CN102302711A - Capsules for clearing away damp toxin - Google Patents
Capsules for clearing away damp toxin Download PDFInfo
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- CN102302711A CN102302711A CN201110257640A CN201110257640A CN102302711A CN 102302711 A CN102302711 A CN 102302711A CN 201110257640 A CN201110257640 A CN 201110257640A CN 201110257640 A CN201110257640 A CN 201110257640A CN 102302711 A CN102302711 A CN 102302711A
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Abstract
The invention relates to capsules for clearing away damp toxin. The capsules are prepared from the following raw materials: capillary wormwood herb, plantain seed, herba houttuyniae, rhizoma smilacis glabrae, atractylodes rhizome and phellodendron. The preparation method of the capsules comprises the following steps: crushing the atractylodes rhizome and one third of the quantity of rhizoma smilacis glabrae into fine powder, and evenly mixing the fine powder for use; respectively decocting the capillary wormwood herb, the plantain seed, the herba houttuyniae, the phellodendron and the rest of rhizoma smilacis glabrae for extraction, combining decoction, filtering and concentrating filtered liquor into thick paste for later use; and mixing the thick paste with the fine powder, drying, crushing, evenly mixing and encapsulating to finally obtain the capsules. According to the invention, the preparation process is simple, cost is low, traditional Chinese herbal medicines are matched scientifically, and the capsules have high bioavailability, high stability, obvious curative effect and no obvious toxic and side effects; moreover the capsules have the efficacy of clearing away heat and toxic materials and removing dampness and can be used for treating damp-toxin patients suffering from gonorrhoea, condyloma acuminatum, nongonococcal urethritis (cervicitis and colpitis), herpes progenitalis, chronic prostatitis and the like. Therefore the invention provides a more convenient and faster Chinese traditional medical treatment mode for clinical treatment of skin diseases.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of clear noxious dampness capsule that patient takes and carries of being convenient to that diseases such as lower limb eczema, erysipelas, papular urticaria, tinea pedis infection, impetigo, gonorrhea, syphilis, condyloma acuminatum, nongonococcal urethritis (cervicitis, vaginitis), genital herpes, chronic prostatitis belong to the noxious dampness person that is used to treat.
Background technology
Though it is tangible visible that dermatosis is sent out at body surface, clinical treatment is obstinate mostly difficult, controls for a long time and does not imitate, and traces it to its cause, and mainly is that pathogenic factors is complicated, and some paathogenic factor can not be summarised among the six climate exopathogens seven emotions, has the factor of the evil morbidity of poison.Cause " poison is evil " of dermatosis morbidity; Be to contain among common food, medicine, animal, plant and natural six gas; These " poison is evil " act on human body; Most people do not fall ill, and have only groups of people not anti-because of body constitution, innate deficiency; The evil human body of invading of poison; Gather the skin space between skin and muscles, and cause the QI and blood cohesion, battalion defends and becomes estranged, meridians block, poison is dull, send out skin outward forms dermatosis.The poison heresy is a kind of special paathogenic factor from exteroreception;, worm beastly poison malicious, dermatitis rhus etc. like bromatotoxin, medicine poison, cosmetics; Be again that human body is subjected to after certain paathogenic factor effect formed pathological product in the disease development process, like pyretic toxicity, blood poison, pathogenic wind toxic, noxious dampness, expectorant poison, stasis of blood poison etc.These pathological products can directly or indirectly act on a certain internal organs of human body and skin again various skin diseases take place after forming.The poison heresy causes that dermatosis has plenty of heat symptom-complex, has plenty of sympotoms caused by cold factors, has plenty of positive disease, has plenty of cloudy disease, says from the cause of disease, also can be concurrent with different causes of disease such as wind and cold heat-damp in summer dryness-fire and the stasis of blood, expectorant.
