CN1173729C - Nano aloe and its preparing method and use - Google Patents
Nano aloe and its preparing method and use Download PDFInfo
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- CN1173729C CN1173729C CNB021157340A CN02115734A CN1173729C CN 1173729 C CN1173729 C CN 1173729C CN B021157340 A CNB021157340 A CN B021157340A CN 02115734 A CN02115734 A CN 02115734A CN 1173729 C CN1173729 C CN 1173729C
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Abstract
The present invention relates to nano alose whose particle diameter is from 1 to 700 nanometers. The nano alose has the preparation method that aloe leaves are used for pulverization and ultra-fine treatment on processed material particles through the cavatition of a high-frequency supersonic wave field in a high-pressure homogenizer, and the jet velocity of 200 m/s to 600 m/s for an instant is generated under a high pressure of 10Mpa to 300Mpa so as to crack the material particles by the cavatition of the material particles and form nano particles of 1 nm to 100 nm in size. Compared with common alose, the nano alose has the function for resisting bacteria and fungi, which is improved by 3 to 5 times; the nano alose also has the functions for treating disease comprising wound infection, female vagina infection, tinea corporis, tinea cruris, tinea pedis, comedo, acne, etc., killing bacteria, preventing corrosion, etc. In addition, the nano alose can rapidly penetrate into the skin to inhibit the formation of melanin, achieve the purposes of skin whitening and speckle removing, increase the elasticity of skin and make the skin smooth and fine. The nano alose has the advantages of no stimulation, no toxic action, no harm and no side effect after being used.
Description
Technical field
The present invention relates to a kind of aloe products and preparation method thereof.
Background technology
Aloe is an a kind of perennial meat section herbaceous plant, and the laudatory title of " first aid plant ", " noiseless doctor ", " ten thousand answer good medicine ", " rare treasures " is just arranged since ancient times, and magical function is arranged at aspects such as medicine, health care, beauty treatments.In recent years aloetic pharmacological research there has been bigger progress, functions such as aloetic medical treatment, health care, beauty treatment have been proved absolutely, think that Aloe has effects such as anti-inflammation, treatment acne, acne, whitening and speckle dispelling, constipation and hemorrhoid also there is special curative effect, the fresh juice of normal directly use Aloe among the people, but easily cause allergic reaction.Multiple external and aloe products for oral administration are also arranged at present, but because aloetic active ingredient dissolution rate particularly water-insoluble and slightly solubility solid content matter is not high, and influenced its result of use.
Summary of the invention
The present invention provides a kind of aloe products and preparation method thereof at the problems referred to above exactly, and the active ingredient of gained aloe products dissolution rate particularly water-insoluble and slightly solubility solid content matter is higher, thereby its result of use is better.
Technical scheme provided by the invention is: a kind of aloe products, its particle diameter are 1～700 nanometer.
In the above-mentioned aloe products, also can contain 0.05%～2.0% antioxidant and/or 0.05%～0.5% antiseptic.
The preparation method of above-mentioned aloe products, inside gelling behind Folium Aloe or the removal leaf skin is handled 5min～30min through refiner or homogenizer under 1000rpm～10000rpm rotating speed, then in high pressure homogenisers, under 10Mpa～300Mpa high pressure, produce the moment effluxvelocity of 200m/s～600m/s, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1nm～700nm size.
Form Aloe and can add 0.05%～2.0% antioxidant and/or 0.05%～0.5% antiseptic before or after the nanoparticle.
Above-mentioned aloe products can be used for treating wound infection, woman vagina infection, tinea corporis, tinea cruris, tinea pedis, acne, acne and other diseases and be used for whitening and speckle dispelling, sterilization is anticorrosion etc.
