CN102335323B - Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition, which achieves the purpose of treating senile colpitis by sterilizing and relieving itching. In order to achieve the purpose, the invention provides the following technical scheme: the active ingredients in the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 30-50 parts of aloe juice, 20-40 parts of cortex meliae and 10-30 parts of mulberry leaf, and a corresponding preparation method is applied. The traditional Chinese medicine composition has the actions of sterilizing, relieving itching, and treating senile colpitis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used for the treatment of senile vaginitis and its preparation method and application.
Background technology
Senile vaginitis is common in postclimacteric elderly woman, and because of the ovarian function decline, a lot of levels of estrogen reduce, the vaginal wall atrophy, the mucosa attenuation, glycogen content reduces in the epithelial cell, intravaginal Ph value rises, and local resistance reduces, and the pathogenic bacterium father and mother easily invade breeding and cause and inflammation.Cardinal symptom is that vaginal secretions increases and pruritus vulvae, burning sensation.Inspection sees that vagina is senile change, upper atrophoderma, and pleat disappears, and it is sliding, poor that epithelium flattens.Vaginal mucosa is congested, and little petechia is arranged, and sometimes sees shallow table ulcer.
At present without special therapeutic method, the general antibiotic bacteria growing inhibiting that adopts, or use disinfectant and estrogen preparation, but the antibiotic life-time service can produce drug resistance, estrogen preparation might produce carcinogenesis, market in urgent need a kind of effective, oneself is confirmed to treat senile vaginitis Chinese medicine by most people.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of senile vaginitis and its preparation method and application.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition that is used for the treatment of senile vaginitis, its contained active component is prepared from by the following raw materials in part by weight proportioning: Aloe juice 30-50 part, Cortex Meliae 20-40 part, Folium Mori 10-30 part.
A kind of Chinese medicine composition that is used for the treatment of senile vaginitis, its contained active component is prepared from by the following raw materials in part by weight proportioning: 40 parts of Aloe juices, 30 parts of Cortex Meliaees, 20 parts on Folium Mori.
The above-mentioned Chinese medicine composition that is used for the treatment of senile vaginitis, described raw material of Chinese medicine add adjuvant and make ointment after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of senile vaginitis, described adjuvant are selected from following one or more: stearic acid, glyceryl monostearate, white vaseline, liquid paraffin, glycerol, triethanolamine, sodium lauryl sulphate and distilled water.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of senile vaginitis is characterized in that preparation process is: take by weighing in proportion Cortex Meliae and Folium Mori two flavor Chinese medicines, add water, decoct 2 times, collecting decoction filters, and it is the extractum of 1.05-1.10 that filtrate is concentrated into 65 ℃ of survey relative densities; Take by weighing an amount of stearic acid, glyceryl monostearate, white vaseline and liquid paraffin, put on the water-bath heated and stirred to fine melt and do oil phase, 70-80 ℃ of insulation; Other gets an amount of glycerol, triethanolamine, sodium lauryl sulphate, distilled water, do water in the water-bath heating, above-mentioned the water extracted immersing paste and Aloe juice are added aqueous phase, 70-80 ℃ of insulation, oil phase is gently added aqueous phase, do not stop to stir, until when being cooled to 45 ℃, continue to stir the fill ointment.
The preparation method of the above-mentioned Chinese medicine composition that is used for the treatment of senile vaginitis, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned a kind of application of Chinese medicine composition in preparation treatment senile vaginitis medicine that is used for the treatment of senile vaginitis.
