CN108117929B - A kind of essential oil and preparation method thereof - Google Patents
A kind of essential oil and preparation method thereof Download PDFInfo
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- CN108117929B CN108117929B CN201711394556.3A CN201711394556A CN108117929B CN 108117929 B CN108117929 B CN 108117929B CN 201711394556 A CN201711394556 A CN 201711394556A CN 108117929 B CN108117929 B CN 108117929B
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0003—Compounds of unspecified constitution defined by the chemical reaction for their preparation
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0007—Aliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0007—Aliphatic compounds
- C11B9/0015—Aliphatic compounds containing oxygen as the only heteroatom
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0026—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring
- C11B9/0034—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring the ring containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0061—Essential oils; Perfumes compounds containing a six-membered aromatic ring not condensed with another ring
Abstract
The present invention provides a kind of essential oil, which can be used for preparing treatment and/prevention mosquito repellent, antipruritic, antibacterial medicines, can be used for preparation treatment and/prevention acne drug.And the composition good effect, it is quality controllable, it is easy to apply.The essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 5~25%, gaultherolin 5~20%, camphor 0.1~5%, eucalyptus oil 0.1~5%, eugenol 0.1~5%, citronellyl acetate 1~5%, phenethyl acetate 2~10%, citronellol 5~20%, geraniol 20~50%, citral 1~5%, rose oxide 1~5%, geranium oil 1~5%, isomethylionone 1~5%.
Description
1, technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of essential oil and preparation method thereof.
2, background technique
Essential wind oil is configured by natural drug and aromatic essential oil, and menthol, gaultherolin, eucalyptus are mainly contained
The ingredients such as leaf oil alcohol, camphor, it is not only orally available, but also can external application, have effects that resuscitation with aromatics, clearing away heat to and alleviating pain, dispelling wind and arresting itching, be occupy
The standing health care product of family's travelling.
Essential wind oil is now embodied in Traditional Chinese medicine historical preparation the 9th, and essential wind oil consists of the following compositions：Menthol 320g, bigcatkin willow
Sour methyl esters 260g, camphor 30g, eucalyptus oil 30g and eugenol 30g.Preparation method is：Menthol, camphor are taken, it is suitable that liquid paraffin is added
Amount, adds eucalyptus oil, gaultherolin, eugenol, essence 100g, appropriate chlorophyll, liquid paraffin is added to make into 1000g, mixes,
Stand 24 hours, take clarified solution, packing to get.This product contain menthol, gaultherolin should be labelled amount 90.0~
110.0%；It should be the 85.0%~115.0% of labelled amount containing camphor；It should be the 90.0~120.0% of labelled amount containing eugenol；
This product is containing eucalyptus oil must not be less than 21mg based on olein.It is refrigerant, antipruritic with anti-inflammatory, analgesia, wind-dispelling effect, for sense of catching cold
Emit caused headache, the dizzy and discomfort as caused by arthralgia, toothache, abdomen distending pain and bite by mosquitos, carsickness etc..External application,
It embrocates in affected part.Oral, one time 4~6 drop, children cut down according to the circumstance or follow the doctor's advice.
The novel clinical use Chinese Medicine guide of Chen Jie essential wind oil, 2012,10 (21):75. describing facing for essential wind oil
Bed new application, from introducing new opplication of the essential wind oil in the work such as clinical Medicine and Surgery research and daily nursing in terms of eight.Wind oil
Essence treat abdominal pain, infantile hyperpyrexia, abscess of throat, superficial gastritis and in terms of effect it is significant.
The such as Qu Ye essential wind oil observes Chinese Journal of Health Laboratory Technology, 2003,2 (13) to the bacteriostasis of eight kinds of bacteriums:97.
