CN102302621A - 一种治疗肝癌的中草药药物 - Google Patents
一种治疗肝癌的中草药药物 Download PDFInfo
- Publication number
- CN102302621A CN102302621A CN201110238237A CN201110238237A CN102302621A CN 102302621 A CN102302621 A CN 102302621A CN 201110238237 A CN201110238237 A CN 201110238237A CN 201110238237 A CN201110238237 A CN 201110238237A CN 102302621 A CN102302621 A CN 102302621A
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- Prior art keywords
- herbal medicine
- chinese herbal
- herba
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- liver cancers
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- 241000411851 herbal medicine Species 0.000 title claims abstract description 12
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- 238000000034 methods Methods 0.000 claims description 6
- 241000688197 Pilosa Species 0.000 claims description 2
- 241000219295 Portulaca Species 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 11
- 208000001848 Dysentery Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 210000001015 Abdomen Anatomy 0.000 abstract description 2
- 229930003451 Vitamin B1 Natural products 0.000 abstract description 2
- 201000009910 diseases by infectious agent Diseases 0.000 abstract description 2
- 230000002401 inhibitory effects Effects 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 239000000126 substances Substances 0.000 abstract description 2
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Abstract
本发明公开了一种治疗肝癌的中草药药物，其特征在于按下列组份制成，慈姑50-100、铁马鞭30-50、马蹄草20-40、马齿苋20-40，本发明的药物配方根据祖国传统医学和现代药理研究成果，选取含维生素B1、胰蛋白酶抑制物，能医治癫犬咬伤的慈姑，配合有泻火解毒。治水泻，痢疾，胸腹饱胀，痛疮肿毒的马蹄草；清热解毒。治痢疾，疮疡的马齿苋迅速抑制肝癌扩散和达到迅速治疗肝癌的发明目的。
Description
一种治疗肝癌的中草药药物
技术领域
[0001] 本发明涉及一种治疗肝癌的药物，尤其涉及一种治疗肝癌的中草药物。 背景技术
[0002] 众所周知当前还没有一种药物能单独治疗癌症，主要治疗手段是进行手术，放疗。 化疗。不仅患者要经历九死一生之痛，患者家庭还要承担高额的医疗费负担，人们最不能接受的是患病的亲人承受过巨大的痛苦，家庭负债累累，到头来还是要经历生死离别。
[0003] 据报道全世界每年新增癌症病人壹千万左右，现代医学研究表明，各种内膜癌的形成与Pinl (多肽脯氨酰基顺反异构酶）有着直接的关系。Pinl作用于细胞周期中多种调节细胞分裂的蛋白，是一种高度保守的、特异的。磷酸化的异构酶，它允许细胞以一种高效而精确的方式打开或关闭某些磷蛋白的功能[1]。这种复杂信号机制的失调可导致细胞转化和肿瘤的发生。利用蛋白质组学技术在胃癌的差异蛋白质研究发现了 Pinl的高表达。 Pinl的表达促进了肝癌的发生，PangR等研究发现，Pinl在肝细胞癌中过表达[2]。Bao等
[3]研究了人类60种肿瘤组织中Pinl的表达情况，结果显示在最常见的肿瘤，如前列腺癌、 乳腺癌、宫颈癌、脑瘤、肺癌、结肠癌中，均检测到Pinl过表达。其中SW620结肠癌细胞系和 PC-3 (前列腺癌细胞系）中Pinl的表达最高。在乳腺癌组织及乳腺癌细胞的研究中显示， Pinl不但在胞核中浓集，而且在胞浆中也高度表达，与正常乳腺组织相比，乳腺癌中Pinl 可高达10倍，Pinl高表达者较低表达者术后更易早期复发。Nakashima和Hangen等m的研究相继发现，Pinl在甲状腺肿瘤和白血病母细胞中过表达。Pinl可通过多种机制诱导细胞增殖和抑制细胞凋亡，导致肿瘤的发生。
