according to the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of any one described a kind of soothing liver-QIization in the claim 1 to 5, it is characterized in that: said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
7. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 6 is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
8. the Chinese medicine composition of the strongly fragrant appetite-stimulating indigestion-relieving of a kind of soothing liver-QIization according to claim 6 is characterized in that: the dosage form of said Chinese medicine composition is pill, tablet, capsule or oral liquid.
9. the method for preparing of the Chinese medicine composition of strongly fragrant, the appetite-stimulating indigestion-relieving of a soothing liver-QIization is characterized in that comprising the steps: to take by weighing 150 parts of Rhizoma Cyperis (vinegar system), 35 parts of Rhizoma Corydalis (vinegar system), 50 parts of Fructus Aurantiis (parched with bran), 35 parts in Lignum Santali Albi, 35 parts of the Radix Aucklandiae, 15 parts of Rhizoma Wenyujin Concisum, 35 parts of Radix Bupleuri, 75 parts of Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), 35 parts of Flos Caryophyllis, 35 parts of Lignum Aquilariae Resinatum, 25 parts of Rhizoma Alpiniae Officinarums, 35 parts on Pericarpium Citri Reticulatae Viride (vinegar system), 100 parts of Pericarpium Citri Reticulataes, 35 parts in Radix Glycyrrhizae, 35 parts in Fructus Amomi Rotundus, 25 parts of Rhizoma Curcumae (vinegar system), 35 parts of Fructus Amomis, 15 parts of Cortex Cinnamomis; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 6～10 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2-3 time, extracts 1-3 hour with 8-12 times of water gaging at every turn, and merge extractive liquid, is concentrated into that relative density is 1.03-1.10 (preferred 1.05-1.08) under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
10. a kind of soothing liver-QIization according to claim 9 is strongly fragrant, the method for preparing of the Chinese medicine composition of appetite-stimulating indigestion-relieving; It is characterized in that: in the said medical material; With Lignum Santali Albi, the Radix Aucklandiae, Rhizoma Wenyujin Concisum, Flos Caryophylli, Lignum Aquilariae Resinatum, Rhizoma Alpiniae Officinarum, Pericarpium Citri Reticulatae, Fructus Amomi Rotundus, Fructus Amomi, Cortex Cinnamomi vapor extraction volatile oil 8 hours, obtain volatile oil A; All the other flavour of a drug water are carried, and water is carried 2 times, extracts 3 hours with 10 times of water gagings at every turn, and merge extractive liquid, is concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, concentrates, and obtains concentrated solution B; Concentrated solution B is dry, obtain dry thing I; With dry thing I and volatile oil A mix homogeneously, obtain dry thing II.
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| CN108524854A (en) * | 2018-05-25 | 2018-09-14 | 滨州越佳医药科技有限公司 | A kind of medicine pill for treating children anorexia |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
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| CN101327313A (en) * | 2008-07-18 | 2008-12-24 | 宝商集团陕西辰济药业有限公司 | Oral medication for treating epigastric pain |
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| CN101327313A (en) * | 2008-07-18 | 2008-12-24 | 宝商集团陕西辰济药业有限公司 | Oral medication for treating epigastric pain |
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| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部药品标准 中药成方制剂第十册》", 31 December 1995 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524854A (en) * | 2018-05-25 | 2018-09-14 | 滨州越佳医药科技有限公司 | A kind of medicine pill for treating children anorexia |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
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Address after: No.21, 10th Street, Binhai New Area Development Zone, Tianjin 300457 Patentee after: Jinyao Darentang Group Co.,Ltd. Darentang Pharmaceutical Factory Address before: 300457 No. tenth, 21 Avenue, Tianjin economic and Technological Development Zone Patentee before: DARENTANG PHARMACEUTICAL FACTORY, TIANJIN ZHONGXIN PHARMACEUTICAL GROUP Co.,Ltd. |