It is strong and weak to determine essential wind oil eight kinds of bacterium standard columns fungistatic effect common to laboratory.Experimental result is with essential wind oil concentration
It reduces, bacteriostasis accordingly weakens.If using on plate absolutely not bacterial growth when essential wind oil concentration as minimum antibacterial
Concentration, then when dilution is 1：When 20, essential wind oil has apparent bacteriostasis to eight kinds of experimental strains, raw without bacterium
It is long, when dilution is 1：When 40, there is complete inhibition effect to staphylococcus aureus, staphylococcus albus, γ-streptococcus, it is right
Escherichia coli etc. cannot completely inhibit, so 1：20 can be used as essential wind oil to G such as Escherichia coli-The minimum inhibitory concentration of bacterium,
1：40 can be used as essential wind oil to G such as staphylococcus aureus, staphylococcus albus, γ-streptococcus+Bacterium it is minimum antibacterial dense
Degree.When increasing due to essential wind oil extension rate, to G such as Escherichia coli, typhoid bacilluses-The fungistatic effect of bacterium obviously weakens, to Portugal
The G such as grape coccus+The fungistatic effect of bacterium weakens slowly, illustrates that essential wind oil is obvious to the bacteriostasis of the gram positive bacterias such as staphylococcus
It is better than the gram-negative bacterias such as Escherichia coli.
Chinese invention patent application CN02113307.7 discloses a kind of solid essential balm, contains following component (weight)：
Menthol 5~35%, wintergreen 5~30%, camphor 0.5~20%, eucalyptus oil 0.5~5%, caryophyllus oil 0.5~5%, solid
Oil components 20~80%.
Chinese invention patent application CN02159441.4 discloses a kind of essential wind oil spray delivery composition, including thin
The medical fluid that lotus brain, gaultherolin, camphor, eucalyptus oil, eugenol, additives and pharmaceutical solvent are configured to.
Chinese invention patent application CN201110459255.0 discloses a kind of with anti-inflammatory analgesic, refrigerant antipruritic and mosquito repellent
The essential oil of function, formula components by menthol, wintergreen, camphorated oil, eucalyptus oil, basil oil, citronella oil, patchouli oil,
The composition such as oil of bay, paraffin oil, flavoring agent and colorant.
3, summary of the invention
The object of the present invention is to provide a kind of new essential oil, which has better mosquito repellent, antipruritic, fungistatic effect, and
It can be used for preparing treatment and/prevention acne drug.And the essential oil good effect, it is quality controllable, it is easy to apply.
In order to achieve the above object of the invention, the invention adopts the following technical scheme：
The present invention provides a kind of essential oil, the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 5~25%,
Gaultherolin 5~20%, camphor 0.1~5%, eucalyptus oil 0.1~5%, eugenol 0.1~5%, citronellyl acetate 1~5%,
Phenethyl acetate 2~10%, citronellol 5~20%, geraniol 20~50%, citral 1~5%, rose oxide 1~5%, spiceleaf
Oil 1~5%, isomethylionone 1~5%.
Preferably, the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 9~20%, gaultherolin 7~
15%, camphor 0.5~2%, eucalyptus oil 0.5~2%, eugenol 0.5~2%, citronellyl acetate 2~3%, phenethyl acetate 5~
7%, citronellol 10~15%, geraniol 30~40%, citral 2~4%, rose oxide 2~4%, geranium oil 1~3%, different first
Base irisone 2~4%.
It is furthermore preferred that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 16%, gaultherolin 13%,
Camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, citronellyl acetate 2.5%, phenethyl acetate 6%, citronellol 14%, spiceleaf
Alcohol 33%, citral 3%, rose oxide 3%, geranium oil 2%, isomethylionone 3%.
It is this that further requirement of the present invention protects a kind of essential oil that can be applied to needs in a manner of oral and extra-parenteral administration etc.
The patient for the treatment of.
