CN102302543A - Traditional Chinese medicine composition used for treating cow mastitis, and purpose thereof - Google Patents
Traditional Chinese medicine composition used for treating cow mastitis, and purpose thereof Download PDFInfo
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- CN102302543A CN102302543A CN201110255923A CN201110255923A CN102302543A CN 102302543 A CN102302543 A CN 102302543A CN 201110255923 A CN201110255923 A CN 201110255923A CN 201110255923 A CN201110255923 A CN 201110255923A CN 102302543 A CN102302543 A CN 102302543A
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Abstract
The invention discloses a traditional Chinese medicine composition used for treating cow mastitis, and a purpose thereof. The composition is prepared form raw materials of, by weight: 4 to 6 parts of dandelion, 4 to 6 parts of licorice, 4 to 8 parts of lightyellow sophora root, and 3 to 6 parts of mongolian snakegourd fruit. As a result of tests, preparations prepared from the traditional Chinese medicine composition provided by the invention provide substantial effects in treating recessive mastitis. The traditional Chinese medicine composition provided by the invention provides good curative effects on cow clinic recessive mastitis, and a recovery rate is higher than 80%.
Description
Technical field
The present invention relates to a kind of Chinese medicine for animals, particularly relate to a kind of Chinese medicine composition and purposes of treating mammitis of cow.
Background technology
Mammitis of cow (bovine mastitis) is that mammary gland receives physics, chemistry, microorganism and stimulates a kind of inflammatory that is caused to change.Mammitis of cow is milch cow commonly encountered diseases, frequently-occurring disease.Its pathological manifestations is that somatic cell content increases in the milk, mammary gland tissue generation physical change.This disease directly causes milk production of cow to descend, and the quality reduction, shortens the service life of milch cow, prolongs post-partum estrus and pregnant time, brings enormous economic loss for the milch cow industry.According to statistics, clinic mastitis accounts for the 21-23% of the total morbidity of milch cow, and the milch cow of eliminating that causes thus accounts for total 40-60% that eliminates.The sickness rate of foreign study report mammitis of cow is at 20-70%, and the sickness rate of China's report is at 40-80%.
The pathogenic factor of mammitis of cow: it is the main path that people generally acknowledge that pathogenic microorganism is invaded papillary duct initiation mastitis; Environmental factors then is the main route of transmission of mammitis of cow, mainly through contact infection, like cowshed dust, unclean, unhygienic etc.; The person of milking technology is improper in addition, can cause the damage of nipple mucous epithelium, and perhaps self both hands health of the person of milking is defective, all can create conditions to the intrusion of pathogenic microorganism.
Antibiotic is the choice drug of treatment mammitis of cow always for many years.But prolonged and repeated use antibiotic causes pathogenic microorganism that antibiotic has been produced drug resistance, and the antibiotic remains increase directly has influence on the quality of milk in the milk products, and indirectly human beings'health is exerted an influence.
Chinese medicine has long use history in China.In recent years along with the fast development of the modernization of Chinese medicine, Chinese medicine on the veterinary application also obtained considerable progress, it also highlights more and more important effect in the treatment of mammitis of cow.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, a kind of Chinese medicine composition of treating mammitis of cow is provided.
Second purpose of the present invention provides a kind of purposes of treating the Chinese medicine composition of mammitis of cow.
Technical scheme of the present invention is summarized as follows:
A kind of Chinese medicine composition of treating mammitis of cow is characterized in that being processed by following raw material by weight: Herba Taraxaci 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Sophorae Flavescentis 4-8 part, Fructus Trichosanthis 3-6 part.
Preferably: said Herba Taraxaci is 5 parts, and Radix Glycyrrhizae is 5 parts, and Radix Sophorae Flavescentis is 6 parts, and Fructus Trichosanthis is 4 parts.
The method for preparing of the Chinese medicine composition of treatment mammitis of cow, it comprises the steps:
1) takes by weighing raw material by weight: Herba Taraxaci 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Sophorae Flavescentis 4-8 part, Fructus Trichosanthis 3-6 part;
2) with said raw material process water or ethanol extraction; Extracting solution is concentrated, add the pharmacy acceptable auxiliary and process Chinese medicine composition.
Preferably the dosage form of Chinese medicine composition is ointment, cream, tincture, injection, powder, decoct or membrane.
Best is that said Herba Taraxaci is 5 parts, and Radix Glycyrrhizae is 5 parts, and Radix Sophorae Flavescentis is 6 parts, and Fructus Trichosanthis is 4 parts.
The application of the Chinese medicine composition of treatment mammitis of cow in preparation treatment mammitis of cow medicine.
