CN102271634B - 即用型经干燥和经辐照的皮肤等同物 - Google Patents

即用型经干燥和经辐照的皮肤等同物 Download PDF

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Publication number
CN102271634B
CN102271634B CN200980154244.2A CN200980154244A CN102271634B CN 102271634 B CN102271634 B CN 102271634B CN 200980154244 A CN200980154244 A CN 200980154244A CN 102271634 B CN102271634 B CN 102271634B
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CN
China
Prior art keywords
skin equivalent
skin
tissue
compositions
irradiated
Prior art date
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Active
Application number
CN200980154244.2A
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English (en)
Chinese (zh)
Other versions
CN102271634A (zh
Inventor
A·R·科默
B·L·艾伦-霍夫曼
B·施泰格利茨
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Stratatech Corp
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Stratatech Corp
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Publication of CN102271634A publication Critical patent/CN102271634A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
CN200980154244.2A 2008-11-04 2009-11-04 即用型经干燥和经辐照的皮肤等同物 Active CN102271634B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11115308P 2008-11-04 2008-11-04
US61/111,153 2008-11-04
US61/111153 2008-11-04
PCT/US2009/063217 WO2010053948A1 (en) 2008-11-04 2009-11-04 Dried and irradiated skin equivalents for ready use

Publications (2)

Publication Number Publication Date
CN102271634A CN102271634A (zh) 2011-12-07
CN102271634B true CN102271634B (zh) 2015-01-14

Family

ID=42153209

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980154244.2A Active CN102271634B (zh) 2008-11-04 2009-11-04 即用型经干燥和经辐照的皮肤等同物

Country Status (10)

Country Link
US (5) US8580314B2 (https=)
EP (1) EP2352472B1 (https=)
JP (2) JP5632383B2 (https=)
CN (1) CN102271634B (https=)
AU (1) AU2009313656B2 (https=)
CA (1) CA2742595C (https=)
DK (1) DK2352472T3 (https=)
ES (1) ES2621324T3 (https=)
PT (1) PT2352472T (https=)
WO (1) WO2010053948A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065005A1 (en) 2007-11-14 2009-05-22 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
PT2352472T (pt) 2008-11-04 2017-04-11 Stratatech Corp Equivalentes de pele secos e irradiados prontos a utilizar
WO2010135655A2 (en) 2009-05-21 2010-11-25 Stratatech Corporation Human skin substitutes expressing il-12
CA3071928A1 (en) * 2013-03-13 2014-10-02 Stratatech Corporation Cryopreservation of viable human skin substitutes
KR101701396B1 (ko) 2014-10-28 2017-02-01 주식회사 엑티저 오디오 신호 처리 장치 및 방법
US20220287298A1 (en) * 2017-01-27 2022-09-15 Stratatech Corporation Tissue container systems
EP4034038A4 (en) * 2019-09-27 2023-11-01 Stratatech Corporation METHODS OF TREATING ACUTE WOUNDS AND IMPROVING RESULTS
WO2021231775A1 (en) * 2020-05-13 2021-11-18 Stratatech Copporation Viable bioengineered skin constructs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050186185A1 (en) * 2003-05-30 2005-08-25 Paul Conrad Room temperature storage of organs
CN1800372A (zh) * 2005-12-02 2006-07-12 王平安 组织工程化细胞外基质的制备方法
US20080145344A1 (en) * 2002-10-18 2008-06-19 Reliance Life Sciences Pvt. Ltd. Three-dimensional tissue equivalent using macromass culture

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US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
RU2135191C1 (ru) 1990-04-24 1999-08-27 Ортек Интернэшнл, Инк. Композиционный эквивалент живой кожи, способ его получения, тест-набор
US6585969B1 (en) 1991-11-20 2003-07-01 N. V. Innogenetics S.A. Non-viable keratinocyte cell composition or lysate for promoting wound healing
ES2149779T3 (es) 1991-11-20 2000-11-16 Innogenetics Nv Lisados derivados de queratinocitos para utilizacion como substancias cicatrizantes.
JPH10509610A (ja) * 1994-11-09 1998-09-22 クリ・ハークチ，ワリド 創傷修復用包帯およびそれらの保存法
US5693332C1 (en) 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
JP3377354B2 (ja) * 1995-12-25 2003-02-17 株式会社メニコン 人工皮膚
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US5989837A (en) 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
DE60027724T2 (de) 1999-07-20 2007-03-01 DFB Pharmaceuticals, Inc., Fort Worth Verbesserte keratinozytenkultur und deren verwendungen
US6866686B2 (en) * 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
US6974697B2 (en) 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
EP1404809B1 (en) 2001-03-02 2013-12-11 Stratatech Corporation Improved skin substitutes and uses thereof
EP1549738B1 (en) 2002-04-30 2010-04-21 Stratatech Corporation Keratinocytes expressing exogenous angiogenic growth factors
EP1546392A4 (en) 2002-08-02 2006-05-24 Stratatech Corp DETECTION OF SPECIFIC DNA FROM SPECIES
CA2534349C (en) * 2003-08-01 2012-04-10 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
CA2758178C (en) 2003-08-01 2016-10-11 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
US8765169B2 (en) * 2004-02-13 2014-07-01 Smith & Nephew, Inc. Wound healing profile
WO2006055931A2 (en) 2004-11-18 2006-05-26 Stratatech Corporation Vectors for stable gene expression
JP4993752B2 (ja) 2005-03-01 2012-08-08 ストラタテック コーポレーション 外因性ポリペプチドを発現するヒト皮膚同等物
JP2008532550A (ja) 2005-03-17 2008-08-21 ストラタテック コーポレーション 純度が改良された代用皮膚
WO2009065005A1 (en) 2007-11-14 2009-05-22 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
PT2352472T (pt) 2008-11-04 2017-04-11 Stratatech Corp Equivalentes de pele secos e irradiados prontos a utilizar
WO2010135655A2 (en) 2009-05-21 2010-11-25 Stratatech Corporation Human skin substitutes expressing il-12

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080145344A1 (en) * 2002-10-18 2008-06-19 Reliance Life Sciences Pvt. Ltd. Three-dimensional tissue equivalent using macromass culture
US20050186185A1 (en) * 2003-05-30 2005-08-25 Paul Conrad Room temperature storage of organs
CN1800372A (zh) * 2005-12-02 2006-07-12 王平安 组织工程化细胞外基质的制备方法

Also Published As

Publication number Publication date
CA2742595A1 (en) 2010-05-14
US9526811B2 (en) 2016-12-27
US8685463B2 (en) 2014-04-01
AU2009313656B2 (en) 2014-02-20
PT2352472T (pt) 2017-04-11
EP2352472A1 (en) 2011-08-10
US9867904B2 (en) 2018-01-16
EP2352472B1 (en) 2017-01-04
US20150196686A1 (en) 2015-07-16
CA2742595C (en) 2014-04-01
ES2621324T3 (es) 2017-07-03
JP2012508064A (ja) 2012-04-05
AU2009313656A1 (en) 2010-05-14
CN102271634A (zh) 2011-12-07
JP2014221417A (ja) 2014-11-27
US20140288165A1 (en) 2014-09-25
WO2010053948A1 (en) 2010-05-14
US20170087276A1 (en) 2017-03-30
US8580314B2 (en) 2013-11-12
DK2352472T3 (en) 2017-04-10
EP2352472A4 (en) 2014-03-05
US20100119615A1 (en) 2010-05-13
JP5632383B2 (ja) 2014-11-26
US8992997B2 (en) 2015-03-31
US20140067064A1 (en) 2014-03-06

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