CN102302655A - Loquat acne removing capsules - Google Patents
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- CN102302655A CN102302655A CN 201110257565 CN201110257565A CN102302655A CN 102302655 A CN102302655 A CN 102302655A CN 201110257565 CN201110257565 CN 201110257565 CN 201110257565 A CN201110257565 A CN 201110257565A CN 102302655 A CN102302655 A CN 102302655A
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Abstract
The invention relates to loquat acne removing capsules. The capsules are prepared from raw materials of: loquat leaf, baikal skullcap root, white mulberry root-bark, gypsum, common anemarrhena, rehmannia root, raw Japanese pogodatree flower, honeysuckle flower, and pulvis talci. The preparation method comprises steps that: raw Japanese pogodatree flower and 1/3 of the gypsum are crushed into fine powders, and the powders are mixed for later use; loquat leaf, baikal skullcap root, white mulberry root-bark, common anemarrhena, rehmannia root, honeysuckle flower and left gypsum are respectively decocted and extracted, the decoction liquids are combined and filtered, and the filtrate is condensed into a thick paste for later use; the thick paste and the fine powder are mixed, dried and crushed; pulvis talci is added to the mixture, the mixture is well mixed, and the mixture is filled into capsules. The preparation technology provided by the invention is simple, and the cost is low. According to the invention, Chinese herbal medicines are scientifically formulated. The bio-availability and the stability of the medicine are high. The medicine has functions of pathogen wind expelling, lung-heat clearing, stomach-fire removing, blood cooling, apthogenic heat removing, and acne removing. The medicine brings substantial curative effects and no obvious toxic or side-effect. Therefore, the invention provides a convenient and rapid treatment method for clinical treatments of dermatosis.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of clear Cuo capsule of Folium Eriobotryae that patient takes and carries of being convenient to of treating acne.
Background technology
Acne is the chronic inflammatory disease of a kind of hair follicle and sebaceous gland, good sending out in adolescence.Be commonly encountered diseases, the frequently-occurring disease of department of dermatologry outpatient service.The people of 80-90% suffered from acne among the adolescence crowd.Because acne often occurs in the face position, influences appearance, patient's study, work, human communication and social life etc. are brought certain influence, so the control of acne comes into one's own day by day.Acne is equivalent to Chinese medicine " rosacea caused by lung-wind ".Chinese medicine think skin of face be mainly lung meridian and stomach through take charge of, acne is because due to the lung stomach heat in blood.Ancient Chinese medicine doctor is discussed numerous: " Waike Zhengzong, Orthodox Manual of External Diseases ": " lung-wind syndrome belongs to lung-heat, and acne, rosacea, whelk belong to lung meridian, and four similar, is not all loose by heat in blood stasis.Good drink person is arranged again, the flavor of waste matter in the stomach, stifling lungs form." " surgery opens profound ": " acne belong to lung ... Always all heat in blood stasis is not loose." " surgery great achievement ": " lung-wind syndrome whelk ... Not all right and give birth to whelk also by lung meridian heat in blood stasis, suitable PIPA QINGFEI YIN, or uses Folium Nelumbinis to boil paste to be ball, white boiling water is obeyed; External Alumen end alcoholizing is coated with it." " Yizong Jinjian surgery heart method gist ": " and rosacea caused by lung-wind, this card is formed by the lung meridian heat in blood ..., should take PIPA QINGFEI YIN orally, the external application DIANDAO SAN is slowly from receiving merit also.”
Modern study finds the etiological cause of the disease a lot; It is too much to mainly contain androgen secretion; Propionibacterium acnes is bred in a large number, and dyshormonia, diet, psychological factor etc. also have much to the medicine of these causes of disease; Like oral retinoic acid, antibiotic, contraceptive, glucocorticoid etc., but the side effect of these medicines is very big: oral retinoic acid can cause fetal anomaly, infertile, blood fat and liver function rising, skin mucosa drying etc.; Oral more or take antibiotic for a long time, can cause drug resistance and dysbacteriosis; Oral contraceptive can cause metrorrhagia, distending pain of the breast etc.Cause treatment to have a big risk, spend higherly, patient physiological, psychological burden are heavy, once have report after taking certain medicine for a long time, to cause the overweight fact that causes suicide of patient's stress.Some are also arranged is the Chinese patent medicine of raw material with the Chinese herbal medicine, exists in various degree that types of medicines is various, mechanism is not clear, curative effect is not high, the course of treatment is very long, complicated process of preparation, cost are crossed high deficiency.