Beneficial effect:
1, the present invention is take Aloe as treatment senile vaginitis principal agent, Aloe property bitter cold, and removing heat from the liver, the external exudative dermatitis has the effect of heat clearing away sterilizing and itch-relieving, and Aloe has the effectiveness that promotes human body natural's immunity in addition, and is very effective to antiinflammatory, analgesia etc.Confirm according to modern pharmacological research, the contained tinctura aloes of Aloe is the very strong material of antibiotic property, the pathogenic bacterias such as energy killing fungus, antibacterial, virus, the growth and breeding of inhibition and eliminating pathogen.Aloe juice confirms through toxicity and clinical preliminary observation: except having functions of loosening bowel relieving constipation, and have good antiinflammatory, antipruritic, antitussive, eliminate the phlegm, calm, the multiple efficacies such as calm the nerves.Cortex Meliae and Folium Mori strengthen the effect of Aloe senile vaginitis.We do not contain caustic, and drug safety makes things convenient for, and have good clinical efficacy and DEVELOPMENT PROSPECT.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, is the pharmacopeia kind, has no side effect low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with the specific embodiment, the present invention is further described as follows:
Listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: part
| Aloe juice | Cortex Meliae | Folium Mori | |
| 1 | 30 | 40 | 10 |
| 2 | 40 | 30 | 20 |
| 3 | 50 | 20 | 30 |
2. Preparation Example
Above table Raw proportioning is example, may further comprise the steps:
Embodiment 1: take by weighing in proportion Cortex Meliae 40g and Folium Mori 10g two flavor Chinese medicines, add water, decoct 2 times, add for the first time 8 times of amounts that water is medical material weight, decoct 1h, add 6 times of amounts that water is medical material weight for the second time, decoct 1h, collecting decoction filters, and filtrate is concentrated into 65 ℃, and to survey relative densities be 1.05 extractum; Take by weighing stearic acid 45g, glyceryl monostearate 26g, white vaseline 27g and liquid paraffin 80g, put on the water-bath heated and stirred to fine melt and do oil phase, 70-80 ℃ of insulation; Other gets an amount of glycerol 53g, triethanolamine 5g, sodium lauryl sulphate 1g, distilled water 400g, do water in the water-bath heating, above-mentioned the water extracted immersing paste and Aloe juice 30g are added aqueous phase, 70-80 ℃ of insulation, oil phase is gently added aqueous phase, do not stop to stir, until when being cooled to 45 ℃, continue to stir the fill ointment.
Embodiment 2: take by weighing in proportion Cortex Meliae 30g and Folium Mori 20g two flavor Chinese medicines, add water, decoct 2 times, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add 8 times of amounts that water is medical material weight for the second time, decoct 1.5h, collecting decoction filters, and filtrate is concentrated into 65 ℃, and to survey relative densities be 1.10 extractum; Take by weighing stearic acid 45g, glyceryl monostearate 26g, white vaseline 27g and liquid paraffin 80g, put on the water-bath heated and stirred to fine melt and do oil phase, 70-80 ℃ of insulation; Other gets an amount of glycerol 53g, triethanolamine 5g, sodium lauryl sulphate 1g, distilled water 400g, do water in the water-bath heating, above-mentioned the water extracted immersing paste and Aloe juice 40g are added aqueous phase, 70-80 ℃ of insulation, oil phase is gently added aqueous phase, do not stop to stir, until when being cooled to 45 ℃, continue to stir the fill ointment.
Embodiment 3: take by weighing in proportion Cortex Meliae 20g and Folium Mori 30g two flavor Chinese medicines, add water, decoct 2 times, add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add 10 times of amounts that water is medical material weight for the second time, decoct 2h, collecting decoction filters, and filtrate is concentrated into 65 ℃, and to survey relative densities be 1.10 extractum; Take by weighing stearic acid 45g, glyceryl monostearate 26g, white vaseline 27g and liquid paraffin 80g, put on the water-bath heated and stirred to fine melt and do oil phase, 70-80 ℃ of insulation; Other gets an amount of glycerol 53g, triethanolamine 5g, sodium lauryl sulphate 1g, distilled water 400g, do water in the water-bath heating, above-mentioned the water extracted immersing paste and Aloe juice 50g are added aqueous phase, 70-80 ℃ of insulation, oil phase is gently added aqueous phase, do not stop to stir, until when being cooled to 45 ℃, continue to stir the fill ointment.
3. clinical observation material
Sample preparation: press above-described embodiment 2 preparation clinical trial samples, specification is that 10g/ props up, and containing the crude drug amount is that 1.37g/ props up, and Nanjing University of Traditional Chinese Medicine provides.
Clinical data
3.1 physical data: 30 routine patients are in April, 2011～2011 year August at my institute's Out-patient Clinic of Department of Gynecology outpatients.Age is more than 45 years old, with reference to " new Chinese medicine is treated colpitic clinical guidance principle ", possesses following condition: 1. menopausal women has clear and definite vaginitis medical history; 2. meet senile vaginitis in, the Western medicine diagnose standard.Vaginal secretions increases after the menopause, water sample or purulence, idol band blood, pruritus vulvae or burning sensation is arranged.3. vaginal mucosa is how level and smooth congested, is dispersed in little petechia, or superficial ulcer, even adhesion occurs.4. cervical scraping smear and posterior fornix plate coating checking are in the majority with the bottom epithelial cell, have no tumor cell.5. the aspiration patient in the know who meets senile vaginitis diagnostic criteria and inclusive criteria.
