CN1377698A - Nano woman's cleaning and nursing aloe lotion and its preparing method - Google Patents
Nano woman's cleaning and nursing aloe lotion and its preparing method Download PDFInfo
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- CN1377698A CN1377698A CN 02115733 CN02115733A CN1377698A CN 1377698 A CN1377698 A CN 1377698A CN 02115733 CN02115733 CN 02115733 CN 02115733 A CN02115733 A CN 02115733A CN 1377698 A CN1377698 A CN 1377698A
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Abstract
The Nano woman's cleaning and nursing aloe lotion contains nano aloe juice, sodium hyaluronate and polymerized material. The cleaning and nursing aloe lotion is prepared through crushing and atomizing aloe leaf inside a homogenizer to form nano grains of 1-700 nm and nano aloe suspension; and mixing the nano aloe suspension with sodium hydraluronate, polymerized material and substrate. The present invention has unique biological slowly releasing function, can repair and protect vagina and uterus wall, nourish vagina, eliminate discomfort in vagina, inhibit various vaginitis, cervical erosino and sexually transmitted diseases, eliminate inflammation and prevent cross infection. The present invention has no irritation, no toxicity and no side effect.
Description
Technical field
The present invention relates to a kind of nano woman's cleaning and nursing aloe lotion and preparation method thereof.
Background technology
Aloe is an a kind of perennial meat section herbaceous plant, and the laudatory title of " first aid plant ", " noiseless doctor ", " ten thousand answer good medicine ", " rare treasures " is just arranged since ancient times, and magical function is arranged at aspects such as medicine, health care, beauty treatments.In recent years aloetic pharmacological research there has been bigger progress, functions such as aloetic medical treatment, health care, beauty treatment have been proved absolutely, think that Aloe has effects such as anti-inflammation, treatment acne, acne, whitening and speckle dispelling, constipation and hemorrhoid also there is special curative effect, the fresh juice of normal directly use Aloe among the people, but easily cause allergic reaction.Multiple external and aloe products for oral administration are also arranged at present, but because aloetic active ingredient dissolution rate particularly water-insoluble and slightly solubility solid content matter is not high, and influenced its result of use.
At present, the gynaecologic vaginal nursing health products on the market is numerous.But only pay attention to Disinfection Effect mostly, and it is shorter to execute the effect time.
Summary of the invention
The present invention provides a kind of nano woman's cleaning and nursing aloe lotion and preparation method thereof at the problems referred to above exactly, and that the gained nano woman's cleaning and nursing aloe lotion has is antibiotic, nursing, lubrication, and has slow-release function and make that to execute the effect time longer.
Technical scheme provided by the invention is: a kind of nano woman's cleaning and nursing aloe lotion, contain 10～98.5% Aloe nano suspending liquid natural juice, 0.05～5% hyaluronate sodium, 0.1～10% polymeric material, 0.85～75% substrate, above percent is percetage by weight, down together.
Above-mentioned nano woman's cleaning and nursing aloe lotion can contain 0.05～2% antioxidant or/and 0.05～0.5% antiseptic; Also can contain the following Margarita powder micropowder of 0.01～0.2% vitamin A or derivatives thereof, 0.01～0.2% vitamin C or derivatives thereof, 0.01～0.5% vitamin E, 0.01～1% 100 orders, 0.01～1% Herba melissae axillaris powder, 0.01～2% propolis and 0.01～1% minerals compositions such as ultrafine zinc oxide particle.
In addition, the present invention also contains 0.01～10% surfactant, to stop particulate oxidation, reunion, improves particulate dispersibility and stability.
The preparation method of above-mentioned nano woman's cleaning and nursing aloe lotion, to clean, inside gelling behind Folium Aloe after disinfecting or the removal leaf skin is handled 5min～30min through refiner or homogenizer under 1000rpm～10000rpm rotating speed, in high pressure homogenisers, the machined object granule is pulverized then by high frequency intense ultrasonic wave field cavitation, ultramicronising, under 10Mpa～300Mpa high pressure, produce the moment effluxvelocity of 200m/s～600m/s, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1nm～700nm size, get Aloe nano suspending liquid natural juice; Gained Aloe nano suspending liquid and hyaluronate sodium, polymeric material and substrate are stirred 5min～20min with 200rpm～5000rpm rotating speed under 20 ℃～80 ℃, promptly get required nano woman's cleaning and nursing aloe lotion.
