CN102302416B - 一种辅酶q-10/egf脂质体、制备方法和应用 - Google Patents
一种辅酶q-10/egf脂质体、制备方法和应用 Download PDFInfo
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- CN102302416B CN102302416B CN 201110247855 CN201110247855A CN102302416B CN 102302416 B CN102302416 B CN 102302416B CN 201110247855 CN201110247855 CN 201110247855 CN 201110247855 A CN201110247855 A CN 201110247855A CN 102302416 B CN102302416 B CN 102302416B
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- coenzyme
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 88
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 45
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 24
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 8
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- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
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CN 201110247855 CN102302416B (zh) | 2011-08-26 | 2011-08-26 | 一种辅酶q-10/egf脂质体、制备方法和应用 |
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Families Citing this family (10)
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CN102949345A (zh) * | 2012-06-15 | 2013-03-06 | 深圳职业技术学院 | 重组人表皮生长因子阳离子脂质体及其制备方法 |
CN103463627B (zh) * | 2013-09-11 | 2015-11-25 | 拉芳家化股份有限公司 | 一种含耐热超氧化物歧化酶和生长因子的口腔护理组合物 |
CN103505403B (zh) * | 2013-09-29 | 2015-08-19 | 广州市娇兰化妆品有限公司 | 表皮生长因子复合物脂质体及其制备方法和应用 |
CN107684561A (zh) * | 2016-08-05 | 2018-02-13 | 上海宣泰生物科技有限公司 | 辅酶q10营养组合物及其应用 |
CN110201147A (zh) * | 2019-05-23 | 2019-09-06 | 中山市粤美医疗生物科技有限公司 | 一种包含肽的组合物及其制备方法 |
CN110742818A (zh) * | 2019-09-17 | 2020-02-04 | 广东润和生物科技有限公司 | 一种抗紫外线损伤的辅酶q10脂质体的制备方法 |
CN112156030A (zh) * | 2020-10-19 | 2021-01-01 | 中国药科大学 | 一种含有辅酶q10脂质体的精华液及其制备方法 |
CN114569500B (zh) * | 2021-11-15 | 2023-09-05 | 广州中康医药科技有限公司 | 一种含纳米级辅酶q的组合物及其制备方法 |
CN114159332B (zh) * | 2021-11-24 | 2023-11-10 | 北京理智之美科技有限公司 | 一种脂质体组合物及其制备方法 |
CN116196237B (zh) * | 2023-05-04 | 2023-07-28 | 山东博科医用材料有限公司 | 一种抗氧化的缓释酶制剂 |
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CN1823748B (zh) * | 2005-12-29 | 2011-07-27 | 沈阳药科大学 | 辅酶q10脂质体的药物制剂及其制备工艺 |
CU23411B6 (es) * | 2005-12-29 | 2009-09-08 | Ct Ingenieria Genetica Biotech | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
KR100768151B1 (ko) * | 2006-04-10 | 2007-10-17 | 주식회사 대웅 | 에스터화 레시딘을 이용한 나노리포좀 |
JP2009234945A (ja) * | 2008-03-26 | 2009-10-15 | Shalom:Kk | h−EGF含有スフィンゴミエリンリポソームおよびこれを配合した化粧料及び医薬品 |
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Address after: 510530 Guangdong high tech Industrial Development Zone, Guangzhou City, Guangzhou, Guangdong Patentee after: Guangdong Marubi Biological Technology Co., Ltd. Address before: Two Tianhe District Lu Ke Mu Lang Cun Shahe town Guangzhou City, Guangdong province 510095 Guangshan No. 96-98 Patentee before: Guangdong Marubi Biological Technology Co., Ltd. |
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Application publication date: 20120104 Assignee: Guangzhou pill Biotechnology Co., Ltd. Assignor: Guangdong Marubi Biological Technology Co., Ltd. Contract record no.: 2018440000016 Denomination of invention: A coenzyme Q-10/EGF liposome preparation method and Application Granted publication date: 20121205 License type: Common License Record date: 20180212 |