Noxious dampness type disease is many, and sweating entry or wet clothing are sat the wetland that crouches because of revealed by white misty rain, live humidity and cause; Or the surfeit greasy and surfeit flavour, tobacco and wine, raw and cold melon and fruit, eating and drinking without temperance, spleen fortune mistakeization is given birth to and cause in the noxious dampness.Its clinical manifestation is: be mainly in human body bottom (comprising genitals).Send out in the bottom skin person, skin lesion is pleomorphism, and erythema, pimple, vesicle, the taste of rotten to the corn stream, incrustation etc. are arranged; Send out in the genitals person, be mostly sexually transmitted disease, flow nebulousurine or painful and swollen testis, distention and pain in the lower abdomen etc. in performance urgent micturition, dysurea, frequent micturition, the urine.Can accompany limbs fatigue, joint aches, constipation, yellow and greasy fur, deep pulse number or sliding number.Common disease: diseases such as lower limb eczema, erysipelas, papular urticaria, tinea pedis infection, impetigo, gonorrhea, syphilis, condyloma acuminatum, nongonococcal urethritis (cervicitis, vaginitis), genital herpes, chronic prostatitis belong to the noxious dampness person.This type dermatosis pilosity of noxious dampness morbidity is born in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels in the modern medicine study; How touching the course of disease is, obstinate difficult; Control no obvious curative effects for a long time; How to cause by infective agent; Be that the treatment of main life-time service anti-infectives causes drug resistance more with anti-infective therapy in the treatment; More likely form dysbacteriosis, this type of modern medicine treatment dermatosis method limitation, curative effect is relatively poor.Though Chinese medicine decoction has better curative effect, just Chinese medicine decoction is boiled medicine loaded down with trivial detailsly, consuming time longer, takes inconvenience, can not large-scale popularization it.
Summary of the invention
The objective of the invention is to the deficiency of prior art and a kind of clear noxious dampness capsule is provided; Chinese herbal medicine is carried out the science compatibility; Bioavailability of medicament is high; Stability is high; Effect with clearing away heat-damp and promoting diuresis detoxifcation; Curative effect is obvious, and no obvious toxic-side effects provides the Chinese traditional treatment mode of more convenient and quicker for the dermatosis clinical treatment.
The technical scheme that the present invention adopted:
A kind of clear noxious dampness capsule is to be processed by following materials of weight proportions: 170~190 parts of Herba Artemisiae Scopariaes, 170~190 parts of Semen Plantaginiss, 170~190 parts of Herba Houttuyniae, 170~190 parts of Rhizoma Smilacis Glabraes, 110~130 parts of Rhizoma Atractylodis, 110~130 parts of Cortex Phellodendris;
Method for preparing is following:
1, by prescription measure Rhizoma Atractylodis and 1/3 the amount Rhizoma Smilacis Glabrae powder be broken into fine powder, mixing, subsequent use.
2, measure Herba Artemisiae Scopariae, Semen Plantaginis, Herba Houttuyniae, Cortex Phellodendri and remaining Rhizoma Smilacis Glabrae by prescription; Adding 7~9 times of decoctings respectively boils and carries out the first time and extract; Adding 5~7 times of decoctings again boils and carries out the second time and extract; Merge decoction liquor; Filter; Filtrating and under room temperature, being concentrated into relative density is 1.10~1.20 thick paste, subsequent use;
3, thick paste is mixed the back with fine powder in 70~80 ℃ of dry down, pulverizing, be mixed the fill capsule.
Among the present invention, the preferred following weight proportion of said raw material: 180 parts of Herba Artemisiae Scopariaes, 180 parts of Semen Plantaginiss, 180 parts of Herba Houttuyniae, 180 parts of Rhizoma Smilacis Glabraes, 120 parts of Rhizoma Atractylodis, 120 parts of Cortex Phellodendris.
Employed Chinese herbal medicine Rhizoma Smilacis Glabrae nature and flavor are sweet, light, flat in the clear noxious dampness capsule provided by the present invention; Return liver, stomach warp; Function detoxifcation dehumidifying, easing joint movement.Herba Artemisiae Scopariae beginning is stated from " herbal classic ", and nature and flavor are bitter, be slightly cold, and returns spleen, stomach, liver, gallbladder meridian; Has clearing away heat-damp and promoting diuresis, the effect of promoting the function of the gallbladder to alleviate jaundice.The two is monarch drug altogether, the heat-clearing and toxic substances removing dampness removing.The Cortex Phellodendri beginning is stated from " herbal classic ", and nature and flavor are bitter, cold, return kidney, bladder, large intestine channel; Have heat clearing and damp drying, eliminating fire and detoxication is brought down a fever and is removed the effect of steaming.The Semen Plantaginis beginning is stated from " herbal classic ", and nature and flavor are sweet, cold, return kidney, liver, lung meridian; The function inducing diuresis for treating stranguria syndrome, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat from the lung and dissipating phlegm.Herba Houttuyniae beginning is stated from " Bencao Jingshu ", and nature and flavor are hot, be slightly cold, and returns lung meridian; The function heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.The three is ministerial drug altogether, auxiliary monarch drug heat-clearing and toxic substances removing dampness removing.Rhizoma Atractylodis are adjuvant, and nature and flavor are hot, bitter, warm; Return spleen, stomach warp; Function is drying damp and strengthening spleen, wind-damp dispelling.Can help and help principal agent dampness.There is the effect of eliminating damp, detoxifying the side of closing, mainly treats diseases such as lower limb eczema, erysipelas, papular urticaria, tinea pedis infection, impetigo, gonorrhea, syphilis, condyloma acuminatum, nongonococcal urethritis (cervicitis, vaginitis), genital herpes, chronic prostatitis and belongs to the noxious dampness person.