Summary of the invention
The objective of the invention is to be directed against the deficiency of prior art and to provide a kind of Folium Eriobotryae clear Cuo capsule, Chinese herbal medicine is carried out the science compatibility, the bioavailability of medicament height; Stability is high, has the dispelling wind heresy, clearing away lung-heat; Remove stomach-fire, the disappear effect of Cuo of removing pathogenic heat from blood and toxic substance from the body, curative effect is obvious; No obvious toxic-side effects provides the Chinese traditional treatment mode of more convenient and quicker for the dermatosis clinical treatment.
The technical scheme that the present invention adopted:
The clear Cuo capsule of a kind of Folium Eriobotryae is to be processed by following materials of weight proportions: 90～110 parts of Folium Eriobotryaes, 90～110 parts of Radix Scutellariaes, 90～110 parts of Cortex Mori, 140～160 parts of Gypsum Fibrosum, 80～100 parts of the Rhizoma Anemarrhenaes, 140～160 parts of Radix Rehmanniae, 90～110 parts of Flos Sophorae, 140～160 parts of Flos Loniceraes, 4～6 parts of Pulvis Talci;
Method for preparing is following:
1, by prescription measure Flos Sophorae and 1/3 the amount gypsum powder be broken into fine powder, mixing, subsequent use;
2, measure Folium Eriobotryae, Radix Scutellariae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Rehmanniae, Flos Lonicerae and remaining Gypsum Fibrosum by prescription; Adding 4～6 times of decoctings respectively boils and carries out the first time and extract; Add 1～3 times of decocting again and boil and carry out the second time and extract, merge decoction liquor, filter; Filtrating and under room temperature, being concentrated into relative density is 1.10～1.20 thick paste, subsequent use;
3, thick paste is mixed the back in 70～80 ℃ of dry down, pulverizing with fine powder, add Pulvis Talci, be mixed the fill capsule.
Among the present invention, the preferred following weight proportion of said raw material: 100 parts of Folium Eriobotryaes, 100 parts of Radix Scutellariaes, 100 parts of Cortex Mori, 150 parts of Gypsum Fibrosum, 100 parts of the Rhizoma Anemarrhenaes, 150 parts of Radix Rehmanniae, 100 parts of Flos Sophorae, 150 parts of Flos Loniceraes, 5 parts of Pulvis Talci.
The clear Cuo capsule of Folium Eriobotryae provided by the present invention is with Folium Eriobotryae, Radix Scutellariae, Cortex Mori removing summer-heat the lung being invaded by pathogenetic wind warm; Gypsum Fibrosum, the Rhizoma Anemarrhenae are removed excess-fire in the stomach; The Radix Rehmanniae, the detoxifcation of Flos Sophorae removing heat from blood and promoting blood circulation; Honeysuckle flower for reducing fever, detoxicating, the side of closing uses lung stomach-fire heat must be disappeared, and the skin acne must be removed, and simultaneously seborrheic dermatitis, rosacea etc. is also had better curative effect.
Folium Eriobotryae: attach to the lung and stomach meridians clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Modern pharmacological research, the effect of have antitussive, eliminate the phlegm, relievining asthma also has antibacterial action.
Radix Scutellariae: bitter in the mouth, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian, heat clearing and damp drying, eliminating fire and detoxication.Have antibiotic, antiviral, antifungal, analgesic, antiinflammatory, antianaphylactic effect.
Cortex Mori: sweet in the mouth is cold, goes into lung meridian, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Also have calmness, diuresis, stable, bacteriostatic effect in addition.
Gypsum Fibrosum: hot, sweet, be slightly cold.The clearing away heat-fire that attaches to the lung and stomach meridians, relieving restlessness is quenched the thirst.For oral administration through the gastric acid effect, a part becomes soluble calcium salt, the concentration to increasing calcium ion in the serum after blood is gone in intestinal absorption, can suppress thermotaxic centre, alleviate skeletal muscle irritability, reduce vascular permeability, so effects such as analgesic, spasmolytic, antiinflammatory are arranged.