3.2 Therapeutic Method
The treatment of senile vaginitis patients: 1: 5000 potassium permanganate washing vagina of the front usefulness of sleeping every night, aseptic dry cotton ball is dried vagina, dips the present invention's ointment with aseptic cotton carrier, ointment is smeared whole vagina, every day 1 time, 2g/ time, follow up a case by regular visits to weekly once, 4 weeks were 1 course for the treatment of.Record per 1 routine patient's subjective symptoms, the inspection of examination per vagina situation and leucorrhea cleannes.
3.3 the observation of curative effect criterion of therapeutical effect is with reference to " new Chinese medicine is treated colpitic clinical guidance principle ".Recovery from illness: symptom and sign all disappears after the treatment, and lower abdomen and vagina pendant are swollen, the complete obiteration of vagina skin pruritus burning sensation.Produce effects: symptom obviously alleviates, and lower abdomen and vagina pendant are swollen, vagina skin pruritus burning sensation alleviates, and obviously disappear before treating behind vaginal mucosa hyperemia or the ulcer treatment.Effectively: sx↓, lower abdomen and vagina pendant are swollen, vagina skin pruritus burning sensation takes a turn for the better, and disappear before treating behind vaginal mucosa hyperemia or the ulcer treatment.Invalid: nothing is improved after the treatment.
3.4 therapeutic outcome:
30 examples are checked after all finishing 1 course for the treatment of immediately.The result is as follows:
Comprehensive therapeutic effect evaluation (table 1)
3.5 conclusion
The present invention has good treatment vaginitis curative effect.
Claims (4)
1. Chinese medicine composition that is used for the treatment of senile vaginitis, it is characterized in that its contained active component is prepared from by the following raw materials in part by weight proportioning: Aloe juice 30-50 part, Cortex Meliae 20-40 part, Folium Mori 10-30 part, preparation process is: take by weighing in proportion Cortex Meliae and Folium Mori two flavor Chinese medicines, add water, decoct 2 times, collecting decoction filters, and it is the extractum of 1.05-1.10 that filtrate is concentrated into 65 ℃ of survey relative densities; Take by weighing an amount of stearic acid, glyceryl monostearate, white vaseline and liquid paraffin, put on the water-bath heated and stirred to fine melt and do oil phase, 70-80 ℃ of insulation; Other gets an amount of glycerol, triethanolamine, sodium lauryl sulphate, distilled water, do water in the water-bath heating, above-mentioned the water extracted immersing paste and Aloe juice are added aqueous phase, 70-80 ℃ of insulation, oil phase is gently added aqueous phase, do not stop to stir, until when being cooled to 45 ℃, continue to stir the fill ointment.
2. a Chinese medicine composition that is used for the treatment of senile vaginitis is characterized in that its contained active component is prepared from by the following raw materials in part by weight proportioning: 40 parts of Aloe juices, 30 parts of Cortex Meliaees, 20 parts on Folium Mori.
3. the preparation method that is used for the treatment of the Chinese medicine composition of senile vaginitis according to claim 1, it is characterized in that, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, the 6-10 that adds for the second time water and be medical material weight doubly measures, and decocts 1-2h.
4. a kind of application of Chinese medicine composition in preparation treatment senile vaginitis medicine that is used for the treatment of senile vaginitis as claimed in claim 1.
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| CN 201110304275 CN102335323B (en) | 2011-10-10 | 2011-10-10 | Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof |
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| CN102335323B true CN102335323B (en) | 2013-02-13 |
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| CN103142747A (en) * | 2013-03-22 | 2013-06-12 | 刘荣彬 | Medicament for treating metritis of sow |
| CN103585321B (en) * | 2013-11-16 | 2015-05-13 | 李伟丽 | Externally used traditional Chinese medicine composition for treating trichomonas vaginitis |
| CN106860733A (en) * | 2017-03-22 | 2017-06-20 | 上林县山水牛畜牧业有限公司 | A kind of Chinese medicine preparation for killing ox parasite and preparation method thereof |
| CN108853183A (en) * | 2018-07-18 | 2018-11-23 | 湖北惠春蕲艾健康产业发展有限公司 | A kind of antibacterial emulsifiable paste of Chinese mugwort and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1377698A (en) * | 2002-04-22 | 2002-11-06 | 武汉大学 | Nano woman's cleaning and nursing aloe lotion and its preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1377698A (en) * | 2002-04-22 | 2002-11-06 | 武汉大学 | Nano woman's cleaning and nursing aloe lotion and its preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 南京中医药大学编著.苦楝皮、桑叶.《中药大辞典第二版》.上海科学技术出版社,2006,1783、2780页. * |
| 张兆旺主编.软膏剂.《中药药剂学》.中国中医药出版社,2003,299-308页. * |
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