Clinical trial:
Use clear noxious dampness capsule to clinical manifestation as noxious dampness disease dermatosis patient detoxify, counteracting toxic substances treatment, obtain better curative effect.
One, clear noxious dampness capsule for treating gonorrhea clinical observation on the therapeutic effect
192 routine patients are treated, male's 128 examples wherein, the oldest 45 years old, minimum 22 years old, the course of disease is the longest 7 days, and was the shortest 2 days; Women's 64 examples, the oldest 42 years old, minimum 20 years old, the course of disease is the longest 10 days, and was the shortest 3 days.
Curative effect judging standard: recovery from illness: symptom all disappears, and plate coating checking is not seen the Gram-positive diplococcus.Produce effects: symptom disappears basically, the accidental Gram-positive diplococcus of plate coating checking.Invalid: symptom does not disappear, the visible Gram-positive diplococcus of plate coating checking.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic scheme: with penicillin 6,400,000 U, add 10% Glucose Liquid 300ml intravenous drip, 1 time/d, 3d altogether, and each 4 with clear noxious dampness capsule, every day 3 times, the morning and evening after the meal boiled water take after mixing it with water, serve on 14 days.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: 1 routine patient's had slight gastrointestinal upset, and through supporting anti symptom treatment, not influence treatment.
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Two, clear noxious dampness capsule for treating condyloma acuminatum clinical observation on the therapeutic effect
240 routine patients are treated male's 186 examples wherein, women's 54 examples; Age is 16~51 years old, and the course of disease is 1 week~6 month, occupation with unemployed with work in the majorityly for a long time outside, 127 routine patients do not deny the history of frequenting brothels in the recent period, 45 routine patients do not deny the sex partner sexual transmission.Positions such as skin lesion is distributed in around genitals, the anus, urethral orifice; Skin lesion shows as and is dispersed in or is fused into crumby pale red pimple or cauliflower-like vegetation; Size from the Semen setariae to the Semen Viciae fabae.
Curative effect judging standard: cure: the wart body disappears fully, and mucocutaneous recovery is normal, and perusal does not have proliferative lesion, and acetic acid is tested (-) in vain, not recurrence in half a year; Produce effects: the wart body disappears, and mucocutaneous recovery is normal, recurrence in 3 months; Do not heal: the wart body does not disappear fully, recurrence in 1 month.
Therapeutic Method: (1) naturopathy---fulgerize: skin lesion surface routine disinfection, the surface is with tetracaine anesthesia, the burning of fulgerizing.(2) treatment by Chinese herbs: each 4 of clear noxious dampness capsule, every day 3 times, 3 weeks were a course of treatment.Adopt said method to treat 2 courses of treatment.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction.
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Three, clear noxious dampness capsule for treating nongonococcal urethritis (vaginitis) clinical observation on the therapeutic effect
180 routine patients are treated 128 examples wherein, women 52 examples; 2~55 years old age, average 28 years old; Course of disease 2d~32d.
Curative effect judging standard: draft with reference to " the up-to-date sexually transmitted disease (STD) diagnosis and treatment standard promulgated by the ministries or commissions of the Central Government and treatment for the sexually transmitted diseases suggested design nongonococcal urethritis (vaginitis) the diagnosis and treatment standards (trying) " of promulgation Ministry of Public Health Department of Disease Control in August, 2000 and to be divided into 4 grades.Recovery from illness: subjective symptoms disappears, the no abnormal secretions of urethra (cervix uteri), secretions smear leukocyte in normal range, the Uu negative culture results, 1 week of drug withdrawal, 3 weeks, check in March are all negative, symptom and sign improvement rate >=90%; Produce effects: subjective symptoms is obviously alleviated, or the not complete obiteration of a kind of Sx is only arranged, and secretions smear leukocyte is in normal range, and Uu negative culture results, symptom and sign improvement rate reach >=70%; Progressive: sb.'s illness took a favorable turn; Secretions smear male is in the following average every visual field >=5 of oily mirror (1000 times), and the women is at oily mirror (1000 times) average every visual field polymorphonuclear leukocyte>10 down, but obviously reduces before the treatment; Uu cultivates still positive, symptom and sign improvement rate >=30%; Invalid: the state of an illness does not have improvement or progressive not obvious, and the pathogen inspection is positive, symptom and sign improvement rate<30%.Total effective rate adds produce effects in recovery from illness.