[0004] 通过Cyclin Dl途径，细胞周期素DKCyclin Dl)是Pinl重要的靶蛋白。Cyclin Dl为Gl周期素家族中重要成员，作用于细胞周期中的Gl期，可与多种蛋白相互作用促进细胞由Gl期进入S期，加快细胞周期转换速度，导致细胞增殖失控，从而形成癌变，P突变是导致肿瘤发生的重要机制，Pinl可通过其ww区与磷酸化的突变P53结合，使其发生顺/反异构，增强突变型P53的稳定性，从而促进肿瘤的发生。
[0005] 总之：Pinl通过多部位，多环节控制许多细胞过程其总体是效应是导致癌信号无限扩大，促进细胞转化和增殖失控，导致肿瘤的发生。
[0006] 肝癌患者一般都是肝区疼痛才到院检查而此时也病情已到中期左右，能手术治疗的可能性极小，医院一般都采用保守治疗，如疼痛就施予镇痛，有腹水就手术抽吸腹水或用中药辅助治疗腹水。而肝癌发生在18岁一 50岁的人群之间时患者存活期一般都很短。大约2-6个月，而发生在50岁以上人群患者存活期稍长。肝癌患者最难忍受的是肝区疼痛， 而肝区疼痛是病灶在癌变过程中生成多肽类物质和有毒蛋白引起，故现有镇痛药对此镇痛效果不大。
发明内容
[0007] 本发明目的在于为克服现有技术的不足而提供一种能够有效治疗肝癌和预防肝癌发生的中草药药物。其具体重量组份为
慈姑50-100 马蹄草20-40
铁马鞭30-50 马齿苋20-40
制备本发明中草药药物的配方选的重量份配比范围是
慈姑50-80 马蹄草20-30
铁马鞭30-40 马齿苋20-30
本发明中草药药物最佳重量份配比是
慈姑75 马蹄草25
铁马鞭35 马齿苋25
本发明中草药组合物制备方法：先将慈姑洗净、晾干，用粉碎机粉碎过80目的筛网，铁马鞭、马蹄草、马齿苋粉碎后按上述组份比例混合分袋包装即可。服药方法和服药量
本发明药物的服用方法：打开包装用冷开水或纯净水兑服，用量为每次柒克，一日两次。
[0008] 采用本发明中草药组合物先后治疗过近百例肝癌患者，患者服药后十分钟左右肝区疼痛消失，服药一个月后病灶缩小边界清析，两个月后痛灶近一步缩小并形成钙化点，三个月后一切肝癌应有的症状消失，患者如常人。为巩固疗效一般要求患者连续服药六个月。
[0009] 赵X X，女，40岁，四川省南充市顺庆区张观桠村人，2010年12月因肝压经常疼痛，到医院就诊，B超检查右叶可见一大小为3.5X2. 5cm低回声团块，边界欠清晰，形态不规则，医生判断可能是肝癌，经活检确诊，服用本发明药物后，自我感觉肝压疼痛消失，连续服用四个多月后，经同一医院B超检查，回声影响无充盈感，病变组织紧贴肝膜显钙化像， 病变组织面积变小，边界清晰。医生诊断判断已痊愈。
[0010] 李XX，男，51岁，四川省西充县晋城镇人，因经常肝压疼痛到医院诊治，经医院检测确诊是中晚期肝癌，住院进行化疗，后经人介绍开始服用本发明药物，服药一个月后病灶缩小，边界清晰，两个月后病灶近一步缩小并形成钙化点，三个月后病症消失。
[0011] 王XX，女，40岁，四川南充高坪区龙门镇人，多年前患肝硬化，后经医院确诊为肝癌，经人介绍开始服用本发明药物，服药后一个月病灶缩小，边界清晰，两个月后病灶近一步缩小并形成钙化点，三个月后已如常人。
[0012] 从本发明的技术方案可以看出，本发明的中草药药物配方根据祖国传统医学和现代药理研究成果，选取含维生素Bl胰蛋白酶抑制物，能医治癫犬咳伤的慈姑，配合有泻火解毒，治湿热痢疾、马痛的铁马鞭，清热解毒、消食和胃，治水泻、痢疾、胸腹饱胀，痛疮肿毒的马蹄草；清热解毒。治痢疾，疮痛的马蹄苋迅速抑制和中和了肝癌病灶内的多肽类物质和有毒蛋白，达到了迅速止痛的目的。并能迅速抑制Pinl〈多肽脯氨酰基顺反异构酶〉，从而达到迅速抑制和治疗肝癌的发明目的。
[0013] 实施例1 ：按下述配比称取原料： 慈姑50、铁马鞭30、马蹄草20、马齿苋30。
[0014] 本发明中草药组合物制备方法为：先将慈姑洗净，晾干，用粉碎机粉碎过80目筛网，将铁马鞭，马蹄草，马齿苋粉碎后按上述组份比例混合后分袋包装即可。
[0015] 实施例2 ：按下述配比称取原料： 慈姑80、铁马鞭40、马蹄草25、马齿苋25。[0016] 本实施例的制备方法同实施例1。
[0017] 实施例3 ：按下述配比称取原料： 慈姑70、铁马鞭40、马蹄草25、马齿苋25。
[0018] 本实施例的制备方法同实施例1。
Claims (3)
1. 一种治疗肝癌的中草药药物，其特征在于：按下列组份制成慈姑50-100 铁马鞭30-50马蹄草20-40 马齿苋20-40。
2.根据权利要求1所述的一种治疗肝癌的中草药药物，其特征在于：按下列组份制成慈姑50-80 铁马鞭30-40马蹄草20-40 马齿苋20-30。
3.根据权利要求1所述的一种治疗肝癌的中草药药物，其特征在于：按下列组份制成慈姑75 铁马鞭35 马蹄草25 马齿苋25。
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