When for taking orally, conventional solid pharmaceutical preparation, such as tablet, capsule, pill, granule can be made into；It may be made as
Oral liquid, such as oral solution, oral suspensions, syrup.Tablet means drug and suitable auxiliary materials and mixing pressure
The solid pharmaceutical preparation of disc-shaped made of system or special-shaped sheet, based on oral ordinary tablet, separately have lozenge, sublingual tablet, mouth paster,
Chewable tablets, dispersible tablet, fuse, effervescent tablet, sustained release tablets, controlled release tablet and enteric coatel tablets etc..Capsule means drug or added with auxiliary material
The solid pharmaceutical preparation for being filled in Capsules or being sealed in soft capsule material can be divided into hard capsule according to its dissolution and release characteristics
(being commonly referred to as capsule), soft capsule (capsule and pill), spansule, controlled release capsule and capsulae enterosolubilis etc..Pill means drug and is suitable for
Auxiliary material uniformly mixes, with spherical made of proper method or near-spherical solid pharmaceutical preparation, including dripping pill, sugar-pill, piller etc..Granule
It means that the dry granular formulation with certain particle size is made in drug and suitable auxiliary material, soluble particles can be divided into and (be commonly referred to as
Grain), mix suspension grain, effervescence granular, enteric coated particles, slow-releasing granules and controlled release granule etc..Oral solution means that drug is dissolved in
It is made in suitable solvent for oral supernatant liquid preparation.Oral suspensions mean insoluble solid drug, are dispersed in liquid Jie
It in matter, is made for oral suspended liquid preparation, also includes dry suspensoid agent or dense suspension.Syrup is meant containing the dense of drug
Aqueous sucrose solution.
When oral preparation is made, suitable filler, adhesive, disintegrating agent, lubricant etc. can be added.Common filler
Including starch, Icing Sugar, calcium phosphate, two water object of calcium sulfate, dextrin, microcrystalline cellulose, lactose, pregelatinized starch, mannitol etc.；Often
With adhesive include sodium carboxymethylcellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose,
Hydroxypropyl methylcellulose, gelling starch etc.；Common disintegrating agent includes dried starch, crospovidone, croscarmellose sodium, carboxylic
Methyl starch sodium, low-substituted hydroxypropyl cellulose etc.；Conventional lubricants include magnesium stearate, talcum powder, lauryl sodium sulfate,
Superfine silica gel powder etc..
Ointment, cream, gelling agent, powder, rubber ointment, Babu cream can also be made in pharmaceutical composition of the present invention
The external solids such as agent, patch, semisolid preparation；The liquid preparation for external application such as lotion, liniment, plastics；Aerosol.Preferred lotion,
Liniment, aerosol.Ointment means that drug and oil or water-soluble base are mixed and made into uniform semisolid external preparation.Cream
Paste means that drug is dissolved or dispersed in emulsion-type matrix and forms uniform semisolid external preparation.Gelling agent mean drug with
The glop or semisolid preparation of uniform, suspension or emulsion-type is made in the auxiliary material that gel can be formed.Powder mean drug or with
Dry powdered preparation of the suitable auxiliary material through crushing, being uniformly mixed, is divided into oral powder and topical powder.Rubber paste
After agent refers to that the matrix such as drug and rubber mix, it is coated on manufactured emplastrum on back lining materials.Babu plaster refer to drug with
After hydrophilic matrix mixes, it is coated on manufactured emplastrum on back lining materials.Patch means Pasting on the skin, and drug can produce
A kind of raw systemic or local action laminar preparation；Said preparation has back sheet, the drug depot for having (or nothing) release-controlled film, sticks
Mixture layer and the protective layer for needing removing before use；It can be used for intact skin surface, it can also be used to have illness or incomplete skin
Surface.Lotion means solution, lotion, the suspension of drug containing, for cleaning or smearing the preparation of no damaged skin.Liniment is meant
Solution, lotion or suspension made of drug ethyl alcohol, oil or suitable solvent, the liquid system rubbed for no damaged skin
Agent.Paint means aqueous or oily solution, lotion, the suspension of drug containing, dips or is applied to for gauze before use or cotton
Skin or the liquid preparation in oral cavity and throat's mucous membrane.Plastics mean that drug is dissolved in organic solvent containing filmogen, and painting is put on the skin
The liquid preparation for external application of film is formed behind affected part.
