CN108117929A - A kind of essential oil and preparation method thereof - Google Patents
A kind of essential oil and preparation method thereof Download PDFInfo
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- CN108117929A CN108117929A CN201711394556.3A CN201711394556A CN108117929A CN 108117929 A CN108117929 A CN 108117929A CN 201711394556 A CN201711394556 A CN 201711394556A CN 108117929 A CN108117929 A CN 108117929A
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- oil
- essential oil
- camphor
- eugenol
- essential
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0003—Compounds of unspecified constitution defined by the chemical reaction for their preparation
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0007—Aliphatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0007—Aliphatic compounds
- C11B9/0015—Aliphatic compounds containing oxygen as the only heteroatom
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0026—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring
- C11B9/0034—Essential oils; Perfumes compounds containing an alicyclic ring not condensed with another ring the ring containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0061—Essential oils; Perfumes compounds containing a six-membered aromatic ring not condensed with another ring
Abstract
The present invention provides a kind of essential oil, which can be used for preparing treatment and/prevention mosquito repellent, antipruritic, antibacterial medicines, can be used for preparing treatment and/prevention acne drug.And said composition good effect, it is quality controllable, it is easy to apply.The essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 5~25%, gaultherolin 5~20%, camphor 0.1~5%, eucalyptus oil 0.1~5%, eugenol 0.1~5%, citronellyl acetate 1~5%, phenethyl acetate 2~10%, citronellol 5~20%, geraniol 20~50%, citral 1~5%, rose oxide 1~5%, geranium oil 1~5%, isomethylionone 1~5%.
Description
1st, technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of essential oil and preparation method thereof.
2nd, background technology
Essential wind oil is configured by natural drug and aromatic essential oil, mainly contains menthol, gaultherolin, eucalyptus
The ingredients such as leaf oil alcohol, camphor, it is not only orally available, but also can external application, there is resuscitation with aromatics, clearing away heat to and alleviating pain, dispelling wind and arresting itching, be occupy
The standing health products of family's travelling.
Essential wind oil is now embodied in Traditional Chinese medicine historical preparation the 9th, and essential wind oil consists of the following compositions：Menthol 320g, bigcatkin willow
Sour methyl esters 260g, camphor 30g, eucalyptus oil 30g and eugenol 30g.Preparation method is：Menthol, camphor are taken, liquid paraffin is added in and fits
Amount, adds eucalyptus oil, gaultherolin, eugenol, essence 100g, appropriate chlorophyll, and liquid paraffin is added to make into 1000g, mixing,
Stand 24 it is small when, take clarified solution, dispense to get.This product contain menthol, gaultherolin should be labelled amount 90.0~
110.0%；The 85.0%~115.0% of labelled amount is should be containing camphor；The 90.0~120.0% of labelled amount are should be containing eugenol；
This product is containing eucalyptus oil based on olein, must not be less than 21mg.Refrigerant, antipruritic with anti-inflammatory, analgesia, wind-dispelling effect is felt for catching cold
Emit caused headache, it is dizzy and as caused by arthralgia, toothache, abdomen distending pain and bite by mosquitos, carsickness etc. it is uncomfortable.External application,
It embrocates in affected part.Oral, one time 4~6 drop, children cut down according to the circumstance or follow the doctor's advice.
The novel clinical use Chinese Medicine guides of Chen Jie essential wind oil, 2012,10 (21):75. describe facing for essential wind oil
Bed new application, introduces new opplication of the essential wind oil in the work such as clinical Medicine and Surgery research and daily nursing in terms of eight.Wind oil
Essence is notable in treatment abdominal pain, infantile hyperpyrexia, abscess of throat, superficial gastritis and antibacterial etc. effect.
The such as Qu Ye essential wind oil observes Chinese Journal of Health Laboratory Technology, 2003,2 (13) to the bacteriostasis of eight kinds of bacteriums:97.