Comparing its active ingredient solid content matter dissolution rate particularly water-insoluble and slightly solubility with common Aloe by gained aloe products of the present invention increases, make script only partly discharge the composition that maybe can't discharge and be able to sufficient release, the miscible effect of volatilization wet goods composition and water improves, stability strengthens, and specific surface area increases, viscosity changes, adhesion strength increases, absorbability improves.In addition, Aloe in the easier infiltration thalline and obviously improve antibacterial effect, increases the absorption of skin to effective ingredient in the Aloe simultaneously behind nanorize.Aloe products is compared with common Aloe, and antibiotic, antifungic action strengthens 3-5 doubly, has treatment wound infection, woman vagina infection, tinea corporis, tinea cruris, tinea pedis, acne, acne and other diseases and sterilizes purposes such as anticorrosion; And can infiltrate skin rapidly, suppress the purpose that melanic formation reaches whitening and speckle dispelling.In addition, can also increase skin elasticity, make the skin smooth exquisiteness, use the back non-stimulated, nontoxic, harmless, without any side effects.
The specific embodiment
Embodiment 1: the inside gelling behind clean Folium Aloe or the removal leaf skin is handled 5min～30min through refiner or homogenizer under 1000rpm～10000rpm rotating speed, then in high pressure homogenisers, under 10Mpa～300Mpa high pressure, produce moment effluxvelocity 200m/s～600m/s speed, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, the nanoparticle that forms 1nm～700nm size promptly gets required aloe products.
Embodiment 2: one or more in the result of embodiment 1 among the antioxidant of adding requirement such as sodium sulfate, sodium sulfite or sodium pyrosulfite and/or antiseptic Nipagin ester, Dowicol 2000, EDTA, the KathonCG etc.
Embodiment 3: adopt more than 3 years the leaf age Aloe as the results object, remove foul and damaged part after clear water cleans, be soaked in the disinfectant solution such as containing 50～500mg/L effective chlorine, available iodine or hydrogen peroxide soaking disinfection and handled in 30 minutes～24 hours, the inside gelling after adopting aloe full leaf or removing the leaf skin.With cutting knife it is processed into below 2 centimetres the block of size, (rotating speed is that 1000rpm～10000rpm) handles 5min～30min with refiner or homogenizer then.Add 0.05%～2.0% sodium sulfite, sodium sulfite or sodium pyrosulfite by process object weight and prevent oxidation deterioration, in adding 0.05%～0.5% Nipagin ester, Dowicol 2000, E D T A, KathonCG or other composition one or more prevent putrid and deteriorated.
Under 10Mpa～300Mpa high pressure, produce moment effluxvelocity 200m/s～600m/s speed, make material particles produce cavitation and make its cracking, promote the increase of amorphous particle ratio in the suspension or become amorphous particle fully, form the nanoparticle of 1nm～100nm size, get the composite aloe nano suspending liquid.
The present invention can by control above-mentioned high pressure range, and then control moment effluxvelocity (pressure is high more, moment effluxvelocity big more, then particle diameter is more little), the particle diameter that makes aloe products is in 1～100 nanometer.
Below be aloetic antibacterial experiment data of gained of the present invention and vaginal mucomembranous irritant test, eye irritant test, chmice acute per os toxicity test result.
The antibacterial experiment data:
Antimicrobial spectrum and antibacterial effect
MIC handled back MIC before the test bacterium was handled
Corynebacterium acnes 7 23
Staphylococcus aureus 16 50
Pyogenesis bacillus 8 15
Hemolytic streptococcus 5 15
Escherichia coli 12 45
Aerogenesis klebsiella 6 35
Alcaligenes faecalis 6 30
Cloaca 6 25
Aspergillus niger 58
Aspergillus fumigatus 5 10
White silk ferment 6 12
Acrothesium floccosum 6 11
Trichophyton mentagrophytes 6 15
Above-mentioned MIC unit is mm, and the antibacterial ring of negative control group is 5mm.