When external solid, semisolid preparation is made in pharmaceutical composition of the present invention, the common oleaginous base of ointment has：It is all
Intellectual circle, paraffin, liquid paraffin, silicone oil, beeswax, stearic acid etc.；Water-soluble base has polyethylene glycol；Emulsion-type matrix there are commonly
Soda soap, triethanolamine soaps, fatty alcohol sulphuric acid (ester) sodium class, poly- mountain plough ester, lanolin, monoglyceride, fatty alcohol etc.；When necessary
Moisturizer, preservative, antioxidant or transdermal enhancer can be added.The water-soluble base of gelling agent generally has water, glycerol or the third two
Alcohol and cellulose derivative, carbomer and alginate, tragacanth, gelatin, starch etc. are constituted；Oil-base gel matrix has liquid
Paraffin and polyoxyethylene or fat oil and colloidal silicon or aluminium soap, zinc soap are constituted；Moisturizer, preservative, antioxygen can be added when necessary
Agent or transdermal enhancer.Rubber ointment often has rubber, thermoplastic rubber, rosin, rosin derivative, vaseline, sheep with matrix
Hair rouge and zinc oxide etc..The common matrix of Babu plaster has Sodium Polyacrylate, sodium carboxymethylcellulose, gelatin, glycerol and micro mist
Silica gel etc..Patch often has ethylene-vinyl acetate copolymer, silicon rubber and polyethylene glycol etc. with matrix.Emplastrum (rubber ointment,
Babu plaster, patch) common back lining materials have cotton, non-woven fabrics, paper etc.；Common cover lining material has separate paper, plastics thin
Film, aluminium foil-polyethylene composite film, stearic gauze etc..Liquid preparation for external application such as lotion, liniment, plastics, common solvent have
Water, ethyl alcohol, glycerol, vegetable oil, liquid paraffin etc.；Common filmogen has polyvinyl alcohol, polyvinylpyrrolidone, acrylic acid
Resinae etc.；Plasticizer has glycerol, propylene glycol, dibutyl phthalate etc.；It is suitable to skin or mucous membrane to add when necessary
Non-stimulated additives.It is resistance to speciality valve system that the aerosol refers to that fine drug powder is mounted in suitable propellant
In the tight envelope container of pressure, the dosage form that when use sprays content in fine mist or other forms by the pressure of propellant is described
Propellant be dichlorodifluoromethan hydro carbons.
The preparation method of the further requirement of the present invention protection essential oil is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and stirring is stood after stopping, inspection by sampling, filters, obtains after qualified
Mixed liquor is spare；
Step 2：Menthol, camphor are taken, liquid paraffin is added, adds eucalyptus oil, gaultherolin, eugenol, step 1 system
Mixed liquor and chlorophyll, liquid paraffin is added, mixes, stands, takes clarified solution, packing to get.
Preferably, the preparation method of essential oil of the present invention is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and control mixing speed is 30 revs/min, and mixing time is 2 hours,
Stirring stands 48 hours after stopping, inspection by sampling, is filtered after qualified with 150 mesh, obtained mixed liquor is spare；
Step 2：Menthol, camphor are taken, liquid paraffin is added, adds eucalyptus oil, gaultherolin, eugenol, step 1 system
Mixed liquor and chlorophyll, liquid paraffin, which is added, makes into 1000g, mixes, stand 24 hours, take clarified solution, packing to get.