It is strong and weak to determine essential wind oil eight kinds of bacterium standard column fungistatic effects common to laboratory.Experimental result is with essential wind oil concentration
It reduces, bacteriostasis accordingly weakens.If essential wind oil concentration when using on tablet completely without bacterial growth is as minimum antibacterial
Concentration, then when dilution factor is 1：When 20, essential wind oil has apparent bacteriostasis to eight kinds of experimental strains, is given birth to without bacterium
It is long, when dilution factor is 1：When 40, there is complete inhibition effect to staphylococcus aureus, staphylococcus albus, γ-streptococcus, it is right
Escherichia coli etc. cannot completely inhibit, so 1：20 can be used as essential wind oil to G such as Escherichia coli-The minimum inhibitory concentration of bacterium,
1：40 can be used as essential wind oil to G such as staphylococcus aureus, staphylococcus albus, γ-streptococcus+Bacterium it is minimum antibacterial dense
Degree.When increasing due to essential wind oil extension rate, to G such as Escherichia coli, typhoid bacilluses-The fungistatic effect of bacterium substantially weakens, to Portugal
The G such as grape coccus+The fungistatic effect of bacterium weakens slowly, illustrates that essential wind oil is apparent to the bacteriostasis of the gram positive bacterias such as staphylococcus
It is better than the gram-negative bacterias such as Escherichia coli.
Chinese invention patent application CN02113307.7 discloses a kind of solid essential balm, contains following component (weight)：
Menthol 5~35%, wintergreen 5~30%, camphor 0.5~20%, eucalyptus oil 0.5~5%, caryophyllus oil 0.5~5%, solid
Oil components 20~80%.
Chinese invention patent application CN02159441.4 discloses a kind of essential wind oil spray delivery composition, including thin
The liquid that lotus brain, gaultherolin, camphor, eucalyptus oil, eugenol, additives and pharmaceutically useful solvent are configured to.
Chinese invention patent application CN201110459255.0 discloses a kind of with anti-inflammatory analgesic, refrigerant antipruritic and mosquito repellent
The essential oil of function, formula components by menthol, wintergreen, camphorated oil, eucalyptus oil, basil oil, citronella oil, patchouli oil,
The compositions such as oil of bay, paraffin oil, flavoring agent and colorant.
3rd, the content of the invention
The object of the present invention is to provide a kind of new essential oil, which has better mosquito repellent, antipruritic, fungistatic effect, and
It is treated and/prevention acne drug available for preparing.And the essential oil good effect, it is quality controllable, it is easy to apply.
In order to reach foregoing invention purpose, present invention employs following technical schemes：
The present invention provides a kind of essential oil, the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 5~25%,
Gaultherolin 5~20%, camphor 0.1~5%, eucalyptus oil 0.1~5%, eugenol 0.1~5%, citronellyl acetate 1~5%,
Phenethyl acetate 2~10%, citronellol 5~20%, geraniol 20~50%, citral 1~5%, rose oxide 1~5%, spiceleaf
Oil 1~5%, isomethylionone 1~5%.
Preferably, the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 9~20%, gaultherolin 7~
15%, camphor 0.5~2%, eucalyptus oil 0.5~2%, eugenol 0.5~2%, citronellyl acetate 2~3%, phenethyl acetate 5~
7%, citronellol 10~15%, geraniol 30~40%, citral 2~4%, rose oxide 2~4%, geranium oil 1~3%, different first
Base irisone 2~4%.
It is furthermore preferred that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 16%, gaultherolin 13%,
Camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, citronellyl acetate 2.5%, phenethyl acetate 6%, citronellol 14%, spiceleaf
Alcohol 33%, citral 3%, rose oxide 3%, geranium oil 2%, isomethylionone 3%.
It is this that further requirement of the present invention protects a kind of essential oil that can be applied to needs in a manner of oral and parenteral administration etc.
The patient for the treatment of.
During for taking orally, conventional solid pharmaceutical preparation, such as tablet, capsule, pill, granule can be made into；It may be made as
Oral liquid, such as oral solution, oral suspensions, syrup.Tablet means drug and suitable auxiliary materials and mixing pressure
Make the disc-shaped that forms or the solid pharmaceutical preparation of special-shaped sheet, based on oral ordinary tablet, separately have lozenge, sublingual tablet, mouth paster,
Chewable tablets, dispersible tablet, fuse, effervescent tablet, sustained release tablets, controlled release tablet and enteric coatel tablets etc..Capsule means drug or added with auxiliary material
Capsules or the solid pharmaceutical preparation being sealed in soft capsule material are filled in, according to its dissolving and release characteristics, hard shell capsules can be divided into
(being commonly referred to as capsule), soft capsule (capsule and pill), spansule, controlled release capsule and capsulae enterosolubilis etc..Pill mean drug with it is suitable
Auxiliary material uniformly mixes, with spherical made of proper method or near-spherical solid pharmaceutical preparation, including dripping pill, sugar-pill, piller etc..Granule
It means that the dry granular formulation with certain particle size is made in drug and suitable auxiliary material, soluble particles can be divided into and (be commonly referred to as
Grain), mix suspension grain, effervescence granular, enteric coated particles, slow-releasing granules and controlled release granule etc..Oral solution means that drug is dissolved in
It is made in suitable solvent for oral supernatant liquid preparation.Oral suspensions means insoluble solid drug, is dispersed in liquid Jie
In matter, it is made for oral suspension liquid preparation, also including dry suspensoid agent or dense suspension.Syrup is meant containing the dense of drug
Aqueous sucrose solution.