The preparation for treating latent mammitis effect that the result of the test proof is processed with Chinese medicine composition of the present invention is obvious.The milch cow clinic mastitis is had good therapeutic effect, and cure rate reaches more than 80%.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1
A kind of ointment of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 500g, Radix Glycyrrhizae 500g, Radix Sophorae Flavescentis 600g, Fructus Trichosanthis 400g;
(2) raw material adopt raw material weight 6 times of water as solvent, 100 ℃ of reflux, extract,, behind the extracting liquid filtering, it is 2 extract that 50 ℃ of concentrating under reduced pressure obtain pol;
(3) glyceryl monostearate 60g, vaseline 40g, hexadecanol 30g, liquid wax 4g, Arlacel-60 5g are put into beaker together and mix, heating in water bath to 80-90 ℃ of fusion gets oil phase; The extract that glycerol 70g, tween 80 5g, step (2) are obtained adds among the Purified Water 500mL, is heated to 70-80 ℃ and obtains water; Under continuous stirring condition, slowly be added to water in the oil phase, stop heating; When being cooled to 60 ℃ of left and right sides; Adding azone 2g, propyl hydroxybenzoate 2g continue to stir under constantly stirring, and adding menthol 2g and essence 0.5g stirred when temperature was reduced to 40-50 ℃, processed ointment.
(antiseptic can also be selected other kind or the quaternary ammonium salt or the benzoic acids of oxybenzene esters for use except that propyl hydroxybenzoate.)
Embodiment 2
A kind of ointment of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 400g, Radix Glycyrrhizae 600g, Radix Sophorae Flavescentis 800g, Fructus Trichosanthis 300g;
(2)-(3) with a kind of ointment of treating mammitis of cow of embodiment 1 preparation.
Embodiment 3
A kind of ointment of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 600g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 500g, Fructus Trichosanthis 600g;
(2)-(3) with a kind of ointment of treating mammitis of cow of embodiment 1 preparation.
Embodiment 4
A kind of ointment of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 400g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 400g, Fructus Trichosanthis 400g;
(2)-(3) with a kind of ointment of treating mammitis of cow of embodiment 1 preparation.
Embodiment 5
A kind of ointment of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 600g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 700g, Fructus Trichosanthis 600g;
(2)-(3) with a kind of ointment of treating mammitis of cow of embodiment 1 preparation.
Embodiment 6
A kind of membrane of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 500g, Radix Glycyrrhizae 500g, Radix Sophorae Flavescentis 600g, Fructus Trichosanthis 500g;
(2) raw material adopt raw material weight 6 times of water as solvent, 100 ℃ of reflux, extract,, behind the extracting liquid filtering, it is 2 extract that 50 ℃ of concentrating under reduced pressure obtain pol;
(3) according to formula proportion, extract is as 1 mass parts, and the glycerol that adds the 0.5wt% ratio is mixed and made into extract solution;
(4) an amount of polyvinyl alcohol is added in the pure water of 9 mass parts, after the stirring and dissolving aqueous solution, according to the ratio of 5wt% polyvinylpyrrolidone is added in the aqueous solution, stirring and dissolving obtains macromolecular solution;
(5) extract solution is added in the macromolecular solution of step (4) acquisition, mix homogeneously, fill promptly gets spray film forming agent in aerosol apparatus.
Embodiment 7
A kind of membrane of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 400g, Radix Glycyrrhizae 600g, Radix Sophorae Flavescentis 800g, Fructus Trichosanthis 300g;
(2)-(3) with a kind of membrane of treating mammitis of cow of embodiment 1 preparation.
Embodiment 8
A kind of membrane of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 600g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 500g, Fructus Trichosanthis 600g;
(2)-(3) with a kind of membrane of treating mammitis of cow of embodiment 1 preparation.
Embodiment 9
A kind of membrane of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 400g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 400g, Fructus Trichosanthis 400g;
(2)-(3) with a kind of membrane of treating mammitis of cow of embodiment 1 preparation.
Embodiment 10
A kind of membrane of treating mammitis of cow, process with following method:
(1) takes by weighing raw material: Herba Taraxaci 600g, Radix Glycyrrhizae 400g, Radix Sophorae Flavescentis 700g, Fructus Trichosanthis 600g;
(2)-(3) with a kind of membrane of treating mammitis of cow of embodiment 1 preparation.
Pharmacodynamic experiment is estimated
1. be used to treat the bovine subclinical mastitis experiment
Test method: adopt international latent mammitis diagnostic method " California, USA mastitis experiment (CMT) " to make an experiment.Testing result is " ++ " or the trouble Niu Zuowei subjects on it.Choose 15 sick cattle and make an experiment, two experimental grouies, 5 every group; Before treatment, clean the breast district of suffering from mastitis with warm water, after drying with dry towel, the ill breast area of each of one of them experimental group is smeared the ointment 5-6g of the embodiment of the invention 1 preparation; Each ill breast area of another experimental group gives the membrane 10-12g of the embodiment of the invention 6 preparations; 1 time/day, continuous use 7 days was a course of treatment, then with blank control group contrast (blank control group is not used any medicine)
Criterion:
Cure: strong positive (+++) or positive (++) transfer feminine gender (-) or suspicious (±) to.
Effectively: strong positive (+++) or positive (++) transfer the weak positive (+) to.
Invalid: no change after the medication.
Experimental result: result of the test demonstration administration group has only lesion, a place to present weak positive findings, and all the other are suffered from the district and all cure.Prove that the preparation for treating latent mammitis effect that Chinese medicine composition of the present invention processes is obvious.See table 1.