The preparation method of the further requirement of the present invention protection essential oil aerosol is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and stirring stands inspection by sampling after stopping, and filters, obtains after qualified
Mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerol are set and are poured into eucalyptus oil, salicylic acid after melting in water-bath
Methyl esters, eugenol, mixed liquor and chlorophyll made from step 1 separately take menthol, camphor that ethyl alcohol is added, by above two solution
After mixing evenly plus water, it pours into the vial of slush moulding and cleaning, drying, is packed into valve and compresses, be pressed into F with pressure tank method12, shake
It is even to obtain the final product.
Preferably, the preparation method of essential oil aerosol of the present invention is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and control mixing speed is 30 revs/min, and mixing time is 2 hours,
Stirring stands 48 hours after stopping, inspection by sampling, is filtered after qualified with 150 mesh, obtained mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerol are set and are poured into eucalyptus oil, salicylic acid after melting in water-bath
Methyl esters, eugenol, mixed liquor and chlorophyll made from step 1 separately take menthol, camphor that ethyl alcohol is added, by above two solution
After mixing evenly plus water, it pours into the vial of slush moulding and cleaning, drying, is packed into valve and compresses, be pressed into F with pressure tank method12, shake
It is even to obtain the final product.
Further requirement of the present invention protects a kind of essential oil in preparation treatment and/or prevention mosquito repellent, antipruritic, antibacterial medicines
Using.
Further requirement of the present invention protects a kind of essential oil preparing the application in treatment and/or prevention acne drug.
The present invention has the following advantages that：
(1) essential oil of the present invention uses safe, and easily controllable product quality is easy to clinical application；
(2) essential oil of the present invention has good repelling effect, in the experiment of mouse bite by mosquitos, at essential oil 3 of the present invention
Side is better than positive controls (essential wind oil) to the effect of walking quickly and keeping away of mosquito, to be also longer than sun to the effective protecting time of bite by mosquitos
Property control group, shows that essential oil of the present invention is better than positive controls to the avoidance effect of bite by mosquitos；
(3) essential oil of the present invention has good itching-relieving action, and in the experiment of mouse skin itch, essential oil of the present invention is antipruritic
Act on obvious (P<0.01), the more significant (P of the itching-relieving action of positive controls<0.05), show that essential oil of the present invention mitigates mouse scabies
The effect itched is better than positive controls；
(4) essential oil of the present invention has good bacteriostasis, in vitro in bacteriostatic experiment, to staphylococcus aureus, table
Skin staphylococcus, propionibacterium acnes, Escherichia coli, typhoid bacillus and Candida albicans have good bacteriostatic activity, especially
It is to lead acnegenic pathogenic bacteria also to staphylococcus aureus, staphylococcus epidermis and 3 kinds of propionibacterium acnes to have good suppression
Bacterium activity；
(5) essential oil of the present invention is in the experiment to the experimental acne of rabbit ear, the visible change of the entire flap thickness of essential oil of the present invention
Thin, pliability increased, and local follicular orifice bicker suppository acne are reduced, and papule flattens reduction；Epidermal thickness is substantially reduced, but
Still see that follicular orifice reduces, it is common less than thering is loose angling substance to fill, have no that infundibulum of hair follicle expands, dermal inflammation is thin in section
Born of the same parents' infiltration is also reduced；And positive controls are similar to model group, positive controls are similar to model control group, cutaneous lesions
It is not improved；Local organization thickens obviously, is hardened, and follicular orifice has black keratotic plug, and epidermis thickens, and follicular orifice expansion, hair follicle has
Angling object.