When oral formulations are made, suitable filler, adhesive, disintegrant, lubricant etc. can be added in.Common filler
Including starch, Icing Sugar, calcium phosphate, two water object of calcium sulfate, dextrin, microcrystalline cellulose, lactose, pregelatinized starch, mannitol etc.；Often
With adhesive include sodium carboxymethylcellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose,
Hydroxypropyl methylcellulose, gelling starch etc.；Common disintegrant includes dried starch, crospovidone, croscarmellose sodium, carboxylic
Methyl starch sodium, low-substituted hydroxypropyl cellulose etc.；Conventional lubricants include magnesium stearate, talcum powder, lauryl sodium sulfate,
Superfine silica gel powder etc..
Ointment, cream, gelling agent, powder, rubber ointment, Babu cream can also be made in pharmaceutical composition of the present invention
The external solids such as agent, patch, semisolid preparation；The liquid preparation for external application such as lotion, liniment, plastics；Aerosol.Preferred lotion,
Liniment, aerosol.Ointment means that drug is mixed and made into uniform semisolid external preparation with oil or water-soluble base.Breast
Paste means that drug is dissolved or dispersed in emulsion-type matrix and forms uniform semisolid external preparation.Gelling agent mean drug with
The glop or semisolid preparation of homogeneous, suspension or emulsion-type is made in the auxiliary material that gel can be formed.Powder mean drug or with
Dry powdered preparation of the suitable auxiliary material through crushing, being uniformly mixed, is divided into oral powder and topical powder.Rubber paste
After agent refers to the matrix mixing such as drug and rubber, manufactured emplastrum on back lining materials is coated on.Babu plaster refer to drug with
After hydrophilic matrix mixing, manufactured emplastrum on back lining materials is coated on.Patch means Pasting on the skin, and drug can produce
A kind of raw systemic or local action laminar preparation；Said preparation has back sheet, the drug depot for having (or nothing) release-controlled film, sticks
Mixture layer and the protective layer for needing removing before use；Available for intact skin surface, it can also be used to have illness or incomplete skin
Surface.Lotion means solution, lotion, the suspension of drug containing, for cleaning or smearing the preparation of no damaged skin.Liniment is meant
Drug ethyl alcohol, oil or solution, lotion or suspension made of suitable solvent, the liquid system rubbed for no damaged skin
Agent.Paint means aqueous or oily solution, lotion, the suspension of drug containing, dips or is applied to for gauze before use or cotton
Skin or oral cavity and the liquid preparation of throat's mucous membrane.Plastics means that drug is dissolved in organic solvent containing filmogen, and painting is put on the skin
The liquid preparation for external application of film is formed behind affected part.
When external solid, semisolid preparation is made in pharmaceutical composition of the present invention, the common oleaginous base of ointment has：It is all
Intellectual circle, paraffin, liquid paraffin, silicone oil, beeswax, stearic acid etc.；Water-soluble base has polyethylene glycol；Emulsion-type matrix is common to be had
Soda soap, triethanolamine soaps, fatty alcohol sulphuric acid (ester) sodium class, poly- mountain plough ester, lanolin, monoglyceride, fatty alcohol etc.；If necessary
Moisturizer, preservative, antioxidant or transdermal enhancer can be added in.The water-soluble base of gelling agent generally has water, glycerine or the third two
The compositions such as alcohol and cellulose derivative, carbomer and alginate, tragacanth, gelatin, starch；Oil-base gel matrix has liquid
Paraffin is formed with polyoxyethylene or fat oil with colloidal silicon or aluminium soap, zinc soap；Moisturizer, preservative, antioxygen can be added in if necessary
Agent or transdermal enhancer.Rubber ointment often has rubber, thermoplastic rubber, rosin, rosin derivative, vaseline, sheep with matrix
Hair fat and zinc oxide etc..The common matrix of Babu plaster has Sodium Polyacrylate, sodium carboxymethylcellulose, gelatin, glycerine and micro mist
Silica gel etc..Patch often has ethylene-vinyl acetate copolymer, silicon rubber and polyethylene glycol etc. with matrix.Emplastrum (rubber ointment,
Babu plaster, patch) common back lining materials have cotton, non-woven fabrics, paper etc.；Common lid lining material has the separate paper, plastics thin
Film, aluminium foil-polyethylene composite film, stearic gauze etc..Liquid preparation for external application such as lotion, liniment, plastics, common solvent have
Water, ethyl alcohol, glycerine, vegetable oil, liquid paraffin etc.；Common filmogen has polyvinyl alcohol, polyvinylpyrrolidone, acrylic acid
Resinae etc.；Plasticizer has glycerine, propylene glycol, dibutyl phthalate etc.；It is suitable to skin or mucous membrane to add if necessary
Non-stimulated additives.It is resistance to speciality valve system that the aerosol refers to that fine drug powder is mounted in suitable propellant
In the tight envelope container of pressure, dosage form that when use sprays content in fine mist or other forms by the pressure of propellant is described
Propellant be dichlorodifluoromethan hydro carbons.