The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel, clearing away heat-fire promotes the production of body fluid and moisturizes, and has antibacterium, antifungal, radiation-resistant effect.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel, clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.The effect that certain heart tonifying, diuresis are arranged, rises blood pressure, blood sugar lowering also has certain Antiradiation injury in addition, suppresses the effect of multiple conk.
Flos Sophorae: bitter in the mouth, cold nature.Return liver, large intestine channel.The function of tool cooling blood for hemostasis, purging liver-fire.Modern pharmacological research finds that Flos Sophorae also has the effect of antiinflammatory, resisting pathogenic microbes.
Flos Lonicerae: sweet in the mouth, cold, attach to the lung and stomach meridians, the effect of heat-clearing and toxic substances removing has resisting pathogenic microbes, antitoxin, antiinflammatory, effect such as analgesic in addition.
Clinical trial:
With the clear Cuo capsule of Folium Eriobotryae to acne, seborrheic dermatitis, rosacea detoxify, counteracting toxic substances treats, and obtains better curative effect.
One, the clear Cuo capsule for treating of Folium Eriobotryae acne vulgaris clinical observation on the therapeutic effect
240 routine patients are treated wherein male 132 examples, women 108 examples; The oldest is 40 years old, and minimum is 13 years old, year mean age (23.98 ± 7.53); Course of disease maximum duration 10 years, the shortest 2 months, average course of disease (4.21 ± 3.12) year; State of an illness classification: I level 128 examples, II level 46 examples, III level 41 examples, IV level 25 examples.
Clinical recovery standard: skin lesion extinction rate >=95%; Produce effects: 95%＞skin lesion extinction rate >=70%; Effectively: 70%＞skin lesion extinction rate >=50%; Invalid: skin lesion extinction rate＜50%, or counter see increase.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic scheme: 4 of the clear Cuo capsules of oral Folium Eriobotryae, 3 times/d, 1 month was 1 course of treatment.Points for attention: eat fat and sweet food less, avoid and use the oils cosmetics, the polyphagia vegetable and fruit is used the hot water wash affected part every day more, ban on opium-smoking and the opium trade wine and pungent stimulation food.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: 1 routine patient's had slight gastrointestinal upset, and through supporting anti symptom treatment, not influence treatment.
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Two, the clear Cuo capsule for treating of Folium Eriobotryae seborrheic dermatitis clinical observation on the therapeutic effect
180 routine patients are treated, and age 18-65 year, in year mean age (24.08 ± 5.83), the course of disease is the longest 3 years, and is the shortest 20 days, average course of disease (2.01 ± 0.82) year.
The clinical recovery standard: do not itch, skin lesion disappears fully or leaves pigmentation; Produce effects: gargalesthesia obviously alleviates, and skin lesion disappears >=and 60%; Effectively: gargalesthesia alleviates, and skin lesion disappears >=and 20%; Invalid: skin lesion disappears＜20%, and gargalesthesia does not have and changes or increase the weight of.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic scheme: 4 of the clear Cuo capsules of oral Folium Eriobotryae, 3 times/d, 1 month was 1 course of treatment.Points for attention: eat fat and sweet food less, avoid and use the oils cosmetics, the polyphagia vegetable and fruit is used the hot water wash affected part every day more, ban on opium-smoking and the opium trade wine and pungent stimulation food.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction.
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Three, the clear Cuo capsule for treating of Folium Eriobotryae rosacea clinical observation on the therapeutic effect
180 routine patients are treated wherein male 156 examples, women 24 examples, age 46-68 year; The course of disease is the shortest 3 months, and is the longest 8 years, erythema phases 152 example, pimple phases 26 example, pachydermatosis phases 2 example.
The clinical recovery standard: 1. recovery from illness: subjective symptoms disappears, the disappearance of going down of face erythra major part, and part patient only leaves over temporary pigmentation.2. produce effects: subjective symptoms obviously alleviates, the facial skin erythema phase, slightly feel pruritus, and maror or hot drink, the ambient temperature flush that raises, acts on a momentary impulse when stimulating is congested on the feed, but does not have recurrent pimple, pustule and telangiectasis.3. take a turn for the better: subjective symptoms alleviates, and nose, buccal, glabella, forehead and chin portion erythema alleviate, and pimple and pustule are dispersed in, and seborrhea alleviates before the treatment, and is facial fuel-displaced not obvious.4. invalid: subjective symptoms does not have improvement, and erythema, pimple, pustule do not have and alleviate, the nose connective tissue proliferation, and the surface is uneven, and telangiectasis is more remarkable, even it is loose nose portion to occur.Total effective rate adds the produce effects statistics with recovery from illness.
