CN102317288A - 作为激酶抑制剂的[1,2,4]三唑并[1,5-a]吡啶 - Google Patents

作为激酶抑制剂的[1,2,4]三唑并[1,5-a]吡啶 Download PDF

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Publication number
CN102317288A
CN102317288A CN2010800077376A CN201080007737A CN102317288A CN 102317288 A CN102317288 A CN 102317288A CN 2010800077376 A CN2010800077376 A CN 2010800077376A CN 201080007737 A CN201080007737 A CN 201080007737A CN 102317288 A CN102317288 A CN 102317288A
Authority
CN
China
Prior art keywords
triazolo
chloro
phenyl
pyridin
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800077376A
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English (en)
Chinese (zh)
Inventor
卡罗琳·勒里什
埃里克·奥克莱尔
雅克·乐鲁
大卫·米德尔米斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fovea Pharmaceuticals SA
Original Assignee
Fovea Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42229029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102317288(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fovea Pharmaceuticals SA filed Critical Fovea Pharmaceuticals SA
Publication of CN102317288A publication Critical patent/CN102317288A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2010800077376A 2009-02-13 2010-02-09 作为激酶抑制剂的[1,2,4]三唑并[1,5-a]吡啶 Pending CN102317288A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09360013.8 2009-02-13
EP09360013 2009-02-13
PCT/EP2010/051556 WO2010092041A1 (en) 2009-02-13 2010-02-09 [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors

Publications (1)

Publication Number Publication Date
CN102317288A true CN102317288A (zh) 2012-01-11

Family

ID=42229029

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800077376A Pending CN102317288A (zh) 2009-02-13 2010-02-09 作为激酶抑制剂的[1,2,4]三唑并[1,5-a]吡啶

Country Status (24)

Country Link
US (1) US20120041195A1 (cg-RX-API-DMAC7.html)
EP (1) EP2396324A1 (cg-RX-API-DMAC7.html)
JP (1) JP2012517971A (cg-RX-API-DMAC7.html)
KR (1) KR20110116160A (cg-RX-API-DMAC7.html)
CN (1) CN102317288A (cg-RX-API-DMAC7.html)
AR (1) AR075411A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI1008850A2 (cg-RX-API-DMAC7.html)
CA (1) CA2751517A1 (cg-RX-API-DMAC7.html)
CL (1) CL2011001947A1 (cg-RX-API-DMAC7.html)
CO (1) CO6420343A2 (cg-RX-API-DMAC7.html)
CR (1) CR20110386A (cg-RX-API-DMAC7.html)
DO (1) DOP2011000248A (cg-RX-API-DMAC7.html)
EA (1) EA201101188A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP11011250A (cg-RX-API-DMAC7.html)
HN (1) HN2011002095A (cg-RX-API-DMAC7.html)
IL (1) IL214426A0 (cg-RX-API-DMAC7.html)
MX (1) MX2011008549A (cg-RX-API-DMAC7.html)
NI (1) NI201100151A (cg-RX-API-DMAC7.html)
NZ (1) NZ594508A (cg-RX-API-DMAC7.html)
PE (1) PE20120110A1 (cg-RX-API-DMAC7.html)
SG (1) SG173610A1 (cg-RX-API-DMAC7.html)
TN (1) TN2011000379A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010092041A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201105896B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI768550B (zh) * 2019-11-22 2022-06-21 大陸商南京明德新藥研發有限公司 作為dna-pk抑制劑的嘧啶并吡咯類螺環化合物及其衍生物

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EP2438066A2 (en) 2009-06-05 2012-04-11 Cephalon, Inc. PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343294A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
UY33452A (es) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
AR081960A1 (es) * 2010-06-22 2012-10-31 Fovea Pharmaceuticals Sa Compuestos heterociclicos, su preparacion y su aplicacion terapeutica
RS54044B1 (sr) 2011-04-21 2015-10-30 Bayer Intellectual Property Gmbh Triazolopiridini
WO2012160029A1 (en) 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
KR20130091464A (ko) 2012-02-08 2013-08-19 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체
WO2013135612A1 (en) 2012-03-14 2013-09-19 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
SG11201408419QA (en) 2012-07-10 2015-01-29 Bayer Pharma AG Method for preparing substituted triazolopyridines
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
AP2015008898A0 (en) 2013-06-11 2015-12-31 Bayer Pharma AG Prodrug derivatives of substituted triazolopyridines

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WO2008025821A1 (en) * 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
CN102131390A (zh) * 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
CN102131389A (zh) * 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
CN102203093A (zh) * 2008-09-08 2011-09-28 西格诺药品有限公司 氨基三唑并吡啶和其作为激酶抑制剂的用途

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WO2008025821A1 (en) * 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
CN102131390A (zh) * 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
CN102131389A (zh) * 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
CN102203093A (zh) * 2008-09-08 2011-09-28 西格诺药品有限公司 氨基三唑并吡啶和其作为激酶抑制剂的用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI768550B (zh) * 2019-11-22 2022-06-21 大陸商南京明德新藥研發有限公司 作為dna-pk抑制劑的嘧啶并吡咯類螺環化合物及其衍生物

Also Published As

Publication number Publication date
IL214426A0 (en) 2011-09-27
WO2010092041A1 (en) 2010-08-19
AR075411A1 (es) 2011-03-30
CA2751517A1 (en) 2010-08-19
NZ594508A (en) 2013-12-20
CO6420343A2 (es) 2012-04-16
PE20120110A1 (es) 2012-02-20
EP2396324A1 (en) 2011-12-21
CR20110386A (es) 2011-12-02
MX2011008549A (es) 2011-12-06
JP2012517971A (ja) 2012-08-09
NI201100151A (es) 2012-10-03
BRPI1008850A2 (pt) 2016-03-15
US20120041195A1 (en) 2012-02-16
KR20110116160A (ko) 2011-10-25
DOP2011000248A (es) 2011-10-31
SG173610A1 (en) 2011-09-29
CL2011001947A1 (es) 2012-03-16
HN2011002095A (es) 2014-01-06
EA201101188A1 (ru) 2012-04-30
ZA201105896B (en) 2012-03-28
ECSP11011250A (es) 2011-10-31
TN2011000379A1 (en) 2013-03-27

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Application publication date: 20120111