The preparation method of the further requirement of the present invention protection essential oil is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and stirring is stood after stopping, inspection by sampling, is filtered, is obtained after qualified
Mixed liquor is spare；
Step 2：Menthol, camphor are taken, liquid paraffin is added in, adds eucalyptus oil, gaultherolin, eugenol, step 1 and make
Mixed liquor and chlorophyll, add in liquid paraffin, mixing, stand, take clarified solution, dispense to get.
Preferably, the preparation method of essential oil of the present invention is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and controls mixing speed as 30 revs/min, when mixing time is 2 small,
When standing 48 is small after stirring stops, inspection by sampling is filtered after qualified with 150 mesh, and obtained mixed liquor is spare；
Step 2：Menthol, camphor are taken, liquid paraffin is added in, adds eucalyptus oil, gaultherolin, eugenol, step 1 and make
Mixed liquor and chlorophyll, adding in liquid paraffin makes into 1000g, mixing, stand 24 it is small when, take clarified solution, dispense to get.
The preparation method of the further requirement of the present invention protection essential oil aerosol is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and stirring stands inspection by sampling after stopping, filtering, obtain after qualified
Mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerine are put and are poured into eucalyptus oil, salicylic acid after being melted in water-bath
Methyl esters, eugenol, mixed liquor and chlorophyll made from step 1 separately take menthol, camphor to add in ethyl alcohol, by above two solution
Hou Jiashui is stirred evenly, is poured into the vial of slush moulding and cleaning, drying, valve is packed into and compresses, with pressure tank method press-in F12, shake
It is even to obtain the final product.
Preferably, the preparation method of essential oil aerosol of the present invention is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and controls mixing speed as 30 revs/min, when mixing time is 2 small,
When standing 48 is small after stirring stops, inspection by sampling is filtered after qualified with 150 mesh, and obtained mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerine are put and are poured into eucalyptus oil, salicylic acid after being melted in water-bath
Methyl esters, eugenol, mixed liquor and chlorophyll made from step 1 separately take menthol, camphor to add in ethyl alcohol, by above two solution
Hou Jiashui is stirred evenly, is poured into the vial of slush moulding and cleaning, drying, valve is packed into and compresses, with pressure tank method press-in F12, shake
It is even to obtain the final product.
Further requirement of the present invention protects a kind of essential oil in treatment and/or prevention mosquito repellent, antipruritic, antibacterial medicines is prepared
Using.
Further requirement of the present invention protects a kind of application of essential oil in treatment and/or prevention acne drug is prepared.