The present invention also can carry out according to the following steps: the inside gelling behind Folium Aloe after will cleaning, disinfecting or the removal leaf skin adds antioxidant, antiseptic, vitamin A or derivatives thereof, vitamin C or derivatives thereof, vitamin E, Margarita powder micropowder, Herba melissae axillaris powder, propolis, ultrafine zinc oxide particle and/or surfactant through refiner or homogenizer after handling 5min～30min under 1000rpm～10000rpm rotating speed, prepare the Aloe nano suspending liquid in high pressure homogenisers as stated above again, and finally make required nano woman's cleaning and nursing aloe lotion.
Above-mentioned antioxidant can adopt antioxidants such as sodium sulfite, sodium sulfite or sodium pyrosulfite; Antiseptic can adopt one or more in Nipagin ester, Dowicol 2000, EDTA, KathonCG or other composition; Surfactant can be used one or more compositions of polyethylene glycols, polyhydric alcohol lipid, polyoxyethylene aliphatic alcohol ether class, polyethenoxy alkylphenols class and lecithin, granulesten; Polymeric material can be used one or several of gelatin, arabic gum, alginate, starch, dextrin, carboxycellulose, chitosan, acrylic copolymer etc.; Substrate can adopt sodium bicarbonate (or sodium carbonate, sodium hydroxide, triethanolamine, carbamide), ethanol (or isopropyl alcohol, glycerol, propylene glycol, butanediol), ammonium lauryl sulfate, AESA, refined wool fat, also available other nursing category substrate commonly used.
The present invention is composite with nano aloe and high efficiency nutritious Moisture factor hyaluronate sodium, by liposome enclose and nanometer emulsified, has the unique biological slow-release function, the active ingredient of nano aloe is kept for a long time in intravaginal, in 12 hours, slowly discharge and make that to execute the effect time longer, in addition, Aloe not only makes its active ingredient solid content matter dissolution rate particularly water-insoluble and slightly solubility increase behind nanorize, the miscible effect of volatilization wet goods composition and water improves, stability strengthens, specific surface area increases, viscosity changes, adhesion strength increases, absorbability improves, make script only partly discharge the composition that maybe can't discharge and be able to sufficient release, and in the easier infiltration thalline and obviously improve antibacterial effect, bacillary to causing, mycotic, infusorian property, senile, and mixed infective vaginitis, the multiple pathogen of cervical erosion and various sexually transmitted disease (STD) has significant pressing down to kill function, can effectively diminish inflammation, and guards against cross infection.Vagina and wall of cervix can effectively be repaired and protect to trophic factors such as aloe extract acemannan (acemannan) that the present invention is rich in and hyaluronate sodium, nourishes comprehensively, eliminates vaginal dryness, pruritus discomfort that a variety of causes causes.Use the back non-stimulated, nontoxic, harmless, without any side effects.The present invention has enlarged the aloetic medicine resource of Chinese medicine, has improved aloetic biological effect, has reduced cost of material; Its preparation technology is suitable for suitability for industrialized production, the yield height, and quality is good, the production efficiency height.
The specific embodiment
Embodiment 1: nano woman's cleaning and nursing aloe lotion, contain 30% Aloe nano suspending liquid natural juice, 2% hyaluronate sodium, 5% polymeric material (1% gelatin, 3% starch, 1% chitosan), 63% substrate (0.3% sodium bicarbonate, 54% ethanol, 4% ammonium lauryl sulfate, 3.5% AESA, 1.2% refined wool fat).