Therapeutic scheme: 4 of the clear Cuo capsules of oral Folium Eriobotryae, 3 times/d, 1 month was 1 course of treatment.
Points for attention: eat fat and sweet food less, avoid and use the oils cosmetics, the polyphagia vegetable and fruit is used the hot water wash affected part every day more, ban on opium-smoking and the opium trade wine and pungent stimulation food.All patients carry out blood, routine urinalysis, hepatic and renal function detection before and after treatment.
The result:
Untoward reaction is observed: do not see obvious adverse reaction.
All patients blood, routine urinalysis, hepatic and renal function before and after treatment detect does not see obvious abnormal change.
Preparation technology of the present invention is simple, and cost is low, is that raw material carries out the science compatibility with the Chinese herbal medicine; Bioavailability of medicament is high, and stability is high, has the dispelling wind heresy; Clearing away lung-heat removes stomach-fire, the disappear effect of Cuo of removing pathogenic heat from blood and toxic substance from the body; Curative effect is obvious, and no obvious toxic-side effects provides the Chinese traditional treatment mode of more convenient and quicker for the dermatosis clinical treatment.
The specific embodiment
With indefiniteness embodiment the present invention is described further below; Should explain; Following examples only are used to explain the present invention, and it should not limit the scope of this invention, and any change that can be easy to make in this area can be deemed to be within the scope of the present invention.
Embodiment one
Raw material: Folium Eriobotryae 90g, Radix Scutellariae 95g, Cortex Mori 100g, Gypsum Fibrosum 140g, Rhizoma Anemarrhenae 85g, Radix Rehmanniae 150g, Flos Sophorae 100g, Flos Lonicerae 160g, Pulvis Talci 6g.
Method for preparing is following:
1, the gypsum powder of getting Flos Sophorae and 1/3 is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use;
2, get Folium Eriobotryae, Radix Scutellariae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Rehmanniae, Flos Lonicerae and remaining Gypsum Fibrosum; Adding 4 times of decoctings respectively boils and carries out the first time and extract; Add 3 times of decoctings again and boil and carry out the second time and extract, merge decoction liquor, filter; Filtrating is concentrated into thick paste (relative density is 1.10,25 ℃), and is subsequent use;
3, with thick paste mix with fine powder the back in 80 ℃ down dry, pulverize, add Pulvis Talci, be mixed, according to indicating weight 0.30g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes 1000 of the clear Cuo capsules of Folium Eriobotryae.
Embodiment two
Raw material: Folium Eriobotryae 100g, Radix Scutellariae 100g, Cortex Mori 100g, Gypsum Fibrosum 150g, Rhizoma Anemarrhenae 100g, Radix Rehmanniae 150g, Flos Sophorae 100g, Flos Lonicerae 150g, Pulvis Talci 5g.
Method for preparing is following:
1, the gypsum powder of getting Flos Sophorae and 1/3 is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use;
2, get Folium Eriobotryae, Radix Scutellariae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Rehmanniae, Flos Lonicerae and remaining Gypsum Fibrosum; Adding 5 times of decoctings respectively boils and carries out the first time and extract; Add 2 times of decoctings again and boil and carry out the second time and extract, merge decoction liquor, filter; Filtrating is concentrated into thick paste (relative density is 1.10,25 ℃), and is subsequent use;
3, with thick paste mix with fine powder the back in 80 ℃ down dry, pulverize, add Pulvis Talci, be mixed, according to indicating weight 0.30g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes 1000 of the clear Cuo capsules of Folium Eriobotryae.
Embodiment three
Raw material: Folium Eriobotryae 110g, Radix Scutellariae 90g, Cortex Mori 110g, Gypsum Fibrosum 160g, Rhizoma Anemarrhenae 95g, Radix Rehmanniae 140g, Flos Sophorae 95g, Flos Lonicerae 145g, Pulvis Talci 4g.