The present invention has the following advantages：
(1) essential oil of the present invention is safe to use, and easily controllable product quality is easy to clinical practice；
(2) essential oil of the present invention has good repelling effect, in the experiment of mouse bite by mosquitos, at essential oil 3 of the present invention
Side is better than positive controls (essential wind oil) to the effect of walking quickly and keeping away of mosquito, to be also longer than sun to the effective protecting time of bite by mosquitos
Property control group, shows that essential oil of the present invention is better than positive controls to the avoidance effect of bite by mosquitos；
(3) essential oil of the present invention has good itching-relieving action, and in the experiment of mouse skin itch, essential oil of the present invention is antipruritic
Apparent (the P of effect<0.01), the more significant (P of the itching-relieving action of positive controls<0.05), show that essential oil of the present invention mitigates mouse scabies
The effect itched is better than positive controls；
(4) essential oil of the present invention has good bacteriostasis, in vitro in bacteriostatic experiment, to staphylococcus aureus, table
Skin staphylococcus, propionibacterium acnes, Escherichia coli, typhoid bacillus and Candida albicans have good bacteriostatic activity, especially
It is to lead acnegenic pathogenic bacteria to 3 kinds of staphylococcus aureus, staphylococcus epidermis and propionibacterium acnes also to have good suppression
Bacterium activity；
(5) essential oil of the present invention is in the experiment to the experimental acne of rabbit ear, the visible change of the entire flap thickness of essential oil of the present invention
Thin, pliability increased, and local follicular orifice bicker suppository acne are reduced, and papule flattens reduction；Epidermal thickness is substantially reduced, but
Still see that follicular orifice reduces, it is common less than thering is loose angling substance to fill, have no that infundibulum of hair follicle expands, dermal inflammation is thin in section
Born of the same parents' infiltration is also reduced；And positive controls are similar to model group, positive controls are similar to model control group, cutaneous lesions
It is not improved；Local organization thickens substantially, is hardened, and follicular orifice has black keratotic plug, and epidermis thickens, and follicular orifice expansion, hair follicle has
Angling object.
4th, specific embodiment
The specific embodiment of form by the following examples makees further specifically the above of the present invention
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
1 essential oil prescription of the present invention of embodiment
Prescription 1：Menthol 10%, gaultherolin 15%, camphor 0.8%, eucalyptus oil 1%, eugenol 1.2%, acetic acid are fragrant
Thatch ester 2%, phenethyl acetate 7%, citronellol 10%, geraniol 40%, citral 4%, rose oxide 2%, geranium oil 3% are different
Methylionone 4%；
Prescription 2：Menthol 20%, gaultherolin 8%, camphor 2%, eucalyptus oil 0.5%, eugenol 0.5%, acetic acid lemongrass
Ester 3%, phenethyl acetate 5%, citronellol 15%, geraniol 35%, citral 2%, rose oxide 4%, geranium oil 1%, different first
Base irisone 2%；
Prescription 3：Menthol 16%, gaultherolin 13%, camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, acetic acid
Citronellyl acrylate 2.5%, phenethyl acetate 6%, citronellol 14%, geraniol 33%, citral 3%, rose oxide 3%, geranium oil
2%, isomethylionone 3%.
The preparation of 2 essential oil of the present invention of embodiment
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and controls mixing speed as 30 revs/min, when mixing time is 2 small,
When standing 48 is small after stirring stops, inspection by sampling is filtered after qualified with 150 mesh, and obtained mixed liquor is spare；
Step 2：Menthol, camphor are taken, addition liquid paraffin is appropriate, adds eucalyptus oil, gaultherolin, eugenol, step
Mixed liquor made from rapid 1 and appropriate chlorophyll, adding in liquid paraffin makes into 1000g, and mixing when standing 24 is small, takes clarified solution, point
Dress to get.
The preparation of 3 essential oil aerosol of the present invention of embodiment
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and
Isomethylionone is added in agitated kettle, is mixed, and controls mixing speed as 30 revs/min, when mixing time is 2 small,
When standing 48 is small after stirring stops, inspection by sampling is filtered after qualified with 150 mesh, and obtained mixed liquor is spare；
Step 2：Sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerine are put and are poured into eucalyptus oil, salicylic acid after being melted in water-bath
Methyl esters, eugenol, mixed liquor and appropriate chlorophyll made from step 1 separately take menthol, camphor to add in appropriate amount of ethanol, will be above-mentioned
Two kinds of solution stir evenly Hou Jiashui, pour into the vial of slush moulding and cleaning, drying, are packed into valve and compress, with pressure tank method pressure
Enter F12, shake up to obtain the final product.
4 essential oil mosquito-repelling function of the present invention of embodiment
Experimental animal：Kunming mouse, half male and half female.
For trying mosquito：Culex quinquefasciatus 90.
Attack is tested：90 mosquitoes do not sucked blood on the 2nd~3 captured are put into confined space and 2 are not smeared
The mouse of any essential oil, record come to stop the mosquito populations fallen in 10 minutes, are that attack is qualified more than 5, the mouse and
The cage mosquito can be used for walking quickly and keeping away experiment.