Table 1:
2. be used to treat the test of milch cow clinic mastitis
Test method: by the diagnostic criteria of milch cow clinic mastitis, choose breast district's swelling, skin rubefaction, the heating of palpation breast; Lump, responsive, the milk yield minimizing of pain are arranged, and milk is unusual, flavescence white or serum appearance; In ziega is arranged, comprehensive diagnos is that the milch cow of clinical mastitis is listed test in.Choosing 15 sick cattle makes an experiment; Two experimental grouies; Every group 5, before treatment, clean the breast district of suffering from mastitis, after drying with dry towel with warm water; One of them experimental group is smeared the ointment 5-6g of the embodiment of the invention 1 preparation in ill breast district, and another experimental group is smeared the membrane 10-11g of the embodiment of the invention 6 preparations in ill breast district.Other 5 blank control group contrasts (blank control group is not used any medicine).
Criterion:
Cure:, pain transference cure red, swollen, hot for breast, the milk perusal is normal, and the milk yield recovery is spiritual, appetite is normal, and somatic number is reduced to normal range in the milk.
Effectively:, pain sx red, swollen, hot for breast, the milk floccule disappears basically or obviously reduces, and milk yield is gone up;
Invalid: breast is red, swollen, hot, the pain symptom does not have obviously and alleviates, the clear rare or jaundice of milk, and flocculus is more obvious, and milk yield is not gone up, and general body state is not seen improvement.
Experimental result: result of the test sees following table 2 for details, and the result shows that preparation of the present invention has good therapeutic effect to the milch cow clinic mastitis, and cure rate reaches 80%.
Table 2:
Experiment proof: the various embodiments of the present invention preparation be that the preparation for treating latent mammitis effect of raw material is all obvious by compositions of the present invention.The milch cow clinic mastitis is all had good therapeutic effect, and cure rate reaches more than 80%.
Claims (6)
1. a Chinese medicine composition of treating mammitis of cow is characterized in that being processed by following raw material by weight: Herba Taraxaci 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Sophorae Flavescentis 4-8 part, Fructus Trichosanthis 3-6 part.
2. according to the said compositions of claim 1, it is characterized in that said Herba Taraxaci is 5 parts, Radix Glycyrrhizae is 5 parts, and Radix Sophorae Flavescentis is 6 parts, and Fructus Trichosanthis is 4 parts.
3. treat the method for preparing of the Chinese medicine composition of mammitis of cow, it comprises the steps:
1) takes by weighing raw material by weight: Herba Taraxaci 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Sophorae Flavescentis 4-8 part, Fructus Trichosanthis 3-6 part;
2) with said raw material process water or ethanol extraction; Extracting solution is concentrated, add the pharmacy acceptable auxiliary and process Chinese medicine composition.
4. method according to claim 3, the dosage form that it is characterized in that Chinese medicine composition is ointment, cream, tincture, injection, powder, decoct or membrane.
5. according to the said preparation of compositions method of claim 3, it is characterized in that said Herba Taraxaci is 5 parts, Radix Glycyrrhizae is 5 parts, and Radix Sophorae Flavescentis is 6 parts, and Fructus Trichosanthis is 4 parts.
6. the application of the Chinese medicine composition of claim 1 or 2 treatment mammitis of cow in preparation treatment mammitis of cow medicine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110255923A CN102302543A (en) | 2011-09-01 | 2011-09-01 | Traditional Chinese medicine composition used for treating cow mastitis, and purpose thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110255923A CN102302543A (en) | 2011-09-01 | 2011-09-01 | Traditional Chinese medicine composition used for treating cow mastitis, and purpose thereof |
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| CN102302543A true CN102302543A (en) | 2012-01-04 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860633A (en) * | 2014-03-13 | 2014-06-18 | 北京康华远景科技有限公司 | Plant composition for preventing bovine mastitis |
| CN105918631A (en) * | 2016-04-28 | 2016-09-07 | 青岛海之星生物科技有限公司 | Feed additive for preventing cow subclinical mastitis and preparation method thereof |
| CN110038045A (en) * | 2019-05-21 | 2019-07-23 | 郑州百瑞动物药业有限公司 | A kind of mammilla of milk cattle disinfectant preparation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014940A (en) * | 2008-05-02 | 2011-04-13 | 株式会社太平洋 | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
-
2011
- 2011-09-01 CN CN201110255923A patent/CN102302543A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014940A (en) * | 2008-05-02 | 2011-04-13 | 株式会社太平洋 | Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860633A (en) * | 2014-03-13 | 2014-06-18 | 北京康华远景科技有限公司 | Plant composition for preventing bovine mastitis |
| CN103860633B (en) * | 2014-03-13 | 2021-04-13 | 北京康华远景科技股份有限公司 | Plant composition for preventing cow mastitis |
| CN105918631A (en) * | 2016-04-28 | 2016-09-07 | 青岛海之星生物科技有限公司 | Feed additive for preventing cow subclinical mastitis and preparation method thereof |
| CN110038045A (en) * | 2019-05-21 | 2019-07-23 | 郑州百瑞动物药业有限公司 | A kind of mammilla of milk cattle disinfectant preparation and preparation method thereof |
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Application publication date: 20120104 |