CN102307903A - 作为抗菌剂的新型半合成糖肽 - Google Patents

作为抗菌剂的新型半合成糖肽 Download PDF

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Publication number
CN102307903A
CN102307903A CN2009801561496A CN200980156149A CN102307903A CN 102307903 A CN102307903 A CN 102307903A CN 2009801561496 A CN2009801561496 A CN 2009801561496A CN 200980156149 A CN200980156149 A CN 200980156149A CN 102307903 A CN102307903 A CN 102307903A
Authority
CN
China
Prior art keywords
group
substituted
compound
alkoxy
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801561496A
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English (en)
Chinese (zh)
Inventor
丹尼尔·楚
叶涛
兵·王
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Biomarin Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2008/085716 external-priority patent/WO2009085562A1/en
Application filed by Biomarin Pharmaceutical Inc filed Critical Biomarin Pharmaceutical Inc
Publication of CN102307903A publication Critical patent/CN102307903A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801561496A 2008-12-05 2009-09-01 作为抗菌剂的新型半合成糖肽 Pending CN102307903A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2008/085716 WO2009085562A1 (en) 2007-12-26 2008-12-05 Novel semi-synthetic glycopeptides as antibacterial agents
USPCT/US2008/085716 2008-12-05
US22016709P 2009-06-24 2009-06-24
US61/220,167 2009-06-24
PCT/US2009/055633 WO2010065174A1 (en) 2008-12-05 2009-09-01 Novel semi-synthetic glycopeptides as antibacterial agents

Publications (1)

Publication Number Publication Date
CN102307903A true CN102307903A (zh) 2012-01-04

Family

ID=41203726

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801561496A Pending CN102307903A (zh) 2008-12-05 2009-09-01 作为抗菌剂的新型半合成糖肽

Country Status (12)

Country Link
US (1) US20110015119A1 (https=)
EP (1) EP2373694A1 (https=)
JP (1) JP2012510999A (https=)
KR (1) KR20110099028A (https=)
CN (1) CN102307903A (https=)
AR (1) AR075354A1 (https=)
AU (1) AU2009322925A1 (https=)
CA (1) CA2745446A1 (https=)
GB (1) GB2465863A (https=)
IL (1) IL213390A0 (https=)
TW (1) TW201021805A (https=)
WO (1) WO2010065174A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017186110A1 (zh) * 2016-04-29 2017-11-02 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140009A1 (en) * 2010-05-04 2011-11-10 Biomarin Pharmaceutical Inc. Methods of using semi-synthetic glycopeptides as antibacterial agents
GB2577420B (en) 2017-05-22 2022-07-06 Insmed Inc Glycopeptide derivative compounds and uses thereof
CN111793076B (zh) * 2020-06-05 2021-10-12 华北制药河北华民药业有限责任公司 一种注射用硫酸头孢匹罗的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0662674B2 (ja) * 1985-01-11 1994-08-17 三共株式会社 抗生物質クロロポリスポリンｂまたはｃ
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
NZ509165A (en) * 1998-07-14 2003-08-29 Univ Princeton Glycopeptide antobiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
DE69908819T2 (de) * 1998-12-23 2004-05-06 Theravance, Inc., South San Francisco Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
AU4054900A (en) * 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
MXPA02006029A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
US6397405B1 (en) * 2000-04-11 2002-06-04 Thetford Corporation Flush toilet for RV's and boats
US6770621B2 (en) * 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6620781B2 (en) * 2000-06-22 2003-09-16 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
CA2588285A1 (en) * 2004-11-29 2006-06-01 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US7632918B2 (en) * 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US8236926B2 (en) * 2006-09-06 2012-08-07 Wisconsin Alumni Research Foundation Rapid glycopeptide optimization via neoglycosylation
WO2008075684A1 (ja) * 2006-12-19 2008-06-26 Shionogi & Co., Ltd. グリコペプチド抗生物質誘導体
GB2449156B8 (en) * 2007-05-08 2010-06-02 Lead Therapeutics Inc Semi-synthetic glycopeptides with antibacterial activity.
US20090062268A1 (en) * 2007-08-27 2009-03-05 Lead Therapeutics, Inc. Novel inhibitors of poly(adp-ribose)polymerase (parp)
CN101959849A (zh) * 2007-12-26 2011-01-26 利德治疗公司 作为抗菌剂的新型半合成糖肽
US20100105607A1 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
US20100216699A1 (en) * 2009-02-09 2010-08-26 Lead Therapeutics, Inc. Semi-synthetic glycopeptides having antibacterial activity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017186110A1 (zh) * 2016-04-29 2017-11-02 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
US10961278B2 (en) 2016-04-29 2021-03-30 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Vancomycin derivative, preparation method, pharmaceutical composition and use thereof
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途

Also Published As

Publication number Publication date
AU2009322925A1 (en) 2011-06-30
GB0915258D0 (en) 2009-10-07
KR20110099028A (ko) 2011-09-05
CA2745446A1 (en) 2010-06-10
AR075354A1 (es) 2011-03-30
US20110015119A1 (en) 2011-01-20
GB2465863A (en) 2010-06-09
JP2012510999A (ja) 2012-05-17
IL213390A0 (en) 2011-07-31
TW201021805A (en) 2010-06-16
EP2373694A1 (en) 2011-10-12
WO2010065174A1 (en) 2010-06-10

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
EE01 Entry into force of recordation of patent licensing contract

Assignee: Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd.

Assignor: Biomarin Pharmaceutical Inc.

Contract record no.: 2012990000415

Denomination of invention: Novel semi-synthetic glycopeptides as antibacterial agents

License type: Exclusive License

Open date: 20120104

Record date: 20120613

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120104