Therapeutic Method: the each 250mg of one after each meal azithromycin, every day 2 times, each 4 of noxious dampness capsule, was taken medicine for 2 weeks continuously at every day 3 times.2 groups of all capable secretions are cultivated after the drug withdrawal.
All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Four, clear noxious dampness capsule for treating genital herpes clinical observation
180 routine patients are treated 19~45 years old age, average 31.2 ± 2.4 years old; The course of disease 3 days~1 year.All case did not heal with medicine in 2 weeks, without other sexually transmitted disease (STD)s.
Criterion of therapeutical effect: by the having that it's too late the light and heavy degree score is 0~3 minute of sings and symptoms such as erythema, pimple, vesicle, erosion, shallow table ulcer, pain or pruritus, according to integral and calculating therapeutic index before and after the treatment: therapeutic index=(integration before treating-treatments back integration)/integration * 100% after treating.Recovery from illness is therapeutic index>95%; Produce effects is therapeutic index>70%; Be therapeutic index>30% effectively; Invalid is therapeutic index<30%.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic Method: oral clear noxious dampness capsule, each 4, every day 3 times, serveing on 30 days is 1 course of treatment, adds up curative effect after 1 course of treatment.Forbid other drug during the treatment.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Five, clear noxious dampness capsule for treating chronic prostatitis clinical observation
180 routine patients are treated 20~68 years old age, average 31.2 ± 2.4 years old; Course of disease March~5 years.All case did not heal with medicine in 2 weeks, without other sexually transmitted disease (STD)s.
Criterion of therapeutical effect: cure: the symptom complete obiteration, prostatic fluid leukocyte<10/HP, lecithin (++ ++), antibacterial culturing is turned out cloudy; Produce effects: symptom is obviously alleviated, prostatic fluid leukocyte<10/HP, lecithin (++ +~++ ++), antibacterial culturing is turned out cloudy; Effectively: symptom is partly alleviated, prostatic fluid leukocyte<10/HP, lecithin (++~+++), more preceding improvement, positive bacterial culture or feminine gender; Invalid: the equal no change of each index.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic Method: oral clear noxious dampness capsule, each 4, every day 3 times, serveing on 30 days is 1 course of treatment, adds up curative effect after 1 course of treatment.Forbid other drug during the treatment.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Preparation technology of the present invention is simple; Cost is low; With the Chinese herbal medicine is that raw material carries out the science compatibility; Bioavailability of medicament is high, and stability is high, has the usefulness of clearing away heat-damp and promoting diuresis detoxifcation; Can be used for diseases such as gonorrhea, condyloma acuminatum, nongonococcal urethritis (cervicitis), genital herpes, chronic prostatitis and belong to the noxious dampness person; Curative effect is obvious, and no obvious toxic-side effects provides the Chinese traditional treatment mode of more convenient and quicker for the dermatosis clinical treatment.
The specific embodiment
With indefiniteness embodiment the present invention is described further below; Should illustrate; Following examples only are used to illustrate the present invention, and it should not limit the scope of this invention, and any change that can be easy to make in this area can be deemed to be within the scope of the present invention.
Embodiment one
Raw material: Herba Artemisiae Scopariae 170g, Semen Plantaginis 185g, Herba Houttuyniae 190g, Rhizoma Smilacis Glabrae 170g, Rhizoma Atractylodis 115g, Cortex Phellodendri 110g.
Method for preparing is following:
1, the Rhizoma Smilacis Glabrae powder of getting Rhizoma Atractylodis and 1/3 amount is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use.
2, get Herba Artemisiae Scopariae, Semen Plantaginis, Herba Houttuyniae, Cortex Phellodendri and remaining Rhizoma Smilacis Glabrae, add 7 times of decoctings respectively and boil and carry out the first time and extract, add 7 times of decoctings again and boil and carry out extraction second time; Merge decoction liquor; Filter, filtrating and under room temperature, being concentrated into relative density is 1.10 thick paste, subsequent use;
3, thick paste is mixed with fine powder the back in 70 ℃ down dry, pulverize, be mixed, according to indicating weight 0.25g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes clearly 1000 of noxious dampness capsules.
Embodiment two
Raw material: Herba Artemisiae Scopariae 180g, Semen Plantaginis 180g, Herba Houttuyniae 180g, Rhizoma Smilacis Glabrae 180g, Rhizoma Atractylodis 120g, Cortex Phellodendri 120g.