4, specific embodiment
The specific embodiment of form by the following examples makees further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
The essential oil prescription of the present invention of embodiment 1
Prescription 1：Menthol 10%, gaultherolin 15%, camphor 0.8%, eucalyptus oil 1%, eugenol 1.2%, acetic acid are fragrant
Thatch ester 2%, phenethyl acetate 7%, citronellol 10%, geraniol 40%, citral 4%, rose oxide 2%, geranium oil 3% are different
Methylionone 4%；
Prescription 2：Menthol 20%, gaultherolin 8%, camphor 2%, eucalyptus oil 0.5%, eugenol 0.5%, acetic acid lemongrass
Ester 3%, phenethyl acetate 5%, citronellol 15%, geraniol 35%, citral 2%, rose oxide 4%, geranium oil 1%, different first
Base irisone 2%；
Prescription 3：Menthol 16%, gaultherolin 13%, camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, acetic acid
Citronellyl acrylate 2.5%, phenethyl acetate 6%, citronellol 14%, geraniol 33%, citral 3%, rose oxide 3%, geranium oil
2%, isomethylionone 3%.
The preparation of the essential oil of the present invention of embodiment 2
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and control mixing speed is 30 revs/min, and mixing time is 2 hours,
Stirring stands 48 hours after stopping, inspection by sampling, is filtered after qualified with 150 mesh, obtained mixed liquor is spare；
Step 2：Menthol, camphor are taken, addition liquid paraffin is appropriate, adds eucalyptus oil, gaultherolin, eugenol, step
Mixed liquor made from rapid 1 and appropriate chlorophyll, liquid paraffin, which is added, makes into 1000g, mixes, and stands 24 hours, takes clarified solution, point
Dress to get.
The preparation of the essential oil aerosol of the present invention of embodiment 3
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and control mixing speed is 30 revs/min, and mixing time is 2 hours,
Stirring stands 48 hours after stopping, inspection by sampling, is filtered after qualified with 150 mesh, obtained mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerol are set and are poured into eucalyptus oil, salicylic acid after melting in water-bath
Methyl esters, eugenol, mixed liquor and appropriate chlorophyll made from step 1 separately take menthol, camphor that appropriate amount of ethanol is added, will be above-mentioned
Two kinds of solution add water after mixing evenly, pour into the vial of slush moulding and cleaning, drying, are packed into valve and compress, with pressure tank method pressure
Enter F12, shake up to obtain the final product.
The essential oil mosquito-repelling function of the present invention of embodiment 4
Experimental animal：Kunming mouse, half male and half female.
For trying mosquito：Culex quinquefasciatus 90.
Attack experiment：It is put into 90 mosquitoes that do not suck blood on the 2nd~3 captured in confined space and 2 are not smeared
The mouse of any essential oil, record come to stop the mosquito populations fallen in 10 minutes, are that attacks are qualified more than 5, the mouse and
The cage mosquito can be used for walking quickly and keeping away experiment.
Zoopery：This experiment sets blank control group, positive controls (commercially available essential wind oil), and according to embodiment 1
1 essential oil of prescription (hereinafter referred to as 1 group of prescription) of the present invention, 2 essential oil of prescription of the present invention is made in the preparation method of prescription and embodiment 2
(hereinafter referred to as 2 groups of prescription), 3 essential oil of prescription of the present invention (hereinafter referred to as 3 groups of prescription).By positive controls, prescription 1,2 and of prescription
Prescription 3 is applied to the back of mice handled well, 2 mouse of every group of smearing.It is marked with the marking pen of different colors.8 are applied
The mouse and 2 mouse for not smearing any essential oil for having smeared different prescriptions are all put into the confined space equipped with 90 mosquitoes, and 2
People observes the mosquito populations stopped with every mouse and record respectively, records data as unit of hour, 2 people is taken to record data
Average, altogether observation, record 6 hours.
Effective protecting time calculation method：It is protected since applying essential oil to the interval time for having the 1st mosquito bite to be effective
Protect the time
Effective Vate of Protection (%)=(control group mosquito bite number-prescription group mosquito bite number)/control group mosquito bite number
× 100%
Experimental result：It can be seen that walk quickly and keep away rate increase with time integrally on a declining curve by 1 result of table, i.e. prescription group essential oil
Effect of walking quickly and keeping away reduce increase with time.Walking quickly and keeping away effect is：3 groups of prescription>2 groups of prescription>1 group of prescription>Positive controls, it is positive
Control group, 1 group of prescription, 2 groups of prescription and 3 groups of prescription are respectively 2h, 4h, 5h, 5h to the effective protecting time of bite by mosquitos.Show
Essential oil of the present invention is better than positive controls to the avoidance effect of bite by mosquitos.