Zoopery：This experiment sets blank control group, positive controls (commercially available essential wind oil) and according to embodiment 1
1 essential oil of prescription of the present invention (hereinafter referred to as 1 group of prescription), 2 essential oil of prescription of the present invention is made in the preparation method of prescription and embodiment 2
(hereinafter referred to as 2 groups of prescription), 3 essential oil of prescription of the present invention (hereinafter referred to as 3 groups of prescription).By positive controls, prescription 1,2 and of prescription
Prescription 3 is applied to the mouse back handled well, 2 mouse of every group of smearing.It is marked with the marking pen of different colors.By 8 paintings
The mouse and 2 mouse for not smearing any essential oil for having smeared different prescriptions are all put into the confined space equipped with 90 mosquitoes, and 2
People observes the mosquito populations stopped with every mouse and record respectively, and record data take 2 people to record data in units of hour
Average, altogether observation, record 6 it is small when.
Effective protecting time computational methods：It is protected since being applied essential oil to the interval time for having the 1st mosquito bite to be effective
Protect the time
Effective Vate of Protection (%)=(control group mosquito bite number-prescription group mosquito bite number)/control group mosquito bite number
× 100%
Experimental result：Can be seen that by 1 result of table increases that walk quickly and keep away rate integrally on a declining curve at any time, i.e. prescription group essential oil
Effect of walking quickly and keeping away increase at any time and reduce.Walking quickly and keeping away effect is：3 groups of prescription>2 groups of prescription>1 group of prescription>Positive controls, it is positive
3 groups of control group, 1 group of prescription, 2 groups of prescription and prescription are respectively 2h, 4h, 5h, 5h to the effective protecting time of bite by mosquitos.Show
Essential oil of the present invention is better than positive controls to the avoidance effect of bite by mosquitos.
1 essential oil of the present invention of table is to the avoidance effect of bite by mosquitos
Influence of 5 essential oil of the present invention of embodiment to mouse skin itch
Experimental animal：Mouse, regular grade, 25~28g of weight, female.
Experimental method：Mouse 50 is only randomly divided into model control group, positive controls (commercially available essential wind oil), according to implementation
1 essential oil of prescription of the present invention (hereinafter referred to as 1 group of prescription), prescription of the present invention 2 is made in the prescription of example 1 and the preparation method of embodiment 2
Essential oil (hereinafter referred to as 2 groups of prescription), 3 essential oil of prescription of the present invention (hereinafter referred to as 3 groups of prescription), every group 10.2d uses de- before experiment
Mouse back is lost hair or feathers in hair agent, and depilation area is about 9cm2, then medicaments uniformity is embrocated in hair removal section, model control group respectively
Normal saline is wiped, is applied twice a day, totally 5 times.It is right to each group mouse tail vein injection 0.025% after last coating 30min
The sugared acid anhydride -40 of rotation.With mouse fore paw itch head, after grab itch trunk, each position of the whole body that bites is as itch feature.It observes and records
Itch number in the time (latent time) scratched for the first time and 30min.
Statistical procedures：Experimental result withIt represents, P ＜ 0.05 represent there is significant difference, and P ＜ 0.01 represent tool
There is pole significant difference.
Experimental result：The following table 3 the result shows that, essential oil of the present invention play an important role of mitigate mouse itch.1 group of prescription, prescription 2
Group and the apparent (P of 3 groups of itching-relieving actions of prescription<0.01), the more significant (P of the itching-relieving action of positive controls<0.05).Essential oil of the present invention
The effect for mitigating mouse itch is better than positive controls.
2 essential oil of the present invention of table is to the itching-relieving action of mouse skin itch
Compared with model control group,*P<0.05,**P<0.01
The bacteriostasis of 6 essential oil of the present invention of embodiment
For trying strain：Following Clinical isolation is bought in public institution
Gram positive bacteria：Staphylococcus aureus, streptococcus pneumonia, propionibacterium acnes；Gram-negative bacteria：Large intestine bar
Bacterium, haemophilus influenzae.
Test sample：Prescription 1, prescription 2, prescription 3, essential wind oil：It is purchased in market.
Experimental method：Agar dilution, reference《Pharmacological test procedures》P1659-1660, People's Health Publisher are main
It compiles：Xu Shuyun etc., release：The 1st edition the 3rd edition the 5th printing January in 2002 of nineteen eighty-two August.
Experimental result and conclusion：
3 present composition of table is to being clinically separated the antibacterial activity of bacterium
By 3 experimental result of table as it can be seen that present composition prescription 1, prescription 2, prescription 3 are to clinically Gram-positive and the moon
Property and the representative strain of fungi have good antibacterial activity, it is strong or quite especially to compare essential wind oil.Above-mentioned experimental result table
Bright, the immediate prior art of the present composition is compared, and effect is more excellent, has the advantages that antibacterial activity is high.