Vaginal mucomembranous irritant test:
By the 3.8th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Choose 12 of healthy White Rabbits, be divided into contamination group, vehicle group and blank group, 4 of every treated animals.The contamination group: the long roundlet cotton sliver of 2.0cm that will scribble test specimen stock solution of the present invention is inserted the experimental animal intravaginal; Vehicle group: soak with sterile saline with onesize cotton sliver, insert the animal intravaginal.Remove after 4 hours and tried thing.Put to death animal after 24 hours, take out local vagina tissue, observation has or not phenomenons such as hyperemia, edema.The result shows that in the observation period, erythema or edema symptom all do not appear in test group, vehicle group, the local vagina tissue of blank treated animal, and the irritant reaction integral mean value is 0.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is to rabbit vagina mucosa nonirritant.
Eye irritant test:
By the 3.7th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Choose 4 of healthy White Rabbits, test specimen stock solution 1-2 of the present invention is splashed in the eye conjunctival sac of White Rabbit left side, make passive closed 4 seconds of eye immediately, used normal saline flushing then 5 minutes.Right eye compares, and splashes into the equivalent normal saline.Behind eye drip 6,24,48 hours, 4 days with 7 days, observe the damage and the recovery situation of rabbit conjunctival, iris and cornea.The result shows, award medicine after, test group animal eye conjunctiva, iris and cornea all do not show irritation, stimulation index integration peak is 0.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is to the lagophthalmos nonirritant.
Chmice acute per os toxicity test result:
By the 3.4th carrying out in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11).
Experimental animal: 50 of kunming mices, body weight 18-22 gram, male and female half and half; The quality certification number: the moving word of doctor 19-082 number is provided by Hubei Province's medical experiment animal center.Viewing duration, each dosage group (1250,2500,5000,10000mg/kg) animal does not show obvious poisoning symptom, no animal dead, decidable test specimen stock solution of the present invention is to kunming mice acute oral LD
50Greater than 5000mg/kg.Judge that according to relevant criterion in " disinfection technology standard " (third edition) first fascicle " experimental technique standard " (Ministry of Public Health, 1999.11) the present invention is actual nontoxic.
Show that more than gained aloe products of the present invention compares with common Aloe, antibiotic, antifungic action strengthens greatly, and non-stimulated, nontoxic, harmless, have no side effect.
Claims (5)
1. aloe products, it is characterized in that: its particle diameter is 1～700 nanometer.
2. aloe products according to claim 1 is characterized in that: its particle diameter is 1～100 nanometer.
3. aloe products according to claim 1 and 2 is characterized in that: contain 0.05%～2.0% antioxidant and/or 0.05%～0.5% antiseptic.
4. the preparation method of the described aloe products of claim 1, inside gelling behind Folium Aloe or the removal leaf skin is handled 5min～30min through refiner or homogenizer under 1000rpm～10000rpm rotating speed, then in high pressure homogenisers, under 10Mpa～300Mpa high pressure, produce the moment effluxvelocity of 200m/s～600m/s, form the nanoparticle of 1nm～700nm size.
5. preparation method according to claim 4 is characterized in that: form Aloe and add 0.05%～2.0% antioxidant and/or 0.05%～0.5% antiseptic before or after the nanoparticle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021157340A CN1173729C (en) | 2002-04-22 | 2002-04-22 | Nano aloe and its preparing method and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021157340A CN1173729C (en) | 2002-04-22 | 2002-04-22 | Nano aloe and its preparing method and use |
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| Publication Number | Publication Date |
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| CN1377699A CN1377699A (en) | 2002-11-06 |
| CN1173729C true CN1173729C (en) | 2004-11-03 |
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| CNB021157340A Expired - Fee Related CN1173729C (en) | 2002-04-22 | 2002-04-22 | Nano aloe and its preparing method and use |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374629C (en) * | 2002-12-18 | 2008-03-12 | 香港理工大学 | Method for pulverizing natural organic matter into nano-grade fiber material |
| CN101912516A (en) * | 2010-08-11 | 2010-12-15 | 哈尔滨大洋制药股份有限公司 | Chinese patent medicament for treating skin infection |
| CN113398045A (en) * | 2021-06-25 | 2021-09-17 | 广州环亚化妆品科技有限公司 | Anti-aging and relieving aloe fermented product and preparation method and application thereof |
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