Avoidance effect of the essential oil of the present invention of table 1 to bite by mosquitos
Influence of the essential oil of the present invention of embodiment 5 to mouse skin itch
Experimental animal：Mouse, regular grade, 25~28g of weight, female.
Experimental method：Mouse 50 is only randomly divided into model control group, positive controls (commercially available essential wind oil), according to implementation
1 essential oil of prescription (hereinafter referred to as 1 group of prescription) of the present invention, prescription of the present invention 2 is made in the preparation method of the prescription of example 1 and embodiment 2
Essential oil (hereinafter referred to as 2 groups of prescription), 3 essential oil of prescription of the present invention (hereinafter referred to as 3 groups of prescription), every group 10.2d uses de- before testing
Back of mice is lost hair or feathers in hair agent, and depilation area is about 9cm2, then medicaments uniformity is embrocated in hair removal section, model control group respectively
Same amount of normal saline is wiped, is applied twice a day, totally 5 times.It is right to each group mouse tail vein injection 0.025% after last coating 30min
Revolve sugared acid anhydride -40.With mouse fore paw itch head, after grab itch trunk, each position of the whole body that bites is as itch feature.It observes and records
Itch number in the time (latent time) scratched for the first time and 30min.
Statistical procedures：Experimental result withIt indicates, P < 0.05 indicates there is significant difference, and P < 0.01 indicates tool
There is extremely significant sex differernce.
Experimental result：The following table 3 the result shows that, essential oil of the present invention have the function of mitigate mouse itch.1 group of prescription, prescription 2
Group and the obvious (P of 3 groups of itching-relieving actions of prescription<0.01), the more significant (P of the itching-relieving action of positive controls<0.05).Essential oil of the present invention
The effect for mitigating mouse itch is better than positive controls.
Itching-relieving action of the essential oil of the present invention of table 2 to mouse skin itch
Compared with model control group,*P<0.05,**P<0.01
The bacteriostasis of the essential oil of the present invention of embodiment 6
For trying strain：Following Clinical isolation is bought in public institution
Gram positive bacteria：Staphylococcus aureus, streptococcus pneumonia, propionibacterium acnes；Gram-negative bacteria：Large intestine bar
Bacterium, haemophilus influenzae.
Test sample：Prescription 1, prescription 2, prescription 3, essential wind oil：It is commercially available.
Experimental method：Agar dilution, reference《Pharmacological test procedures》P1659-1660, People's Health Publisher are main
It compiles：Xu Shuyun etc., release：The 1st edition the 3rd edition the 5th printing January in 2002 of nineteen eighty-two August.
Experimental result and conclusion：
3 present composition of table is to the antibacterial activity for being clinically separated bacterium
By 3 experimental result of table as it can be seen that present composition prescription 1, prescription 2, prescription 3 are to clinically Gram-positive and yin
Property and the representative strain of fungi have a good antibacterial activity, especially comparison essential wind oil is strong or quite.Above-mentioned experimental result table
Bright, the immediate prior art of the present composition is compared, and effect is more excellent, has the advantages that antibacterial activity is high.
Therapeutic effect of 7 present composition of embodiment to the experimental acne of rabbit ear
Experimental animal：New Zealand White Rabbit 24, if blank control group, model group, positive controls (commercially available essential wind oil) and
3 groups of prescription.