Therapeutic effect of 7 present composition of embodiment to the experimental acne of rabbit ear
Experimental animal：New Zealand White Rabbit 24, if blank control group, model group, positive controls (commercially available essential wind oil) and
3 groups of prescription.
Experimental method：Blank control group does not apply any drug, remaining 24 rabbit, in left and right ear medial surface syrinx opening
2cm × 2cm scopes, it is daily to apply coal tar 1 time, each 0.5ml, continuous 2 weeks.24 rabbit are randomly divided into 4 groups, are respectively mould
Type control group (local apply outside excipient, 2 times/d), positive controls (commercially available essential wind oil, d times/d), 1 group of prescription, 2 groups of prescription and
3 groups of prescription (2 times/d), continuous use 2 weeks.Daily in addition to administration, the variation of skin at local administration should be visually observed, ear is thick
Thin, hardness, degree of roughness, follicular orifice whether there is black keratotic plug etc..After the last administration for 24 hours, drug is washed away with warm water, removes every rabbit ear
Piece essentially identical skin part, after 10% formalin solution is fixed, after HE dyeing, light Microscopic observation Histopathology changes
Become, and carry out the variation of microscope tissues observed.
Histology criterion：
" 0 " is no acne；
"+" is the visible a small amount of fine and close angling substance in infundibulum of hair follicle portion；
" ++ " is the visible moderate densification angling substance in infundibulum of hair follicle portion, and extends to sebaceous glands；
" +++ " has extensive angling substance for expansion hair follicle, similar to mankind's open comedones.
Experimental result：
(1) naked eyes：Normal rabbit ear is belittled, is soft, has good light transmittance, it is seen that clearly capillary network, rabbit ear are opened
The hair follicle of visible proper alignment and very thin hair at mouthful；During coal tar is applied, local organization thickens substantially model group, becomes
Firmly, follicular orifice has black keratotic plug, into the blackhead village, opens when applying thick coal tar scab, it is seen that and hair follicle keratotic plug is ridden in attachment,
The lower increased follicular orifice of visible open, protuberance is in papulosquamous；The entire flap thickness of 3 groups of prescription is visible thinning, and pliability is increased
Add, local follicular orifice bicker suppository acne are reduced, and papule flattens reduction；Positive controls are similar to model control group, skin disease
Change is not improved；
(2) tissue：Normal rabbit ear epidermis is relatively thin, one layer of particle group, about layer 2-4 acantholysis cell, it is seen that hair follicle, corium, table
Skin has a common boundary clear；Model group epidermis thickens, and hyperkeratinization occurs, and stratum spinosum epidermidis is plump, and hair follicle sebum hylperadenosis is apparent, it is seen that angle
Compound matter, infundibulum of hair follicle portion is full of angling substance and is expanded into gyalectiform；The apparent telangiectasis of dermis, diffuses and is dispersed in inflammation
Property cellular infiltration, also free inflammatory cell；3 groups of epidermal thicknesses of prescription are substantially reduced, but still see that follicular orifice reduces, in section
It is common less than thering is loose angling substance to fill, have no that infundibulum of hair follicle expands, dermal inflammation cellular infiltration is also reduced；It is positive
Control group is similar to model group, and local organization thickens substantially, is hardened, and follicular orifice has black keratotic plug, and epidermis thickens, and follicular orifice expands
, hair follicle has angling object；It is shown in Table 4.
4 present composition of table is to the pathological change after the treatment of rabbit ear experimental Acne Model
Claims (10)
1. a kind of essential oil, which is characterized in that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Menthol 5~25%, bigcatkin willow
Sour methyl esters 5~20%, camphor 0.1~5%, eucalyptus oil 0.1~5%, eugenol 0.1~5%, citronellyl acetate 1~5%, acetic acid
Phenethyl ester 2~10%, citronellol 5~20%, geraniol 20~50%, citral 1~5%, rose oxide 1~5%, geranium oil 1
~5%, isomethylionone 1~5%.
2. essential oil as described in claim 1, which is characterized in that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Peppermint
Brain 9~20%, gaultherolin 7~15%, camphor 0.5~2%, eucalyptus oil 0.5~2%, eugenol 0.5~2%, acetic acid lemongrass
Ester 2~3%, phenethyl acetate 5~7%, citronellol 10~15%, geraniol 30~40%, citral 2~4%, rose oxide 2
~4%, geranium oil 1~3%, isomethylionone 2~4%.