Method for preparing is following:
1, the Rhizoma Smilacis Glabrae powder of getting Rhizoma Atractylodis and 1/3 amount is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use.
2, get Herba Artemisiae Scopariae, Semen Plantaginis, Herba Houttuyniae, Cortex Phellodendri and remaining Rhizoma Smilacis Glabrae, add 8 times of decoctings respectively and boil and carry out the first time and extract, add 6 times of decoctings again and boil and carry out extraction second time; Merge decoction liquor; Filter, filtrating and under room temperature, being concentrated into relative density is 1.10 thick paste, subsequent use;
3, thick paste is mixed with fine powder the back in 80 ℃ down dry, pulverize, be mixed, according to indicating weight 0.25g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes clearly 1000 of noxious dampness capsules.
Embodiment three
Raw material: Herba Artemisiae Scopariae 185g, Semen Plantaginis 175g, Herba Houttuyniae 170g, Rhizoma Smilacis Glabrae 185g, Rhizoma Atractylodis 125g, Cortex Phellodendri 125g.
Method for preparing is following:
1, the Rhizoma Smilacis Glabrae powder of getting Rhizoma Atractylodis and 1/3 amount is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use.
2, get Herba Artemisiae Scopariae, Semen Plantaginis, Herba Houttuyniae, Cortex Phellodendri and remaining Rhizoma Smilacis Glabrae, add 9 times of decoctings respectively and boil and carry out the first time and extract, add 5 times of decoctings again and boil and carry out extraction second time; Merge decoction liquor; Filter, filtrating and under room temperature, being concentrated into relative density is 1.20 thick paste, subsequent use;
3, thick paste is mixed with fine powder the back in 80 ℃ down dry, pulverize, be mixed, according to indicating weight 0.25g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes clearly 1000 of noxious dampness capsules.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from know-why of the present invention; Can also make some improvement and retouching, these improvement and retouching also should be considered as protection scope of the present invention.
Claims (2)
1. a clear noxious dampness capsule is characterized in that being processed by following materials of weight proportions: 170~190 parts of Herba Artemisiae Scopariaes, 170~190 parts of Semen Plantaginiss, 170~190 parts of Herba Houttuyniae, 170~190 parts of Rhizoma Smilacis Glabraes, 110~130 parts of Rhizoma Atractylodis, 110~130 parts of Cortex Phellodendris;
Method for preparing is following:
1), by prescription measure Rhizoma Atractylodis and 1/3 the amount Rhizoma Smilacis Glabrae powder be broken into fine powder, mixing, subsequent use.
2), measure Herba Artemisiae Scopariae, Semen Plantaginis, Herba Houttuyniae, Cortex Phellodendri and remaining Rhizoma Smilacis Glabrae by prescription; Adding 7~9 times of decoctings respectively boils and carries out the first time and extract; Adding 5~7 times of decoctings again boils and carries out the second time and extract; Merge decoction liquor; Filter; Filtrating and under room temperature, being concentrated into relative density is 1.10~1.20 thick paste, subsequent use;
3), with thick paste mix with fine powder the back in 70~80 ℃ down dry, pulverize, be mixed the fill capsule.
2. clear noxious dampness capsule according to claim 1 is characterized in that: the preferred following weight proportion of said raw material: 180 parts of Herba Artemisiae Scopariaes, 180 parts of Semen Plantaginiss, 180 parts of Herba Houttuyniae, 180 parts of Rhizoma Smilacis Glabraes, 120 parts of Rhizoma Atractylodis, 120 parts of Cortex Phellodendris.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103495087A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating erysipelas of lower limbs |
CN103735717A (en) * | 2014-01-02 | 2014-04-23 | 李梅香 | Freckle and acne removal medicine |
CN105194470A (en) * | 2015-11-16 | 2015-12-30 | 田虬 | Traditional Chinese medicine compositions for preventing and treating swine erysipelas disease |
-
2011
- 2011-08-31 CN CN 201110257640 patent/CN102302711B/en active Active
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103495087A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating erysipelas of lower limbs |
CN103735717A (en) * | 2014-01-02 | 2014-04-23 | 李梅香 | Freckle and acne removal medicine |
CN103735717B (en) * | 2014-01-02 | 2016-01-20 | 李梅香 | A kind of medicine of speckle removing, acne removing |
CN105194470A (en) * | 2015-11-16 | 2015-12-30 | 田虬 | Traditional Chinese medicine compositions for preventing and treating swine erysipelas disease |
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