Embodiment 2: nano woman's cleaning and nursing aloe lotion, contain 10% Aloe nano suspending liquid natural juice, 1.5% sodium sulfite, 0.2% Nipagin ester, Dowicol 2000, EDTA, in KathonCG or other composition one or more, 0.1% vitamin A (or derivatives thereof), 0.05% vitamin C (or derivatives thereof), 0.3% vitamin E (or derivatives thereof), 1% Margarita powder micropowder (100 orders are following), 0.01% Herba melissae axillaris powder, 1% propolis, 0.04% ultrafine zinc oxide particle, 5% hyaluronate sodium, 8% polymeric material (2% arabic gum, 4% alginate, 1% carboxycellulose, 1% acrylic copolymer), 70.7% substrate (0.1% carbamide, 57% glycerol, 8% ammonium lauryl sulfate, 0.7% AESA, 5% refined wool fat), 2% surfactant (polyethylene glycols, polyhydric alcohol lipid, the polyoxyethylene aliphatic alcohol ether class, polyethenoxy alkylphenols class and lecithin, one or more compositions of granulesten), 0.05% essence, 0.05% pigment.
Embodiment 3: nano woman's cleaning and nursing aloe lotion, contain 90% Aloe nano suspending liquid natural juice, 1% sodium pyrosulfite, 0.5% Nipagin ester, Dowicol 2000, EDTA, in KathonCG or other composition one or more, 0.05% vitamin A (or derivatives thereof), 0.5% vitamin E (or derivatives thereof), 0.5% Herba melissae axillaris powder, 1% hyaluronate sodium, 0.45% polymeric material, 6% substrate (0.5% triethanolamine, 5% isopropyl alcohol, 0.1% ammonium lauryl sulfate, the refined wool fat of 0.3% AESA 0.1%).
Embodiment 4: will be clean (through cleaning, routine disinfection) Folium Aloe or remove the leaf skin after the inside gelling (rotating speed is 1000～10000rpm) to handle 5～30min with refiner or homogenizer, again by high pressure homogenisers high frequency intense ultrasonic wave field cavitation, the machined object granule is pulverized, ultramicronising, under 10～300Mpa high pressure, produce moment effluxvelocity 200～600m/s speed, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1～700nm size, get the Aloe nano suspending liquid; Get Aloe nano suspending liquid, hyaluronate sodium, polymeric material and substrate (also can add pigment, essence as required, supply deionized water), under 20～80 ℃, stir 5～20min, promptly get required product with 200～5000rpm rotating speed.Product relative viscosity 3000～30000 centipoises, transparent, 60 ℃ of 24 hours or-4 ℃ 24 hours are not stratified, haze-free, product antibacterial effect excellence.
Embodiment 5: adopt more than 3 years the leaf age Aloe as the results object, remove foul and damaged part after clear water cleans, be soaked in the disinfectant solution such as containing 50～500mg/L effective chlorine, available iodine or hydrogen peroxide soaking disinfection and handled in 30 minutes～24 hours, the inside gelling after adopting aloe full leaf or removing the leaf skin.With its block that is processed into size below 2 centimetres, handle 5～30min with refiner or homogenizer with cutting knife then.Add antioxidant such as sodium sulfite, sodium sulfite or sodium pyrosulfite and prevent oxidation deterioration, and/or add in antiseptic such as Nipagin ester, Dowicol 2000, EDTA, KathonCG or other composition one or more, prevent putrid and deteriorated; Add the vitamin A or derivatives thereof, the vitamin C or derivatives thereof, vitamin E, the Margarita powder micropowder, the Herba melissae axillaris powder, propolis, ultrafine zinc oxide particle and/or surfactant, in high pressure homogenisers, the machined object granule is pulverized then by high frequency intense ultrasonic wave field cavitation, ultramicronising, under 10Mpa～300Mpa high pressure, produce the moment effluxvelocity of 200m/s～600m/s, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1nm～700nm size, get the Aloe nano suspending liquid; Gained composite aloe nano suspending liquid and hyaluronate sodium, polymeric material and substrate are stirred 5min～20min with 200rpm～5000rpm rotating speed under 20 ℃～80 ℃, promptly get required nano woman's cleaning and nursing aloe lotion.
Below be the antibacterial experiment data of gained nano woman's cleaning and nursing aloe lotion of the present invention and vaginal mucomembranous irritant test, eye irritant test, chmice acute per os toxicity test result.