3. essential oil as claimed in claim 2, which is characterized in that the essential oil is made of the bulk pharmaceutical chemicals of following weight：Peppermint
Brain 16%, gaultherolin 13%, camphor 1.5%, eucalyptus oil 1.5%, eugenol 1.5%, citronellyl acetate 2.5%, acetic acid benzene
Ethyl ester 6%, citronellol 14%, geraniol 33%, citral 3%, rose oxide 3%, geranium oil 2%, isomethylionone
3%.
4. prepare essential oil as described in any one of claims 1 to 3 claim, which is characterized in that preparation method is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and different first
Base irisone is added in agitated kettle, is mixed, and stirring is stood after stopping, inspection by sampling, is filtered after qualified, obtained mixing
Liquid is spare；
Step 2：Take menthol, camphor, add in liquid paraffin, add eucalyptus oil, gaultherolin, eugenol, made from step 1
Mixed liquor and chlorophyll, add in liquid paraffin, mixing, stand, take clarified solution, dispense to get.
5. the preparation method of essential oil as claimed in claim 4, which is characterized in that be：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and different first
Base irisone is added in agitated kettle, is mixed, and controls mixing speed as 30 revs/min, when mixing time is 2 small, stirring
When standing 48 is small after stopping, inspection by sampling is filtered after qualified with 150 mesh, and obtained mixed liquor is spare；
Step 2：Take menthol, camphor, add in liquid paraffin, add eucalyptus oil, gaultherolin, eugenol, made from step 1
Mixed liquor and chlorophyll, add in liquid paraffin, mixing, stand 24 it is small when, take clarified solution, dispense to get.
6. a kind of essential oil, which is characterized in that including the essential oil as described in any one of claims 1 to 3 claim and it is a kind of or
A variety of pharmaceutically acceptable auxiliary materials.
7. essential oil as claimed in claim 6, which is characterized in that be liniment, paint or aerosol.
8. essential oil as claimed in claim 7, which is characterized in that the preparation method of aerosol is：
Step 1：Weigh citronellyl acetate, phenethyl acetate, citronellol, geraniol, citral, rose oxide, geranium oil and different first
Base irisone is added in agitated kettle, is mixed, and stirring stands inspection by sampling after stopping, being filtered after qualified, obtained mixing
Liquid is spare；
Step 2：By sodium lauryl sulfate, octadecyl alcolol, lanonol, glycerine put in water-bath melt after be poured into eucalyptus oil, gaultherolin,
Mixed liquor made from eugenol, step 1 and chlorophyll separately take menthol, camphor to add in ethyl alcohol, above two solution are stirred equal
Add water after even, pour into the vial of slush moulding and cleaning, drying, be packed into valve and compress, F is pressed into pressure tank method12, shake up to obtain the final product.
9. the essential oil as described in any one of claims 1 to 3 claim, which is characterized in that the essential oil is preparing treatment
And/or prevention mosquito repellent, antipruritic, in antibacterial medicines application.
10. the essential oil as described in any one of claims 1 to 3 claim, which is characterized in that the essential oil is preparing treatment
And/or the application in prevention acne drug.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908204A (en) * | 2019-03-04 | 2019-06-21 | 广东一力集团制药股份有限公司 | A kind of essential wind oil and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369302A (en) * | 2002-01-28 | 2002-09-18 | 赵子珍 | Solid essential balm |
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN102512609A (en) * | 2011-12-27 | 2012-06-27 | 浙江景岳堂药业有限公司 | Essential oil with anti-inflammatory, analgesic, cooling, itching-relieving and mosquito-dispelling functions |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369302A (en) * | 2002-01-28 | 2002-09-18 | 赵子珍 | Solid essential balm |
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN102512609A (en) * | 2011-12-27 | 2012-06-27 | 浙江景岳堂药业有限公司 | Essential oil with anti-inflammatory, analgesic, cooling, itching-relieving and mosquito-dispelling functions |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908204A (en) * | 2019-03-04 | 2019-06-21 | 广东一力集团制药股份有限公司 | A kind of essential wind oil and its preparation process |
| CN109908204B (en) * | 2019-03-04 | 2021-11-19 | 一力制药股份有限公司 | Essential balm and preparation process thereof |
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| CN108117929B (en) | 2018-11-20 |
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