Experimental method：Blank control group does not apply any drug, remaining 24 rabbit, in left and right ear medial surface syrinx opening
2cm × 2cm range, it is daily to apply coal tar 1 time, each 0.5ml, continuous 2 weeks.24 rabbit are randomly divided into 4 groups, respectively mould
Type control group (part apply outside excipient, 2 times/d), positive controls (commercially available essential wind oil, d times/d), 1 group of prescription, 2 groups of prescription and
3 groups of prescription (2 times/d), continuous use 2 weeks.Daily in addition to administration, the variation of skin at local administration should be visually observed, ear is thick
Whether there is or not black keratotic plugs etc. for thin, hardness, degree of roughness, follicular orifice.After the last administration for 24 hours, drug is washed away with warm water, removes every rabbit ear
Piece essentially identical skin part, after 10% formalin solution is fixed, after HE dyeing, light microscopic observation Histopathology changes
Become, and carries out microscope observation histological change.
Histology criterion：
" 0 " is no acne；
"+" is the visible a small amount of fine and close angling substance in infundibulum of hair follicle portion；
" ++ " is the visible moderate densification angling substance in infundibulum of hair follicle portion, and extends to sebaceous glands；
" +++ " is that expansion hair follicle has extensive angling substance, similar to mankind's open comedones.
Experimental result：
(1) naked eyes：Normal rabbit ear is poor, soft, has good light transmittance, it is seen that clearly capillary network, rabbit ear are opened
The hair follicle and very thin hair of visible proper alignment at mouthful；During applying coal tar, local organization thickens obviously model group, becomes
Firmly, follicular orifice has black keratotic plug, at the blackhead village, when opening the coal tar scab for applying thickness, it is seen that and hair follicle keratotic plug is ridden in attachment,
The follicular orifice that lower visible open increases, protuberance are in papulosquamous；3 groups of prescription entire flap thickness are visible thinning, and pliability is increased
Add, local follicular orifice bicker suppository acne are reduced, and papule flattens reduction；Positive controls are similar to model control group, skin disease
Change is not improved；
(2) tissue：Normal rabbit ear epidermis is relatively thin, one layer of particle group, about layer 2-4 acantholysis cell, it is seen that hair follicle, corium, table
Skin has a common boundary clear；Model group epidermis thickens, and hyperkeratinization occurs, and stratum spinosum epidermidis is plump, and hair follicle sebum hylperadenosis is obvious, it is seen that angle
Compound matter, infundibulum of hair follicle portion is full of angling substance and is expanded into gyalectiform；The obvious telangiectasis of dermis, diffuses and is dispersed in inflammation
Property cellular infiltration, there are also free inflammatory cells；3 groups of epidermal thicknesses of prescription are substantially reduced, but still see that follicular orifice reduces, in section
It is common less than thering is loose angling substance to fill, have no that infundibulum of hair follicle expands, dermal inflammation cellular infiltration is also reduced；It is positive
Control group is similar to model group, and local organization thickens obviously, is hardened, and follicular orifice has black keratotic plug, and epidermis thickens, and follicular orifice expands
, hair follicle has angling object；It is shown in Table 4.
4 present composition of table is to the pathological change after the treatment of rabbit ear experimental Acne Model
Claims (3)
1. a kind of essential oil, which is characterized in that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 16%, salicylic acid
Methyl esters 13%, camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, citronellyl acetate 2.5%, phenethyl acetate 6%, citronellol
14%, geraniol 33%, citral 3%, rose oxide 3%, geranium oil 2%, isomethylionone 3%.
2. essential oil as described in claim 1, which is characterized in that the essential oil is preparing treatment and/or prevention mosquito repellent, stopping
Itch, the application in antibacterial medicines.
3. essential oil as described in claim 1, which is characterized in that the essential oil is in preparation treatment and/or prevention acne drug
In application.
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| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
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| CN102512609A (en) * | 2011-12-27 | 2012-06-27 | 浙江景岳堂药业有限公司 | Essential oil with anti-inflammatory, analgesic, cooling, itching-relieving and mosquito-dispelling functions |
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