The antibacterial experiment data:
Antimicrobial spectrum and antibacterial effect
MIC handled back MIC before the test bacterium was handled
Corynebacterium acnes 7 23
Staphylococcus aureus 16 50
Pyogenesis bacillus 8 15
Hemolytic streptococcus 5 15
Escherichia coli 12 45
Aerogenesis klebsiella 6 35
Alcaligenes faecalis 6 30
Cloaca 6 25
Aspergillus niger 58
Aspergillus fumigatus 5 10
White silk yeast 6 12
Acrothesium floccosum 6 11
Trichophyton mentagrophytes 6 15
Above-mentioned MIC unit is mm, and the antibacterial ring of negative control group is 5mm.
Vaginal mucomembranous irritant test:
By the 3.8th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Choose 12 of healthy White Rabbits, be divided into contamination group, vehicle group and blank group, 4 of every treated animals.The contamination group: the long roundlet cotton sliver of 2.0cm that will scribble test specimen stock solution of the present invention is inserted the experimental animal intravaginal; Vehicle group: soak with sterile saline with onesize cotton sliver, insert the animal intravaginal.Remove after 4 hours and tried thing.Put to death animal after 24 hours, take out local vagina tissue, observation has or not phenomenons such as hyperemia, edema.The result shows that in the observation period, erythema or edema symptom all do not appear in test group, vehicle group, the local vagina tissue of blank treated animal, and the irritant reaction integral mean value is 0.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is to rabbit vagina mucosa nonirritant.
Eye irritant test:
By the 3.7th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Choose 4 of healthy White Rabbits, test specimen stock solution 1-2 of the present invention is splashed in the eye conjunctival sac of White Rabbit left side, make passive closed 4 seconds of eye immediately, used normal saline flushing then 5 minutes.Right eye compares, and splashes into the equivalent normal saline.Behind eye drip 6,24,48 hours, 4 days with 7 days, observe the damage and the recovery situation of rabbit conjunctival, iris and cornea.The result shows, award medicine after, test group animal eye conjunctiva, iris and cornea all do not show irritation, stimulation index integration peak is 0.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is to the lagophthalmos nonirritant.
Chmice acute per os toxicity test result:
By the 3.4th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Experimental animal: 50 of kunming mices, body weight 18-22 gram, male and female half and half; The quality certification number: the moving word of doctor 19-082 number is provided by Hubei Province's medical experiment animal center.Viewing duration, each dosage group (1250,2500,5000,10000mg/kg) animal does not show obvious poisoning symptom, no animal dead, decidable test specimen stock solution of the present invention is to kunming mice acute oral LD
50Greater than 5000mg/kg.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is actual nontoxic.
More than show gained nano woman's cleaning and nursing aloe lotion of the present invention have preferably press down kill antibacterial, superficial mycosis, deep fungal, the effect effect, and non-stimulated, nontoxic, harmless, have no side effect.
Claims (6)
1. a nano woman's cleaning and nursing aloe lotion contains 10～99% Aloe nano suspending liquid natural juice, 0.05～5% hyaluronate sodium, 0.1～10% polymeric material, 0.85～75% substrate, and above percent is percetage by weight.
2. nano woman's cleaning and nursing aloe lotion according to claim 1 is characterized in that: contain 0.05～2% antioxidant or/and 0.05～0.5% antiseptic.
3. nano woman's cleaning and nursing aloe lotion according to claim 1 and 2 is characterized in that: contain the following Margarita powder micropowder of 0.01～0.2% vitamin A or derivatives thereof, 0.01～0.2% vitamin C or derivatives thereof, 0.01～0.5% vitamin E, 0.01～1% 100 orders, 0.01～1% Herba melissae axillaris powder, 0.01～2% propolis and 0.01～1% ultrafine zinc oxide particle.
4. nano woman's cleaning and nursing aloe lotion according to claim 1 is characterized in that: also contain 0.01～10% surfactant.