Method for preparing is following:
1, the gypsum powder of getting Flos Sophorae and 1/3 is broken into fine powder, and mixing is crossed 80 mesh sieves, and is subsequent use;
2, get Folium Eriobotryae, Radix Scutellariae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Rehmanniae, Flos Lonicerae and remaining Gypsum Fibrosum; Adding 6 times of decoctings respectively boils and carries out the first time and extract; Add 1 times of decocting again and boil and carry out the second time and extract, merge decoction liquor, filter; Filtrating is concentrated into thick paste (relative density is 1.20,25 ℃), and is subsequent use;
3, with thick paste mix with fine powder the back in 80 ℃ down dry, pulverize, add Pulvis Talci, be mixed, according to indicating weight 0.30g/ grain, carry out the capsule fill with Autocapsulefillingmachine, content uniformity is controlled at ± 10%, processes 1000 of the clear Cuo capsules of Folium Eriobotryae.
The above only is a preferred implementation of the present invention; Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from know-why of the present invention; Can also make some improvement and retouching, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (2)
1. the clear Cuo capsule of Folium Eriobotryae is characterized in that being processed by following materials of weight proportions: 90～110 parts of Folium Eriobotryaes, 90～110 parts of Radix Scutellariaes, 90～110 parts of Cortex Mori, 140～160 parts of Gypsum Fibrosum, 80～100 parts of the Rhizoma Anemarrhenaes, 140～160 parts of Radix Rehmanniae, 90～110 parts of Flos Sophorae, 140～160 parts of Flos Loniceraes, 4～6 parts of Pulvis Talci;
Method for preparing is following:
1), the gypsum powder of measuring Flos Sophorae and 1/3 by prescription is broken into fine powder, mixing, subsequent use;
2), measure Folium Eriobotryae, Radix Scutellariae, Cortex Mori, the Rhizoma Anemarrhenae, Radix Rehmanniae, Flos Lonicerae and remaining Gypsum Fibrosum by prescription; Adding 4～6 times of decoctings respectively boils and carries out the first time and extract; Add 1～3 times of decocting again and boil and carry out the second time and extract, merge decoction liquor, filter; Filtrating and under room temperature, being concentrated into relative density is 1.10～1.20 thick paste, subsequent use;
3), with thick paste mix with fine powder the back in 70～80 ℃ down dry, pulverize, add Pulvis Talci, be mixed the fill capsule.
2. the clear Cuo capsule of Folium Eriobotryae according to claim 1 is characterized in that: the preferred following weight proportion of said raw material: 100 parts of Folium Eriobotryaes, 100 parts of Radix Scutellariaes, 100 parts of Cortex Mori, 150 parts of Gypsum Fibrosum, 100 parts of the Rhizoma Anemarrhenaes, 150 parts of Radix Rehmanniae, 100 parts of Flos Sophorae, 150 parts of Flos Loniceraes, 5 parts of Pulvis Talci.
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| CN 201110257565 CN102302655B (en) | 2011-08-31 | 2011-08-31 | Loquat acne removing capsules |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491522A (en) * | 2014-12-06 | 2015-04-08 | 周连才 | Pharmaceutical composition for treating seborrheic dermatitis |
| CN105343472A (en) * | 2015-11-30 | 2016-02-24 | 陈本钦 | Traditional Chinese medicine composition for treating lung channel intrinsic heat acnes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454616A (en) * | 2002-04-29 | 2003-11-12 | 缪昌秀 | Medicine for curing haemorrhoids |
| CN101152421A (en) * | 2007-09-24 | 2008-04-02 | 肖金华 | Traditional Chinese medicine for treating lung channel intrinsic heat type acne |
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2011
- 2011-08-31 CN CN 201110257565 patent/CN102302655B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454616A (en) * | 2002-04-29 | 2003-11-12 | 缪昌秀 | Medicine for curing haemorrhoids |
| CN101152421A (en) * | 2007-09-24 | 2008-04-02 | 肖金华 | Traditional Chinese medicine for treating lung channel intrinsic heat type acne |
Non-Patent Citations (1)
| Title |
|---|
| 《中医药信息》 20010331 鲁美君, 张友堂 中医药治疗痤疮的研究进展 10－12 1－2 第18卷, 第3期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491522A (en) * | 2014-12-06 | 2015-04-08 | 周连才 | Pharmaceutical composition for treating seborrheic dermatitis |
| CN105343472A (en) * | 2015-11-30 | 2016-02-24 | 陈本钦 | Traditional Chinese medicine composition for treating lung channel intrinsic heat acnes |
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| CN102302655B (en) | 2013-01-02 |
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