5. the preparation method of the described nano woman's cleaning and nursing aloe lotion of claim 1, it is characterized in that: will clean, inside gelling behind Folium Aloe after disinfecting or the removal leaf skin is handled 5min～30min through refiner or homogenizer under 1000rpm～10000rpm rotating speed, in high pressure homogenisers, the machined object granule is pulverized then by high frequency intense ultrasonic wave field cavitation, ultramicronising, under 10Mpa～300Mpa high pressure, produce the moment effluxvelocity of 200m/s～600m/s, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1nm～700nm size, get the Aloe nano suspending liquid; Gained Aloe nano suspending liquid and hyaluronate sodium, polymeric material and substrate are stirred 5min～20min with 200rpm～5000rpm rotating speed under 20 ℃～80 ℃, promptly get required nano woman's cleaning and nursing aloe lotion.
6. preparation method according to claim 5, it is characterized in that: the inside gelling behind Folium Aloe after will cleaning, disinfecting or the removal leaf skin adds antioxidant, antiseptic, vitamin A or derivatives thereof, vitamin C or derivatives thereof, vitamin E, Margarita powder micropowder, Herba melissae axillaris powder, propolis, ultrafine zinc oxide particle and/or surfactant through refiner or homogenizer after handling 5min～30min under 1000rpm～10000rpm rotating speed, then preparation Aloe nano suspending liquid in high pressure homogenisers.
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| CN1213761C CN1213761C (en) | 2005-08-10 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164583A (en) * | 2006-10-16 | 2008-04-23 | 海南森瑞谱生命科学药业股份有限公司 | Composite preparation for treating epithelial erosion and preparation method thereof |
| CN102335323A (en) * | 2011-10-10 | 2012-02-01 | 南京中医药大学 | Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof |
| CN103156966A (en) * | 2013-03-18 | 2013-06-19 | 陈树杰 | Female natural pudenda protection health liquid |
| CN104547344A (en) * | 2015-01-21 | 2015-04-29 | 何玉明 | Aloe care lotion and preparation method thereof |
| CN107536923A (en) * | 2017-09-18 | 2018-01-05 | 杨平芝 | A kind of oldenlandia diffusa antibacterial gel |
| CN107714733A (en) * | 2017-11-28 | 2018-02-23 | 吉安市御美丽健康产业股份有限公司 | A kind of preparation method of antibacterial peptide gynaecologic washing lotion |
| CN114432395A (en) * | 2022-02-14 | 2022-05-06 | 南宁摩米生物科技有限公司 | Preparation method of gel for cleaning and nursing female vagina |
-
2002
- 2002-04-22 CN CN 02115733 patent/CN1213761C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164583A (en) * | 2006-10-16 | 2008-04-23 | 海南森瑞谱生命科学药业股份有限公司 | Composite preparation for treating epithelial erosion and preparation method thereof |
| CN101164583B (en) * | 2006-10-16 | 2016-01-27 | 海南森瑞谱生命科学药业股份有限公司 | Compound formulation for the treatment of epithelial erosion and preparation method thereof |
| CN102335323A (en) * | 2011-10-10 | 2012-02-01 | 南京中医药大学 | Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof |
| CN102335323B (en) * | 2011-10-10 | 2013-02-13 | 南京中医药大学 | Traditional Chinese medicine composition for treating senile colpitis as well as preparation method and application thereof |
| CN103156966A (en) * | 2013-03-18 | 2013-06-19 | 陈树杰 | Female natural pudenda protection health liquid |
| CN103156966B (en) * | 2013-03-18 | 2014-05-07 | 陈树杰 | Female natural pudenda protection health liquid |
| CN104547344A (en) * | 2015-01-21 | 2015-04-29 | 何玉明 | Aloe care lotion and preparation method thereof |
| CN107536923A (en) * | 2017-09-18 | 2018-01-05 | 杨平芝 | A kind of oldenlandia diffusa antibacterial gel |
| CN107714733A (en) * | 2017-11-28 | 2018-02-23 | 吉安市御美丽健康产业股份有限公司 | A kind of preparation method of antibacterial peptide gynaecologic washing lotion |
| CN114432395A (en) * | 2022-02-14 | 2022-05-06 | 南宁摩米生物科技有限公司 | Preparation method of gel for cleaning and nursing female vagina |
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